Published in J Biol Chem on January 22, 2004
Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev (2008) 5.28
Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals. Am J Pathol (2006) 1.75
Hyperphosphatemia of chronic kidney disease. Kidney Int (2008) 1.63
Lean phenotype and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue. Endocrinology (2008) 1.58
Genetic disorders and defects in vitamin d action. Endocrinol Metab Clin North Am (2010) 1.53
Global analysis of the impact of environmental perturbation on cis-regulation of gene expression. PLoS Genet (2011) 1.51
Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol (2014) 1.42
Vitamin D receptor activators can protect against vascular calcification. J Am Soc Nephrol (2008) 1.35
Role of the vitamin D receptor in FGF23 action on phosphate metabolism. Biochem J (2005) 1.26
Autocrine and paracrine actions of vitamin d. Clin Biochem Rev (2010) 1.26
Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. Physiol Rev (2016) 1.25
Intestinal vitamin D receptor is required for normal calcium and bone metabolism in mice. Gastroenterology (2008) 1.15
Genomic determinants of gene regulation by 1,25-dihydroxyvitamin D3 during osteoblast-lineage cell differentiation. J Biol Chem (2014) 1.11
Relevance of vitamin D in reproduction. Hum Reprod (2012) 1.09
Vitamin D and bone. Curr Osteoporos Rep (2012) 1.08
Vitamin D Receptor Gene Ablation in the Conceptus Has Limited Effects on Placental Morphology, Function and Pregnancy Outcome. PLoS One (2015) 1.08
Hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia resulting from a novel missense mutation in the DNA-binding domain of the vitamin D receptor. Mol Genet Metab (2010) 1.00
Snail1 controls bone mass by regulating Runx2 and VDR expression during osteoblast differentiation. EMBO J (2009) 1.00
Evolution of the interaction between Runx2 and VDR, two transcription factors involved in osteoblastogenesis. BMC Evol Biol (2010) 0.98
Vitamin D Receptor Genetic Polymorphisms and Prostate Cancer Risk: A Meta-analysis of 36 Published Studies. Int J Clin Exp Med (2009) 0.98
Mutations in the vitamin D receptor and hereditary vitamin D-resistant rickets. Bonekey Rep (2014) 0.97
The rachitic tooth. Endocr Rev (2013) 0.96
Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2. J Clin Invest (2010) 0.95
The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease. Naunyn Schmiedebergs Arch Pharmacol (2005) 0.94
Vitamin D status in gastrointestinal and liver disease. Curr Opin Gastroenterol (2008) 0.92
VDR haploinsufficiency impacts body composition and skeletal acquisition in a gender-specific manner. Calcif Tissue Int (2011) 0.92
Peripubertal vitamin D(3) deficiency delays puberty and disrupts the estrous cycle in adult female mice. Biol Reprod (2012) 0.91
1, 25(OH)₂D₃ inhibits hepatocellular carcinoma development through reducing secretion of inflammatory cytokines from immunocytes. Curr Med Chem (2013) 0.90
Middle-term use of Cinacalcet in paediatric dialysis patients. Pediatr Nephrol (2009) 0.89
Vitamin D: a hormone for all seasons--how much is enough? Clin Biochem Rev (2005) 0.88
Skeletal health of children and adolescents with inflammatory bowel disease. J Pediatr Gastroenterol Nutr (2011) 0.88
Age-related changes in the epithelial and stromal compartments of the mammary gland in normocalcemic mice lacking the vitamin D3 receptor. PLoS One (2011) 0.87
1,25-Dihydroxyvitamin D3 Controls a Cohort of Vitamin D Receptor Target Genes in the Proximal Intestine That Is Enriched for Calcium-regulating Components. J Biol Chem (2015) 0.86
Mitochondrial localization of vitamin D receptor in human platelets and differentiated megakaryocytes. PLoS One (2010) 0.86
