Sindbis virus nucleocapsid assembly: RNA folding promotes capsid protein dimerization.

PubWeight™: 0.95‹?› | Rank: Top 15%

🔗 View Article (PMC 1370524)

Published in RNA on January 01, 2004

Authors

Benjamin R Linger1, Lyudmyla Kunovska, Richard J Kuhn, Barbara L Golden

Author Affiliations

1: Department of Biochemistry and Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA.

Articles citing this

A structural and functional perspective of alphavirus replication and assembly. Future Microbiol (2009) 1.72

Cis-acting RNA elements in human and animal plus-strand RNA viruses. Biochim Biophys Acta (2009) 1.67

Capsid protein of eastern equine encephalitis virus inhibits host cell gene expression. J Virol (2007) 1.35

Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization. Elife (2013) 1.10

Alphavirus capsid protein helix I controls a checkpoint in nucleocapsid core assembly. J Virol (2006) 1.01

Role of sindbis virus capsid protein region II in nucleocapsid core assembly and encapsidation of genomic RNA. J Virol (2008) 0.98

Self-assembly approaches to nanomaterial encapsulation in viral protein cages. J Mater Chem (2008) 0.95

A novel coding-region RNA element modulates infectious dengue virus particle production in both mammalian and mosquito cells and regulates viral replication in Aedes aegypti mosquitoes. Virology (2012) 0.94

A five-amino-acid deletion of the eastern equine encephalitis virus capsid protein attenuates replication in mammalian systems but not in mosquito cells. J Virol (2008) 0.92

Interactions of the cytoplasmic domain of Sindbis virus E2 with nucleocapsid cores promote alphavirus budding. J Virol (2011) 0.90

Bovine viral diarrhea virus core is an intrinsically disordered protein that binds RNA. J Virol (2007) 0.87

Probing the early temporal and spatial interaction of the Sindbis virus capsid and E2 proteins with reverse genetics. J Virol (2012) 0.78

Dominance effects of deleterious and beneficial mutations in a single gene of the RNA virus ϕ6. PLoS One (2014) 0.77

A novel system for visualizing alphavirus assembly. J Virol Methods (2015) 0.75

Identification of Interactions between Sindbis Virus Capsid Protein and Cytoplasmic vRNA as Novel Virulence Determinants. PLoS Pathog (2017) 0.75

Articles cited by this

Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res (2003) 77.89

Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates. Nucleic Acids Res (1987) 25.34

The alphaviruses: gene expression, replication, and evolution. Microbiol Rev (1994) 16.68

Crystal structure of a group I ribozyme domain: principles of RNA packing. Science (1996) 13.99

The kink-turn: a new RNA secondary structure motif. EMBO J (2001) 8.58

Three-dimensional structure of a hammerhead ribozyme. Nature (1994) 7.14

Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast. Mol Cell (2000) 6.39

The crystal structure of an all-RNA hammerhead ribozyme: a proposed mechanism for RNA catalytic cleavage. Cell (1995) 4.79

Structure of the HIV-1 nucleocapsid protein bound to the SL3 psi-RNA recognition element. Science (1998) 4.52

Structure of Sindbis virus core protein reveals a chymotrypsin-like serine proteinase and the organization of the virion. Nature (1991) 4.24

The human immunodeficiency virus type 1 encapsidation site is a multipartite RNA element composed of functional hairpin structures. J Virol (1996) 3.91

Crystal structure of an RNA bacteriophage coat protein-operator complex. Nature (1994) 3.65

Placement of the structural proteins in Sindbis virus. J Virol (2002) 2.81

Deletion analysis of the capsid protein of Sindbis virus: identification of the RNA binding region. J Virol (1993) 2.03

Identification of a region in the Sindbis virus nucleocapsid protein that is involved in specificity of RNA encapsidation. J Virol (1996) 1.96

Specific binding of a basic peptide from HIV-1 Rev. EMBO J (1992) 1.84

The major human immunodeficiency virus type 2 (HIV-2) packaging signal is present on all HIV-2 RNA species: cotranslational RNA encapsidation and limitation of Gag protein confer specificity. J Virol (2001) 1.79

Interactions between Sindbis virus RNAs and a 68 amino acid derivative of the viral capsid protein further defines the capsid binding site. Nucleic Acids Res (1994) 1.70

Cooperation of an RNA packaging signal and a viral envelope protein in coronavirus RNA packaging. J Virol (2001) 1.56

