Published in Regul Pept on March 15, 2004
Orexin/hypocretin and histamine: distinct roles in the control of wakefulness demonstrated using knock-out mouse models. J Neurosci (2009) 2.35
Clinical and neurobiological aspects of narcolepsy. Sleep Med (2007) 1.26
Orexin, stress, and anxiety/panic states. Prog Brain Res (2012) 1.11
Central chemoreceptors: locations and functions. Compr Physiol (2012) 1.04
Hypocretin/orexin in arousal and stress. Brain Res (2009) 1.03
Respiration and autonomic regulation and orexin. Prog Brain Res (2012) 0.96
The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold. BMC Neurosci (2013) 0.92
Changes in brain orexin levels in a rat model of depression induced by neonatal administration of clomipramine. J Psychopharmacol (2008) 0.91
Hypocretin/Orexin neuropeptides: participation in the control of sleep-wakefulness cycle and energy homeostasis. Curr Neuropharmacol (2009) 0.90
MCH-containing neurons in the hypothalamus of the cat: searching for a role in the control of sleep and wakefulness. Brain Res (2006) 0.89
Relationship of arousal to circadian anticipatory behavior: ventromedial hypothalamus: one node in a hunger-arousal network. Eur J Neurosci (2009) 0.87
The waking brain: an update. Cell Mol Life Sci (2011) 0.86
State-dependent central chemoreception: a role of orexin. Respir Physiol Neurobiol (2010) 0.82
Effects of rapid eye movement sleep deprivation on hypocretin neurons in the hypothalamus of a rat model of depression. Neuropeptides (2007) 0.80
Influence of paradoxical sleep deprivation and sleep recovery on testosterone level in rats of different ages. Asian J Androl (2011) 0.80
Neuroendocrine and sympathetic responses to an orexin receptor antagonist, SB-649868, and alprazolam following insulin-induced hypoglycemia in humans. Psychopharmacology (Berl) (2014) 0.79
Role of orexin in respiratory and sleep homeostasis during upper airway obstruction in rats. Sleep (2014) 0.78
Lack of hypocretin attenuates behavioral changes produced by glutamatergic activation of the perifornical-lateral hypothalamic area. Sleep (2014) 0.78
The effect of clomipramine on wake/sleep and orexinergic expression in rats. J Psychopharmacol (2008) 0.77
Continuous Aerobic Training in Individualized Intensity Avoids Spontaneous Physical Activity Decline and Improves MCT1 Expression in Oxidative Muscle of Swimming Rats. Front Physiol (2016) 0.77
Waking with the hypothalamus. Pflugers Arch (2011) 0.77
Exercise Influence on Hippocampal Function: Possible Involvement of Orexin-A. Front Physiol (2017) 0.75
Neuroprotective Effects of Physical Activity: Evidence from Human and Animal Studies. Front Neurol (2017) 0.75
Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med (2009) 33.09
Somatic mutations affect key pathways in lung adenocarcinoma. Nature (2008) 30.02
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med (2013) 19.87
Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature (2010) 19.68
Characterizing the cancer genome in lung adenocarcinoma. Nature (2007) 16.48
VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing. Genome Res (2012) 15.90
DNMT3A mutations in acute myeloid leukemia. N Engl J Med (2010) 14.07
Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med (2004) 11.17
The origin and evolution of mutations in acute myeloid leukemia. Cell (2012) 9.66
Narcolepsy with cataplexy. Lancet (2007) 4.81
History of the development of sleep medicine in the United States. J Clin Sleep Med (2005) 4.22
Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China. Ann Neurol (2011) 4.09
Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet (2009) 3.33
CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell (2011) 3.31
Rapid detection and identification of metallo-beta-lactamase-encoding genes by multiplex real-time PCR assay and melt curve analysis. J Clin Microbiol (2006) 3.30
Post-H1N1 narcolepsy-cataplexy. Sleep (2010) 3.10
Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset. Sleep (2009) 3.06
Kleine-Levin syndrome: a systematic study of 108 patients. Ann Neurol (2008) 3.03
Further validation of actigraphy for sleep studies. Sleep (2003) 2.83
Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. Am J Hum Genet (2003) 2.71
Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells. Mol Cancer (2011) 2.56
Retracted CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy. Sci Transl Med (2013) 2.51
Correlates of sleep-onset REM periods during the Multiple Sleep Latency Test in community adults. Brain (2006) 2.35
Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants. PLoS Biol (2007) 2.34
Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection. Hum Mol Genet (2005) 2.28
The role of hypocretins (orexins) in sleep regulation and narcolepsy. Annu Rev Neurosci (2002) 2.28
Genetics of sleep and sleep disorders. Cell (2011) 2.26
Cysteine: a potential biomarker for obstructive sleep apnea. Chest (2010) 2.19
Highly coordinated gene regulation in mouse skeletal muscle regeneration. J Biol Chem (2002) 2.17
Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells. Cell Stem Cell (2012) 2.11
Variant between CPT1B and CHKB associated with susceptibility to narcolepsy. Nat Genet (2008) 2.09
Correlates of serum C-reactive protein (CRP)--no association with sleep duration or sleep disordered breathing. Sleep (2007) 1.88
Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis. Sci Transl Med (2012) 1.86
DQB1*0602 predicts interindividual differences in physiologic sleep, sleepiness, and fatigue. Neurology (2010) 1.86
Diagnosis, disease course, and management of patients with Kleine-Levin syndrome. Lancet Neurol (2012) 1.83
The narcoleptic borderland: a multimodal diagnostic approach including cerebrospinal fluid levels of hypocretin-1 (orexin A). Sleep Med (2003) 1.72
Altered function of the SCN1A voltage-gated sodium channel leads to gamma-aminobutyric acid-ergic (GABAergic) interneuron abnormalities. J Biol Chem (2010) 1.70
Long term treatment with ACE inhibitor enalapril decreases body weight gain and increases life span in rats. Biochem Pharmacol (2009) 1.70
A novel superhydrophilic and underwater superoleophobic hydrogel-coated mesh for oil/water separation. Adv Mater (2011) 1.67
A link between short sleep and obesity: building the evidence for causation. Sleep (2005) 1.67
Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression. J Clin Invest (2011) 1.66
Common variants in P2RY11 are associated with narcolepsy. Nat Genet (2010) 1.65
Clinical and therapeutic aspects of childhood narcolepsy-cataplexy: a retrospective study of 51 children. Sleep (2010) 1.64
Circadian and homeostatic regulation of hypocretin in a primate model: implications for the consolidation of wakefulness. J Neurosci (2003) 1.64
Clinical aspects of narcolepsy-cataplexy across ethnic groups. Sleep (2002) 1.59
Sleep in post-menopausal women: differences between early and late post-menopause. Eur J Obstet Gynecol Reprod Biol (2009) 1.59
Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. Proc Natl Acad Sci U S A (2007) 1.58
Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression. Oncogene (2005) 1.56
ImmunoChip study implicates antigen presentation to T cells in narcolepsy. PLoS Genet (2013) 1.55
Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease. PLoS Med (2007) 1.55
PER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation. PLoS One (2009) 1.54
Association of the length polymorphism in the human Per3 gene with the delayed sleep-phase syndrome: does latitude have an influence upon it? Sleep (2005) 1.52
The relationship between sleep and epilepsy: evidence from clinical trials and animal models. J Neurol Sci (2010) 1.49
Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy. Hum Mol Genet (2012) 1.48
Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy. Sleep (2010) 1.47
Head and neck physical examination: comparison between nonapneic and obstructive sleep apnea patients. Laryngoscope (2005) 1.47
PathScan: a tool for discerning mutational significance in groups of putative cancer genes. Bioinformatics (2011) 1.46
Heterozygous mutations of the voltage-gated sodium channel SCN8A are associated with spike-wave discharges and absence epilepsy in mice. Hum Mol Genet (2009) 1.45
Will Nonasthmatic Eosinophilic Bronchitis Develop Into Chronic Airway Obstruction?: A Prospective, Observational Study. Chest (2015) 1.45
Autophagy in idiopathic pulmonary fibrosis. PLoS One (2012) 1.45
Does the chronotype classification need to be updated? Preliminary findings. Chronobiol Int (2010) 1.43
Pre-eclampsia and nasal CPAP: part 2. Hypertension during pregnancy, chronic snoring, and early nasal CPAP intervention. Sleep Med (2007) 1.43
Sleep deprivation induced by the modified multiple platform technique: quantification of sleep loss and recovery. Brain Res (2004) 1.42
Homocysteine and cysteine levels in prepubertal children: association with waist circumference and lipid profile. Nutrition (2012) 1.41
Evaluation of periodic limb movements in a putative animal model of restless leg syndrome. Mov Disord (2011) 1.40
Is serotonin responsible for the relationship between sleep debt and suicide? A comment on Kohyama's hypothesis. Med Hypotheses (2010) 1.40
Hepatic perfusion disorder associated with focal liver lesions: contrast-enhanced US patterns--correlation study with contrast-enhanced CT. Radiology (2011) 1.39
A novel algorithm combining oversampling and digital lock-in amplifier of high speed and precision. Rev Sci Instrum (2011) 1.39
Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease. Free Radic Biol Med (2009) 1.38
Complex movement disorders at disease onset in childhood narcolepsy with cataplexy. Brain (2011) 1.35
Circadian and homeostatic regulation of structural synaptic plasticity in hypocretin neurons. Neuron (2010) 1.33
Validation of a portable monitoring system for the diagnosis of obstructive sleep apnea syndrome. Sleep (2009) 1.32
A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation. Neurobiol Dis (2009) 1.32
Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression. Mol Cell (2009) 1.31
Phthalate levels and low birth weight: a nested case-control study of Chinese newborns. J Pediatr (2009) 1.30
Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy. J Physiol (2007) 1.30
Relationship between CSF hypocretin levels and hypocretin neuronal loss. Exp Neurol (2003) 1.28
Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy. Sleep (2012) 1.28
Endocrinological and catecholaminergic alterations during sleep deprivation and recovery in male rats. J Sleep Res (2005) 1.27