Essential role of survivin, an inhibitor of apoptosis protein, in T cell development, maturation, and homeostasis.

PubWeight™: 1.83‹?› | Rank: Top 3%

🔗 View Article (PMC 1887718)

Published in J Exp Med on December 29, 2003

Authors

Zheng Xing1, Edward M Conway, Chulho Kang, Astar Winoto

Author Affiliations

1: Department of Molecular and Cell Biology, Division of Immunology and Cancer Research Laboratory, University of California at Berkeley, 469 LSA, Berkeley, CA 94720, USA.

Articles citing this

Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. Nat Immunol (2009) 1.84

New wirings in the survivin networks. Oncogene (2008) 1.76

Survivin is not required for the endomitotic cell cycle of megakaryocytes. Blood (2009) 1.57

Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells. J Exp Med (2007) 1.52

Apoptosis and the homeostatic control of immune responses. Curr Opin Immunol (2007) 1.49

Differential requirements for survivin in hematopoietic cell development. Proc Natl Acad Sci U S A (2005) 1.43

Role of the Survivin gene in pathophysiology. Am J Pathol (2006) 1.28

Survivin as a preferential target for cancer therapy. Int J Mol Sci (2014) 1.28

Impacting tumor cell-fate by targeting the inhibitor of apoptosis protein survivin. Mol Cancer (2011) 1.26

Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia. Blood (2011) 1.24

Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils. J Exp Med (2004) 1.22

Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation. Dev Cell (2008) 1.21

Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3. Blood (2009) 1.09

Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure. Blood (2007) 1.07

Dectin-1 is inducible and plays a crucial role in Aspergillus-induced innate immune responses in human bronchial epithelial cells. Eur J Clin Microbiol Infect Dis (2012) 1.07

Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice. Proc Natl Acad Sci U S A (2008) 1.04

Overexpression of survivin initiates hematologic malignancies in vivo. Leukemia (2010) 1.04

IFN-γ upregulates survivin and Ifi202 expression to induce survival and proliferation of tumor-specific T cells. PLoS One (2010) 0.96

Characterization of the 12C4 survivin monoclonal antibody and insight into the expression of survivin in human adult tissues. Histopathology (2006) 0.94

High mobility group box2 promoter-controlled suicide gene expression enables targeted glioblastoma treatment. Mol Ther (2009) 0.93

FoxM1, a forkhead transcription factor is a master cell cycle regulator for mouse mature T cells but not double positive thymocytes. PLoS One (2010) 0.92

Inhibition of apoptosis by survivin improves transplantation of pancreatic islets for treatment of diabetes in mice. EMBO Rep (2006) 0.92

Survivin-specific T cell receptor targets tumor but not T cells. J Clin Invest (2014) 0.91

Activation of Fms-like tyrosine kinase 3 signaling enhances survivin expression in a mouse model of rheumatoid arthritis. PLoS One (2012) 0.91

Survivin is an essential mediator of arthritis interacting with urokinase signalling. J Cell Mol Med (2009) 0.91

BIRC5/Survivin as a target for glycolysis inhibition in high-stage neuroblastoma. Oncogene (2015) 0.88

Functional polymorphism -31C/G in the promoter of BIRC5 gene and risk of nasopharyngeal carcinoma among chinese. PLoS One (2011) 0.86

Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma. Oncogene (2014) 0.84

Transgenic expression of survivin compensates for OX40-deficiency in driving Th2 development and allergic inflammation. Eur J Immunol (2013) 0.84

Survivin mediates renal proximal tubule recovery from AKI. J Am Soc Nephrol (2013) 0.83

Loss of survivin in the prostate epithelium impedes carcinogenesis in a mouse model of prostate adenocarcinoma. PLoS One (2013) 0.82

Differential immunotoxicity induced by two different windows of developmental trichloroethylene exposure. Autoimmune Dis (2014) 0.82

Dissecting the role of endothelial SURVIVIN DeltaEx3 in angiogenesis. Blood (2006) 0.82

Influence of survivin-targeted therapy on chemosensitivity in the treatment of acute myeloid leukemia. Cancer Lett (2015) 0.82

Increased levels of survivin, via association with heat shock protein 90, in mucosal T cells from patients with Crohn's disease. Gastroenterology (2012) 0.81