In vitro assembly of alphavirus cores by using nucleocapsid protein expressed in Escherichia coli. J Virol (1999) 1.54

Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures. J Mol Biol (1993) 1.49

cis-Acting signals in encapsidation of Hantaan virus S-segment viral genomic RNA by its N protein. J Virol (2001) 1.48

Alphavirus nucleocapsid protein contains a putative coiled coil alpha-helix important for core assembly. J Virol (2001) 1.46

Specific RNA binding by amino-terminal peptides of alfalfa mosaic virus coat protein. EMBO J (1994) 1.44

The RNA binding domain of the hantaan virus N protein maps to a central, conserved region. J Virol (2002) 1.40

The packaging signal of influenza viral RNA molecules. RNA (2001) 1.35

Interaction of the Bacillus stearothermophilus ribosomal protein S15 with 16 S rRNA: I. Defining the minimal RNA site. J Mol Biol (1996) 1.34

Nucleic acid-dependent cross-linking of the nucleocapsid protein of Sindbis virus. J Virol (2000) 1.25

Structural analysis of Sindbis virus capsid mutants involving assembly and catalysis. J Mol Biol (1996) 1.16

In vitro assembly of Sindbis virus core-like particles from cross-linked dimers of truncated and mutant capsid proteins. J Virol (2001) 1.13

Secondary structure analysis of a minimal avian leukosis-sarcoma virus packaging signal. J Virol (2000) 1.12

Identification of a bovine coronavirus packaging signal. J Virol (2000) 1.09

In vitro-assembled alphavirus core-like particles maintain a structure similar to that of nucleocapsid cores in mature virus. J Virol (2002) 1.06

cis-Acting elements important for retroviral RNA packaging specificity. J Virol (2002) 0.92

Genetic and biochemical studies on the assembly of an enveloped virus. Genet Eng (N Y) (2001) 0.90

Articles by these authors

A structural perspective of the flavivirus life cycle. Nat Rev Microbiol (2005) 5.02

Visualization of membrane protein domains by cryo-electron microscopy of dengue virus. Nat Struct Biol (2003) 4.11

Structure of the immature dengue virus at low pH primes proteolytic maturation. Science (2008) 3.86

Conformational changes of the flavivirus E glycoprotein. Structure (2004) 3.66

Structures of immature flavivirus particles. EMBO J (2003) 3.62

Structure of West Nile virus. Science (2003) 3.48

Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins. Nat Struct Mol Biol (2008) 3.27

The flavivirus precursor membrane-envelope protein complex: structure and maturation. Science (2008) 3.26

Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis. Proc Natl Acad Sci U S A (2010) 2.97

Placement of the structural proteins in Sindbis virus. J Virol (2002) 2.81

Structural changes of envelope proteins during alphavirus fusion. Nature (2010) 2.32

Picornavirus-receptor interactions. Trends Microbiol (2002) 2.23

Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system. Science (2014) 2.16

Structural insights into the mechanisms of antibody-mediated neutralization of flavivirus infection: implications for vaccine development. Cell Host Microbe (2008) 2.16

Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN. Cell (2006) 2.08

The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation. Proc Natl Acad Sci U S A (2004) 2.05

Characterization of the early events in dengue virus cell entry by biochemical assays and single-virus tracking. J Virol (2007) 2.03

Structural basis for the preferential recognition of immature flaviviruses by a fusion-loop antibody. EMBO J (2009) 1.85

Solution structure of dengue virus capsid protein reveals another fold. Proc Natl Acad Sci U S A (2004) 1.85

West Nile virus in complex with the Fab fragment of a neutralizing monoclonal antibody. Proc Natl Acad Sci U S A (2006) 1.83

The crystal structure of coxsackievirus A21 and its interaction with ICAM-1. Structure (2005) 1.82

Crystal structure of human enterovirus 71. Science (2012) 1.79

Structure of immature West Nile virus. J Virol (2007) 1.77

Dengue structure differs at the temperatures of its human and mosquito hosts. Proc Natl Acad Sci U S A (2013) 1.75

A structural and functional perspective of alphavirus replication and assembly. Future Microbiol (2009) 1.72

Mapping the structure and function of the E1 and E2 glycoproteins in alphaviruses. Structure (2006) 1.68

Construction and applications of yellow fever virus replicons. Virology (2005) 1.66

Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing. J Virol (2005) 1.65

Yellow Fever virus NS3 plays an essential role in virus assembly independent of its known enzymatic functions. J Virol (2008) 1.59

