Published in Proc Natl Acad Sci U S A on July 18, 2003
Denosumab Versus Zoledronic Acid in Thalassemia-Induced Osteoporosis (DOHA) | NCT03040765
Building strong bones: molecular regulation of the osteoblast lineage. Nat Rev Mol Cell Biol (2011) 3.51
PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss. Cell Metab (2010) 1.77
Biphasic and dosage-dependent regulation of osteoclastogenesis by β-catenin. Mol Cell Biol (2011) 1.70
Molecular genetic studies of gene identification for osteoporosis: a 2004 update. J Bone Miner Res (2006) 1.52
The role of estrogen and androgen receptors in bone health and disease. Nat Rev Endocrinol (2013) 1.48
Premature ovarian failure in androgen receptor-deficient mice. Proc Natl Acad Sci U S A (2005) 1.44
Osteoporosis - a current view of pharmacological prevention and treatment. Drug Des Devel Ther (2013) 1.29
Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats. Endocrinology (2005) 1.27
Sex steroid actions in male bone. Endocr Rev (2014) 1.26
Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs). Drug Discov Today (2007) 1.18
CX3CR1 is expressed by prostate epithelial cells and androgens regulate the levels of CX3CL1/fractalkine in the bone marrow: potential role in prostate cancer bone tropism. Cancer Res (2008) 1.15
Differential effects on bone of estrogen receptor alpha and androgen receptor activation in orchidectomized adult male mice. Proc Natl Acad Sci U S A (2003) 1.11
Selective androgen receptor modulators in preclinical and clinical development. Nucl Recept Signal (2008) 1.11
Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA. Mol Endocrinol (2009) 1.06
Direct transcriptional targets of sex steroid hormones in bone. J Cell Biochem (2011) 0.99
Sex hormones and their receptors in bone homeostasis: insights from genetically modified mouse models. Osteoporos Int (2009) 0.98
The pituitary function of androgen receptor constitutes a glucocorticoid production circuit. Mol Cell Biol (2007) 0.97
The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts. Mol Endocrinol (2009) 0.95
Sex hormones, their receptors and bone health. Osteoporos Int (2008) 0.94
Estrogen receptor α in osteocytes regulates trabecular bone formation in female mice. Bone (2013) 0.94
Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer. Proc Natl Acad Sci U S A (2011) 0.92
Biological and clinical effects of abiraterone on anti-resorptive and anabolic activity in bone microenvironment. Oncotarget (2015) 0.92
Effect of aromatase inhibition on bone metabolism in elderly hypogonadal men. Osteoporos Int (2005) 0.91
Leaky ribosomal scanning in mammalian genomes: significance of histone H4 alternative translation in vivo. Nucleic Acids Res (2005) 0.90
Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis. Int J Endocrinol (2014) 0.89
The Effects of Androgens on Murine Cortical Bone Do Not Require AR or ERα Signaling in Osteoblasts and Osteoclasts. J Bone Miner Res (2015) 0.88
Inhibition of osteoclast formation and function by bicarbonate: role of soluble adenylyl cyclase. J Cell Physiol (2009) 0.88
Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells. Nucl Recept Signal (2013) 0.88
Dimethandrolone (7alpha,11beta-dimethyl-19-nortestosterone) and 11beta-methyl-19-nortestosterone are not converted to aromatic A-ring products in the presence of recombinant human aromatase. J Steroid Biochem Mol Biol (2008) 0.87
Nuclear receptors in bone physiology and diseases. Physiol Rev (2013) 0.86
Androgens and estrogens in skeletal sexual dimorphism. Asian J Androl (2014) 0.85
Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice. J Clin Invest (2007) 0.85
Altered TNSALP expression and phosphate regulation contribute to reduced mineralization in mice lacking androgen receptor. Mol Cell Biol (2008) 0.85
Human androgen deficiency: insights gained from androgen receptor knockout mouse models. Asian J Androl (2014) 0.84
Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling. Circulation (2013) 0.84
Male osteoporosis: A review. World J Orthop (2012) 0.83
Recent experimental and clinical findings in the skeleton associated with loss of estrogen hormone or estrogen receptor activity. J Steroid Biochem Mol Biol (2009) 0.82
Inactivation of the androgen receptor in bone-forming cells leads to trabecular bone loss in adult female mice. Bonekey Rep (2013) 0.82
Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity. Proc Natl Acad Sci U S A (2009) 0.82
Disruption of four-and-a-half LIM 2 decreases bone mineral content and bone mineral density in femur and tibia bones of female mice. Calcif Tissue Int (2006) 0.82
Testosterone and the male skeleton: a dual mode of action. J Osteoporos (2011) 0.81
Molecular mechanisms underlying the effects of sex steroids on bone and mineral metabolism. J Bone Miner Metab (2009) 0.81
The androgen receptor confers protection against diet-induced atherosclerosis, obesity, and dyslipidemia in female mice. FASEB J (2014) 0.81
The effect of oxandrolone treatment on human osteoblastic cells. J Burns Wounds (2007) 0.81
Testosterone delivered with a scaffold is as effective as bone morphologic protein-2 in promoting the repair of critical-size segmental defect of femoral bone in mice. PLoS One (2013) 0.81
Estrogens and Androgens in Skeletal Physiology and Pathophysiology. Physiol Rev (2017) 0.81
Minireview: nuclear receptor regulation of osteoclast and bone remodeling. Mol Endocrinol (2014) 0.80