Alterations in phosphorus, calcium and PTHrP contribute to defects in dental and dental alveolar bone formation in calcium-sensing receptor-deficient mice. Development (2010) 0.86
Nuclear receptors in bone physiology and diseases. Physiol Rev (2013) 0.86
Cemento-ossifying fibroma in a patient with end-stage renal disease. Case Rep Dent (2013) 0.84
Endogenous PTH deficiency impairs fracture healing and impedes the fracture-healing efficacy of exogenous PTH(1-34). PLoS One (2011) 0.83
Vitamin D activities for health outcomes. Ann Lab Med (2014) 0.83
Fibroblast Growth Factor 23 Regulation by Systemic and Local Osteoblast-Synthesized 1,25-Dihydroxyvitamin D. J Am Soc Nephrol (2016) 0.82
Comparison between calcitriol and calcitriol plus low-dose cinacalcet for the treatment of moderate to severe secondary hyperparathyroidism in chronic dialysis patients. Nutrients (2013) 0.82
The abnormal phenotypes of cartilage and bone in calcium-sensing receptor deficient mice are dependent on the actions of calcium, phosphorus, and PTH. PLoS Genet (2011) 0.80
CBX7 deficiency plays a positive role in dentin and alveolar bone development. J Mol Histol (2016) 0.80
Fat-Soluble Vitamins: Clinical Indications and Current Challenges for Chromatographic Measurement. Clin Biochem Rev (2016) 0.79
Role of local vitamin D signaling and cellular calcium transport system in bone homeostasis. J Bone Miner Metab (2013) 0.79
1,25(OH)2D3 alters growth plate maturation and bone architecture in young rats with normal renal function. PLoS One (2011) 0.79
Comparison of active vitamin D compounds and a calcimimetic in mineral homeostasis. J Am Soc Nephrol (2010) 0.78
The Pathophysiology of Secondary Hyperparathyroidism and the Consequences of Uncontrolled Mineral Metabolism in Chronic Kidney Disease: The Role of COSMOS. NDT Plus (2008) 0.78
Role of bone biopsy in stages 3 to 4 chronic kidney disease. Clin J Am Soc Nephrol (2008) 0.78
Mineral and bone disorders in chronic kidney disease and end-stage renal disease patients: new insights into vitamin D receptor activation. Kidney Int Suppl (2011) (2011) 0.78
Vitamin D deficiency aggravates ischemic acute kidney injury in rats. Physiol Rep (2015) 0.77
Recombinant human parathyroid hormone related protein 1-34 and 1-84 and their roles in osteoporosis treatment. PLoS One (2014) 0.77
Parathyroid hormone administration improves bone marrow microenvironment and partially rescues haematopoietic defects in Bmi1-null mice. PLoS One (2014) 0.77
The vitamin D receptor functions as a transcription regulator in the absence of 1,25-dihydroxyvitamin D3. J Steroid Biochem Mol Biol (2015) 0.77
Transplantation of bone marrow-derived mesenchymal stem cells rescues partially rachitic phenotypes induced by 1,25-Dihydroxyvitamin D deficiency in mice. Am J Transl Res (2016) 0.76
Vitamin D Status: Current Opinion on Critical Levels for Plasma Calcium and Bone Mineral Homeostasis. EJIFCC (2011) 0.75
The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights. J Clin Invest (2017) 0.75
Osteoporosis and cardiovascular disease: lessons from chronic kidney disease. Clin Cases Miner Bone Metab (2008) 0.75
Regulation of Long Bone Growth in Vertebrates; It Is Time to Catch Up. Endocr Rev (2015) 0.75
VDR and gemini ligands. Oncotarget (2015) 0.75
Synergistic effects of high dietary calcium and exogenous parathyroid hormone in promoting osteoblastic bone formation in mice. Br J Nutr (2015) 0.75
A High-Calcium and Phosphate Rescue Diet and VDR-Expressing Transgenes Normalize Serum Vitamin D Metabolite Profiles and Renal Cyp27b1 and Cyp24a1 Expression in VDR Null Mice. Endocrinology (2015) 0.75
Vitamin D receptor expression in human bone tissue and dose-dependent activation in resorbing osteoclasts. Bone Res (2016) 0.75