Silencing of Survivin Expression Leads to Reduced Proliferation and Cell Cycle Arrest in Cancer Cells. J Cancer (2015) 0.80

Survivin but not Fms-like tyrosine kinase 3 ligand is up-regulated before the onset of rheumatoid arthritis: a pilot study. Arthritis Res Ther (2014) 0.80

The role of survivin in podocyte injury induced by puromycin aminonucleoside. Int J Mol Sci (2014) 0.80

Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin. BMC Neurosci (2010) 0.79

Localization and upregulation of survivin in cancer health disparities: a clinical perspective. Biologics (2015) 0.79

Lymphocyte apoptosis in murine Pneumocystis pneumonia. Respir Res (2009) 0.79

α-Tomatine-mediated anti-cancer activity in vitro and in vivo through cell cycle- and caspase-independent pathways. PLoS One (2012) 0.79

Functional promoter -31G/C variant of Survivin gene predict prostate cancer susceptibility among Chinese: a case control study. BMC Cancer (2013) 0.79

Suppressed diversity of survivin splicing in active rheumatoid arthritis. Arthritis Res Ther (2015) 0.79

Loss of Survivin influences liver regeneration and is associated with impaired Aurora B function. Cell Death Differ (2013) 0.79

Recognizing rheumatoid arthritis: oncoprotein survivin opens new possibilities: a population-based case-control study. Medicine (Baltimore) (2015) 0.78

Survivin modulates genes with divergent molecular functions and regulates proliferation of hematopoietic stem cells through Evi-1. Leukemia (2014) 0.77

Serum survivin predicts responses to treatment in active rheumatoid arthritis: a post hoc analysis from the SWEFOT trial. BMC Med (2015) 0.77

1,1-Bis(3'-indolyl)-1-(p-bromophenyl)methane and related compounds repress survivin and decrease gamma-radiation-induced survivin in colon and pancreatic cancer cells. Int J Oncol (2009) 0.77

Advanced antigen delivery of murine survivin: chimeric virus-like particles in cancer vaccine research. Int J Biomed Sci (2007) 0.76

Survivin co-ordinates formation of follicular T-cells acting in synergy with Bcl-6. Oncotarget (2015) 0.76

Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum. Sci Rep (2017) 0.75

Enhanced expression of Survivin has distinct roles in adipocyte homeostasis. Cell Death Dis (2017) 0.75

Essential Role for Survivin in the Proliferative Expansion of Progenitor and Mature B Cells. J Immunol (2016) 0.75

Impact of inhibitor of apoptosis proteins on immune modulation and inflammation. Immunol Cell Biol (2016) 0.75

Foxn1[Cre] Expression in the Male Germline. PLoS One (2016) 0.75

c-Myc-Induced Survivin Is Essential for Promoting  the Notch-Dependent T Cell Differentiation from  Hematopoietic Stem Cells. Genes (Basel) (2017) 0.75

Articles cited by this

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med (1997) 12.65

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell (2000) 11.90

IAP family proteins--suppressors of apoptosis. Genes Dev (1999) 9.96

Social controls on cell survival and cell death. Nature (1992) 9.81

A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity (2001) 9.45

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell (2000) 8.69

Control of apoptosis and mitotic spindle checkpoint by survivin. Nature (1998) 8.60

IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity (1998) 8.29

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature (2002) 5.98

Validating survivin as a cancer therapeutic target. Nat Rev Cancer (2003) 5.73

Maintaining the norm: T-cell homeostasis. Nat Rev Immunol (2002) 5.63

CD95's deadly mission in the immune system. Nature (2000) 5.55

IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res (1998) 5.41

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature (1998) 4.97

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. Curr Biol (2000) 4.27

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity (1994) 4.26

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function. Nat Cell Biol (1999) 4.11

Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat Immunol (2003) 3.82

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nat Immunol (2002) 3.58

Apoptosis in the development and maintenance of the immune system. Nat Immunol (2003) 3.02

Positive selection of lymphocytes. Cell (1994) 2.86

Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. Nat Struct Biol (2000) 2.85

Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes. Immunity (2002) 2.83

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J (1998) 2.82

Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis. Curr Biol (1999) 2.65

Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice. Nat Immunol (2003) 2.59

Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation. Mol Biol Cell (2002) 2.56

Neonates support lymphopenia-induced proliferation. Immunity (2003) 2.51

Survivin is required for stable checkpoint activation in taxol-treated HeLa cells. J Cell Sci (2003) 2.48

Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev (1996) 2.47

Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions. Blood (2000) 2.44

Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas. Cancer Res (1998) 2.38

An exegesis of IAPs: salvation and surprises from BIR motifs. Trends Cell Biol (1999) 2.33

Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting. J Biol Chem (1998) 2.27

Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells. Nat Immunol (2002) 2.20

How alpha beta T cells deal with induced TCR alpha ablation. Proc Natl Acad Sci U S A (2001) 2.19

Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis. J Biol Chem (2003) 2.06

Cancer gene therapy using a survivin mutant adenovirus. J Clin Invest (2001) 2.05

Livin, a novel inhibitor of apoptosis protein family member. J Biol Chem (2000) 1.92

Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs. Genome Biol (2001) 1.78

Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division. Proc Natl Acad Sci U S A (1999) 1.77

Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53. J Clin Invest (2001) 1.64

A function of Fas-associated death domain protein in cell cycle progression localized to a single amino acid at its C-terminal region. Immunity (2003) 1.53

Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation. Proc Natl Acad Sci U S A (1999) 1.52

Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes. Proc Natl Acad Sci U S A (2002) 1.45

Improved generation of germline-competent embryonic stem cell lines from inbred mouse strains. Stem Cells (2003) 1.36

T cell-specific FADD-deficient mice: FADD is required for early T cell development. Proc Natl Acad Sci U S A (2001) 1.33

A role for Fas in negative selection of thymocytes in vivo. J Exp Med (1998) 1.30

Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways. Gastroenterology (2002) 1.22

Thymic selection and cell division. J Exp Med (1995) 1.14

Intrathymic proliferation of perinatal mouse alpha beta and gamma delta T cell receptor-expressing mature T cells. Int Immunol (1990) 1.12

Competition and compensation: coupled to death in development and cancer. Cell (2002) 1.10

Cellular localization, expression, and structure of the nuclear dot protein 52. J Cell Biol (1997) 1.02

Apoptosis during lymphoid development. Curr Opin Immunol (2003) 1.02

Survivin acts as an antiapoptotic factor during the development of mouse preimplantation embryos. Dev Biol (2003) 1.00

Murine neonatal lymphocytes show rapid early cell cycle entry and cell division. J Immunol (2003) 0.98

Ribozyme-mediated cleavage of the human survivin mRNA and inhibition of antiapoptotic function of survivin in MCF-7 cells. Cancer Gene Ther (2003) 0.97

Signals involved in gamma/delta T cell versus alpha/beta T cell lineage commitment. Semin Immunol (1999) 0.96

Normal thymocyte negative selection in TRAIL-deficient mice. J Exp Med (2003) 0.94

Regulation and kinetics of premigrant thymocyte expansion. Eur J Immunol (2000) 0.91

Quantitative and qualitative adjustment of thymic T cell production by clonal expansion of premigrant thymocytes. J Immunol (2002) 0.90

Participation of Survivin in mitotic and apoptotic activities of normal and tumor-derived cells. J Cell Biochem (2001) 0.85

Articles by these authors

Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype. Clin J Am Soc Nephrol (2010) 3.82

Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nat Neurosci (2004) 3.31

Thrombomodulin mutations in atypical hemolytic-uremic syndrome. N Engl J Med (2009) 3.24

Aire-dependent thymic development of tumor-associated regulatory T cells. Science (2013) 3.23

Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nat Med (2003) 3.17

Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. Cell Metab (2011) 2.47

Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1). J Clin Invest (2003) 2.21

Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation. Arterioscler Thromb Vasc Biol (2004) 2.18

Recognition of a ubiquitous self antigen by prostate cancer-infiltrating CD8+ T lymphocytes. Science (2008) 1.99

Polybromo protein BAF180 functions in mammalian cardiac chamber maturation. Genes Dev (2004) 1.93

Redundant and unique roles of two enhancer elements in the TCRgamma locus in gene regulation and gammadelta T cell development. Immunity (2002) 1.88

AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. Nat Med (2009) 1.88

A genetic Xenopus laevis tadpole model to study lymphangiogenesis. Nat Med (2005) 1.85

TRAIL-R as a negative regulator of innate immune cell responses. Immunity (2004) 1.83

Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity. Diabetes (2009) 1.82

Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis. Proc Natl Acad Sci U S A (2010) 1.67

Constitutive display of cryptic translation products by MHC class I molecules. Science (2003) 1.67

During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain. J Exp Med (2008) 1.66

ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression. J Biol Chem (2002) 1.62

Coagulation and innate immune responses: can we view them separately? Blood (2009) 1.61

Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest (2005) 1.55

A function of Fas-associated death domain protein in cell cycle progression localized to a single amino acid at its C-terminal region. Immunity (2003) 1.53

Helium/oxygen-driven albuterol nebulization in the management of children with status asthmaticus: a randomized, placebo-controlled trial. Pediatr Crit Care Med (2010) 1.48

Survivin splice variants regulate the balance between proliferation and cell death. Oncogene (2005) 1.46

Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities. Mol Cell (2005) 1.45

Essential role for survivin in early brain development. J Neurosci (2005) 1.44

Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals. Proc Natl Acad Sci U S A (2004) 1.42

Transcriptional regulation of tissue-specific genes by the ERK5 mitogen-activated protein kinase. Mol Cell Biol (2005) 1.38

Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor. EMBO J (2003) 1.31

Occupancy and function of the -150 sterol regulatory element and -65 E-box in nutritional regulation of the fatty acid synthase gene in living animals. Mol Cell Biol (2003) 1.31

Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway. Blood (2012) 1.26

Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia. Blood (2011) 1.24

Apoptosis during negative selection of autoreactive thymocytes. Curr Opin Immunol (2007) 1.23

Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils. J Exp Med (2004) 1.22

Survivin determines cardiac function by controlling total cardiomyocyte number. Circulation (2008) 1.18

Role of Gas6 in erythropoiesis and anemia in mice. J Clin Invest (2008) 1.16

Dominant inhibitory adipocyte-specific secretory factor (ADSF)/resistin enhances adipogenesis and improves insulin sensitivity. Proc Natl Acad Sci U S A (2004) 1.09

Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3. Blood (2009) 1.09

Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles. Nanomedicine (2011) 1.08

Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure. Blood (2007) 1.07

Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice. Proc Natl Acad Sci U S A (2008) 1.04

Apoptosis during lymphoid development. Curr Opin Immunol (2003) 1.02

CD248 and its cytoplasmic domain: a therapeutic target for arthritis. Arthritis Rheum (2010) 1.02

Novel functions of thrombomodulin in inflammation. Crit Care Med (2004) 1.01

Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain. Blood (2011) 1.00

Fas-associated death domain (FADD) and the E3 ubiquitin-protein ligase TRIM21 interact to negatively regulate virus-induced interferon production. J Biol Chem (2010) 0.99

Non-redundant function of the MEK5-ERK5 pathway in thymocyte apoptosis. EMBO J (2008) 0.99

CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy in established tumors. J Immunol (2010) 0.98

The orphan steroid receptor Nur77 family member Nor-1 is essential for early mouse embryogenesis. J Biol Chem (2003) 0.95

Opposing chemokine gradients control human thymocyte migration in situ. J Clin Invest (2013) 0.94

Protein kinase C regulates mitochondrial targeting of Nur77 and its family member Nor-1 in thymocytes undergoing apoptosis. Eur J Immunol (2010) 0.94

Constitutive phosphorylation mutation in Fas-associated death domain (FADD) results in early cell cycle defects. J Biol Chem (2007) 0.94

Role of the 2 zebrafish survivin genes in vasculo-angiogenesis, neurogenesis, cardiogenesis and hematopoiesis. BMC Dev Biol (2009) 0.93

Protective role of the inhibitor of apoptosis protein, survivin, in toxin-induced acute renal failure. FASEB J (2007) 0.93

CD248 facilitates tumor growth via its cytoplasmic domain. BMC Cancer (2011) 0.93

FoxM1, a forkhead transcription factor is a master cell cycle regulator for mouse mature T cells but not double positive thymocytes. PLoS One (2010) 0.92