Copy number variation in CNP267 region may be associated with hip bone size. PLoS One (2011) 0.79
Loss of androgen receptor promotes adipogenesis but suppresses osteogenesis in bone marrow stromal cells. Stem Cell Res (2013) 0.78
Effect of the combined extracts of herba epimedii and fructus ligustri lucidi on sex hormone functional levels in osteoporosis rats. Evid Based Complement Alternat Med (2015) 0.78
Peripheral androgen action helps modulate vocal production in a suboscine passerine. Auk (2014) 0.77
Hematopoietic androgen receptor deficiency promotes visceral fat deposition in male mice without impairing glucose homeostasis. Andrology (2015) 0.77
Effects of sex steroids on bones and muscles: Similarities, parallels, and putative interactions in health and disease. Bone (2015) 0.77
Molecular targets of androgen signaling that characterize skeletal muscle recovery and regeneration. Nucl Recept Signal (2015) 0.76
Quantitative trait locus on chromosome X affects bone loss after maturation in mice. J Bone Miner Metab (2010) 0.76
Effects of the anti-receptor activator of nuclear factor kappa B ligand denusomab on beta thalassemia major-induced osteoporosis. Indian J Endocrinol Metab (2014) 0.76
Androgen Receptor Structure, Function and Biology: From Bench to Bedside. Clin Biochem Rev (2016) 0.76
Association of serum inorganic phosphate with sex steroid hormones and vitamin D in a nationally representative sample of men. Andrology (2014) 0.76
A cross-sectional survey of factors influencing bone mass in junior high school students. Environ Health Prev Med (2012) 0.75
Local delivery of a selective androgen receptor modulator failed as an anabolic agent in a rat bone marrow ablation model. Acta Orthop (2015) 0.75
Functional differences between AMPK α1 and α2 subunits in osteogenesis, osteoblast-associated induction of osteoclastogenesis, and adipogenesis. Sci Rep (2016) 0.75
Paradoxical response of prostate cancer skeletal metastases to androgen deprivation therapy. Radiol Case Rep (2015) 0.75
Androgen receptors and experimental bone loss - an in vivo and in vitro study. Bone (2015) 0.75
Influence of Androgen Receptor in Vascular Cells on Reperfusion following Hindlimb Ischaemia. PLoS One (2016) 0.75
Pathogenesis of Osteoporosis. Transl Endocrinol Metab (2010) 0.75
The nuclear receptor superfamily: the second decade. Cell (1995) 24.99
Bone resorption by osteoclasts. Science (2000) 11.68
The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev (2000) 11.65
Combinatorial control of gene expression by nuclear receptors and coregulators. Cell (2002) 8.01
Estrogen receptor null mice: what have we learned and where will they lead us? Endocr Rev (1999) 7.06
Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev (2002) 6.38
The osteoblast: a sophisticated fibroblast under central surveillance. Science (2000) 3.93
Reversal of bone loss in mice by nongenotropic signaling of sex steroids. Science (2002) 3.46
Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. Proc Natl Acad Sci U S A (2002) 3.08
Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression. Proc Natl Acad Sci U S A (2000) 2.20
Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila. Neuron (2002) 2.15
Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males. Bone (2002) 2.13
Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice. Proc Natl Acad Sci U S A (2000) 1.90
Sex steroids and bone. Physiol Rev (2001) 1.88
A single base deletion in the Tfm androgen receptor gene creates a short-lived messenger RNA that directs internal translation initiation. Proc Natl Acad Sci U S A (1991) 1.84
Retracted Nuclear receptor function requires a TFTC-type histone acetyl transferase complex. Mol Cell (2002) 1.75
Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover. J Clin Invest (2000) 1.67
Late onset of obesity in male androgen receptor-deficient (AR KO) mice. Biochem Biophys Res Commun (2003) 1.30
Stimulation of osteoclast formation by 1,25-dihydroxyvitamin D requires its binding to vitamin D receptor (VDR) in osteoblastic cells: studies using VDR knockout mice. Endocrinology (1999) 1.24
Steroid hormone receptor expression and action in bone. Clin Sci (Lond) (2000) 1.18
Promoter structure of mouse RANKL/TRANCE/OPGL/ODF gene. Biochim Biophys Acta (1999) 1.12
Androgens suppress osteoclast formation induced by RANKL and macrophage-colony stimulating factor. Endocrinology (2001) 1.01
Chondromodulin I is a bone remodeling factor. Mol Cell Biol (2003) 0.97
The role of androgens in male gender role behavior. Endocr Rev (1999) 0.97
Estrogen receptor alpha, but not estrogen receptor beta, is involved in the regulation of the OPG/RANKL (osteoprotegerin/receptor activator of NF-kappa B ligand) ratio and serum interleukin-6 in male mice. J Endocrinol (2001) 0.96
Sex- and age-related response to aromatase deficiency in bone. Biochem Biophys Res Commun (2001) 0.93
Androgen effects on bone metabolism: recent progress and controversies. Eur J Endocrinol (1999) 0.83
Sex steroids, mice, and men: when androgens and estrogens get very close to each other. J Bone Miner Res (2002) 0.82
Another role highlighted for estrogens in the male: sexual behavior. Proc Natl Acad Sci U S A (2000) 0.82
A large-area, flexible pressure sensor matrix with organic field-effect transistors for artificial skin applications. Proc Natl Acad Sci U S A (2004) 8.15
Suppression of aging in mice by the hormone Klotho. Science (2005) 8.11
