Published in Pflugers Arch on May 06, 2003
The Concise Guide to PHARMACOLOGY 2013/14: transporters. Br J Pharmacol (2013) 2.07
Analysis and update of the human solute carrier (SLC) gene superfamily. Hum Genomics (2009) 1.62
A review of the biochemistry, metabolism and clinical benefits of thiamin(e) and its derivatives. Evid Based Complement Alternat Med (2006) 1.53
A wide spectrum of clinical and brain MRI findings in patients with SLC19A3 mutations. BMC Med Genet (2010) 1.35
H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine. Exp Physiol (2007) 1.22
Cloning and functional characterization of the proton-coupled electrogenic folate transporter and analysis of its expression in retinal cell types. Invest Ophthalmol Vis Sci (2007) 1.20
A putative thiamine transport protein is a receptor for feline leukemia virus subgroup A. J Virol (2006) 1.17
Sodium-coupled and electrogenic transport of B-complex vitamin nicotinic acid by slc5a8, a member of the Na/glucose co-transporter gene family. Biochem J (2005) 1.12
Biotin deficiency reduces expression of SLC19A3, a potential biotin transporter, in leukocytes from human blood. J Nutr (2005) 1.09
Quantitative analysis and diagnostic significance of methylated SLC19A3 DNA in the plasma of breast and gastric cancer patients. PLoS One (2011) 1.01
Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). Mol Pharm (2015) 0.96
Thiamine diphosphate in whole blood, thiamine and thiamine monophosphate in breast-milk in a refugee population. PLoS One (2012) 0.96
Genome-wide association analysis identifies a mutation in the thiamine transporter 2 (SLC19A3) gene associated with Alaskan Husky encephalopathy. PLoS One (2013) 0.93
Identification of a feline leukemia virus variant that can use THTR1, FLVCR1, and FLVCR2 for infection. J Virol (2009) 0.91
Molecular and biochemical characterization of folate transport proteins in retinal Müller cells. Invest Ophthalmol Vis Sci (2010) 0.88
Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen. Oncotarget (2015) 0.83
Linking vitamin B1 with cancer cell metabolism. Cancer Metab (2013) 0.82
Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study. BMC Med Genet (2011) 0.82
Defects of thiamine transport and metabolism. J Inherit Metab Dis (2014) 0.81
Expression Profiling of Solute Carrier Gene Families at the Blood-CSF Barrier. Front Pharmacol (2012) 0.81
Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation? World J Diabetes (2014) 0.81
Regulation of Cell Proliferation by the Guanosine-Adenosine Mechanism: Role of Adenosine Receptors. Physiol Rep (2013) 0.80
Subcellular localization and distribution of the reduced folate carrier in normal rat tissues. Eur J Histochem (2011) 0.79
Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine. PLoS One (2012) 0.78
High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate. Cancer Chemother Pharmacol (2014) 0.77
Identification of critical variants within SLC44A4, an ulcerative colitis susceptibility gene identified in a GWAS in north Indians. Genes Immun (2016) 0.77
Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion. J Physiol (2016) 0.75
Growing Mouse Oocytes Transiently Activate Folate Transport via Folate Receptors As They Approach Full Size. Biol Reprod (2016) 0.75
Genetic Polymorphisms Associated to Folate Transport as Predictors of Increased Risk for Acute Lymphoblastic Leukemia in Mexican Children. Front Pharmacol (2016) 0.75
A Study of Single Nucleotide Polymorphisms of the SLC19A1/RFC1 Gene in Subjects with Autism Spectrum Disorder. Int J Mol Sci (2016) 0.75
The gene mutated in thiamine-responsive anaemia with diabetes and deafness (TRMA) encodes a functional thiamine transporter. Nat Genet (1999) 1.69
Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness. Nat Genet (1999) 1.62
Mutations in a new gene encoding a thiamine transporter cause thiamine-responsive megaloblastic anaemia syndrome. Nat Genet (1999) 1.62
Homocysteinemia due to folate deficiency. Metabolism (1987) 1.51
Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells. J Biol Chem (1995) 1.42
Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epithelium. J Biol Chem (2000) 1.33
SLC19A3 encodes a second thiamine transporter ThTr2. Biochim Biophys Acta (2001) 1.32
Identification and characterization of the human and mouse SLC19A3 gene: a novel member of the reduced folate family of micronutrient transporter genes. Mol Genet Metab (2000) 1.31
Cloning of the human thiamine transporter, a member of the folate transporter family. J Biol Chem (1999) 1.31
Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis. Biochim Biophys Acta (2001) 1.29
A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells. J Biol Chem (1994) 1.23
The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter. Biochem J (2002) 1.21
Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells. Cancer Res (1995) 1.20
Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency. Am J Physiol Cell Physiol (2000) 1.18
Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs. J Biol Chem (2001) 1.18
Targeted disruption of Slc19a2, the gene encoding the high-affinity thiamin transporter Thtr-1, causes diabetes mellitus, sensorineural deafness and megaloblastosis in mice. Hum Mol Genet (2002) 1.18
Molecular cloning of the human placental folate transporter. Biochem Biophys Res Commun (1995) 1.15
Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion. J Biol Chem (1999) 1.11
Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake. J Biol Chem (1995) 1.07
Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells. Am J Physiol Cell Physiol (2002) 1.07
Effects of the loss of capacity for N-glycosylation on the transport activity and cellular localization of the human reduced folate carrier. Biochim Biophys Acta (1998) 1.05
Impact of the reduced folate carrier on the accumulation of active thiamin metabolites in murine leukemia cells. J Biol Chem (2001) 1.03
Recent advances in the understanding of the mechanism of membrane transport of folates and antifolates. Semin Oncol (1999) 1.01
Defective high-affinity thiamine transporter leads to cell death in thiamine-responsive megaloblastic anemia syndrome fibroblasts. J Clin Invest (1999) 1.00
Thiamine-responsive megaloblastic anemia syndrome: a disorder of high-affinity thiamine transport. Blood Cells Mol Dis (2001) 1.00
Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake. J Biol Chem (1994) 1.00
Isolation and characterization of genomic sequences involved in the regulation of the human reduced folate carrier gene (RFC1). Gene (1999) 0.97
Analysis of membrane topology of the human reduced folate carrier protein by hemagglutinin epitope insertion and scanning glycosylation insertion mutagenesis. Biochim Biophys Acta (2002) 0.95
Downregulation of reduced-folate transporter by glucose in cultured RPE cells and in RPE of diabetic mice. Invest Ophthalmol Vis Sci (2002) 0.95
Characterization of a murine high-affinity thiamine transporter, Slc19a2. Mol Genet Metab (2001) 0.94
The transmembrane pH gradient drives uphill folate transport in rabbit jejunum. Direct evidence for folate/hydroxyl exchange in brush border membrane vesicles. J Clin Invest (1985) 0.93
Regulation of the reduced-folate transporter by nitric oxide in cultured human retinal pigment epithelial cells. Biochem Biophys Res Commun (1999) 0.92
Structural organization of the human reduced folate carrier gene: evidence for 5' heterogeneity in lymphoblast mRNA. Somat Cell Mol Genet (1998) 0.89
Cytoplasmic domains of the reduced folate carrier are essential for trafficking, but not function. Biochem J (2002) 0.86
Expression of the reduced folate carrier SLC19A1 in IEC-6 cells results in two distinct transport activities. Am J Physiol Cell Physiol (2001) 0.85
The spectrum of mutations, including four novel ones, in the thiamine-responsive megaloblastic anemia gene SLC19A2 of eight families. Hum Mutat (2000) 0.84
Repression of human reduced folate carrier gene expression by wild type p53. J Biol Chem (2000) 0.83
Role of the C-terminus and the long cytoplasmic loop in reduced folate carrier expression and function. Biochem Pharmacol (2002) 0.81
Functional role of specific amino acid residues in human thiamine transporter SLC19A2: mutational analysis. Am J Physiol Gastrointest Liver Physiol (2002) 0.81
Slc19a2: cloning and characterization of the murine thiamin transporter cDNA and genomic sequence, the orthologue of the human TRMA gene. Mol Genet Metab (2001) 0.80
Localization of a human reduced folate carrier protein in the mitochondrial as well as the cell membrane of leukemia cells. Cancer Res (2001) 0.80
Assignment of the human folate transporter gene to chromosome 21q22.3 by somatic cell hybrid analysis and in situ hybridization. Biochem Biophys Res Commun (1995) 0.80
Structure and organization of the human reduced folate carrier gene. Biochim Biophys Acta (1998) 0.80
Identification of transcriptional start sites and splicing of mouse thiamine transporter gene THTR-1 (Slc19a2). Biochim Biophys Acta (2002) 0.75
Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. Pharmacol Ther (2008) 2.79
Death of retinal neurons in streptozotocin-induced diabetic mice. Invest Ophthalmol Vis Sci (2004) 2.62
GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon. Cancer Res (2009) 1.89
High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice. FASEB J (2008) 1.66
The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities. Antioxid Redox Signal (2012) 1.64
A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistance. Mol Cancer Ther (2008) 1.64
Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. AAPS J (2008) 1.56
Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain. J Neurochem (2006) 1.43
SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter. Life Sci (2005) 1.40
Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe. Biochem J (2008) 1.36
Prevention of excitotoxicity in primary retinal ganglion cells by (+)-pentazocine, a sigma receptor-1 specific ligand. Invest Ophthalmol Vis Sci (2007) 1.35
Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3. Biochem J (2009) 1.32
Structure, function, and expression pattern of a novel sodium-coupled citrate transporter (NaCT) cloned from mammalian brain. J Biol Chem (2002) 1.27
SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases. Cancer Res (2006) 1.25
Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate. J Biol Chem (2004) 1.24
Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transporters. Endocrinology (2011) 1.23
The sigma receptor ligand (+)-pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate. Brain Res Mol Brain Res (2004) 1.23
SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer. Cancer Res (2011) 1.21
Effects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity. Biochem Pharmacol (2007) 1.21
Expression, subcellular localization, and regulation of sigma receptor in retinal muller cells. Invest Ophthalmol Vis Sci (2006) 1.20
Cloning and functional characterization of the proton-coupled electrogenic folate transporter and analysis of its expression in retinal cell types. Invest Ophthalmol Vis Sci (2007) 1.20
Sodium-coupled transport of the short chain fatty acid butyrate by SLC5A8 and its relevance to colon cancer. J Gastrointest Surg (2008) 1.19
Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases. J Biol Chem (2010) 1.18
Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract. Pharm Res (2007) 1.18
Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery. J Pharmacol Exp Ther (2003) 1.17
Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host. Curr Opin Pharmacol (2013) 1.15
Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action. Biochem J (2003) 1.12
Sodium-coupled and electrogenic transport of B-complex vitamin nicotinic acid by slc5a8, a member of the Na/glucose co-transporter gene family. Biochem J (2005) 1.12
Endogenous elevation of homocysteine induces retinal neuron death in the cystathionine-beta-synthase mutant mouse. Invest Ophthalmol Vis Sci (2009) 1.10
Analysis of sigma receptor (sigmaR1) expression in retinal ganglion cells cultured under hyperglycemic conditions and in diabetic mice. Brain Res Mol Brain Res (2002) 1.10
Expression and polarized localization of the hemochromatosis gene product HFE in retinal pigment epithelium. Invest Ophthalmol Vis Sci (2006) 1.10
c/ebpdelta Null mouse as a model for the double knock-out of slc5a8 and slc5a12 in kidney. J Biol Chem (2006) 1.09
Expression and function of glutamine transporters SN1 (SNAT3) and SN2 (SNAT5) in retinal Müller cells. Invest Ophthalmol Vis Sci (2005) 1.08
Induction of cystine-glutamate transporter xc- by human immunodeficiency virus type 1 transactivator protein tat in retinal pigment epithelium. Invest Ophthalmol Vis Sci (2004) 1.07
Expression of the iron-regulatory protein haemojuvelin in retina and its regulation during cytomegalovirus infection. Biochem J (2009) 1.05
Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger. Biochem J (2009) 1.05
Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2). Biochem J (2005) 1.05
Brief hyperglycaemia in the early pregnant rat increases fetal weight at term by stimulating placental growth and affecting placental nutrient transport. J Physiol (2007) 1.03
Expression and function of iron-regulatory proteins in retina. IUBMB Life (2010) 1.03
Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (σR1). Invest Ophthalmol Vis Sci (2011) 1.03
Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy. Biochem J (2008) 1.02
Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons. Invest Ophthalmol Vis Sci (2011) 1.02
Serine racemase expression and D-serine content are developmentally regulated in neuronal ganglion cells of the retina. J Neurochem (2007) 1.00
Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines. Am J Physiol Gastrointest Liver Physiol (2006) 0.99
Homocysteine-mediated modulation of mitochondrial dynamics in retinal ganglion cells. Invest Ophthalmol Vis Sci (2011) 0.99
SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer. J Biol Chem (2011) 0.99
Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans. Biochim Biophys Acta (2005) 0.99
Effects of hyperglycemia and oxidative stress on the glutamate transporters GLAST and system xc- in mouse retinal Müller glial cells. Cell Tissue Res (2009) 0.98
Transport of D-serine via the amino acid transporter ATB(0,+) expressed in the colon. Biochem Biophys Res Commun (2002) 0.98
Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2(-/-)) mice. Mol Genet Metab (2007) 0.98
Up-regulation of the amino acid transporter ATB(0,+) (SLC6A14) in carcinoma of the cervix. Gynecol Oncol (2005) 0.97
Alterations of retinal vasculature in cystathionine-Beta-synthase mutant mice, a model of hyperhomocysteinemia. Invest Ophthalmol Vis Sci (2013) 0.97
Interaction of ibuprofen and other structurally related NSAIDs with the sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8). Pharm Res (2006) 0.96
Downregulation of reduced-folate transporter by glucose in cultured RPE cells and in RPE of diabetic mice. Invest Ophthalmol Vis Sci (2002) 0.95
Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium. Invest Ophthalmol Vis Sci (2011) 0.95
Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate. Cancer (2009) 0.94
Identification of a novel Na+- and Cl--coupled transport system for endogenous opioid peptides in retinal pigment epithelium and induction of the transport system by HIV-1 Tat. Biochem J (2003) 0.94
Age-related changes in visual function in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia. Exp Eye Res (2011) 0.94
Expression of the sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in retina. Invest Ophthalmol Vis Sci (2007) 0.94
Osmoregulation of taurine transporter function and expression in retinal pigment epithelial, ganglion, and müller cells. Invest Ophthalmol Vis Sci (2004) 0.94
Sigma receptor 1 modulates ER stress and Bcl2 in murine retina. Cell Tissue Res (2014) 0.93
Reduced-folate carrier (RFC) is expressed in placenta and yolk sac, as well as in cells of the developing forebrain, hindbrain, neural tube, craniofacial region, eye, limb buds and heart. BMC Dev Biol (2003) 0.93
Iron-mediated retinal degeneration in haemojuvelin-knockout mice. Biochem J (2012) 0.93
Stimulation of Na+/Cl--coupled opioid peptide transport system in SK-N-SH cells by L-kyotorphin, an endogenous substrate for H+-coupled peptide transporter PEPT2. Drug Metab Pharmacokinet (2008) 0.92
Cystathionine beta synthase expression in mouse retina. Curr Eye Res (2013) 0.91
The role of N-methyl-D-aspartate receptor activation in homocysteine-induced death of retinal ganglion cells. Invest Ophthalmol Vis Sci (2011) 0.91
Transport of N-acetylaspartate via murine sodium/dicarboxylate cotransporter NaDC3 and expression of this transporter and aspartoacylase II in ocular tissues in mouse. Biochim Biophys Acta (2004) 0.91
Differential modulation of sodium- and chloride-dependent opioid peptide transport system by small nonopioid peptides and free amino acids. J Pharmacol Exp Ther (2007) 0.90
Transcellular transfer of folate across the retinal pigment epithelium. Curr Eye Res (2002) 0.90
Functional identification of a novel transport system for endogenous and synthetic opioid peptides in the rabbit conjunctival epithelial cell line CJVE. Pharm Res (2008) 0.89
Ciliary neurotrophic factor induces glial fibrillary acidic protein in retinal Müller cells through the JAK/STAT signal transduction pathway. Curr Eye Res (2002) 0.89
Inhibition of amino acid transport system a by interleukin-1beta in trophoblasts. J Soc Gynecol Investig (2005) 0.89
Sodium-dependent vitamin C transporter SVCT2: expression and function in bone marrow stromal cells and in osteogenesis. Stem Cell Res (2012) 0.88
Molecular and biochemical characterization of folate transport proteins in retinal Müller cells. Invest Ophthalmol Vis Sci (2010) 0.88
Role of transporters in placental transfer of drugs. Toxicol Appl Pharmacol (2005) 0.88
Diabetes and overexpression of proNGF cause retinal neurodegeneration via activation of RhoA pathway. PLoS One (2013) 0.88
Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor beta. Exp Eye Res (2006) 0.87
Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1. Mol Vis (2012) 0.87
Sensitivity of staurosporine-induced differentiated RGC-5 cells to homocysteine. Curr Eye Res (2010) 0.87
Cutting edge: IRF8 regulates Bax transcription in vivo in primary myeloid cells. J Immunol (2011) 0.86
Diabetes Accelerates Retinal Neuronal Cell Death In A Mouse Model of Endogenous Hyperhomocysteinemia. Ophthalmol Eye Dis (2009) 0.86
Molecular mechanism of SLC5A8 inactivation in breast cancer. Mol Cell Biol (2013) 0.86
The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival. Cancer Res (2013) 0.86
Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis. Biochem Biophys Res Commun (2011) 0.85
Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells. Invest Ophthalmol Vis Sci (2008) 0.85
Regulation of proton-coupled folate transporter in retinal Müller cells by the antipsoriatic drug monomethylfumarate. Glia (2011) 0.85
Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci (2009) 0.85