Published in Mol Immunol on January 01, 2004
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet (2008) 4.69
The role of complement in inflammatory diseases from behind the scenes into the spotlight. Am J Pathol (2007) 3.12
The role of the anaphylatoxins in health and disease. Mol Immunol (2009) 2.95
The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns. BMC Genomics (2007) 1.63
Complement System Part I - Molecular Mechanisms of Activation and Regulation. Front Immunol (2015) 1.52
Diverse range of small peptides associated with high-density lipoprotein. Biochem Biophys Res Commun (2005) 1.34
Complement System Part II: Role in Immunity. Front Immunol (2015) 1.31
Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1alpha in the circulation. Blood (2005) 1.27
Complement activation, regulation, and molecular basis for complement-related diseases. EMBO J (2015) 1.12
Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets. J Biol Chem (2008) 1.06
Structure and function of human plasma carboxypeptidase N, the anaphylatoxin inactivator. Int Immunopharmacol (2007) 1.05
Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a. Mol Immunol (2007) 1.01
Targeted disruption of the gene encoding the murine small subunit of carboxypeptidase N (CPN1) causes susceptibility to C5a anaphylatoxin-mediated shock. J Immunol (2009) 0.98
Proteolytic regulatory mechanism of chemerin bioactivity. Acta Biochim Biophys Sin (Shanghai) (2009) 0.90
Metallopeptidase activities in hereditary angioedema: effect of androgen prophylaxis on plasma aminopeptidase P. J Allergy Clin Immunol (2007) 0.88
Carboxypeptidase Z (CPZ) links thyroid hormone and Wnt signaling pathways in growth plate chondrocytes. J Bone Miner Res (2009) 0.87
Supplementation with tocotrienol-rich fraction alters the plasma levels of Apolipoprotein A-I precursor, Apolipoprotein E precursor, and C-reactive protein precursor from young and old individuals. Eur J Nutr (2013) 0.84
Deletion of carboxypeptidase N delays onset of experimental cerebral malaria. Parasite Immunol (2012) 0.83
Plasma protein profiling of Mild Cognitive Impairment and Alzheimer's disease using iTRAQ quantitative proteomics. Proteome Sci (2014) 0.83
Human C3a and C3a desArg anaphylatoxins have conserved structures, in contrast to C5a and C5a desArg. Protein Sci (2012) 0.82
Innate and adaptive immunologic functions of complement in the host response to Listeria monocytogenes infection. Immunobiology (2016) 0.82
Carboxypeptidase U (TAFIa): a new drug target for fibrinolytic therapy? J Thromb Haemost (2009) 0.81
The complement system: history, pathways, cascade and inhibitors. Eur J Microbiol Immunol (Bp) (2012) 0.81
C3a, C5a renal expression and their receptors are correlated to severity of IgA nephropathy. J Clin Immunol (2013) 0.80
The extreme anterior domain is an essential craniofacial organizer acting through Kinin-Kallikrein signaling. Cell Rep (2014) 0.80
Complementing the inflammasome. Immunology (2016) 0.79
Plasma protein biomarkers of hepatocellular carcinoma in HCV-infected alcoholic patients with cirrhosis. PLoS One (2015) 0.79
Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists. Sci Rep (2016) 0.78
Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity. J Exp Med (2016) 0.77
Transcriptional fingerprinting of "browning" white fat identifies NRG4 as a novel adipokine. Adipocyte (2014) 0.77
The role of the complement system in cancer. J Clin Invest (2017) 0.75
Carboxypeptidase N-deficient mice present with polymorphic disease phenotypes on induction of experimental autoimmune encephalomyelitis. Immunobiology (2013) 0.75
Carboxypeptidase D: a novel TGF-beta target gene dysregulated in patients with lupus erythematosus. J Clin Immunol (2007) 0.75
The Evolving Landscape for Complement Therapeutics in Rheumatic and Autoimmune Diseases. Arthritis Rheumatol (2017) 0.75
Generation of C5a in the absence of C3: a new complement activation pathway. Nat Med (2006) 5.26
Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood (2007) 2.72
Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest (2003) 2.39
A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A (2007) 1.74
Complement: a novel factor in basal and ischemia-induced neurogenesis. EMBO J (2006) 1.70
Inhibition of complement activation by a secreted Staphylococcus aureus protein. J Infect Dis (2004) 1.62