Modulation of microRNA processing by p53. Nature (2009) 7.88
Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis (2004) 6.83
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet (2010) 6.81
Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med (2007) 5.58
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1. Dev Cell (2007) 5.45
Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature (2013) 5.43
Conformable, flexible, large-area networks of pressure and thermal sensors with organic transistor active matrixes. Proc Natl Acad Sci U S A (2005) 5.37
PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest (2004) 5.29
Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell (2010) 5.08
Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev (2004) 4.78
Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell (2007) 4.71
Jarid2 and PRC2, partners in regulating gene expression. Genes Dev (2010) 4.65
Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature (2008) 4.60
A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell (2007) 4.59
Autophagy is required to maintain muscle mass. Cell Metab (2009) 4.46
Retracted DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs. Nat Cell Biol (2007) 4.45
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Nature (2002) 4.44
SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell (2002) 4.31
Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc Natl Acad Sci U S A (2005) 4.25
Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. N Engl J Med (2014) 4.00
Retracted A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation. Nat Cell Biol (2007) 3.97
A wheat gene encoding an aluminum-activated malate transporter. Plant J (2004) 3.89
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Mol Cell (2008) 3.60
Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature (2007) 3.59
Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nat Med (2010) 3.59
Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature (2003) 3.49
Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis. Nat Med (2012) 3.46
Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development (2004) 3.46
Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis. Annu Rev Pharmacol Toxicol (2006) 3.39
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science (2008) 3.38
Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs. Cell (2013) 3.34
Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland. Proc Natl Acad Sci U S A (2006) 3.32
Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study. J Bone Miner Metab (2009) 3.27
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity (2008) 3.25
Retracted GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. Nature (2009) 3.10
An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. Nat Genet (2005) 3.00
Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts. J Cell Biol (2004) 3.00
Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat. Gastroenterology (2002) 2.97
Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse. EMBO J (2003) 2.94
Retracted DNA demethylation in hormone-induced transcriptional derepression. Nature (2009) 2.90
A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. J Exp Med (2005) 2.80
Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network. J Exp Med (2009) 2.77
Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivo. J Biol Chem (2004) 2.72
NSD1 is essential for early post-implantation development and has a catalytically active SET domain. EMBO J (2003) 2.72
Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol Cell (2002) 2.69
Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse. Blood (2011) 2.66
A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse. Nat Biotechnol (2003) 2.65
Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model. Arthritis Rheum (2009) 2.64
Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci U S A (2006) 2.60
Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice. Nat Med (2005) 2.59
Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat Med (2012) 2.59
Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. Immunity (2003) 2.56
Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation. J Bone Miner Res (2012) 2.53
Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis. Nat Rev Rheumatol (2009) 2.50
Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression. Genes Dev (2004) 2.49
Retracted Maturation of microRNA is hormonally regulated by a nuclear receptor. Mol Cell (2009) 2.48
The Chlorella variabilis NC64A genome reveals adaptation to photosymbiosis, coevolution with viruses, and cryptic sex. Plant Cell (2010) 2.47
Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse. Proc Natl Acad Sci U S A (2004) 2.46
Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development. Nat Genet (2002) 2.45
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell (2012) 2.45
PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell (2005) 2.44
FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML. Blood (2009) 2.44
A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis. J Neurosci (2006) 2.40
The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP. Mol Cell Biol (2002) 2.40
Apoptotic extinction of germ cells in testes of Cyp26b1 knockout mice. Endocrinology (2007) 2.40
AtALMT1, which encodes a malate transporter, is identified as one of several genes critical for aluminum tolerance in Arabidopsis. Proc Natl Acad Sci U S A (2006) 2.33