Published in J Mol Biol on February 06, 2004
SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53. J Biol Chem (2010) 0.97
p53 gene in treatment of hepatic carcinoma: status quo. World J Gastroenterol (2007) 0.95
Structural effects of the L145Q, V157F, and R282W cancer-associated mutations in the p53 DNA-binding core domain. Biochemistry (2011) 0.92
Stability of the core domain of p53: insights from computer simulations. BMC Bioinformatics (2008) 0.87
Regulation of ASPP2 interaction with p53 core domain by an intramolecular autoinhibitory mechanism. PLoS One (2013) 0.82
Biopharmaceuticals and monoclonal antibodies in oncology trials--a cross-sectional analysis. Protein Eng Des Sel (2010) 0.79
QM-MM simulations on p53-DNA complex: a study of hot spot and rescue mutants. J Mol Model (2013) 0.77
Multisite aggregation of p53 and implications for drug rescue. Proc Natl Acad Sci U S A (2017) 0.75
Awakening guardian angels: drugging the p53 pathway. Nat Rev Cancer (2009) 5.12
The complete folding pathway of a protein from nanoseconds to microseconds. Nature (2003) 3.61
The crystal structure of human CD1d with and without alpha-galactosylceramide. Nat Immunol (2005) 3.53
Structural biology of the tumor suppressor p53. Annu Rev Biochem (2008) 3.36
Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A (2006) 3.35
A transient and low-populated protein-folding intermediate at atomic resolution. Science (2010) 3.08
Is there a unifying mechanism for protein folding? Trends Biochem Sci (2003) 2.63
LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy. Mol Cell (2012) 2.41
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Nat Struct Mol Biol (2010) 2.31
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci U S A (2008) 2.30
Cooperative binding of tetrameric p53 to DNA. J Mol Biol (2004) 2.26
Unifying features in protein-folding mechanisms. Proc Natl Acad Sci U S A (2003) 2.24
Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1. Nat Struct Mol Biol (2010) 2.15
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain. Proc Natl Acad Sci U S A (2008) 2.14
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. Proc Natl Acad Sci U S A (2007) 2.09
PRIMA-1 reactivates mutant p53 by covalent binding to the core domain. Cancer Cell (2009) 2.09
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell (2013) 2.05
Molecular mechanism of the interaction between MDM2 and p53. J Mol Biol (2002) 2.03
FtsA forms actin-like protofilaments. EMBO J (2012) 2.00
Comparative binding of p53 to its promoter and DNA recognition elements. J Mol Biol (2005) 1.96
Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations. J Biol Chem (2003) 1.94
Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome. Genes Dev (2011) 1.89
Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53. Proc Natl Acad Sci U S A (2007) 1.86
General structural motifs of amyloid protofilaments. Proc Natl Acad Sci U S A (2006) 1.72
Tumor suppressor p53 slides on DNA with low friction and high stability. Biophys J (2008) 1.70
Testing protein-folding simulations by experiment: B domain of protein A. Proc Natl Acad Sci U S A (2004) 1.70
Kinetic instability of p53 core domain mutants: implications for rescue by small molecules. J Biol Chem (2003) 1.68
Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations. J Biol Chem (2005) 1.67
The central region of HDM2 provides a second binding site for p53. Proc Natl Acad Sci U S A (2006) 1.67
Direct observation of barrier-limited folding of BBL by single-molecule fluorescence resonance energy transfer. Proc Natl Acad Sci U S A (2009) 1.65
The tumor suppressor p53: from structures to drug discovery. Cold Spring Harb Perspect Biol (2010) 1.64
The crystal structure of human CD1b with a bound bacterial glycolipid. J Immunol (2004) 1.64
Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains. J Biol Chem (2006) 1.61
Core domain interactions in full-length p53 in solution. Proc Natl Acad Sci U S A (2006) 1.59
A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants. Proc Natl Acad Sci U S A (2002) 1.58
Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA. Nucleic Acids Res (2008) 1.58
Solution structure of p53 core domain: structural basis for its instability. Proc Natl Acad Sci U S A (2006) 1.53
Noble metals strip peptides from class II MHC proteins. Nat Chem Biol (2006) 1.53
Phi-analysis at the experimental limits: mechanism of beta-hairpin formation. J Mol Biol (2006) 1.53
Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor. Proc Natl Acad Sci U S A (2005) 1.52
Ultra-fast barrier-limited folding in the peripheral subunit-binding domain family. J Mol Biol (2005) 1.52
