Published in J Neurochem on February 01, 2004
Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis. Clin Neuropharmacol (2010) 3.26
Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects. J Clin Invest (2005) 1.94
Fingolimod provides long-term protection in rodent models of cerebral ischemia. Ann Neurol (2010) 1.62
Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy. J Neurol Sci (2013) 1.52
Identification of a Chr 11 quantitative trait locus that modulates proliferation in the rostral migratory stream of the adult mouse brain. Eur J Neurosci (2010) 1.42
An update on the biology of sphingosine 1-phosphate receptors. J Lipid Res (2014) 1.37
Fingolimod is a potential novel therapy for multiple sclerosis. Nat Rev Neurol (2010) 1.36
Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors. Chem Rev (2011) 1.29
Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons. Mol Cell Biol (2007) 1.26
Lysophospholipids and their receptors in the central nervous system. Biochim Biophys Acta (2012) 1.21
Current status of the immunomodulation and immunomediated therapeutic strategies for multiple sclerosis. Clin Dev Immunol (2011) 1.18
Subcellular origin of sphingosine 1-phosphate is essential for its toxic effect in lyase-deficient neurons. J Biol Chem (2009) 1.12
Retracted Multiple sclerosis: the role of cytokines in pathogenesis and in therapies. Int J Mol Sci (2012) 1.11
Distribution of sphingosine kinase activity and mRNA in rodent brain. J Neurochem (2007) 1.11
Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence. Am J Med Genet B Neuropsychiatr Genet (2010) 1.03
Regulating survival and development in the retina: key roles for simple sphingolipids. J Lipid Res (2010) 1.02
An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway. J Neurosci (2013) 1.00
Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism. Cell Death Differ (2011) 0.97
Sphingosine kinase 2 mediates cerebral preconditioning and protects the mouse brain against ischemic injury. Stroke (2011) 0.96
Fingolimod phosphate attenuates oligomeric amyloid β-induced neurotoxicity via increased brain-derived neurotrophic factor expression in neurons. PLoS One (2013) 0.95
Ceramide signaling in cancer and stem cells. Future Lipidol (2008) 0.92
Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis. J Neurosci (2010) 0.91
Cellular localization of sphingosine-1-phosphate receptor 1 expression in the human central nervous system. J Histochem Cytochem (2010) 0.88
Human neural progenitors express functional lysophospholipid receptors that regulate cell growth and morphology. BMC Neurosci (2008) 0.85
Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation. PLoS One (2014) 0.83
G-protein-coupled receptors in adult neurogenesis. Pharmacol Rev (2012) 0.83
Fingolimod for multiple sclerosis and emerging indications: appropriate patient selection, safety precautions, and special considerations. Ther Clin Risk Manag (2016) 0.82
Rho/ROCK pathway is essential to the expansion, differentiation, and morphological rearrangements of human neural stem/progenitor cells induced by lysophosphatidic acid. J Lipid Res (2013) 0.82
Sphingosine-1-phosphate elicits receptor-dependent calcium signaling in retinal amacrine cells. J Neurophysiol (2009) 0.82
A herbal medicine for Alzheimer's disease and its active constituents promote neural progenitor proliferation. Aging Cell (2015) 0.82
Autosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2. Am J Hum Genet (2016) 0.81
Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells. Neuropharmacology (2011) 0.81
Sphingosine-1-phosphate receptor 3 influences cell cycle progression in muscle satellite cells. Dev Biol (2013) 0.81
Sphingosine 1-phosphate signaling pathway in inner ear biology. New therapeutic strategies for hearing loss? Front Aging Neurosci (2015) 0.81
GPCRs in stem cell function. Prog Mol Biol Transl Sci (2013) 0.80
Critical Role of the Sphingolipid Pathway in Stroke: a Review of Current Utility and Potential Therapeutic Targets. Transl Stroke Res (2016) 0.80
Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons. J Biol Chem (2014) 0.79
Oxygen glucose deprivation inhibits the growth and ERK phosphorylation of neural progenitor cells in vitro. Neurosci Lett (2007) 0.79
Sphingosine-1-Phosphate Receptor Antagonism Enhances Proliferation and Migration of Engrafted Neural Progenitor Cells in a Model of Viral-Induced Demyelination. Am J Pathol (2015) 0.79
The sphingosine-1-phosphate receptor: A novel therapeutic target for multiple sclerosis and other autoimmune diseases. Clin Immunol (2016) 0.78
The sphingosine-1-phosphate analogue, FTY-720, promotes the proliferation of embryonic neural stem cells, enhances hippocampal neurogenesis and learning and memory abilities in adult mice. Br J Pharmacol (2016) 0.78
Fingolimod induces neurogenesis in adult mouse hippocampus and improves contextual fear memory. Transl Psychiatry (2015) 0.77