Structural proteomics of dengue virus. Curr Opin Microbiol (2008) 1.57

Neutralization of West Nile virus by cross-linking of its surface proteins with Fab fragments of the human monoclonal antibody CR4354. Proc Natl Acad Sci U S A (2010) 1.57

Structure-guided insights on the role of NS1 in flavivirus infection. Bioessays (2015) 1.46

Dengue virus infection perturbs lipid homeostasis in infected mosquito cells. PLoS Pathog (2012) 1.45

Direct measurement of a pK(a) near neutrality for the catalytic cytosine in the genomic HDV ribozyme using Raman crystallography. J Am Chem Soc (2007) 1.43

Flavivirus capsid is a dimeric alpha-helical protein. J Virol (2003) 1.43

Influence of pr-M cleavage on the heterogeneity of extracellular dengue virus particles. J Virol (2010) 1.41

A 1.9 A crystal structure of the HDV ribozyme precleavage suggests both Lewis acid and general acid mechanisms contribute to phosphodiester cleavage. Biochemistry (2010) 1.39

Structure of a tyrosyl-tRNA synthetase splicing factor bound to a group I intron RNA. Nature (2008) 1.36

Complexes of poliovirus serotypes with their common cellular receptor, CD155. J Virol (2003) 1.31

Maturation of flaviviruses starts from one or more icosahedrally independent nucleation centres. EMBO Rep (2011) 1.31

Ultrastructural analysis of hepatitis C virus particles. Proc Natl Acad Sci U S A (2013) 1.29

Design, synthesis, and biological evaluation of antiviral agents targeting flavivirus envelope proteins. J Med Chem (2008) 1.28

Functional characterization of cis and trans activity of the Flavivirus NS2B-NS3 protease. J Biol Chem (2007) 1.25

Capturing a flavivirus pre-fusion intermediate. PLoS Pathog (2009) 1.24

Heparin binding sites on Ross River virus revealed by electron cryo-microscopy. Virology (2005) 1.18

Ultrastructural characterization and three-dimensional architecture of replication sites in dengue virus-infected mosquito cells. J Virol (2014) 1.17

Structure of decay-accelerating factor bound to echovirus 7: a virus-receptor complex. Proc Natl Acad Sci U S A (2002) 1.17

A catalytic metal ion interacts with the cleavage Site G.U wobble in the HDV ribozyme. Biochemistry (2009) 1.14

Catalytic core of alphavirus nonstructural protein nsP4 possesses terminal adenylyltransferase activity. J Virol (2006) 1.13

Closing the door on flaviviruses: entry as a target for antiviral drug design. Antiviral Res (2008) 1.09

Metal binding motif in the active site of the HDV ribozyme binds divalent and monovalent ions. Biochemistry (2011) 1.07

Raman crystallography of RNA. Methods (2009) 1.06

Antiviral compounds discovered by virtual screening of small-molecule libraries against dengue virus E protein. ACS Chem Biol (2008) 1.06

In vitro-assembled alphavirus core-like particles maintain a structure similar to that of nucleocapsid cores in mature virus. J Virol (2002) 1.06

Characterization of purified Sindbis virus nsP4 RNA-dependent RNA polymerase activity in vitro. Virology (2008) 1.05

The coiled-coil domain structure of the Sin Nombre virus nucleocapsid protein. J Mol Biol (2006) 1.04

Mechanistic strategies in the HDV ribozyme: chelated and diffuse metal ion interactions and active site protonation. J Phys Chem B (2011) 1.04

A physical interaction network of dengue virus and human proteins. Mol Cell Proteomics (2011) 1.03

Alphavirus capsid protein helix I controls a checkpoint in nucleocapsid core assembly. J Virol (2006) 1.01

Aura virus structure suggests that the T=4 organization is a fundamental property of viral structural proteins. J Virol (2002) 1.00

Detection of innersphere interactions between magnesium hydrate and the phosphate backbone of the HDV ribozyme using Raman crystallography. J Am Chem Soc (2008) 0.99

Role of sindbis virus capsid protein region II in nucleocapsid core assembly and encapsidation of genomic RNA. J Virol (2008) 0.98

Structure of human enterovirus 71 in complex with a capsid-binding inhibitor. Proc Natl Acad Sci U S A (2013) 0.98

Molecular links between the E2 envelope glycoprotein and nucleocapsid core in Sindbis virus. J Mol Biol (2011) 0.98

