Published in J Gene Med on January 01, 2004
Amphiphilic block copolymers enhance cellular uptake and nuclear entry of polyplex-delivered DNA. Bioconjug Chem (2008) 1.31
AAV's anatomy: roadmap for optimizing vectors for translational success. Curr Gene Ther (2010) 1.27
Balancing protection and release of DNA: tools to address a bottleneck of non-viral gene delivery. J R Soc Interface (2009) 1.22
Missing pieces in understanding the intracellular trafficking of polycation/DNA complexes. J Control Release (2009) 1.12
Addition of "charge-shifting" side chains to linear poly(ethyleneimine) enhances cell transfection efficiency. Biomacromolecules (2008) 0.94
Nuclear delivery of NFkappaB-assisted DNA/polymer complexes: plasmid DNA quantitation by confocal laser scanning microscopy and evidence of nuclear polyplexes by FRET imaging. Nucleic Acids Res (2008) 0.93
Intracellular trafficking and decondensation kinetics of chitosan-pDNA polyplexes. Mol Ther (2010) 0.87
Investigation of Polyethylenimine/DNA Polyplex Transfection to Cultured Cells Using Radiolabeling and Subcellular Fractionation Methods. Mol Pharm (2013) 0.86
Polyethylenimine-mediated gene delivery to the lung and therapeutic applications. Drug Des Devel Ther (2009) 0.84
Quantitative analysis of condensation/decondensation status of pDNA in the nuclear sub-domains by QD-FRET. Nucleic Acids Res (2011) 0.82
Dynamics of nucleic acid/cationic polymer complexation and disassembly under biologically simulated conditions using in situ atomic force microscopy. Microsc Res Tech (2010) 0.81
DNA nuclear targeting sequences for non-viral gene delivery. Pharm Res (2011) 0.80
Correlating intracellular nonviral polyplex localization with transfection efficiency using high-content screening. Biotechnol Prog (2015) 0.79
Stable DNA Nanomachine Based on Duplex-Triplex Transition for Ratiometric Imaging Instantaneous pH Changes in Living Cells. Anal Chem (2015) 0.76
Bioreducible polycations as shuttles for therapeutic nucleic acid and protein transfection. Antioxid Redox Signal (2014) 0.76
In vivo gene delivery with L-tyrosine polyphosphate nanoparticles. Mol Pharm (2013) 0.76
Characterization of exogenous DNA mobility in live cells through fluctuation correlation spectroscopy. Sci Rep (2015) 0.75
A large-area, flexible pressure sensor matrix with organic field-effect transistors for artificial skin applications. Proc Natl Acad Sci U S A (2004) 8.15
Suppression of aging in mice by the hormone Klotho. Science (2005) 8.11
Conformable, flexible, large-area networks of pressure and thermal sensors with organic transistor active matrixes. Proc Natl Acad Sci U S A (2005) 5.37
PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest (2004) 5.29
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Nature (2002) 4.44
Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nat Med (2010) 3.59
Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study. J Bone Miner Metab (2009) 3.27
PEGylated nanoparticles for biological and pharmaceutical applications. Adv Drug Deliv Rev (2003) 3.19
An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. Nat Genet (2005) 3.00
Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery. Pharmacol Ther (2006) 2.48
Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice. Cancer Res (2003) 2.47
Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change. Angew Chem Int Ed Engl (2003) 2.37
Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling. Proc Natl Acad Sci U S A (2007) 2.30
Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO J (2003) 2.30
Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum (2006) 2.19
The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. Arthritis Rheum (2004) 2.08
Opposing extracellular signal-regulated kinase and Akt pathways control Schwann cell myelination. J Neurosci (2004) 2.04
Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes. Genes Dev (2004) 2.00
Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery. Mol Biosyst (2005) 1.92
Preclinical and clinical studies of anticancer agent-incorporating polymer micelles. Cancer Sci (2009) 1.88
A "super-aged" society and the "locomotive syndrome". J Orthop Sci (2008) 1.87
Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy. Bioconjug Chem (2005) 1.82
Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system. Immunol Rev (2005) 1.81
Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis (2010) 1.75
Prognostic factors for patients with spinal metastases from lung cancer. Spine (Phila Pa 1976) (2006) 1.72
Suppressive function of androgen receptor in bone resorption. Proc Natl Acad Sci U S A (2003) 1.72
Klotho gene polymorphisms associated with bone density of aged postmenopausal women. J Bone Miner Res (2002) 1.69
A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese. Hum Mol Genet (2005) 1.67
Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells. J Am Chem Soc (2005) 1.66
Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1. J Biol Chem (2004) 1.65
