Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils.

PubWeight™: 1.79‹?› | Rank: Top 3%

🔗 View Article (PMID 16901726)

Published in Immunity on August 10, 2006

Authors

Hong Zhang1, Ulrich Y Schaff, Chad E Green, Hua Chen, Melissa R Sarantos, Yongmei Hu, Diane Wara, Scott I Simon, Clifford A Lowell

Author Affiliations

1: Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA.

Articles citing this

GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo. Bioessays (2007) 3.26

The ins and outs of leukocyte integrin signaling. Annu Rev Immunol (2009) 2.76

WASP: a key immunological multitasker. Nat Rev Immunol (2010) 2.38

The multifaceted functions of neutrophils. Annu Rev Pathol (2013) 1.97

Bringing up the rear: defining the roles of the uropod. Nat Rev Mol Cell Biol (2009) 1.74

Neutrophil adhesion and activation under flow. Microcirculation (2009) 1.67

Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice. J Clin Invest (2007) 1.47

DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory. Eur J Immunol (2011) 1.46

WIP regulates the stability and localization of WASP to podosomes in migrating dendritic cells. Curr Biol (2006) 1.43

Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis. Blood (2008) 1.35

Wiskott-Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation. Immunobiology (2009) 1.32

Autoimmunity in wiskott-Aldrich syndrome: an unsolved enigma. Front Immunol (2012) 1.27

Type Igamma PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis. Mol Biol Cell (2007) 1.27

Orai1 regulates intracellular calcium, arrest, and shape polarization during neutrophil recruitment in shear flow. Blood (2009) 1.18

Evidence for long-term efficacy and safety of gene therapy for Wiskott-Aldrich syndrome in preclinical models. Mol Ther (2009) 1.15

The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling. Blood (2009) 1.15

The multiple faces of leukocyte interstitial migration. Semin Immunopathol (2014) 1.12

Novel aspects in the regulation of the leukocyte adhesion cascade. Thromb Haemost (2009) 1.11

Rapid platelet turnover in WASP(-) mice correlates with increased ex vivo phagocytosis of opsonized WASP(-) platelets. Exp Hematol (2008) 1.06

Generation of membrane structures during phagocytosis and chemotaxis of macrophages: role and regulation of the actin cytoskeleton. Immunol Rev (2013) 1.01

Chemokines, selectins and intracellular calcium flux: temporal and spatial cues for leukocyte arrest. Front Immunol (2012) 1.00

Impaired NK-cell migration in WAS/XLT patients: role of Cdc42/WASp pathway in the control of chemokine-induced beta2 integrin high-affinity state. Blood (2010) 1.00

Cleavage of the CD11b extracellular domain by the leukocyte serprocidins is critical for neutrophil detachment during chemotaxis. Blood (2011) 0.99

Mechanisms of neutrophil transendothelial migration. Front Biosci (Landmark Ed) (2009) 0.98

The molecular basis of phospholipase D2-induced chemotaxis: elucidation of differential pathways in macrophages and fibroblasts. Mol Cell Biol (2010) 0.96

Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules. Blood (2012) 0.96

Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivo. BMC Immunol (2007) 0.95

Leukocyte function antigen-1, kindlin-3, and calcium flux orchestrate neutrophil recruitment during inflammation. J Immunol (2012) 0.95

Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking. Proc Natl Acad Sci U S A (2010) 0.93

Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells. J Immunol (2009) 0.91

The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation. J Exp Med (2014) 0.91

The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF). Cell Signal (2011) 0.91

Actin cytoskeletal defects in immunodeficiency. Immunol Rev (2013) 0.90

Intracellular signalling during neutrophil recruitment. Cardiovasc Res (2015) 0.87

Neutrophilic granulocytes modulate invariant NKT cell function in mice and humans. J Immunol (2012) 0.82

Hold on to your endothelium: postarrest steps of the leukocyte adhesion cascade. Immunity (2006) 0.82

The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation. Immunity (2016) 0.81

