Published in Cancer Metab on July 24, 2013
Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition. Semin Cancer Biol (2015) 0.99
Metabolic effects of acute thiamine depletion are reversed by rapamycin in breast and leukemia cells. PLoS One (2014) 0.79
Bayesian pathway analysis of cancer microarray data. PLoS One (2014) 0.78
Micronutrients Involved in One-Carbon Metabolism and Risk of Breast Cancer Subtypes. PLoS One (2015) 0.76
A first immunohistochemistry study of transketolase and transketolase-like 1 expression in canine hyperplastic and neoplastic mammary lesions. BMC Vet Res (2017) 0.75
Differential Expression of MicroRNAs in Leprosy Skin Lesions. Front Immunol (2017) 0.75
Biochemistry and molecular cell biology of diabetic complications. Nature (2001) 25.43
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab (2008) 18.87
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature (2008) 18.20
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A (2007) 15.88
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov (2009) 10.32
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell (2007) 9.20
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature (2011) 7.94
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci U S A (1998) 6.90
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab (2005) 6.85
Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature (2011) 6.57
Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis (2000) 5.78
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science (2011) 5.72
Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol (2005) 5.25
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci U S A (2011) 5.24
Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells. Int J Biochem Cell Biol (2010) 3.72
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer. Br J Cancer (2008) 3.39
Molecular biology and biochemistry of pyruvate dehydrogenase complexes. FASEB J (1990) 2.86
Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation. Biochem Soc Trans (2003) 2.81
Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma. Cancer Res (2006) 2.68
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med (2003) 2.61
Branched-chain amino acid metabolism. Annu Rev Nutr (1984) 2.58
Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation. Cancer Res (1997) 2.35
Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells. J Biol Chem (2008) 2.07
Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. Diabetes (2003) 1.99
Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted. Br J Cancer (2006) 1.91
Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. Cell Mol Life Sci (2007) 1.87
Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha-induced metabolic reprograming. Oncogene (2010) 1.63
Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma. Neoplasia (2005) 1.62
Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites. Biochem J (2001) 1.60
The role of thiamine deficiency in alcoholic brain disease. Alcohol Res Health (2003) 1.57
Hypoxic reactive oxygen species regulate the integrated stress response and cell survival. J Biol Chem (2008) 1.51
Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells. Br J Cancer (2010) 1.49
Regulation of the branched chain 2-oxoacid dehydrogenase kinase reaction. FEBS Lett (1982) 1.48
Hypoxia induced upregulation and function of the thiamine transporter, SLC19A3 in a breast cancer cell line. Cancer Biol Ther (2010) 1.44
Mechanisms responsible for regulation of branched-chain amino acid catabolism. Biochem Biophys Res Commun (2004) 1.40
Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase. J Biol Chem (2001) 1.38
Exercise promotes BCAA catabolism: effects of BCAA supplementation on skeletal muscle during exercise. J Nutr (2004) 1.35
SLC19: the folate/thiamine transporter family. Pflugers Arch (2003) 1.34
Regulation of mitochondrial alpha-ketoglutarate metabolism by product inhibition at alpha-ketoglutarate dehydrogenase. J Biol Chem (1974) 1.33
The role of phosphometabolites in cell proliferation, energy metabolism, and tumor therapy. J Bioenerg Biomembr (1997) 1.32
SLC19A3 encodes a second thiamine transporter ThTr2. Biochim Biophys Acta (2001) 1.32
Cloning of the human thiamine transporter, a member of the folate transporter family. J Biol Chem (1999) 1.31
Transforming growth factor beta2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells. Cancer Res (2000) 1.28
