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Hin-mediated DNA knotting and recombining promote replicon dysfunction and mutation. BMC Mol Biol (2007) 1.22

Strong effects of molecular topology on diffusion of entangled DNA molecules. Proc Natl Acad Sci U S A (2007) 1.11

Tightening the knot in phytochrome by single-molecule atomic force microscopy. Biophys J (2009) 1.06

Brownian dynamics simulation of knot diffusion along a stretched DNA molecule. Biophys J (2005) 1.03

Compression and self-entanglement of single DNA molecules under uniform electric field. Proc Natl Acad Sci U S A (2011) 1.02

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Sequence-specific size, structure, and stability of tight protein knots. Biophys J (2009) 0.89

Scanning a DNA molecule for bound proteins using hybrid magnetic and optical tweezers. PLoS One (2013) 0.85

Influence of Rigidity and Knot Complexity on the Knotting of Confined Polymers. Macromolecules (2014) 0.84

Direct observation of DNA knots using a solid-state nanopore. Nat Nanotechnol (2016) 0.84

Tightness of knots in a polymer chain. Phys Rev E Stat Nonlin Soft Matter Phys (2010) 0.79

A Monte Carlo Study of Knots in Long Double-Stranded DNA Chains. PLoS Comput Biol (2016) 0.77

How molecular knots can pass through each other. Proc Natl Acad Sci U S A (2014) 0.76

Knots can impair protein degradation by ATP-dependent proteases. Proc Natl Acad Sci U S A (2017) 0.75

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Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature (2009) 10.31

Clinical assessment incorporating a personal genome. Lancet (2010) 10.18

Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood. Proc Natl Acad Sci U S A (2008) 8.38

Single-molecule sequencing of an individual human genome. Nat Biotechnol (2009) 8.35

Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol (2011) 7.84

Dissecting biological "dark matter" with single-cell genetic analysis of rare and uncultivated TM7 microbes from the human mouth. Proc Natl Acad Sci U S A (2007) 7.82

Microfluidic large-scale integration. Science (2002) 7.64

Whole-genome molecular haplotyping of single cells. Nat Biotechnol (2010) 6.77

Developing optofluidic technology through the fusion of microfluidics and optics. Nature (2006) 5.82

Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing. Nature (2010) 5.27

Sequence information can be obtained from single DNA molecules. Proc Natl Acad Sci U S A (2003) 5.24

Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR. Proc Natl Acad Sci U S A (2006) 5.21

A systems approach to measuring the binding energy landscapes of transcription factors. Science (2007) 5.06

High-throughput sequencing of the zebrafish antibody repertoire. Science (2009) 4.46

A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion. Proc Natl Acad Sci U S A (2002) 4.16

Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Sci Transl Med (2012) 4.05

Genome of a low-salinity ammonia-oxidizing archaeon determined by single-cell and metagenomic analysis. PLoS One (2011) 4.04

Microfluidic digital PCR enables multigene analysis of individual environmental bacteria. Science (2006) 3.84

Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding. Nat Biotechnol (2011) 3.81

Single cell profiling of circulating tumor cells: transcriptional heterogeneity and diversity from breast cancer cell lines. PLoS One (2012) 3.74

Long-term monitoring of bacteria undergoing programmed population control in a microchemostat. Science (2005) 3.54

Genome-wide single-cell analysis of recombination activity and de novo mutation rates in human sperm. Cell (2012) 3.52

An integrated microfabricated cell sorter. Anal Chem (2002) 3.43

Microfluidic large-scale integration: the evolution of design rules for biological automation. Annu Rev Biophys Biomol Struct (2007) 3.32

Versatile, fully automated, microfluidic cell culture system. Anal Chem (2007) 3.19

Non-invasive prenatal measurement of the fetal genome. Nature (2012) 3.11

A synthetic Escherichia coli predator-prey ecosystem. Mol Syst Biol (2008) 2.92

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line. Nat Biotechnol (2011) 2.87

Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics. Science (2005) 2.83

Nanoliter reactors improve multiple displacement amplification of genomes from single cells. PLoS Genet (2007) 2.79

Temporal response of the human virome to immunosuppression and antiviral therapy. Cell (2013) 2.72

Lineage structure of the human antibody repertoire in response to influenza vaccination. Sci Transl Med (2013) 2.71

Integrated nanoliter systems. Nat Biotechnol (2003) 2.68

Partial genome assembly for a candidate division OP11 single cell from an anoxic spring (Zodletone Spring, Oklahoma). Appl Environ Microbiol (2011) 2.61

Digital PCR provides sensitive and absolute calibration for high throughput sequencing. BMC Genomics (2009) 2.60

Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol (2008) 2.52

Microfluidic single-cell mRNA isolation and analysis. Anal Chem (2006) 2.47

Analysis of the size distributions of fetal and maternal cell-free DNA by paired-end sequencing. Clin Chem (2010) 2.38

Genetic measurement of memory B-cell recall using antibody repertoire sequencing. Proc Natl Acad Sci U S A (2013) 2.25

Single-cell genomics. Nat Methods (2011) 2.24

A microfluidic processor for gene expression profiling of single human embryonic stem cells. Lab Chip (2007) 2.17

Sensitivity of noninvasive prenatal detection of fetal aneuploidy from maternal plasma using shotgun sequencing is limited only by counting statistics. PLoS One (2010) 2.11

Microfluidic memory and control devices. Science (2003) 2.08

Solving the "world-to-chip" interface problem with a microfluidic matrix. Anal Chem (2003) 2.07

De novo identification and biophysical characterization of transcription-factor binding sites with microfluidic affinity analysis. Nat Biotechnol (2010) 2.05

Single-cell DNA-methylation analysis reveals epigenetic chimerism in preimplantation embryos. Science (2013) 2.03

Digital MDA for enumeration of total nucleic acid contamination. Nucleic Acids Res (2010) 2.02

Genomic analysis at the single-cell level. Annu Rev Genet (2011) 1.96

Significance and statistical errors in the analysis of DNA microarray data. Proc Natl Acad Sci U S A (2002) 1.92

A nanoliter-scale nucleic acid processor with parallel architecture. Nat Biotechnol (2004) 1.90

Systematic investigation of protein phase behavior with a microfluidic formulator. Proc Natl Acad Sci U S A (2004) 1.88

The genome sequence of the colonial chordate, Botryllus schlosseri. Elife (2013) 1.86

Parallel picoliter rt-PCR assays using microfluidics. Anal Chem (2006) 1.84

Detection of aneuploidy with digital polymerase chain reaction. Anal Chem (2007) 1.80

Microfluidics in structural biology: smaller, faster em leader better. Curr Opin Struct Biol (2003) 1.80

Universal noninvasive detection of solid organ transplant rejection. Proc Natl Acad Sci U S A (2011) 1.78

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Determinism and stochasticity during maturation of the zebrafish antibody repertoire. Proc Natl Acad Sci U S A (2011) 1.68

Identification of a colonial chordate histocompatibility gene. Science (2013) 1.68

A microfluidic device for kinetic optimization of protein crystallization and in situ structure determination. J Am Chem Soc (2006) 1.65

An in vitro microfluidic approach to generating protein-interaction networks. Nat Methods (2008) 1.59

Number, density, and surface/cytoplasmic distribution of GABA transporters at presynaptic structures of knock-in mice carrying GABA transporter subtype 1-green fluorescent protein fusions. J Neurosci (2002) 1.58

Microfluidic single-cell real-time PCR for comparative analysis of gene expression patterns. Nat Protoc (2012) 1.53

A microfluidic rectifier: anisotropic flow resistance at low Reynolds numbers. Phys Rev Lett (2004) 1.52

Microfluidic digital PCR enables rapid prenatal diagnosis of fetal aneuploidy. Am J Obstet Gynecol (2009) 1.50