Roles of Rho GTPases in leucocyte and leukaemia cell transendothelial migration. Philos Trans R Soc Lond B Biol Sci (2013) 0.81

Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1. Immunology (2012) 0.80

Dendritic cell functional improvement in a preclinical model of lentiviral-mediated gene therapy for Wiskott-Aldrich syndrome. Gene Ther (2011) 0.79

Tyrosine phosphorylation of Wiskott-Aldrich syndrome protein (WASP) by Hck regulates macrophage function. J Biol Chem (2014) 0.76

Congenital defects in neutrophil dynamics. J Immunol Res (2014) 0.76

Mechanism of Diapedesis: Importance of the Transcellular Route. Adv Immunol (2015) 0.75

Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions. J Exp Med (2017) 0.75

The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection. Sci Immunol (2017) 0.75

Articles cited by this

Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J Immunol (1999) 3.67

A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. J Cell Biol (2004) 3.66

Syk is required for integrin signaling in neutrophils. Immunity (2002) 3.39

Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J Cell Biol (1996) 2.96

Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity (1998) 2.92

Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. J Exp Med (1999) 2.81

Molecular mechanics and dynamics of leukocyte recruitment during inflammation. Annu Rev Biomed Eng (2005) 2.34

Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome. Br J Haematol (1998) 1.87

Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol (2004) 1.87

Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigration. J Exp Med (2004) 1.85

Src and Syk kinases: key regulators of phagocytic cell activation. Trends Immunol (2005) 1.81

Dynamic regulation of LFA-1 activation and neutrophil arrest on intercellular adhesion molecule 1 (ICAM-1) in shear flow. J Biol Chem (2002) 1.62

Chemoattractant signals and beta 2 integrin occupancy at apical endothelial contacts combine with shear stress signals to promote transendothelial neutrophil migration. J Immunol (2004) 1.56

Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck. J Immunol (1999) 1.51

Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands. Curr Opin Hematol (2002) 1.43

Shear-dependent capping of L-selectin and P-selectin glycoprotein ligand 1 by E-selectin signals activation of high-avidity beta2-integrin on neutrophils. J Immunol (2004) 1.42

Cellular activation of leukocyte function-associated antigen-1 and its affinity are regulated at the I domain allosteric site. J Immunol (2001) 1.38

The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling. J Immunol (2003) 1.37

Monocytes from Wiskott-Aldrich patients display reduced chemotaxis and lack of cell polarization in response to monocyte chemoattractant protein-1 and formyl-methionyl-leucyl-phenylalanine. J Immunol (1998) 1.37

Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein. Blood (2004) 1.35

Maturation of DC is associated with changes in motile characteristics and adherence. Cell Motil Cytoskeleton (2004) 1.31

Mechanisms of WASp-mediated hematologic and immunologic disease. Blood (2004) 1.26

The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B. Immunity (2005) 1.25

Dynamic shifts in LFA-1 affinity regulate neutrophil rolling, arrest, and transmigration on inflamed endothelium. Blood (2005) 1.22

Restoration of podosomes and chemotaxis in Wiskott-Aldrich syndrome macrophages following induced expression of WASp. Int J Biochem Cell Biol (2002) 1.12

Involvement of the Wiskott-Aldrich syndrome protein and other actin regulatory adaptors in T cell activation. Semin Immunol (2004) 1.11

Identification of WASP mutations in patients with Wiskott-Aldrich syndrome and isolated thrombocytopenia reveals allelic heterogeneity at the WAS locus. Hum Mol Genet (1995) 1.11

Synergy between L-selectin signaling and chemotactic activation during neutrophil adhesion and transmigration. J Immunol (1997) 0.98

Articles by these authors

A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature (2012) 11.68

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia. Nat Genet (2002) 4.06

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol (2006) 3.68

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science (2003) 3.60

Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood (2005) 3.57

Syk is required for integrin signaling in neutrophils. Immunity (2002) 3.39

Antiretroviral therapy during pregnancy and the risk of an adverse outcome. N Engl J Med (2002) 3.31