The denatured state of Engrailed Homeodomain under denaturing and native conditions. J Mol Biol (2003) 1.51
Molecular basis for regulation of the heat shock transcription factor sigma32 by the DnaK and DnaJ chaperones. Mol Cell (2008) 1.51
Characterization of the p53-rescue drug CP-31398 in vitro and in living cells. Oncogene (2002) 1.51
Halogen-enriched fragment libraries as leads for drug rescue of mutant p53. J Am Chem Soc (2012) 1.50
Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Proc Natl Acad Sci U S A (2009) 1.46
A single-molecule characterization of p53 search on DNA. Proc Natl Acad Sci U S A (2010) 1.43
Sequential unfolding of ankyrin repeats in tumor suppressor p16. Structure (2003) 1.43
Direct observation of ultrafast folding and denatured state dynamics in single protein molecules. Proc Natl Acad Sci U S A (2009) 1.39
NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation. Proc Natl Acad Sci U S A (2010) 1.38
14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers. Nucleic Acids Res (2008) 1.36
Distinguishing between cooperative and unimodal downhill protein folding. Proc Natl Acad Sci U S A (2007) 1.35
Rapid amyloid fiber formation from the fast-folding WW domain FBP28. Proc Natl Acad Sci U S A (2003) 1.33
Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53. J Biol Chem (2004) 1.31
Early events in protein folding. Curr Opin Struct Biol (2003) 1.28
Assembly, analysis and architecture of atypical ubiquitin chains. Nat Struct Mol Biol (2013) 1.27
Correlation of levels of folded recombinant p53 in escherichia coli with thermodynamic stability in vitro. J Mol Biol (2007) 1.27
Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant. Chem Biol (2010) 1.27
Simulation and experiment conspire to reveal cryptic intermediates and a slide from the nucleation-condensation to framework mechanism of folding. J Mol Biol (2005) 1.27
Modulation of the oligomerization state of p53 by differential binding of proteins of the S100 family to p53 monomers and tetramers. J Biol Chem (2009) 1.25
Small molecule induced reactivation of mutant p53 in cancer cells. Nucleic Acids Res (2013) 1.24
One-state downhill versus conventional protein folding. J Mol Biol (2004) 1.24
The helix-turn-helix motif as an ultrafast independently folding domain: the pathway of folding of Engrailed homeodomain. Proc Natl Acad Sci U S A (2007) 1.23
Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL. J Biol Chem (2007) 1.23
Recognition of DNA by p53 core domain and location of intermolecular contacts of cooperative binding. J Mol Biol (2002) 1.22
Regulation of DNA binding of p53 by its C-terminal domain. J Mol Biol (2004) 1.22
Demonstration of a low-energy on-pathway intermediate in a fast-folding protein by kinetics, protein engineering, and simulation. Proc Natl Acad Sci U S A (2004) 1.21
Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition. Proc Natl Acad Sci U S A (2012) 1.21
Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53. Nucleic Acids Res (2010) 1.20
Carboxyl pK(a) values and acid denaturation of BBL. J Mol Biol (2010) 1.20
Binding of natively unfolded HIF-1alpha ODD domain to p53. Mol Cell (2005) 1.18
Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53. Nucleic Acids Res (2008) 1.18
Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53. Proc Natl Acad Sci U S A (2002) 1.18
CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90. Proc Natl Acad Sci U S A (2002) 1.17
Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration. Proc Natl Acad Sci U S A (2011) 1.16
Conformational entropy of alanine versus glycine in protein denatured states. Proc Natl Acad Sci U S A (2007) 1.13
Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer. Proc Natl Acad Sci U S A (2009) 1.13
Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53. Nucleic Acids Res (2009) 1.13
Sequence-dependent sliding kinetics of p53. Proc Natl Acad Sci U S A (2012) 1.13
A structural double-mutant cycle: estimating the strength of a buried salt bridge in barnase. Acta Crystallogr D Biol Crystallogr (2002) 1.10
The structure of the major transition state for folding of an FF domain from experiment and simulation. J Mol Biol (2005) 1.10
Novel Hsp90 partners discovered using complementary proteomic approaches. Cell Stress Chaperones (2009) 1.09
The kinetic pathway of folding of barnase. J Mol Biol (2003) 1.09
Hydrophobic core fluidity of homologous protein domains: relation of side-chain dynamics to core composition and packing. Biochemistry (2004) 1.08
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. Proc Natl Acad Sci U S A (2010) 1.08