Middle-term use of Cinacalcet in paediatric dialysis patients.

PubWeight™: 0.89‹?›

🔗 View Article (PMID 19838738)

Published in Pediatr Nephrol on October 17, 2009

Authors

Caroline Platt1, Carol Inward, Mary McGraw, Jan Dudley, Jane Tizard, Christine Burren, Moin A Saleem

Author Affiliations

1: Children's Renal Unit, Bristol Royal Hospital for Children, Upper Maudlin Street, Bristol BS2 8BJ, UK. cazardron@doctors.org.uk

Associated clinical trials:

Cinacalcet in Paediatric Secondary Hyperparathyroidism (SHPT) Due to Chronic Kidney Disease (CKD) | NCT01479088

Articles cited by this

Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med (2000) 8.47

Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: a national study. Am J Kidney Dis (1998) 7.79

Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis. N Engl J Med (2004) 6.52

Cinacalcet HCl, an oral calcimimetic agent for the treatment of secondary hyperparathyroidism in hemodialysis and peritoneal dialysis: a randomized, double-blind, multicenter study. J Am Soc Nephrol (2005) 2.91

Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology (1998) 2.48

A multicenter study on the effects of lanthanum carbonate (Fosrenol) and calcium carbonate on renal bone disease in dialysis patients. Kidney Int Suppl (2003) 2.04

Achieving NKF-K/DOQI bone metabolism and disease treatment goals with cinacalcet HCl. Kidney Int (2005) 1.96

Inactivation of the 25-hydroxyvitamin D 1alpha-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis. J Biol Chem (2004) 1.91

Vascular calcification: a stiff challenge for the nephrologist: does preventing bone disease cause arterial disease? Kidney Int (2004) 1.72

Effects of the calcimimetic cinacalcet HCl on cardiovascular disease, fracture, and health-related quality of life in secondary hyperparathyroidism. Kidney Int (2005) 1.64

Development of adynamic bone in patients with secondary hyperparathyroidism after intermittent calcitriol therapy. Kidney Int (1994) 1.28

Cinacalcet HCI (Sensipar/Mimpara) is an effective chronic therapy for hemodialysis patients with secondary hyperparathyroidism. Clin Nephrol (2007) 1.14

Prevention and treatment of renal osteodystrophy in children on chronic renal failure: European guidelines. Pediatr Nephrol (2005) 1.09

Diminished linear growth during intermittent calcitriol therapy in children undergoing CCPD. Kidney Int (1998) 1.05

Intermittent calcitriol therapy in secondary hyperparathyroidism: a comparison between oral and intraperitoneal administration. Kidney Int (1998) 1.04

Cinacalcet for secondary hyperparathyroidism in children with end-stage renal disease. Pediatr Nephrol (2008) 0.97

Optimal correction of acidosis changes progression of dialysis osteodystrophy. Kidney Int (1989) 0.96

Cinacalcet is efficacious in pediatric dialysis patients. Pediatr Nephrol (2008) 0.94

Calcimimetic agents and secondary hyperparathyroidism: rationale for use and results from clinical trials. Pediatr Nephrol (2003) 0.93

New strategies for the treatment of hyperparathyroidism incorporating calcimimetics. Expert Opin Pharmacother (2008) 0.90

Effects of Ca2+ sensing receptor activation in the growth plate. FASEB J (2003) 0.88

Adynamic renal osteodystrophy: is there a problem? J Am Soc Nephrol (2001) 0.87

Cinacalcet for the treatment of primary hyperparathyroidism. Metabolism (2008) 0.85

Catch-up growth with normal parathyroid hormone levels in chronic renal failure. Pediatr Nephrol (2003) 0.84

Cloning and characterization of an extracellular Ca(2+)-sensing receptor from parathyroid and kidney: new insights into the physiology and pathophysiology of calcium metabolism. Nephrol Dial Transplant (1994) 0.83

Cinacalcet does not affect longitudinal growth but increases body weight gain in experimental uraemia. Nephrol Dial Transplant (2008) 0.80

Management of renal osteodystrophy in children. Turk J Pediatr (2005) 0.78

Articles by these authors

(truncated to the top 100)