Maternal Vitamin D Deficiency Programs Reproductive Dysfunction in Female Mice Offspring Through Adverse Effects on the Neuroendocrine Axis. Endocrinology (2016) 0.75
Cinacalcet in pediatric and adolescent chronic kidney disease: a single-center experience. Medicine (Baltimore) (2015) 0.75
Vitamin D Receptor Gene Polymorphisms Associated with Childhood Autism. Brain Sci (2017) 0.75
(+)-Cholesten-3-one induces osteogenic differentiation of bone marrow mesenchymal stem cells by activating vitamin D receptor. Exp Ther Med (2017) 0.75
Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions. Sci Rep (2017) 0.75
Insulin resistance in vitamin D-deficient mice is alleviated by n-acetylcysteine. Oncotarget (2017) 0.75
Vitamin D deficiency causes insulin resistance by provoking oxidative stress in hepatocytes. Oncotarget (2017) 0.75
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Effect of selective serotonin reuptake inhibitors on the risk of fracture. Arch Intern Med (2007) 4.68
Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study. CMAJ (2009) 2.64
Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice. Kidney Int (2008) 2.59
Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders. Endocrinology (2004) 2.40
The relationship between proton pump inhibitor use and longitudinal change in bone mineral density: a population-based study [corrected] from the Canadian Multicentre Osteoporosis Study (CaMos). Am J Gastroenterol (2012) 2.24
Parathyroid hormone-related peptide is required for increased trabecular bone volume in parathyroid hormone-null mice. Endocrinology (2004) 2.14
Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. Mol Cell Biol (2006) 2.01
The autosomal dominant hypophosphatemic rickets R176Q mutation in fibroblast growth factor 23 resists proteolytic cleavage and enhances in vivo biological potency. J Biol Chem (2003) 1.99
Altered ovarian function affects skeletal homeostasis independent of the action of follicle-stimulating hormone. Endocrinology (2007) 1.94
Up-regulation of Wnt-1 and beta-catenin production in patients with advanced metastatic prostate carcinoma: potential pathogenetic and prognostic implications. Cancer (2004) 1.90
Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34. J Clin Invest (2005) 1.88
Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Genes Dev (2004) 1.84
Autosomal dominant pseudohypoparathyroidism type Ib is associated with a heterozygous microdeletion that likely disrupts a putative imprinting control element of GNAS. J Clin Invest (2003) 1.77
Parathyroid hormone is essential for normal fetal bone formation. J Clin Invest (2002) 1.76
Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation. Cancer (2006) 1.75
Parathyroid hormone for the treatment of osteoporosis: a systematic review. CMAJ (2006) 1.74
Rosiglitazone impacts negatively on bone by promoting osteoblast/osteocyte apoptosis. J Endocrinol (2004) 1.67
Bisphosphonates for treatment of osteoporosis: expected benefits, potential harms, and drug holidays. Can Fam Physician (2014) 1.63
Assessment of gene-by-sex interaction effect on bone mineral density. J Bone Miner Res (2012) 1.58
A meta-analysis of the association of fracture risk and body mass index in women. J Bone Miner Res (2014) 1.56
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. PLoS Genet (2012) 1.55
The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone. J Clin Invest (2003) 1.53
Human calcium-sensing receptor gene. Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin D. J Biol Chem (2002) 1.51
CYP24 inhibition as a therapeutic target in FGF23-mediated renal phosphate wasting disorders. J Clin Invest (2016) 1.51
The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography. Atherosclerosis (2011) 1.50