The Direct Effects of Fingolimod in the Central Nervous System: Implications for Relapsing Multiple Sclerosis. CNS Drugs (2016) 0.77
Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs. Cell Signal (2016) 0.75
Fingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal Neurons. Sci Rep (2017) 0.75
Harnessing the power of yeast to elucidate the role of sphingolipids in metabolic and signaling processes pertinent to psychiatric disorders. Clin Lipidol (2014) 0.75
Effects of FTY720 (Fingolimod) on Proliferation, Differentiation, and Migration of Brain-Derived Neural Stem Cells. Stem Cells Int (2016) 0.75
Activation of Sphingosine 1-Phosphate Receptor 1 Enhances Hippocampus Neurogenesis in a Rat Model of Traumatic Brain Injury: An Involvement of MEK/Erk Signaling Pathway. Neural Plast (2016) 0.75
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol (2005) 11.63
Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci (2003) 6.53
Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med (2002) 4.86
Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proc Natl Acad Sci U S A (2005) 4.63
Myocardial infarction accelerates atherosclerosis. Nature (2012) 4.48
Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase. Nat Med (2002) 3.17
Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. J Exp Med (2012) 2.92
Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation. Opt Lett (2003) 2.70
Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex. J Cereb Blood Flow Metab (2004) 2.59
Vasoconstrictive neurovascular coupling during focal ischemic depolarizations. J Cereb Blood Flow Metab (2005) 2.32
Early release of HMGB-1 from neurons after the onset of brain ischemia. J Cereb Blood Flow Metab (2007) 2.31
Suppression of cortical spreading depression in migraine prophylaxis. Ann Neurol (2006) 2.25
Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke (2005) 2.13
Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab (2008) 2.06
Cortical spreading depression activates and upregulates MMP-9. J Clin Invest (2004) 1.93
Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia. Brain (2007) 1.92
Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase. Proc Natl Acad Sci U S A (2008) 1.91
Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex. J Neurosci (2008) 1.89
Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1. J Clin Invest (2008) 1.81
Rapid nongenomic actions of thyroid hormone. Proc Natl Acad Sci U S A (2006) 1.79
Pathophysiology of migraine. Annu Rev Physiol (2012) 1.73
Exciting, radical, suicidal: how brain cells die after stroke. Stroke (2005) 1.68
The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. J Clin Invest (2007) 1.67
Stroke program review group: an interim report. Stroke (2008) 1.67
Fingolimod provides long-term protection in rodent models of cerebral ischemia. Ann Neurol (2010) 1.62
Targeting eNOS for stroke protection. Trends Neurosci (2004) 1.60
Mild induced hypertension improves blood flow and oxygen metabolism in transient focal cerebral ischemia. Stroke (2008) 1.58
Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy. Brain (2007) 1.55
Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic stroke. J Neurol Sci (2005) 1.54
Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase dependent mechanisms. Circulation (2007) 1.53
Migraine as an inflammatory disorder. Neurology (2005) 1.53
Dopamine modulates cell cycle in the lateral ganglionic eminence. J Neurosci (2003) 1.50
tPA and proteolysis in the neurovascular unit. Stroke (2004) 1.47
Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia. J Biomed Opt (2008) 1.46
EGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia. J Clin Invest (2003) 1.45
Microemboli may link spreading depression, migraine aura, and patent foramen ovale. Ann Neurol (2010) 1.45
Poly(ADP-ribose) polymerase-1 activity promotes NF-kappaB-driven transcription and microglial activation: implication for neurodegenerative disorders. J Neurochem (2003) 1.44
Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR. Sci Signal (2009) 1.43
Phosphorylation of histone H4 serine 1 during DNA damage requires casein kinase II in S. cerevisiae. Curr Biol (2005) 1.41
Nasal vaccination with myelin oligodendrocyte glycoprotein reduces stroke size by inducing IL-10-producing CD4+ T cells. J Immunol (2003) 1.40
Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia. J Cereb Blood Flow Metab (2004) 1.40
Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids. J Clin Invest (2002) 1.40
Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Proc Natl Acad Sci U S A (2002) 1.36
Traumatic brain injury in mice deficient in Bid: effects on histopathology and functional outcome. J Cereb Blood Flow Metab (2006) 1.34
Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms. J Cereb Blood Flow Metab (2006) 1.32
High-mobility group box 1 promotes metalloproteinase-9 upregulation through Toll-like receptor 4 after cerebral ischemia. Stroke (2010) 1.30
Migraine mutations increase stroke vulnerability by facilitating ischemic depolarizations. Circulation (2011) 1.28
