Published in Circ Res on January 08, 2004
Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Cold Spring Harb Perspect Biol (2010) 2.46
Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29
Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure. Circ Res (2008) 2.24
Abnormal intrastore calcium signaling in chronic heart failure. Proc Natl Acad Sci U S A (2005) 2.20
Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc Natl Acad Sci U S A (2005) 1.99
Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice. J Clin Invest (2010) 1.77
Altered intracellular Ca2+ handling in heart failure. J Clin Invest (2005) 1.70
Beta-adrenergic receptor signaling in the heart: role of CaMKII. J Mol Cell Cardiol (2009) 1.65
Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice. J Clin Invest (2010) 1.60
Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes. Biochem Biophys Res Commun (2008) 1.57
Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon beta-adrenergic stimulation in normal and failing hearts. Biochem J (2006) 1.52
Localization of a disease-associated mutation site in the three-dimensional structure of the cardiac muscle ryanodine receptor. J Biol Chem (2005) 1.32
Cellular mechanisms of arrhythmogenic cardiac alternans. Prog Biophys Mol Biol (2008) 1.32
Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts. Cardiovasc Res (2008) 1.27
K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem J (2007) 1.27
Three-dimensional localization of serine 2808, a phosphorylation site in cardiac ryanodine receptor. J Biol Chem (2007) 1.24
Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias. J Biol Chem (2007) 1.17
Mechanisms and potential therapeutic targets for ventricular arrhythmias associated with impaired cardiac calcium cycling. J Mol Cell Cardiol (2007) 1.17
Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice. Proc Natl Acad Sci U S A (2006) 1.13
The ryanodine receptor in cardiac physiology and disease. Adv Pharmacol (2010) 1.09
Dysregulated sarcoplasmic reticulum calcium release: potential pharmacological target in cardiac disease. Pharmacol Ther (2008) 1.09
Ryanodine receptor-mediated arrhythmias and sudden cardiac death. Pharmacol Ther (2009) 1.08
Ryanodine receptors. Skelet Muscle (2011) 1.06
Localization of PKA phosphorylation site, Ser(2030), in the three-dimensional structure of cardiac ryanodine receptor. Biochem J (2008) 1.02
Genetic ablation of ryanodine receptor 2 phosphorylation at Ser-2808 aggravates Ca(2+)-dependent cardiomyopathy by exacerbating diastolic Ca2+ release. J Physiol (2014) 0.99
Molecular basis of diastolic dysfunction. Heart Fail Clin (2008) 0.97
Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart. Pflugers Arch (2008) 0.94
Na/K-ATPase--an integral player in the adrenergic fight-or-flight response. Trends Cardiovasc Med (2009) 0.94
Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytes. Cardiovasc Res (2009) 0.92
Ryanodine receptor studies using genetically engineered mice. FEBS Lett (2010) 0.92
Is ryanodine receptor phosphorylation key to the fight or flight response and heart failure? J Clin Invest (2010) 0.91
CaMKII regulation of cardiac ryanodine receptors and inositol triphosphate receptors. Front Pharmacol (2014) 0.89
Single-channel characterization of the rabbit recombinant RyR2 reveals a novel inactivation property of physiological concentrations of ATP. J Membr Biol (2008) 0.88
Posttranslational modifications of cardiac ryanodine receptors: Ca(2+) signaling and EC-coupling. Biochim Biophys Acta (2012) 0.86
Ion Channels in the Heart. Compr Physiol (2015) 0.83
Excitation-contraction coupling gain and cooperativity of the cardiac ryanodine receptor: a modeling approach. Biophys J (2005) 0.81
Calcium handling proteins: structure, function, and modulation by exercise. Heart Fail Rev (2014) 0.79
Type 2 ryanodine receptors are highly sensitive to alcohol. FEBS Lett (2014) 0.78
Transgenic analysis of the role of FKBP12.6 in cardiac function and intracellular calcium release. Assay Drug Dev Technol (2011) 0.78
Calcium/calmodulin-dependent kinase II and nitric oxide synthase 1-dependent modulation of ryanodine receptors during β-adrenergic stimulation is restricted to the dyadic cleft. J Physiol (2016) 0.76
The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis. Heart Fail Rev (2013) 0.76
Murine Electrophysiological Models of Cardiac Arrhythmogenesis. Physiol Rev (2017) 0.75
Structures and metal-ion-binding properties of the Ca2+-binding helix-loop-helix EF-hand motifs. Biochem J (2007) 3.69
Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death. Circ Res (2005) 3.34
RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR). Proc Natl Acad Sci U S A (2004) 3.25
Enhanced basal activity of a cardiac Ca2+ release channel (ryanodine receptor) mutant associated with ventricular tachycardia and sudden death. Circ Res (2002) 2.64
Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis. Circ Res (2011) 2.37
Key role of Kv1 channels in vasoregulation. Circ Res (2006) 2.01
Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes. Circ Res (2007) 1.98
Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nat Med (2011) 1.88
The myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1δ. Arch Biochem Biophys (2011) 1.86
Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure. Circ Res (2005) 1.86
Computational analysis and identification of an emergent human adenovirus pathogen implicated in a respiratory fatality. Virology (2010) 1.82
Rho-kinase-mediated suppression of KDR current in cerebral arteries requires an intact actin cytoskeleton. Am J Physiol Heart Circ Physiol (2009) 1.60
Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase. Biochem J (2002) 1.60
Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase. Biochem J (2002) 1.59
Red fluorescent genetically encoded Ca2+ indicators for use in mitochondria and endoplasmic reticulum. Biochem J (2014) 1.57
Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon beta-adrenergic stimulation in normal and failing hearts. Biochem J (2006) 1.52
Localization of an NH(2)-terminal disease-causing mutation hot spot to the "clamp" region in the three-dimensional structure of the cardiac ryanodine receptor. J Biol Chem (2007) 1.43
Integrin-linked kinase is responsible for Ca2+-independent myosin diphosphorylation and contraction of vascular smooth muscle. Biochem J (2005) 1.42
Loss of luminal Ca2+ activation in the cardiac ryanodine receptor is associated with ventricular fibrillation and sudden death. Proc Natl Acad Sci U S A (2007) 1.38
The role of RhoA and Rho-associated kinase in vascular smooth muscle contraction. Curr Hypertens Rep (2003) 1.37
Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor. Biochem J (2008) 1.33
Computational analysis of human adenovirus type 22 provides evidence for recombination among species D human adenoviruses in the penton base gene. J Virol (2009) 1.32
Localization of a disease-associated mutation site in the three-dimensional structure of the cardiac muscle ryanodine receptor. J Biol Chem (2005) 1.32
Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation. PLoS One (2010) 1.31
Ca2+ sensitization via phosphorylation of myosin phosphatase targeting subunit at threonine-855 by Rho kinase contributes to the arterial myogenic response. J Physiol (2009) 1.30
Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase. Biochem J (2002) 1.29
K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem J (2007) 1.27
Three-dimensional reconstruction of the recombinant type 2 ryanodine receptor and localization of its divergent region 1. J Biol Chem (2002) 1.27
Requirement of ryanodine receptors for pacemaker Ca2+ activity in ICC and HEK293 cells. J Cell Sci (2004) 1.26
Three-dimensional localization of serine 2808, a phosphorylation site in cardiac ryanodine receptor. J Biol Chem (2007) 1.24
Wavefront velocity oscillations of carbon-nanotube-guided thermopower waves: nanoscale alternating current sources. ACS Nano (2010) 1.22
PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes. Circ Res (2007) 1.22
A highly sensitive technique to measure myosin regulatory light chain phosphorylation: the first quantification in renal arterioles. Am J Physiol Renal Physiol (2008) 1.20
AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase. J Biol Chem (2008) 1.19
Three-dimensional localization of divergent region 3 of the ryanodine receptor to the clamp-shaped structures adjacent to the FKBP binding sites. J Biol Chem (2003) 1.17
Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias. J Biol Chem (2007) 1.17
Patellar height and tibial slope after opening-wedge proximal tibial osteotomy: a prospective study. Am J Sports Med (2009) 1.17
Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store overload-induced Ca2+ release. J Biol Chem (2007) 1.15
Store overload-induced Ca2+ release as a triggering mechanism for CPVT and MH episodes caused by mutations in RYR and CASQ genes. J Physiol (2009) 1.14
Localization of the 12.6-kDa FK506-binding protein (FKBP12.6) binding site to the NH2-terminal domain of the cardiac Ca2+ release channel (ryanodine receptor). J Biol Chem (2002) 1.12
Abnormal termination of Ca2+ release is a common defect of RyR2 mutations associated with cardiomyopathies. Circ Res (2012) 1.11
Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential. PLoS One (2012) 1.10
Ca2+ activation of smooth muscle contraction: evidence for the involvement of calmodulin that is bound to the triton insoluble fraction even in the absence of Ca2+. J Biol Chem (2001) 1.07
Dynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptor. J Cell Sci (2010) 1.07
Stromatoxin-sensitive, heteromultimeric Kv2.1/Kv9.3 channels contribute to myogenic control of cerebral arterial diameter. J Physiol (2010) 1.07
Characterization of protein kinase pathways responsible for Ca2+ sensitization in rat ileal longitudinal smooth muscle. Am J Physiol Gastrointest Liver Physiol (2007) 1.07
Predicting the next eye pathogen: analysis of a novel adenovirus. MBio (2013) 1.06
The predicted TM10 transmembrane sequence of the cardiac Ca2+ release channel (ryanodine receptor) is crucial for channel activation and gating. J Biol Chem (2003) 1.06
Residue Gln4863 within a predicted transmembrane sequence of the Ca2+ release channel (ryanodine receptor) is critical for ryanodine interaction. J Biol Chem (2003) 1.06
Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor. J Biol Chem (2011) 1.05
Smooth muscle tissues express a major dominant negative splice variant of the type 3 Ca2+ release channel (ryanodine receptor). J Biol Chem (2002) 1.03