Parathyroid hormone increases beta-catenin levels through Smad3 in mouse osteoblastic cells. Endocrinology (2006) 1.43
Plasma FGF23 levels increase rapidly after acute kidney injury. Kidney Int (2013) 1.42
Calcium sensing receptor in human colon carcinoma: interaction with Ca(2+) and 1,25-dihydroxyvitamin D(3). Cancer Res (2005) 1.39
Co-treatment of PTH with osteoprotegerin or alendronate increases its anabolic effect on the skeleton of oophorectomized mice. J Bone Miner Res (2007) 1.38
Peak bone mass from longitudinal data: implications for the prevalence, pathophysiology, and diagnosis of osteoporosis. J Bone Miner Res (2010) 1.37
Redetermination at 113 K of 2,2-tetra-methyl-ene-1,2-dihydro-quinazolin-4(3H)-one. Acta Crystallogr Sect E Struct Rep Online (2008) 1.36
Functional characterization of GATA3 mutations causing the hypoparathyroidism-deafness-renal (HDR) dysplasia syndrome: insight into mechanisms of DNA binding by the GATA3 transcription factor. Hum Mol Genet (2007) 1.36
The proinflammatory cytokine, interleukin-6, up-regulates calcium-sensing receptor gene transcription via Stat1/3 and Sp1/3. J Biol Chem (2008) 1.34
Bone formation regulates circulating concentrations of fibroblast growth factor 23. Endocrinology (2009) 1.33
Change in bone mineral density as a function of age in women and men and association with the use of antiresorptive agents. CMAJ (2008) 1.33
The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion. Am J Physiol Endocrinol Metab (2009) 1.32
Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression. Mol Endocrinol (2002) 1.32
Changes to osteoporosis prevalence according to method of risk assessment. J Bone Miner Res (2007) 1.28
Skeletal abnormalities in Pth-null mice are influenced by dietary calcium. Endocrinology (2003) 1.26
Familial isolated hyperparathyroidism: clinical and genetic characteristics of 36 kindreds. Medicine (Baltimore) (2002) 1.25
Defective bone mineralization and osteopenia in young adult FGFR3-/- mice. Hum Mol Genet (2003) 1.21
Association between change in BMD and fragility fracture in women and men. J Bone Miner Res (2009) 1.19
Bone strength: the whole is greater than the sum of its parts. Semin Arthritis Rheum (2006) 1.18
Temporal trends and determinants of longitudinal change in 25-hydroxyvitamin D and parathyroid hormone levels. J Bone Miner Res (2012) 1.18
Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women. J Bone Miner Res (2013) 1.16
Blood ionized calcium is associated with clustered polymorphisms in the carboxyl-terminal tail of the calcium-sensing receptor. J Clin Endocrinol Metab (2004) 1.15
Repeat low-trauma fractures occur frequently among men and women who have osteopenic BMD. J Bone Miner Res (2009) 1.15
Defects in mesenchymal stem cell self-renewal and cell fate determination lead to an osteopenic phenotype in Bmi-1 null mice. J Bone Miner Res (2010) 1.12
Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2. J Biol Chem (2004) 1.12
Familial isolated hyperparathyroidism is rarely caused by germline mutation in HRPT2, the gene for the hyperparathyroidism-jaw tumor syndrome. J Clin Endocrinol Metab (2004) 1.12
Identification and functional characterization of novel calcium-sensing receptor mutations in familial hypocalciuric hypercalcemia and autosomal dominant hypocalcemia. J Clin Endocrinol Metab (2002) 1.11
Osteoporosis-related fracture case definitions for population-based administrative data. BMC Public Health (2012) 1.11
(S)-2-(3-Nitro-phen-yl)-1,2-dihydro-quinazolin-4(3H)-one. Acta Crystallogr Sect E Struct Rep Online (2008) 1.11
Neonatal hyperparathyroidism with a heterozygous calcium-sensing receptor (CASR) R185Q mutation: clinical benefit from cinacalcet. J Clin Endocrinol Metab (2011) 1.10
