Published in J Biol Chem on July 02, 2007
Optical single-channel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes. Proc Natl Acad Sci U S A (2009) 2.29
Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor. Circ Res (2010) 1.61
Ryanodine receptor structure: progress and challenges. J Biol Chem (2008) 1.29
Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction. Biochem Biophys Res Commun (2010) 1.16
The ryanodine receptor in cardiac physiology and disease. Adv Pharmacol (2010) 1.09
Ryanodine receptor-mediated arrhythmias and sudden cardiac death. Pharmacol Ther (2009) 1.08
Ryanodine receptors. Skelet Muscle (2011) 1.06
Mapping the ryanodine receptor FK506-binding protein subunit using fluorescence resonance energy transfer. J Biol Chem (2010) 1.05
Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor. J Biol Chem (2011) 1.05
CLIC2-RyR1 interaction and structural characterization by cryo-electron microscopy. J Mol Biol (2009) 1.04
Localization of PKA phosphorylation site, Ser(2030), in the three-dimensional structure of cardiac ryanodine receptor. Biochem J (2008) 1.02
Structural determination of the phosphorylation domain of the ryanodine receptor. FEBS J (2012) 0.95
Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytes. Cardiovasc Res (2009) 0.92
FRET-based localization of fluorescent protein insertions within the ryanodine receptor type 1. PLoS One (2012) 0.91
Ryanodine receptor phosphorylation and heart failure: phasing out S2808 and "criminalizing" S2814. Circ Res (2012) 0.90
Ligand-dependent conformational changes in the clamp region of the cardiac ryanodine receptor. J Biol Chem (2012) 0.87
Posttranslational modifications of cardiac ryanodine receptors: Ca(2+) signaling and EC-coupling. Biochim Biophys Acta (2012) 0.86
Regulation of Ryanodine Receptor Ion Channels Through Posttranslational Modifications. Curr Top Membr (2010) 0.84
Conformational dynamics inside amino-terminal disease hotspot of ryanodine receptor. Structure (2013) 0.82
Modeling a ryanodine receptor N-terminal domain connecting the central vestibule and the corner clamp region. J Biol Chem (2012) 0.82
Three-dimensional localization of the α and β subunits and of the II-III loop in the skeletal muscle L-type Ca2+ channel. J Biol Chem (2012) 0.82
Two potential calmodulin-binding sequences in the ryanodine receptor contribute to a mobile, intra-subunit calmodulin-binding domain. J Cell Sci (2013) 0.79
Identification of ATP-binding regions in the RyR1 Ca²⁺ release channel. PLoS One (2012) 0.78
Regulation of Ca(2+) transient by PP2A in normal and failing heart. Front Physiol (2015) 0.78
Exome analysis identifies Brody myopathy in a family diagnosed with malignant hyperthermia susceptibility. Mol Genet Genomic Med (2014) 0.77
Structure of glutaraldehyde cross-linked ryanodine receptor. J Struct Biol (2013) 0.76
Counteracting Protein Kinase Activity in the Heart: The Multiple Roles of Protein Phosphatases. Front Pharmacol (2015) 0.75
A guide to the 3D structure of the ryanodine receptor type 1 by cryoEM. Protein Sci (2016) 0.75
FK506-binding proteins 12 and 12.6 (FKBPs) as regulators of cardiac Ryanodine Receptors: insights from new functional and structural knowledge. Channels (Austin) (2017) 0.75
SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields. J Struct Biol (1996) 22.89
PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell (2000) 10.25
Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia. Circulation (2002) 5.94
Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia. Circulation (2001) 5.68
FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell (2003) 4.68
Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. Cell (1994) 4.26
Purification of the ryanodine receptor and identity with feet structures of junctional terminal cisternae of sarcoplasmic reticulum from fast skeletal muscle. J Biol Chem (1987) 3.66
Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia. Circulation (2001) 3.34
RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR). Proc Natl Acad Sci U S A (2004) 3.25
FK506 binding protein associated with the calcium release channel (ryanodine receptor). J Biol Chem (1992) 3.02
Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failure. Circ Res (2002) 2.79
Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation (2004) 2.69
Cryo-electron microscopy and three-dimensional reconstruction of the calcium release channel/ryanodine receptor from skeletal muscle. J Cell Biol (1994) 2.58
Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes. Circ Res (2003) 2.44
Targeted mutational analysis of the RyR2-encoded cardiac ryanodine receptor in sudden unexplained death: a molecular autopsy of 49 medical examiner/coroner's cases. Mayo Clin Proc (2004) 2.40
Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes. Circ Res (2002) 2.06
Internal structure and visualization of transmembrane domains of the RyR1 calcium release channel by cryo-EM. Nat Struct Mol Biol (2005) 1.92
Ryanodine receptor mutations in malignant hyperthermia and central core disease. Hum Mutat (2000) 1.87
Escherichia coli 70 S ribosome at 15 A resolution by cryo-electron microscopy: localization of fMet-tRNAfMet and fitting of L1 protein. J Mol Biol (1998) 1.84
Caffeine and halothane sensitivity of intracellular Ca2+ release is altered by 15 calcium release channel (ryanodine receptor) mutations associated with malignant hyperthermia and/or central core disease. J Biol Chem (1997) 1.74
Locations of calmodulin and FK506-binding protein on the three-dimensional architecture of the skeletal muscle ryanodine receptor. J Biol Chem (1997) 1.66
Regulation of calcium release by interdomain interaction within ryanodine receptors. Front Biosci (2002) 1.64
Effects of rapamycin on ryanodine receptor/Ca(2+)-release channels from cardiac muscle. Circ Res (1996) 1.62
Functional characterization of the recombinant type 3 Ca2+ release channel (ryanodine receptor) expressed in HEK293 cells. J Biol Chem (1997) 1.61
Characterization of recombinant skeletal muscle (Ser-2843) and cardiac muscle (Ser-2809) ryanodine receptor phosphorylation mutants. J Biol Chem (2003) 1.58
Spectrum and frequency of cardiac channel defects in swimming-triggered arrhythmia syndromes. Circulation (2004) 1.58
Protein kinase A phosphorylation at serine-2808 of the cardiac Ca2+-release channel (ryanodine receptor) does not dissociate 12.6-kDa FK506-binding protein (FKBP12.6). Circ Res (2004) 1.58
Localization of an NH(2)-terminal disease-causing mutation hot spot to the "clamp" region in the three-dimensional structure of the cardiac ryanodine receptor. J Biol Chem (2007) 1.43
The relative position of RyR feet and DHPR tetrads in skeletal muscle. J Mol Biol (2004) 1.39
Localization of a disease-associated mutation site in the three-dimensional structure of the cardiac muscle ryanodine receptor. J Biol Chem (2005) 1.32
Three-dimensional reconstruction of the recombinant type 2 ryanodine receptor and localization of its divergent region 1. J Biol Chem (2002) 1.27
Three-dimensional reconstruction of the recombinant type 3 ryanodine receptor and localization of its amino terminus. Proc Natl Acad Sci U S A (2001) 1.26
Arrhythmogenic mutation-linked defects in ryanodine receptor autoregulation reveal a novel mechanism of Ca2+ release channel dysfunction. Circ Res (2005) 1.26
FKBP binding characteristics of cardiac microsomes from diverse vertebrates. Biochem Biophys Res Commun (2001) 1.24
Three-dimensional localization of divergent region 3 of the ryanodine receptor to the clamp-shaped structures adjacent to the FKBP binding sites. J Biol Chem (2003) 1.17
Characterization of recombinant rabbit cardiac and skeletal muscle Ca2+ release channels (ryanodine receptors) with a novel [3H]ryanodine binding assay. J Biol Chem (1998) 1.13
The predicted TM10 transmembrane sequence of the cardiac Ca2+ release channel (ryanodine receptor) is crucial for channel activation and gating. J Biol Chem (2003) 1.06
Three-dimensional visualization of FKBP12.6 binding to an open conformation of cardiac ryanodine receptor. Biophys J (2005) 1.03
Differential Ca2+ sensitivity of RyR2 mutations reveals distinct mechanisms of channel dysfunction in sudden cardiac death. Biochem Biophys Res Commun (2005) 0.99
The genome of the mesopolyploid crop species Brassica rapa. Nat Genet (2011) 8.23
Heritable individual-specific and allele-specific chromatin signatures in humans. Science (2010) 5.94
Structural basis for double-stranded RNA processing by Dicer. Science (2006) 5.86
Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity. Genome Res (2011) 4.43
A2A adenosine receptor protects tumors from antitumor T cells. Proc Natl Acad Sci U S A (2006) 4.25
RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer. J Clin Oncol (2012) 3.72
Classification of real and pseudo microRNA precursors using local structure-sequence features and support vector machine. BMC Bioinformatics (2005) 3.69
Piezo proteins are pore-forming subunits of mechanically activated channels. Nature (2012) 3.54
Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death. Circ Res (2005) 3.34
A prospective multicenter clinical study of extralevator abdominoperineal resection for locally advanced low rectal cancer. Dis Colon Rectum (2014) 3.30
RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR). Proc Natl Acad Sci U S A (2004) 3.25
GOSemSim: an R package for measuring semantic similarity among GO terms and gene products. Bioinformatics (2010) 3.20
An ion channel essential for sensing chemical damage. J Neurosci (2007) 3.03
Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese. J Allergy Clin Immunol (2009) 2.68
Large-area vapor-phase growth and characterization of MoS(2) atomic layers on a SiO(2) substrate. Small (2012) 2.66
Enhanced basal activity of a cardiac Ca2+ release channel (ryanodine receptor) mutant associated with ventricular tachycardia and sudden death. Circ Res (2002) 2.64
End-Stage Heart Failure With COVID-19: Strong Evidence of Myocardial Injury by 2019-nCoV. JACC Heart Fail (2020) 2.57
MicroRNA identification based on sequence and structure alignment. Bioinformatics (2005) 2.52
Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis. Circ Res (2011) 2.37
Targeted migration of mesenchymal stem cells modified with CXCR4 gene to infarcted myocardium improves cardiac performance. Mol Ther (2008) 2.25
Spectrum of oncogenic driver mutations in lung adenocarcinomas from East Asian never smokers. PLoS One (2011) 2.17
Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95. Nat Med (2010) 2.15
RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Nature (2012) 2.11
Similarities and differences between selective and nonselective BAFF blockade in murine SLE. J Clin Invest (2006) 2.05
NMDA receptors in dopaminergic neurons are crucial for habit learning. Neuron (2011) 2.02
Direct laser writing of micro-supercapacitors on hydrated graphite oxide films. Nat Nanotechnol (2011) 2.02
Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes. Circ Res (2007) 1.98
A novel intracellular protein delivery platform based on single-protein nanocapsules. Nat Nanotechnol (2009) 1.94
Internal structure and visualization of transmembrane domains of the RyR1 calcium release channel by cryo-EM. Nat Struct Mol Biol (2005) 1.92
Composition and phase dependence of the intrinsic and extrinsic piezoelectric activity of domain engineered (1-x)Pb(Mg(13)Nb(23))O(3)-xPbTiO(3) crystals. J Appl Phys (2010) 1.92
Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway. Ann Rheum Dis (2011) 1.91
Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nat Med (2011) 1.88
Ultra-stable nanoparticles of CdSe revealed from mass spectrometry. Nat Mater (2004) 1.86
Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure. Circ Res (2005) 1.86
The leptin-deficient (ob/ob) mouse: a new animal model of peripheral neuropathy of type 2 diabetes and obesity. Diabetes (2006) 1.84
Vapour phase growth and grain boundary structure of molybdenum disulphide atomic layers. Nat Mater (2013) 1.83
RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II. Nature (2011) 1.79
Graphene quantum dots derived from carbon fibers. Nano Lett (2012) 1.79
Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy. Diabetes (2004) 1.79
A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase. Proc Natl Acad Sci U S A (2006) 1.78
Apocalmodulin and Ca2+-calmodulin bind to neighboring locations on the ryanodine receptor. J Biol Chem (2001) 1.75
Structure of the hepatitis E virus-like particle suggests mechanisms for virus assembly and receptor binding. Proc Natl Acad Sci U S A (2009) 1.71
A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature (2009) 1.71
Synthesis and characterization of chiral mesoporous silica. Nature (2004) 1.66
Electromechanical properties of tetragonal Pb(In(12)Nb(12))O(3)-Pb(Mg(13)Nb(23))O(3)-PbTiO(3) ferroelectric crystals. J Appl Phys (2010) 1.60
Cyclophilin A is overexpressed in human pancreatic cancer cells and stimulates cell proliferation through CD147. Cancer (2006) 1.59
Risk of bone fractures associated with glucagon-like peptide-1 receptor agonists' treatment: a meta-analysis of randomized controlled trials. Endocrine (2014) 1.58
Protein kinase A phosphorylation at serine-2808 of the cardiac Ca2+-release channel (ryanodine receptor) does not dissociate 12.6-kDa FK506-binding protein (FKBP12.6). Circ Res (2004) 1.58
Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease. J Biol Chem (2011) 1.58
Red fluorescent genetically encoded Ca2+ indicators for use in mitochondria and endoplasmic reticulum. Biochem J (2014) 1.57