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71

Insulin signaling to the glomerular podocyte is critical for normal kidney function. Cell Metab (2010) 3.05

Mutant chromatin remodeling protein SMARCAL1 causes Schimke immuno-osseous dysplasia. Nat Genet (2002) 2.64

Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors. J Cell Sci (2008) 2.09

Prorenin receptor is essential for normal podocyte structure and function. J Am Soc Nephrol (2011) 2.08

WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing. Cancer Cell (2011) 2.06

Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes. Am J Physiol Renal Physiol (2003) 2.00

The podocyte cytoskeleton--key to a functioning glomerulus in health and disease. Nat Rev Nephrol (2011) 1.86

Human podocytes adhere to the KRGDS motif of the alpha3alpha4alpha5 collagen IV network. J Am Soc Nephrol (2008) 1.81

Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1. Diabetes (2005) 1.75

ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption. J Clin Invest (2013) 1.74

Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains. Hum Mol Genet (2003) 1.70

Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy. Nephrol Dial Transplant (2009) 1.68

Simultaneous sequencing of 24 genes associated with steroid-resistant nephrotic syndrome. Clin J Am Soc Nephrol (2013) 1.64

Interferon-beta reduces proteinuria in experimental glomerulonephritis. J Am Soc Nephrol (2007) 1.63

Randomised, double-blind, placebo-controlled trial to determine whether steroids reduce the incidence and severity of nephropathy in Henoch-Schonlein Purpura (HSP). Arch Dis Child (2013) 1.63

A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. Cell Metab (2006) 1.59

Hemolytic uremic syndrome associated with invasive pneumococcal disease: the United kingdom experience. J Pediatr (2007) 1.56

Nephrin is critical for the action of insulin on human glomerular podocytes. Diabetes (2007) 1.55

Identification of 70 calcium-sensing receptor mutations in hyper- and hypo-calcaemic patients: evidence for clustering of extracellular domain mutations at calcium-binding sites. Hum Mol Genet (2012) 1.51

The human glomerular podocyte is a novel target for insulin action. Diabetes (2005) 1.49

Comparative promoter analysis allows de novo identification of specialized cell junction-associated proteins. Proc Natl Acad Sci U S A (2006) 1.43

Regulation of nephrin gene by the Ets transcription factor, GA-binding protein. Nephrol Dial Transplant (2012) 1.43

Characteristics and survival of young adults who started renal replacement therapy during childhood. Nephrol Dial Transplant (2008) 1.43

VEGF regulates local inhibitory complement proteins in the eye and kidney. J Clin Invest (2016) 1.39

KIBRA modulates directional migration of podocytes. J Am Soc Nephrol (2008) 1.36

Nephrin-signature molecule of the glomerular podocyte? J Pathol (2010) 1.35

Assuring validity of multisource feedback in a national programme. Arch Dis Child (2010) 1.34

Vascular endothelial growth factor and nephrin interact and reduce apoptosis in human podocytes. Am J Physiol Renal Physiol (2004) 1.29

mTOR regulates expression of slit diaphragm proteins and cytoskeleton structure in podocytes. Am J Physiol Renal Physiol (2008) 1.27

Statin-sensitive endocytosis of albumin by glomerular podocytes. Am J Physiol Renal Physiol (2006) 1.27

Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins. J Cell Sci (2011) 1.27

New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes. Am J Physiol Renal Physiol (2008) 1.26

Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes. J Am Soc Nephrol (2005) 1.26

Globotriaosylsphingosine actions on human glomerular podocytes: implications for Fabry nephropathy. Nephrol Dial Transplant (2010) 1.26

Inhibition of p66ShcA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis. J Biol Chem (2009) 1.24

Toll-like receptor 3 ligands induce CD80 expression in human podocytes via an NF-κB-dependent pathway. Nephrol Dial Transplant (2011) 1.23

The MIF receptor CD74 in diabetic podocyte injury. J Am Soc Nephrol (2008) 1.22

Hepatocyte growth factor signaling ameliorates podocyte injury and proteinuria. Kidney Int (2010) 1.22

Modulation of notch-1 signaling alleviates vascular endothelial growth factor-mediated diabetic nephropathy. Diabetes (2010) 1.21