siRNA-based therapy ameliorates glomerulonephritis. J Am Soc Nephrol (2010) 1.58
Block copolymer micelles for delivery of gene and related compounds. Adv Drug Deliv Rev (2002) 1.56
Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency. Dev Dyn (2007) 1.56
Akt1 in osteoblasts and osteoclasts controls bone remodeling. PLoS One (2007) 1.56
Statistics for orthopedic surgery 2006-2007: data from the Japanese Diagnosis Procedure Combination database. J Orthop Sci (2010) 1.55
In situ quantitative monitoring of polyplexes and polyplex micelles in the blood circulation using intravital real-time confocal laser scanning microscopy. J Control Release (2011) 1.55
Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity. Dev Cell (2008) 1.54
Venous sampling for fibroblast growth factor-23 confirms preoperative diagnosis of tumor-induced osteomalacia. J Clin Endocrinol Metab (2004) 1.54
A comparison of the defective granulopoiesis in childhood cyclic neutropenia and in severe congenital neutropenia. Haematologica (2005) 1.53
Prediction of strength and strain of the proximal femur by a CT-based finite element method. J Biomech (2006) 1.53
3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells. Biomaterials (2009) 1.50
Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-kappaB ligand. J Biol Chem (2006) 1.49
Smart multilayered assembly for biocompatible siRNA delivery featuring dissolvable silica, endosome-disrupting polycation, and detachable PEG. ACS Nano (2012) 1.49
Enhanced photodynamic cancer treatment by supramolecular nanocarriers charged with dendrimer phthalocyanine. J Control Release (2008) 1.49
Lack of a chondroprotective effect of cyclooxygenase 2 inhibition in a surgically induced model of osteoarthritis in mice. Arthritis Rheum (2012) 1.49
Reduction of Peritendinous adhesions by hydrogel containing biocompatible phospholipid polymer MPC for tendon repair. J Bone Joint Surg Am (2011) 1.48
Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation. J Biol Chem (2005) 1.47
Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression. J Am Chem Soc (2004) 1.46
Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo. Proc Natl Acad Sci U S A (2004) 1.46
Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. J Cell Biochem (2006) 1.46
Dnm3os, a non-coding RNA, is required for normal growth and skeletal development in mice. Dev Dyn (2008) 1.45
Intelligent polymeric micelles from functional poly(ethylene glycol)-poly(amino acid) block copolymers. Adv Drug Deliv Rev (2009) 1.45
Growth factor treatment and genetic manipulation stimulate neurogenesis and oligodendrogenesis by endogenous neural progenitors in the injured adult spinal cord. J Neurosci (2006) 1.43
Effects of dual blockade of the renin-angiotensin system on renal and cardiovascular outcomes in type 2 diabetes with overt nephropathy and hypertension in the ORIENT: a post-hoc analysis (ORIENT-Hypertension). Hypertens Res (2013) 1.42
Cohort profile: research on Osteoarthritis/Osteoporosis Against Disability study. Int J Epidemiol (2009) 1.39
Biodegradable nanogels prepared by atom transfer radical polymerization as potential drug delivery carriers: synthesis, biodegradation, in vitro release, and bioconjugation. J Am Chem Soc (2007) 1.38
C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes. Hum Mol Genet (2011) 1.37
Factors associated with mortality following hip fracture in Japan. J Bone Miner Metab (2006) 1.37
S100A1 and S100B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes. EMBO Rep (2007) 1.36
PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors. J Am Chem Soc (2008) 1.35
The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner. Biochem Biophys Res Commun (2005) 1.33
Surgical results and related factors for ossification of posterior longitudinal ligament of the thoracic spine: a multi-institutional retrospective study. Spine (Phila Pa 1976) (2008) 1.31
Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts. J Cell Biol (2002) 1.30
Polyplexes from poly(aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity. J Am Chem Soc (2008) 1.30
GSK-3beta controls osteogenesis through regulating Runx2 activity. PLoS One (2007) 1.29
In vivo antitumor activity of the folate-conjugated pH-sensitive polymeric micelle selectively releasing adriamycin in the intracellular acidic compartments. Bioconjug Chem (2007) 1.29
Association of knee osteoarthritis with the accumulation of metabolic risk factors such as overweight, hypertension, dyslipidemia, and impaired glucose tolerance in Japanese men and women: the ROAD study. J Rheumatol (2011) 1.29
A PEG-based biocompatible block catiomer with high buffering capacity for the construction of polyplex micelles showing efficient gene transfer toward primary cells. ChemMedChem (2006) 1.28
Supramolecular nanodevices: from design validation to theranostic nanomedicine. Acc Chem Res (2011) 1.28
Conservative treatment for adolescent idiopathic scoliosis: can it reduce the incidence of surgical treatment? Pediatr Rehabil (2004) 1.27