A heterologous coiled coil can substitute for helix I of the Sindbis virus capsid protein. J Virol (2003) 0.98

Thio effects and an unconventional metal ion rescue in the genomic hepatitis delta virus ribozyme. Biochemistry (2013) 0.97

Role for conserved residues of sindbis virus nonstructural protein 2 methyltransferase-like domain in regulation of minus-strand synthesis and development of cytopathic infection. J Virol (2008) 0.96

Functional requirements of the yellow fever virus capsid protein. J Virol (2007) 0.96

Identification of the catalytic Mg²⁺ ion in the hepatitis delta virus ribozyme. Biochemistry (2013) 0.95

Association of sindbis virus capsid protein with phospholipid membranes and the E2 glycoprotein: implications for alphavirus assembly. Biochemistry (2005) 0.93

Mechanistic characterization of the HDV genomic ribozyme: the cleavage site base pair plays a structural role in facilitating catalysis. RNA (2008) 0.92

An investigation of phenylthiazole antiflaviviral agents. Bioorg Med Chem (2011) 0.92

Cryo-electron tomography of rubella virus. J Virol (2012) 0.92

Competition between Co(NH(3)(6)3+ and inner sphere Mg2+ ions in the HDV ribozyme. Biochemistry (2009) 0.91

RNA molecules with conserved catalytic cores but variable peripheries fold along unique energetically optimized pathways. RNA (2011) 0.91

Interactions of the cytoplasmic domain of Sindbis virus E2 with nucleocapsid cores promote alphavirus budding. J Virol (2011) 0.90

Identification of inhibitors of yellow fever virus replication using a replicon-based high-throughput assay. Antimicrob Agents Chemother (2009) 0.88

Rescue of infectious particles from preassembled alphavirus nucleocapsid cores. J Virol (2011) 0.87

Loss of MLK3 signaling impedes ulcer healing by modulating MAPK signaling in mouse intestinal mucosa. Am J Physiol Gastrointest Liver Physiol (2012) 0.87

Design, synthesis, and biological evaluation of thiazoles targeting flavivirus envelope proteins. J Med Chem (2011) 0.86

Functional characterization of the alphavirus TF protein. J Virol (2013) 0.86

Structure determination of enterovirus 71. Acta Crystallogr D Biol Crystallogr (2012) 0.86

Regulation of epithelial differentiation in rat intestine by intraluminal delivery of an adenoviral vector or silencing RNA coding for Schlafen 3. PLoS One (2013) 0.85

Neutralizing antibodies can initiate genome release from human enterovirus 71. Proc Natl Acad Sci U S A (2014) 0.85

Capturing a virus while it catches its breath. Structure (2012) 0.85

Directed evolution of a virus exclusively utilizing human epidermal growth factor receptor as the entry receptor. J Virol (2013) 0.84

Novel approaches to flavivirus drug discovery. Expert Opin Drug Discov (2012) 0.83

Heterologous production, purification and characterization of enzymatically active Sindbis virus nonstructural protein nsP1. Protein Expr Purif (2011) 0.83

Functional characterization of the Sindbis virus E2 glycoprotein by transposon linker-insertion mutagenesis. Virology (2007) 0.83

Synthesis of dioxane-based antiviral agents and evaluation of their biological activities as inhibitors of Sindbis virus replication. Bioorg Med Chem (2007) 0.82

Membrane curvature in flaviviruses. J Struct Biol (2013) 0.82

Reactive oxygen species formation by UV-A irradiation of urocanic acid and the role of trace metals in this chemistry. Photochem Photobiol (2003) 0.81

PICKLE is a CHD subfamily II ATP-dependent chromatin remodeling factor. Biochim Biophys Acta (2012) 0.81

Design, expression, and purification of a Flaviviridae polymerase using a high-throughput approach to facilitate crystal structure determination. Protein Sci (2004) 0.80

Crystallization, high-resolution data collection and preliminary crystallographic analysis of Aura virus capsid protease and its complex with dioxane. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.79

Evolution of I-SceI homing endonucleases with increased DNA recognition site specificity. J Mol Biol (2010) 0.79

West Nile virus methyltransferase domain interacts with protein kinase G. Virol J (2013) 0.79

Probing the early temporal and spatial interaction of the Sindbis virus capsid and E2 proteins with reverse genetics. J Virol (2012) 0.78

Crystal structure of aura virus capsid protease and its complex with dioxane: new insights into capsid-glycoprotein molecular contacts. PLoS One (2012) 0.78