Localization of PKA phosphorylation site, Ser(2030), in the three-dimensional structure of cardiac ryanodine receptor. Biochem J (2008) 1.02
The CH-domain of calponin does not determine the modes of calponin binding to F-actin. J Mol Biol (2006) 1.02
The functional consequence of RhoA knockdown by RNA interference in rat cerebral arteries. Am J Physiol Heart Circ Physiol (2007) 1.00
Intravascular pressure augments cerebral arterial constriction by inducing voltage-insensitive Ca2+ waves. J Physiol (2010) 0.98
Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation. PLoS One (2011) 0.97
Spontaneous diastolic contractions and phosphorylation of the cardiac ryanodine receptor at serine-2808 in congestive heart failure in rat. Cardiovasc Res (2005) 0.97
Chemical genetics of zipper-interacting protein kinase reveal myosin light chain as a bona fide substrate in permeabilized arterial smooth muscle. J Biol Chem (2011) 0.97
Deep Sequence Analysis of Non-Small Cell Lung Cancer: Integrated Analysis of Gene Expression, Alternative Splicing, and Single Nucleotide Variations in Lung Adenocarcinomas with and without Oncogenic KRAS Mutations. Front Oncol (2012) 0.96
Myosin regulatory light chain diphosphorylation slows relaxation of arterial smooth muscle. J Biol Chem (2012) 0.96
Calmodulin regulation and identification of calmodulin binding region of type-3 ryanodine receptor calcium release channel. Biochemistry (2005) 0.96
Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+. Biophys J (2007) 0.96
Pressure-dependent contribution of Rho kinase-mediated calcium sensitization in serotonin-evoked vasoconstriction of rat cerebral arteries. J Physiol (2010) 0.96
Genomic and bioinformatics analyses of HAdV-14p, reference strain of a re-emerging respiratory pathogen and analysis of B1/B2. Virus Res (2009) 0.94
Myosin light chains are not a physiological substrate of AMPK in the control of cell structure changes. FEBS Lett (2008) 0.93
Cross-talk between Rho-associated kinase and cyclic nucleotide-dependent kinase signaling pathways in the regulation of smooth muscle myosin light chain phosphatase. J Biol Chem (2012) 0.93
Phospholamban knockout breaks arrhythmogenic Ca²⁺ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice. Circ Res (2013) 0.92
Applying genomic and bioinformatic resources to human adenovirus genomes for use in vaccine development and for applications in vector development for gene delivery. Viruses (2010) 0.92
Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors). J Biol Chem (2002) 0.91
Protein kinase C modulation of recombinant ATP-sensitive K(+) channels composed of Kir6.1 and/or Kir6.2 expressed with SUR2B. J Physiol (2002) 0.91
Inhibition of zipper-interacting protein kinase function in smooth muscle by a myosin light chain kinase pseudosubstrate peptide. Am J Physiol Cell Physiol (2007) 0.90
Phosphorylation of protein phosphatase type-1 inhibitory proteins by integrin-linked kinase and cyclic nucleotide-dependent protein kinases. Biochem Biophys Res Commun (2003) 0.90
Comparative kinematic evaluation of all-inside single-bundle and double-bundle anterior cruciate ligament reconstruction: a biomechanical study. Am J Sports Med (2009) 0.90
Ca2+ sensitization due to myosin light chain phosphatase inhibition and cytoskeletal reorganization in the myogenic response of skeletal muscle resistance arteries. J Physiol (2012) 0.90
Characterization of a novel mutation in the cardiac ryanodine receptor that results in catecholaminergic polymorphic ventricular tachycardia. Channels (Austin) (2010) 0.89
Phosphorylation of the protein phosphatase type 1 inhibitor protein CPI-17 by protein kinase C. Methods Mol Biol (2007) 0.89
Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia. J Biol Chem (2008) 0.88
Characterization of tightly associated smooth muscle myosin-myosin light-chain kinase-calmodulin complexes. J Mol Biol (2009) 0.88
In situ confocal imaging in intact heart reveals stress-induced Ca(2+) release variability in a murine catecholaminergic polymorphic ventricular tachycardia model of type 2 ryanodine receptor(R4496C+/-) mutation. Circ Arrhythm Electrophysiol (2012) 0.88
Unmasking the annexin I interaction from the structure of Apo-S100A11. Structure (2003) 0.88
Changes in negative charge at the luminal mouth of the pore alter ion handling and gating in the cardiac ryanodine-receptor. Biophys J (2009) 0.87
Computational analysis of four human adenovirus type 4 genomes reveals molecular evolution through two interspecies recombination events. Virology (2013) 0.87
Role of CaMKII and ROS in rapid pacing-induced apoptosis. J Mol Cell Cardiol (2013) 0.87
Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. ACS Chem Biol (2013) 0.87
Ligand-dependent conformational changes in the clamp region of the cardiac ryanodine receptor. J Biol Chem (2012) 0.87
The contribution of hydrophobic residues in the pore-forming region of the ryanodine receptor channel to block by large tetraalkylammonium cations and Shaker B inactivation peptides. J Gen Physiol (2012) 0.86
Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+ release. Biochem J (2013) 0.86
Activation of smooth muscle myosin light chain kinase by calmodulin. Role of LYS(30) and GLY(40). J Biol Chem (2001) 0.85