Mycobacteria-primed macrophages and dendritic cells induce an up-regulation of complement C5a anaphylatoxin receptor (CD88) in CD3+ murine T cells. J Leukoc Biol (2006) 1.53
C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury. J Immunol (2004) 1.48
Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis. FASEB J (2003) 1.42
Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy. J Immunol (2002) 1.40
A new mechanism regulating the initiation of allergic airway inflammation. J Allergy Clin Immunol (2007) 1.37
Transplantation of human embryonic stem cell-derived alveolar epithelial type II cells abrogates acute lung injury in mice. Mol Ther (2010) 1.36
C5a receptor deficiency attenuates T cell function and renal disease in MRLlpr mice. J Am Soc Nephrol (2005) 1.26
Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis. FASEB J (2012) 1.21
The alternative activation pathway and complement component C3 are critical for a protective immune response against Pseudomonas aeruginosa in a murine model of pneumonia. Infect Immun (2004) 1.21
Deletion of the complement anaphylatoxin C3a receptor attenuates, whereas ectopic expression of C3a in the brain exacerbates, experimental autoimmune encephalomyelitis. J Immunol (2004) 1.21
The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization. Proc Natl Acad Sci U S A (2013) 1.21
The regulation of liver cell survival by complement. J Immunol (2009) 1.15
A protective role for the fifth complement component (c5) in allergic airway disease. Am J Respir Crit Care Med (2006) 1.09
Regulatory role of C5a on macrophage migration inhibitory factor release from neutrophils. J Immunol (2004) 1.07
Complement C5a anaphylatoxin is an innate determinant of dendritic cell-induced Th1 immunity to Mycobacterium bovis BCG infection in mice. J Leukoc Biol (2007) 1.06
Effect of complement component C3 deficiency on experimental Lyme borreliosis in mice. Infect Immun (2003) 1.02
Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a. Mol Immunol (2007) 1.01
Targeted disruption of the gene encoding the murine small subunit of carboxypeptidase N (CPN1) causes susceptibility to C5a anaphylatoxin-mediated shock. J Immunol (2009) 0.98
Role of different pathways of the complement cascade in experimental bullous pemphigoid. J Clin Invest (2006) 0.90
Analysis of C4 and the C4 binding protein in the MRL/lpr mouse. Arthritis Res Ther (2007) 0.88
A defect in the synthesis of Interferon-γ by the T cells of Complement-C5 deficient mice leads to enhanced susceptibility for tuberculosis. Tuberculosis (Edinb) (2011) 0.87
The complement anaphylatoxin C3a receptor (C3aR) contributes to the inflammatory response in dextran sulfate sodium (DSS)-induced colitis in mice. PLoS One (2013) 0.84
Receptor for complement peptide C3a: a therapeutic target for neonatal hypoxic-ischemic brain injury. FASEB J (2013) 0.83
C3a receptor deficiency accelerates the onset of renal injury in the MRL/lpr mouse. Mol Immunol (2009) 0.83
Complement C3a regulates Muc5ac expression by airway Clara cells independently of Th2 responses. Am J Respir Crit Care Med (2007) 0.82
A site-specific genetic modification for induction of pluripotency and subsequent isolation of derived lung alveolar epithelial type II cells. Stem Cells (2014) 0.81
Expression of the third complement component (C3) and carboxypeptidase N small subunit (CPN1) during mouse embryonic development. Dev Comp Immunol (2004) 0.81
Negative regulation of pulmonary Th17 responses by C3a anaphylatoxin during allergic inflammation in mice. PLoS One (2012) 0.80
Ablation of the complement C3a anaphylatoxin receptor causes enhanced killing of Pseudomonas aeruginosa in a mouse model of pneumonia. Am J Physiol Lung Cell Mol Physiol (2006) 0.80
The complement C3a receptor is critical in defense against Chlamydia psittaci in mouse lung infection and required for antibody and optimal T cell response. J Infect Dis (2013) 0.79
Isolation and characterization of alveolar epithelial type II cells derived from mouse embryonic stem cells. Tissue Eng Part C Methods (2013) 0.77
Denaturation and unfolding of human anaphylatoxin C3a: an unusually low covalent stability of its native disulfide bonds. Arch Biochem Biophys (2008) 0.76
Correction: Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence. PLoS Pathog (2016) 0.75