Calcium-sensing receptor dimerizes in the endoplasmic reticulum: biochemical and biophysical characterization of CASR mutants retained intracellularly. Hum Mol Genet (2006) 1.10
Primary hyperparathyroidism and the presence of kidney stones are associated with different haplotypes of the calcium-sensing receptor. J Clin Endocrinol Metab (2006) 1.10
Impaired endochondral bone development and osteopenia in Gli2-deficient mice. Exp Cell Res (2004) 1.10
Dietary patterns in Canadian men and women ages 25 and older: relationship to demographics, body mass index, and bone mineral density. BMC Musculoskelet Disord (2010) 1.08
A syndrome of hypocalciuric hypercalcemia caused by autoantibodies directed at the calcium-sensing receptor. J Clin Endocrinol Metab (2003) 1.08
Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein. Proc Natl Acad Sci U S A (2008) 1.08
Impaired cotranslational processing of the calcium-sensing receptor due to signal peptide missense mutations in familial hypocalciuric hypercalcemia. Hum Mol Genet (2005) 1.07
Dietary patterns and incident low-trauma fractures in postmenopausal women and men aged ≥ 50 y: a population-based cohort study. Am J Clin Nutr (2010) 1.06
Parathyroid hormone-related peptide interacts with bone morphogenetic protein 2 to increase osteoblastogenesis and decrease adipogenesis in pluripotent C3H10T 1/2 mesenchymal cells. Endocrinology (2003) 1.04
Genetic models show that parathyroid hormone and 1,25-dihydroxyvitamin D3 play distinct and synergistic roles in postnatal mineral ion homeostasis and skeletal development. Hum Mol Genet (2005) 1.04
Spiro-[cyclo-pentane-1,2'(1'H)-pyrido[2,3-d]pyrimidin]-4'(3'H)-one. Acta Crystallogr Sect E Struct Rep Online (2010) 1.03
Pretreatment with anticatabolic agents blunts but does not eliminate the skeletal anabolic response to parathyroid hormone in oophorectomized mice. Endocrinology (2007) 1.02
Vertebral fracture status and the World Health Organization risk factors for predicting osteoporotic fracture risk. J Bone Miner Res (2009) 1.00
Calcium-sensing receptor (CASR) mutations in hypercalcemic states: studies from a single endocrine clinic over three years. J Clin Endocrinol Metab (2010) 1.00
Geographic variation of bone mineral density and selected risk factors for prediction of incident fracture among Canadians 50 and older. Bone (2008) 1.00
Coding GNAS mutations leading to hormone resistance impair in vitro agonist- and cholera toxin-induced adenosine cyclic 3',5'-monophosphate formation mediated by human XLalphas. Endocrinology (2006) 1.00
Calcium and vitamin D intake and mortality: results from the Canadian Multicentre Osteoporosis Study (CaMos). J Clin Endocrinol Metab (2013) 0.99
Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype. J Biol Chem (2003) 0.98
Parathyroid hormone-related peptide and survival of patients with cancer and hypercalcemia. Am J Med (2003) 0.98
Bone and mineral metabolism and fibroblast growth factor 23 levels after kidney donation. Am J Kidney Dis (2011) 0.97
Interferon-γ plays a role in bone formation in vivo and rescues osteoporosis in ovariectomized mice. J Bone Miner Res (2011) 0.97
Spine-hip T-score difference predicts major osteoporotic fracture risk independent of FRAX(®): a population-based report from CAMOS. J Clin Densitom (2011) 0.97
LRP5, serotonin, and bone: complexity, contradictions, and conundrums. J Bone Miner Res (2011) 0.96
In healthy adults, biological activity of vitamin D, as assessed by serum PTH, is largely independent of DBP concentrations. J Bone Miner Res (2014) 0.96
Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo. Am J Physiol Endocrinol Metab (2012) 0.95