TNF-like weak inducer of apoptosis (TWEAK) induces inflammatory and proliferative effects in human kidney cells. Cytokine (2009) 1.20

Mitochondrial dysfunction in patients with primary congenital insulin resistance. J Clin Invest (2011) 1.19

Schimke immunoosseous dysplasia: suggestions of genetic diversity. Hum Mutat (2007) 1.19

Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes. J Am Soc Nephrol (2008) 1.18

Mechanism of perturbation of integrin-mediated cell-matrix interactions by reactive carbonyl compounds and its implication for pathogenesis of diabetic nephropathy. Diabetes (2005) 1.18

Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1. J Biol Chem (2008) 1.16

Podocyte injury induced by mesangial-derived cytokines in IgA nephropathy. Nephrol Dial Transplant (2008) 1.16

Receptor-mediated endocytosis of α-galactosidase A in human podocytes in Fabry disease. PLoS One (2011) 1.15

Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters. Cell Tissue Res (2009) 1.14

Functional expression of the renin-angiotensin system in human podocytes. Am J Physiol Renal Physiol (2005) 1.12

Podocytes express ADAMTS13 in normal renal cortex and in patients with thrombotic thrombocytopenic purpura. Br J Haematol (2007) 1.11

Activation of podocytes by mesangial-derived TNF-alpha: glomerulo-podocytic communication in IgA nephropathy. Am J Physiol Renal Physiol (2008) 1.07

Shiga toxin 2 targets the murine renal collecting duct epithelium. Infect Immun (2009) 1.07

Expression of functional CCR and CXCR chemokine receptors in podocytes. J Immunol (2002) 1.07

Human podocytes possess a stretch-sensitive, Ca2+-activated K+ channel: potential implications for the control of glomerular filtration. J Am Soc Nephrol (2004) 1.05

Human podocytes express angiopoietin 1, a potential regulator of glomerular vascular endothelial growth factor. J Am Soc Nephrol (2002) 1.03

Aliskiren inhibits intracellular angiotensin II levels without affecting (pro)renin receptor signals in human podocytes. Am J Hypertens (2010) 1.03

A novel non-synonymous polymorphism (p.Arg240His) in C4b-binding protein is associated with atypical hemolytic uremic syndrome and leads to impaired alternative pathway cofactor activity. J Immunol (2008) 1.03

Randomized trial of tacrolimus versus cyclosporin microemulsion in renal transplantation. Pediatr Nephrol (2002) 1.02

Disease activity, severity, and damage in the UK Juvenile-Onset Systemic Lupus Erythematosus Cohort. Arthritis Rheum (2012) 1.00

Associations among genotype, clinical phenotype, and intracellular localization of trafficking proteins in ARC syndrome. Hum Mutat (2012) 1.00

UK Renal Registry 12th Annual Report (December 2009): chapter 14: demography of the UK paediatric renal replacement therapy population in 2008. Nephron Clin Pract (2010) 0.99

Altered nephrin and podoplanin distribution is associated with disturbed polarity protein PARD-3 and PARD-6 expressions in podocytes from preeclampsia. Reprod Sci (2011) 0.99

Does rituximab treat recurrent focal segmental glomerulosclerosis post-renal transplantation? Pediatr Nephrol (2006) 0.98

Flufenamic acid is a tool for investigating TRPC6-mediated calcium signalling in human conditionally immortalised podocytes and HEK293 cells. Cell Calcium (2009) 0.97

Prognosis, treatment and outcome of childhood mesangiocapillary (membranoproliferative) glomerulonephritis. Nephrol Dial Transplant (2004) 0.97

Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis. Kidney Int (2010) 0.96

LPS and PAN-induced podocyte injury in an in vitro model of minimal change disease: changes in TLR profile. J Cell Commun Signal (2012) 0.96

Anion exchanger 1 interacts with nephrin in podocytes. J Am Soc Nephrol (2010) 0.96

The bioactivity of plasma factors in focal segmental glomerulosclerosis. Nephron Exp Nephrol (2006) 0.96