Pronounced hypoperfusion during spreading depression in mouse cortex. J Cereb Blood Flow Metab (2004) 1.28
Linking Notch signaling to ischemic stroke. Proc Natl Acad Sci U S A (2008) 1.28
Acute plasmalemma permeability and protracted clearance of injured cells after controlled cortical impact in mice. J Cereb Blood Flow Metab (2007) 1.27
Cell biology. PARP-1--a perpetrator of apoptotic cell death? Science (2002) 1.26
FGF-2 regulates neurogenesis and degeneration in the dentate gyrus after traumatic brain injury in mice. J Clin Invest (2003) 1.24
Multicolored stain-free histopathology with coherent Raman imaging. Lab Invest (2012) 1.22
Regenerative response in ischemic brain restricted by p21cip1/waf1. J Exp Med (2004) 1.22
Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation. Stroke (2009) 1.21
Rapid cerebral ischemic preconditioning in mice deficient in endothelial and neuronal nitric oxide synthases. Stroke (2003) 1.19
Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia. J Cereb Blood Flow Metab (2005) 1.18
Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts. Int J Mol Med (2007) 1.16
S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate. Eur J Pharmacol (2003) 1.16
Upregulation of the Fas receptor death-inducing signaling complex after traumatic brain injury in mice and humans. J Neurosci (2002) 1.15
Migraine aura pathophysiology: the role of blood vessels and microembolisation. Lancet Neurol (2010) 1.15
Mechanisms of pain modulation in chronic syndromes. Neurology (2002) 1.13
Distribution of sphingosine kinase activity and mRNA in rodent brain. J Neurochem (2007) 1.11
New insights into migraine pathophysiology. Curr Opin Neurol (2006) 1.09
Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease. Proc Natl Acad Sci U S A (2011) 1.08
STAT1 is activated in neurons after ischemia and contributes to ischemic brain injury. J Cereb Blood Flow Metab (2002) 1.08
Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice. Biol Psychiatry (2008) 1.07
Enhanced subcortical spreading depression in familial hemiplegic migraine type 1 mutant mice. J Neurosci (2011) 1.07
Hypoxia and hypotension transform the blood flow response to cortical spreading depression from hyperemia into hypoperfusion in the rat. J Cereb Blood Flow Metab (2008) 1.06
Connectivity alterations assessed by combining fMRI and MR-compatible hand robots in chronic stroke. Neuroimage (2009) 1.05
The impact of anesthetics and hyperoxia on cortical spreading depression. Exp Neurol (2008) 1.05
Selectivity and specificity of sphingosine-1-phosphate receptor ligands: caveats and critical thinking in characterizing receptor-mediated effects. Front Pharmacol (2011) 1.01
Additive effects of statin and dipyridamole on cerebral blood flow and stroke protection. J Cereb Blood Flow Metab (2008) 1.00
The challenge of connecting the dots in the B.R.A.I.N. Neuron (2013) 0.99
Perfusion pressure-dependent recovery of cortical spreading depression is independent of tissue oxygenation over a wide physiologic range. J Cereb Blood Flow Metab (2010) 0.98
The pathophysiology of migraine: year 2005. J Headache Pain (2005) 0.98
Nitric oxide: considerations for the treatment of ischemic stroke. J Cereb Blood Flow Metab (2012) 0.97
MR contrast probes that trace gene transcripts for cerebral ischemia in live animals. FASEB J (2007) 0.97
Fingolimod reduces hemorrhagic transformation associated with delayed tissue plasminogen activator treatment in a mouse thromboembolic model. Stroke (2013) 0.96
Selective neuronal vulnerability following mild focal brain ischemia in the mouse. Brain Pathol (2003) 0.96
Sphingosine kinase 2 mediates cerebral preconditioning and protects the mouse brain against ischemic injury. Stroke (2011) 0.96
Inhibition of cerebral vasoconstriction by dantrolene and nimodipine. Neurocrit Care (2008) 0.96
Recommendations of the National Heart, Lung, and Blood Institute working group on cerebrovascular biology and disease. Stroke (2006) 0.96
Context dependent neuroprotective properties of prion protein (PrP). Prion (2009) 0.95
Blood vessels, migraine, and stroke. Stroke (2007) 0.95
p27Kip1 constrains proliferation of neural progenitor cells in adult brain under homeostatic and ischemic conditions. Stem Cells (2009) 0.94
Glutamate excitoxicity is the key molecular mechanism which is influenced by body temperature during the acute phase of brain stroke. PLoS One (2012) 0.94
Androgenic suppression of spreading depression in familial hemiplegic migraine type 1 mutant mice. Ann Neurol (2009) 0.93
Therapeutic implications of central and peripheral neurologic mechanisms in migraine. Neurology (2003) 0.92
Animal models of migraine headache and aura. Curr Opin Neurol (2008) 0.91
Effect of basic fibroblast growth factor treatment on brain progenitor cells after permanent focal ischemia in rats. Stroke (2003) 0.91
S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells. Am J Physiol Cell Physiol (2011) 0.91