The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci U S A (2004) 3.15

Transfusion-related acute lung injury: incidence and risk factors. Blood (2011) 3.12

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest (2009) 3.08

Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat Immunol (2005) 2.97

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol (2002) 2.92

Increasing women's leadership in academic medicine: report of the AAMC Project Implementation Committee. Acad Med (2002) 2.84

Triglyceride-rich lipoproteins prime aortic endothelium for an enhanced inflammatory response to tumor necrosis factor-alpha. Circ Res (2007) 2.83

The ins and outs of leukocyte integrin signaling. Annu Rev Immunol (2009) 2.76

Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity (2008) 2.67

Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest (2006) 2.50

Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1. Immunity (2007) 2.43

Molecular mechanics and dynamics of leukocyte recruitment during inflammation. Annu Rev Biomed Eng (2005) 2.34

A scalable system for production of functional pancreatic progenitors from human embryonic stem cells. PLoS One (2012) 2.24

Functional role of CD11c+ monocytes in atherogenesis associated with hypercholesterolemia. Circulation (2009) 2.19

Modeling recent human evolution in mice by expression of a selected EDAR variant. Cell (2013) 2.17

Electron-pinned defect-dipoles for high-performance colossal permittivity materials. Nat Mater (2013) 2.05

Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol (2003) 2.04

When the time comes to talk about HIV: factors associated with diagnostic disclosure and emotional distress in HIV-infected children. J Acquir Immune Defic Syndr (2002) 2.01

The multifaceted functions of neutrophils. Annu Rev Pathol (2013) 1.97

The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity. Immunity (2010) 1.97

Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI. Proc Natl Acad Sci U S A (2003) 1.94

Structural genomics: a pipeline for providing structures for the biologist. Protein Sci (2002) 1.91

Genetic alteration of a bispecific ligand-directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancy. Leuk Res (2009) 1.84

Src and Syk kinases: key regulators of phagocytic cell activation. Trends Immunol (2005) 1.81

Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice. Immunity (2013) 1.80

PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J Exp Med (2008) 1.79

The role of surface oxygen in the growth of large single-crystal graphene on copper. Science (2013) 1.79

Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas. Mol Biol Evol (2010) 1.77

Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proc Natl Acad Sci U S A (2011) 1.76

Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero. J Natl Cancer Inst (2004) 1.73

Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells. Immunity (2011) 1.72

Ultrasound radiation force enables targeted deposition of model drug carriers loaded on microbubbles. J Control Release (2005) 1.68

Molecular modification of a recombinant, bivalent anti-human CD3 immunotoxin (Bic3) results in reduced in vivo toxicity in mice. Leuk Res (2005) 1.68

Neutrophils mediate antibody-induced antitumor effects in mice. Blood (2013) 1.66

MOCAT: a metagenomics assembly and gene prediction toolkit. PLoS One (2012) 1.64

Vascular mimetics based on microfluidics for imaging the leukocyte--endothelial inflammatory response. Lab Chip (2007) 1.62

Dynamic regulation of LFA-1 activation and neutrophil arrest on intercellular adhesion molecule 1 (ICAM-1) in shear flow. J Biol Chem (2002) 1.62

Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury. J Clin Invest (2004) 1.58

Vertically aligned carbon nanofiber arrays: an advance toward electrical-neural interfaces. Small (2006) 1.57

Molecular editing of cellular responses by the high-affinity receptor for IgE. Science (2014) 1.53

A mouse model of post-arthroplasty Staphylococcus aureus joint infection to evaluate in vivo the efficacy of antimicrobial implant coatings. PLoS One (2010) 1.52

Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice. PLoS Pathog (2012) 1.52

Comparative effectiveness of individual angiotensin receptor blockers on risk of mortality in patients with chronic heart failure. Pharmacoepidemiol Drug Saf (2011) 1.50

The expanding role for ITAM-based signaling pathways in immune cells. Sci STKE (2007) 1.50

Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung. Cell Rep (2012) 1.45

G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth. Blood (2005) 1.45

TST, as a polysomnographic variable, is superior to the apnea hypopnea index for evaluating intermittent hypoxia in severe obstructive sleep apnea. Eur Arch Otorhinolaryngol (2014) 1.42

Shear-dependent capping of L-selectin and P-selectin glycoprotein ligand 1 by E-selectin signals activation of high-avidity beta2-integrin on neutrophils. J Immunol (2004) 1.42

Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma. Clin Cancer Res (2013) 1.42

Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging. J Invest Dermatol (2008) 1.42

Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med (2010) 1.41

1,1,3-Trimethyl-3-phenyl-indane. Acta Crystallogr Sect E Struct Rep Online (2008) 1.41

Long-term efficacy of enzyme replacement therapy for adenosine deaminase (ADA)-deficient severe combined immunodeficiency (SCID). Clin Immunol (2005) 1.40

Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells. J Immunol (2004) 1.40

Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors. Nat Immunol (2004) 1.39

CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1. Arterioscler Thromb Vasc Biol (2010) 1.37

Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood (2009) 1.34

Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development (2002) 1.33

Identification of the proliferation/differentiation switch in the cellular network of multicellular organisms. PLoS Comput Biol (2006) 1.32

G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells. Blood (2003) 1.30

Classification of inflammation activity in ulcerative colitis by confocal laser endomicroscopy. Am J Gastroenterol (2009) 1.30

Interferon-γ production by neutrophils during bacterial pneumonia in mice. Am J Respir Crit Care Med (2010) 1.29

Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. J Biol Chem (2009) 1.29

Endemic polycythemia in Russia: mutation in the VHL gene. Blood Cells Mol Dis (2002) 1.28

Hydrodynamic shear rate regulates melanoma-leukocyte aggregation, melanoma adhesion to the endothelium, and subsequent extravasation. Ann Biomed Eng (2008) 1.28

Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination. Genome Res (2009) 1.27

A bispecific recombinant immunotoxin, DT2219, targeting human CD19 and CD22 receptors in a mouse xenograft model of B-cell leukemia/lymphoma. Clin Cancer Res (2005) 1.26

Multiple roles of Lyn kinase in myeloid cell signaling and function. Immunol Rev (2009) 1.25

Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. J Immunol (2005) 1.25

Determining the folding and unfolding rate constants of nucleic acids by biosensor. Application to telomere G-quadruplex. J Am Chem Soc (2004) 1.25

The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B. Immunity (2005) 1.25

Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma. Eur J Immunol (2008) 1.24

Leukocyte function-associated antigen 1-mediated adhesion stability is dynamically regulated through affinity and valency during bond formation with intercellular adhesion molecule-1. J Biol Chem (2005) 1.24

The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood (2007) 1.24

Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens. J Biol Chem (2012) 1.23

CD11c/CD18: novel ligands and a role in delayed-type hypersensitivity. J Leukoc Biol (2007) 1.23

Ultrasound radiation force modulates ligand availability on targeted contrast agents. Mol Imaging (2006) 1.23

Spatial regulation of inflammation by human aortic endothelial cells in a linear gradient of shear stress. Microcirculation (2008) 1.23

Vav1 is essential for mechanotactic crawling and migration of neutrophils out of the inflamed microvasculature. J Immunol (2009) 1.23

The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells. Immunol Rev (2009) 1.23

Genetic evidence of paleolithic colonization and neolithic expansion of modern humans on the tibetan plateau. Mol Biol Evol (2013) 1.22

Neutrophil survival and c-kit(+)-progenitor proliferation in Staphylococcus aureus-infected skin wounds promote resolution. Blood (2011) 1.22

Dihydroartemisinin inactivates NF-kappaB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo. Cancer Lett (2010) 1.22

Dynamic shifts in LFA-1 affinity regulate neutrophil rolling, arrest, and transmigration on inflamed endothelium. Blood (2005) 1.22