Published in Elife on October 18, 2016
Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol (2009) 13.01
SNAREs--engines for membrane fusion. Nat Rev Mol Cell Biol (2006) 12.74
Membrane fusion: grappling with SNARE and SM proteins. Science (2009) 8.98
The Golgi apparatus (complex)-(1954-1981)-from artifact to center stage. J Cell Biol (1981) 6.54
Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle. Dev Cell (2007) 4.26
The proprotein convertases. Curr Opin Chem Biol (1998) 3.79
Insulin gene mutations as a cause of permanent neonatal diabetes. Proc Natl Acad Sci U S A (2007) 3.77
Transport-vesicle targeting: tethers before SNAREs. Nat Cell Biol (1999) 3.55
Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion. Diabetologia (2010) 3.48
Visualization of acidic organelles in intact cells by electron microscopy. Proc Natl Acad Sci U S A (1984) 3.09
Organellar relationships in the Golgi region of the pancreatic beta cell line, HIT-T15, visualized by high resolution electron tomography. Proc Natl Acad Sci U S A (2001) 2.77
Sorting and storage during secretory granule biogenesis: looking backward and looking forward. Biochem J (1998) 2.61
RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J Biol Chem (2005) 2.32
A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1. Cell (2009) 2.24
Tethering factors as organizers of intracellular vesicular traffic. Annu Rev Cell Dev Biol (2010) 2.21
The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged? Annu Rev Cell Dev Biol (2012) 2.19
Membrane fusion: five lipids, four SNAREs, three chaperones, two nucleotides, and a Rab, all dancing in a ring on yeast vacuoles. Annu Rev Cell Dev Biol (2010) 2.13
Cell-free protein sorting to the regulated and constitutive secretory pathways. Cell (1990) 2.12
Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles. J Cell Biol (1986) 2.06
Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex. Nat Struct Mol Biol (2011) 1.95
Mechanisms of pH regulation in the regulated secretory pathway. J Biol Chem (2001) 1.87
Characterization of the immature secretory granule, an intermediate in granule biogenesis. J Cell Biol (1991) 1.87
Commensal bacteria direct selective cargo sorting to promote symbiosis. Nat Immunol (2015) 1.84
Secretory granule biogenesis: rafting to the SNARE. Trends Cell Biol (2001) 1.73
Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3. Proc Natl Acad Sci U S A (2002) 1.73
Function, structure and regulation of the vacuolar (H+)-ATPases. Arch Biochem Biophys (2008) 1.68
Sorting and processing of secretory proteins. Biochem J (1994) 1.65
Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3. Proc Natl Acad Sci U S A (1992) 1.65
Expedited approaches to whole cell electron tomography and organelle mark-up in situ in high-pressure frozen pancreatic islets. J Struct Biol (2007) 1.64
Dense-core secretory granule biogenesis. Physiology (Bethesda) (2006) 1.62
Homotypic fusion of early endosomes: SNAREs do not determine fusion specificity. Proc Natl Acad Sci U S A (2006) 1.59
Counting Synapses Using FIB/SEM Microscopy: A True Revolution for Ultrastructural Volume Reconstruction. Front Neuroanat (2009) 1.54
Homotypic fusion of immature secretory granules during maturation requires syntaxin 6. Mol Biol Cell (2001) 1.52
Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2. J Biol Chem (1998) 1.51
The insulin secretory granule. Diabetologia (1989) 1.42
PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance. PLoS Biol (2013) 1.41
Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth. Trends Endocrinol Metab (2010) 1.33
PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance. PLoS Biol (2013) 1.31
Ion channels in secretory granules of the pancreas and their role in exocytosis and release of secretory proteins. Am J Physiol Cell Physiol (2002) 1.19
Isolation and characterization of high-temperature-induced Dauer formation mutants in Caenorhabditis elegans. Genetics (2003) 1.16
Sorting ourselves out: seeking consensus on trafficking in the beta-cell. Traffic (2004) 1.14
Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cells. J Cell Biol (2006) 1.13
High resolution analysis of the secretory pathway in mammotrophs of the rat anterior pituitary. J Cell Biol (1981) 1.13
The family of pro-hormone and pro-protein convertases. Biochem Soc Trans (1993) 1.12
Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2. J Cell Biol (2009) 1.11
Protein discharge from immature secretory granules displays both regulated and constitutive characteristics. J Biol Chem (1991) 1.08
Homotypic fusion of immature secretory granules during maturation in a cell-free assay. J Cell Biol (1998) 1.08
Lysosome function in the regulation of the secretory process in cells of the anterior pituitary gland. J Cell Biol (1966) 1.07
Large dense-core vesicle exocytosis in pancreatic beta-cells monitored by capacitance measurements. Methods (2004) 1.07
Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic beta-cells. Hum Mol Genet (2011) 1.06
Munc13-1 is required for the sustained release of insulin from pancreatic beta cells. Cell Metab (2006) 1.06
Studies on the molecular organization of rat insulin secretory granules. J Biol Chem (1987) 1.04
Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate. Proc Natl Acad Sci U S A (2008) 1.03
Syntaxin-6 SNARE involvement in secretory and endocytic pathways of cultured pancreatic beta-cells. Mol Biol Cell (2004) 1.03
Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming. Nat Struct Mol Biol (2015) 1.02
Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population. Mol Biol Rep (2011) 1.01
pH-independent and -dependent cleavage of proinsulin in the same secretory vesicle. J Cell Biol (1994) 0.97
Direct measurement of plasma proinsulin in normal and diabetic subjects. Am J Med (1972) 0.96
HID-1, a new component of the peptidergic signaling pathway. Genetics (2010) 0.91
Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway. Dev Cell (2013) 0.90
The proteolytic maturation of prohormone convertase 2 (PC2) is a pH-driven process. Arch Biochem Biophys (1999) 0.90
Cocrystallization of proinsulin and insulin. Nature (1973) 0.89
Intact and total proinsulin: new aspects for diagnosis and treatment of type 2 diabetes mellitus and insulin resistance. Clin Lab (2004) 0.87
A unique ball-shaped Golgi apparatus in the rat pituitary gonadotrope: its functional implications in relation to the arrangement of the microtubule network. J Histochem Cytochem (2012) 0.84
HID-1 is a novel player in the regulation of neuropeptide sorting. Biochem J (2011) 0.84
Two Rab2 interactors regulate dense-core vesicle maturation. Neuron (2014) 0.84
Proinsulin: biosynthesis, conversion, assay methods and clinical studies. Clin Biochem (1991) 0.83
Maturation of secretory granules. Results Probl Cell Differ (2010) 0.83
HID-1 is a peripheral membrane protein primarily associated with the medial- and trans- Golgi apparatus. Protein Cell (2011) 0.82
Defective goblet cell exocytosis contributes to murine cystic fibrosis-associated intestinal disease. J Clin Invest (2015) 0.81
The association between impaired proinsulin processing and type 2 diabetes mellitus in non-obese Japanese individuals. Endocr J (2015) 0.79
Some aspects of the morphology of insulin-secreting cells. Acta Histochem (1976) 0.78
Differential kinetics of rat insulin I and II processing in rat islets of Langerhans. FEBS Lett (1987) 0.78
An efficient two-step subcellular fractionation method for the enrichment of insulin granules from INS-1 cells. Biophys Rep (2015) 0.76
Three-dimensional shape of the Golgi apparatus in different cell types: serial section scanning electron microscopy of the osmium-impregnated Golgi apparatus. Microscopy (Oxf) (2015) 0.76
The stealthy nano-machine behind mast cell granule size distribution. Mol Immunol (2014) 0.76