NPHS2 mutations in steroid-resistant nephrotic syndrome: a mutation update and the associated phenotypic spectrum. Hum Mutat (2013) 0.95

Identification of the glomerular podocyte as a target for growth hormone action. Endocrinology (2007) 0.94

HSP27/HSPB1 as an adaptive podocyte antiapoptotic protein activated by high glucose and angiotensin II. Lab Invest (2011) 0.94

HIV compromises integrity of the podocyte actin cytoskeleton through downregulation of the vitamin D receptor. Am J Physiol Renal Physiol (2013) 0.93

Regulation of Neph3 gene in podocytes--key roles of transcription factors NF-kappaB and Sp1. BMC Mol Biol (2009) 0.93

RhCG is the major putative ammonia transporter expressed in the human kidney, and RhBG is not expressed at detectable levels. Am J Physiol Renal Physiol (2009) 0.93

Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS-deficient mouse. Am J Physiol Renal Physiol (2012) 0.93

Four-year data after pediatric renal transplantation: a randomized trial of tacrolimus vs. cyclosporin microemulsion. Pediatr Transplant (2005) 0.92

Chronic exposure to laminar shear stress induces Kruppel-like factor 2 in glomerular endothelial cells and modulates interactions with co-cultured podocytes. Int J Biochem Cell Biol (2012) 0.91

Dysregulated autophagy contributes to podocyte damage in Fabry's disease. PLoS One (2013) 0.91

PPARalpha activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism. Biochem Biophys Res Commun (2005) 0.90

Monocyte- and endothelial-derived microparticles induce an inflammatory phenotype in human podocytes. Nephron Exp Nephrol (2011) 0.89

Transcription of nephrin-Neph3 gene pair is synergistically activated by WT1 and NF-κB and silenced by DNA methylation. Nephrol Dial Transplant (2011) 0.89

Sam68-like mammalian protein 2, identified by digital differential display as expressed by podocytes, is induced in proteinuria and involved in splice site selection of vascular endothelial growth factor. J Am Soc Nephrol (2005) 0.89

Redistribution of connexin43 expression in glomerular podocytes predicts poor renal prognosis in patients with type 2 diabetes and overt nephropathy. Nephrol Dial Transplant (2006) 0.89

Active proteases in nephrotic plasma lead to a podocin-dependent phosphorylation of VASP in podocytes via protease activated receptor-1. J Pathol (2013) 0.89

Genetics in clinical practice: nephrotic and proteinuric syndromes. Nephron Exp Nephrol (2010) 0.89

Human immunodeficiency virus downregulates podocyte apoE expression. Am J Physiol Renal Physiol (2009) 0.88

Republished paper: Assuring validity of multisource feedback in a national programme. Postgrad Med J (2010) 0.88

MicroRNA-26a inhibits TGF-β-induced extracellular matrix protein expression in podocytes by targeting CTGF and is downregulated in diabetic nephropathy. Diabetologia (2015) 0.88

Serum from minimal change patients in relapse increases CD80 expression in cultured podocytes. Pediatr Nephrol (2013) 0.88

IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro. PLoS One (2012) 0.88

Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors. J Biol Chem (2012) 0.87

A proteomic investigation of glomerular podocytes from a Denys-Drash syndrome patient with a mutation in the Wilms tumour suppressor gene WT1. Proteomics (2007) 0.87

Effects of p38 mitogen-activated protein kinase inhibition on anti-neutrophil cytoplasmic autoantibody pathogenicity in vitro and in vivo. Ann Rheum Dis (2010) 0.87

Impact of graft loss among kidney diseases with a high risk of post-transplant recurrence in the paediatric population. Nephrol Dial Transplant (2013) 0.87

Expression of CCN1 (CYR61) in developing, normal, and diseased human kidney. Am J Physiol Renal Physiol (2007) 0.85

Rapamycin-induced modulation of HIV gene transcription attenuates progression of HIVAN. Exp Mol Pathol (2012) 0.85

Establishment of conditionally immortalized human glomerular mesangial cells in culture, with unique migratory properties. Am J Physiol Renal Physiol (2011) 0.84

Morphine induces albuminuria by compromising podocyte integrity. PLoS One (2013) 0.84