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. J Clin Invest (2014) 1.55
Cell-type specific and combinatorial usage of diverse transcription factors revealed by genome-wide binding studies in multiple human cells. Genome Res (2011) 1.53
Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon beta-adrenergic stimulation in normal and failing hearts. Biochem J (2006) 1.52
Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance. Cancer Res (2002) 1.50
Pulsed magnetic field induces angiogenesis and improves cardiac function of surgically induced infarcted myocardium in Sprague-Dawley rats. Cardiology (2010) 1.49
A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma. Int J Cancer (2010) 1.46
Localization of an NH(2)-terminal disease-causing mutation hot spot to the "clamp" region in the three-dimensional structure of the cardiac ryanodine receptor. J Biol Chem (2007) 1.43
Early prediction of organ failure under the revised Atlanta classification. Turk J Gastroenterol (2016) 1.43
Complex zeolite structure solved by combining powder diffraction and electron microscopy. Nature (2006) 1.43
An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans. PLoS Genet (2009) 1.42
Deferoxamine attenuates iron-induced long-term neurotoxicity in rats with traumatic brain injury. Neurol Sci (2012) 1.42
Intrinsic structural defects in monolayer molybdenum disulfide. Nano Lett (2013) 1.38
Loss of luminal Ca2+ activation in the cardiac ryanodine receptor is associated with ventricular fibrillation and sudden death. Proc Natl Acad Sci U S A (2007) 1.38
Visualizing and identifying single atoms using electron energy-loss spectroscopy with low accelerating voltage. Nat Chem (2009) 1.34
Recent Developments on High Curie Temperature PIN-PMN-PT Ferroelectric Crystals. J Cryst Growth (2011) 1.34
Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor. Biochem J (2008) 1.33
Growth of bilayer graphene on insulating substrates. ACS Nano (2011) 1.33
Fecal microbiota transplantation through mid-gut for refractory Crohn's disease: safety, feasibility, and efficacy trial results. J Gastroenterol Hepatol (2015) 1.33
MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene. J Biol Chem (2012) 1.33
Inflammatory signals enhance piezo2-mediated mechanosensitive currents. Cell Rep (2012) 1.32
FXR signaling in the enterohepatic system. Mol Cell Endocrinol (2012) 1.32
Localization of a disease-associated mutation site in the three-dimensional structure of the cardiac muscle ryanodine receptor. J Biol Chem (2005) 1.32
Insect-Specific microRNA Involved in the Development of the Silkworm Bombyx mori. PLoS One (2009) 1.31
Localization of cerebral functional deficits in treatment-naive, first-episode schizophrenia using resting-state fMRI. Neuroimage (2009) 1.30
Hsa-mir-182 suppresses lung tumorigenesis through down regulation of RGS17 expression in vitro. Biochem Biophys Res Commun (2010) 1.29
Large-pore apertures in a series of metal-organic frameworks. Science (2012) 1.29
Particle-verification for single-particle, reference-based reconstruction using multivariate data analysis and classification. J Struct Biol (2008) 1.27
K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem J (2007) 1.27
Three-dimensional reconstruction of the recombinant type 2 ryanodine receptor and localization of its divergent region 1. J Biol Chem (2002) 1.27
Gated tunability and hybridization of localized plasmons in nanostructured graphene. ACS Nano (2013) 1.27
Proteomic analysis on a high salt tolerance introgression strain of Triticum aestivum/Thinopyrum ponticum. Proteomics (2008) 1.26
Abundant conserved microRNA target sites in the 5'-untranslated region and coding sequence. Genetica (2009) 1.26
A stable cathode for the aprotic Li-O2 battery. Nat Mater (2013) 1.26
Requirement of ryanodine receptors for pacemaker Ca2+ activity in ICC and HEK293 cells. J Cell Sci (2004) 1.26
Gs protein-coupled adenosine receptor signaling and lytic function of activated NK cells. J Immunol (2005) 1.26
Sulfur-doped graphene as an efficient metal-free cathode catalyst for oxygen reduction. ACS Nano (2011) 1.25
Actinobacillus actinomycetemcomitans lipopolysaccharide-mediated experimental bone loss model for aggressive periodontitis. J Periodontol (2007) 1.25
Investigation of single and multidomain Pb(In(0.5)Nb(0.5))O(3)-Pb(Mg(1∕3)Nb(2∕3))O(3)-PbTiO(3) crystals with mm2 symmetry. Appl Phys Lett (2010) 1.25
Graphene-antenna sandwich photodetector. Nano Lett (2012) 1.24