Digital PCR provides absolute quantitation of viral load for an occult RNA virus. J Virol Methods (2011) 1.50

An information theoretic, microfluidic-based single cell analysis permits identification of subpopulations among putatively homogeneous stem cells. PLoS One (2011) 1.47

Single-cell and metagenomic analyses indicate a fermentative and saccharolytic lifestyle for members of the OP9 lineage. Nat Commun (2013) 1.42

Quantitative analysis of the human airway microbial ecology reveals a pervasive signature for cystic fibrosis. Sci Transl Med (2012) 1.40

Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice. Gastroenterology (2012) 1.32

Dissecting genomic diversity, one cell at a time. Nat Methods (2014) 1.31

Engineering cooperativity in biomotor-protein assemblies. Science (2006) 1.30

Single-cell sequencing provides clues about the host interactions of segmented filamentous bacteria (SFB). Genome Res (2012) 1.28

Cartography of neurexin alternative splicing mapped by single-molecule long-read mRNA sequencing. Proc Natl Acad Sci U S A (2014) 1.26

Migration of cells in a social context. Proc Natl Acad Sci U S A (2012) 1.23

A microfluidic oligonucleotide synthesizer. Nucleic Acids Res (2010) 1.23

High-throughput multi-antigen microfluidic fluorescence immunoassays. Biotechniques (2006) 1.23

Single molecule measurement of the "speed limit" of DNA polymerase. Proc Natl Acad Sci U S A (2009) 1.21

Transcriptional instability is not a universal attribute of aging. Aging Cell (2007) 1.21

Microfluidic device reads up to four consecutive base pairs in DNA sequencing-by-synthesis. Nucleic Acids Res (2004) 1.21

High-throughput single-molecule optofluidic analysis. Nat Methods (2011) 1.18

Automated microfluidic chromatin immunoprecipitation from 2,000 cells. Lab Chip (2009) 1.17

The RootChip: an integrated microfluidic chip for plant science. Plant Cell (2011) 1.16

Polyelectrolyte surface interface for single-molecule fluorescence studies of DNA polymerase. Biotechniques (2003) 1.16

Colloidal lenses allow high-temperature single-molecule imaging and improve fluorophore photostability. Nat Nanotechnol (2009) 1.14

Phase knowledge enables rational screens for protein crystallization. Proc Natl Acad Sci U S A (2006) 1.13

Dynamic chromatin localization of Sirt6 shapes stress- and aging-related transcriptional networks. PLoS Genet (2011) 1.13

Experimental determination of the evolvability of a transcription factor. Proc Natl Acad Sci U S A (2009) 1.12

Ostwald ripening of clusters during protein crystallization. Phys Rev Lett (2010) 1.11

Systematic reconstruction of RNA functional motifs with high-throughput microfluidics. Nat Methods (2012) 1.09

Fluorescence near-field microscopy of DNA at sub-10 nm resolution. Phys Rev Lett (2006) 1.05

Biocompatibility and reduced drug absorption of sol-gel-treated poly(dimethyl siloxane) for microfluidic cell culture applications. Anal Chem (2010) 1.04

DNA sequencing: clinical applications of new DNA sequencing technologies. Circulation (2012) 1.03

Proteome-wide protein interaction measurements of bacterial proteins of unknown function. Proc Natl Acad Sci U S A (2012) 1.02

In vitro embryo culture in defined, sub-microliter volumes. Dev Dyn (2009) 1.01

Crystal structure of a hyperactive Escherichia coli glycerol kinase mutant Gly230 --> Asp obtained using microfluidic crystallization devices. Biochemistry (2007) 1.01

Identification and confirmation of a module of coexpressed genes. Genome Res (2002) 1.01

Velocity-independent microfluidic flow cytometry. Electrophoresis (2002) 1.00

Microfluidic very large scale integration (mVLSI) with integrated micromechanical valves. Lab Chip (2012) 0.98