Commensal microbiota are required for systemic inflammation triggered by necrotic dendritic cells. Cell Rep (2013) 0.91

Gene placement and competition control T cell receptor gamma variable region gene rearrangement. J Exp Med (2008) 0.89

Impairment of thymocyte development by dominant-negative Kuzbanian (ADAM-10) is rescued by the Notch ligand, delta-1. J Immunol (2005) 0.89

The genomic arrangement of T cell receptor variable genes is a determinant of the developmental rearrangement pattern. Proc Natl Acad Sci U S A (2003) 0.88

Reduction of the incidence and severity of collagen-induced arthritis by constitutive Nur77 expression in the T cell lineage. Arthritis Rheum (2005) 0.88

The lectin-like domain of thrombomodulin ameliorates diabetic glomerulopathy via complement inhibition. Thromb Haemost (2012) 0.88

VEGF inhibitors make blood. Nat Med (2006) 0.86

Pax5 activates immunoglobulin heavy chain V to DJ rearrangement in transgenic thymocytes. J Exp Med (2004) 0.86

CD248: reviewing its role in health and disease. Curr Drug Targets (2012) 0.86

Another angiogenic gene linked to amyotrophic lateral sclerosis. Trends Mol Med (2006) 0.85

Polyphosphate suppresses complement via the terminal pathway. Blood (2013) 0.85

The role of the PI3K-AKT kinase pathway in T-cell development beyond the beta checkpoint. Eur J Immunol (2008) 0.85

Thrombomodulin's lectin-like domain reduces myocardial damage by interfering with HMGB1-mediated TLR2 signalling. Cardiovasc Res (2013) 0.84

Lymph makes you fat. Nat Genet (2005) 0.83

Monitoring left ventricular dilation in mice with PET. J Nucl Med (2005) 0.83

Inhibition of allergic bronchial asthma by thrombomodulin is mediated by dendritic cells. Am J Respir Crit Care Med (2010) 0.83

Hi-Fi SELEX: A High-Fidelity Digital-PCR Based Therapeutic Aptamer Discovery Platform. Biotechnol Bioeng (2015) 0.83

Survivin mediates renal proximal tubule recovery from AKI. J Am Soc Nephrol (2013) 0.83

Loss of survivin in the prostate epithelium impedes carcinogenesis in a mouse model of prostate adenocarcinoma. PLoS One (2013) 0.82

Comparative study of hematopoietic differentiation between human embryonic stem cell lines. PLoS One (2011) 0.82

Coupling of the cell cycle and apoptotic machineries in developing T cells. J Biol Chem (2010) 0.81

Lack of the lectin-like domain of thrombomodulin worsens Shiga toxin-associated hemolytic uremic syndrome in mice. J Immunol (2012) 0.81

Hepatic loss of survivin impairs postnatal liver development and promotes expansion of hepatic progenitor cells in mice. Hepatology (2013) 0.80

Modulation of complement activation and amplification on nanoparticle surfaces by glycopolymer conformation and chemistry. ACS Nano (2014) 0.80

Cutting into innate immunity. Nat Immunol (2004) 0.80

Survivin selectively modulates genes deregulated in human leukemia stem cells. J Oncol (2010) 0.79

Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin. BMC Neurosci (2010) 0.79

Mice lacking the lectin-like domain of thrombomodulin are protected against melioidosis. Crit Care Med (2014) 0.79

Cardiovascular biology: signalling silenced. Nature (2003) 0.78

Gas6 gains entry into the coagulation cascade. Blood (2013) 0.78

Design of novel artemisinin-like derivatives with cytotoxic and anti-angiogenic properties. J Cell Mol Med (2010) 0.78

Evaluation of the anti-angiogenic activity of saponins from Maesa lanceolata by different assays. Nat Prod Commun (2012) 0.77

The clock is ticking as the clot thickens. Arterioscler Thromb Vasc Biol (2011) 0.75

The lectin-like domain of thrombomodulin hampers host defence in pneumococcal pneumonia. Eur Respir J (2012) 0.75

The type XIV family of C-type lectin-like domain (CTLD) containing proteins. Curr Drug Targets (2012) 0.75

The thrombomodulin lectin-like domain does not change host responses to tuberculosis. Thromb Haemost (2013) 0.75