The effect of thiamine supplementation on tumour proliferation. A metabolic control analysis study. Eur J Biochem (2001) 1.28
Detection of resistance to imatinib by metabolic profiling: clinical and drug development implications. Am J Pharmacogenomics (2005) 1.27
TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization. Clin Cancer Res (2010) 1.27
Expression and functional contribution of hTHTR-2 in thiamin absorption in human intestine. Am J Physiol Gastrointest Liver Physiol (2003) 1.26
Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis. J Biol Chem (2012) 1.25
Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells. PLoS One (2010) 1.25
Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells. Cancer Lett (2007) 1.24
Transketolase-like 1 expression correlates with subtypes of ovarian cancer and the presence of distant metastases. Int J Gynecol Cancer (2007) 1.22
Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Proc Natl Acad Sci U S A (2006) 1.21
Pentose phosphate cycle oxidative and nonoxidative balance: A new vulnerable target for overcoming drug resistance in cancer. Int J Cancer (2006) 1.18
Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle. FEBS Lett (1999) 1.18
The TKTL1 gene influences total transketolase activity and cell proliferation in human colon cancer LoVo cells. Anticancer Drugs (2007) 1.17
Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells. Int J Cancer (2009) 1.17
Overview of the molecular and biochemical basis of branched-chain amino acid catabolism. J Nutr (2005) 1.16
Quantification of tumor type M2 pyruvate kinase (Tu M2-PK) in human carcinomas. Anticancer Res (1997) 1.15
Thiamine intestinal transport and related issues: recent aspects. Proc Soc Exp Biol Med (2000) 1.14
Dietary intake of selected B vitamins in relation to risk of major cancers in women. Br J Cancer (2008) 1.13
Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose. J Biol Chem (2006) 1.13
Lessons from genetic disorders of branched-chain amino acid metabolism. J Nutr (2006) 1.12
Current status of tumor M2 pyruvate kinase (tumor M2-PK) as a biomarker of gastrointestinal malignancy. Ann Surg Oncol (2007) 1.11
Glycolytic phenotype in breast cancer: activation of Akt, up-regulation of GLUT1, TKTL1 and down-regulation of M2PK. J Cancer Res Clin Oncol (2009) 1.10
The thiamin status of early cancer patients with particular reference to those with breast and bronchial carcinomas. Oncology (1976) 1.10
Transketolase protein TKTL1 overexpression: A potential biomarker and therapeutic target in breast cancer. Oncol Rep (2007) 1.09
Therapeutic use of branched-chain amino acids in burn, trauma, and sepsis. J Nutr (2006) 1.09
TKTL1 is overexpressed in a large portion of non-small cell lung cancer specimens. Diagn Pathol (2008) 1.09
Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells. Am J Physiol Cell Physiol (2002) 1.07
Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer. Oncol Rep (2006) 1.06
The metabolomic signature of malignant glioma reflects accelerated anabolic metabolism. Cancer Res (2012) 1.05
The thiamine status of patients with cancer as determined by the red cell transketolase activity. Int J Vitam Nutr Res (1974) 1.05
Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro. Diabetes Metab Res Rev (2008) 1.05
The crystal structure of human transketolase and new insights into its mode of action. J Biol Chem (2010) 1.04
Cell biology of the human thiamine transporter-1 (hTHTR1). Intracellular trafficking and membrane targeting mechanisms. J Biol Chem (2002) 1.04
Overexpression of transketolase TKTL1 is associated with shorter survival in laryngeal squamous cell carcinomas. Eur Arch Otorhinolaryngol (2007) 1.03
Impact of the reduced folate carrier on the accumulation of active thiamin metabolites in murine leukemia cells. J Biol Chem (2001) 1.03
Transketolase-like 1 expression is modulated during colorectal cancer progression and metastasis formation. PLoS One (2011) 1.03
Understanding and managing cancer cachexia. J Am Coll Surg (2003) 1.03
Investigations of branched-chain amino acids and their metabolites in animal models of cancer. J Nutr (2006) 1.03
In vivo and in vitro response of human branched chain alpha-ketoacid dehydrogenase to thiamine and thiamine pyrophosphate. Pediatr Res (1978) 1.02
Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer. Am J Pathol (2011) 1.02
Quantitative analysis and diagnostic significance of methylated SLC19A3 DNA in the plasma of breast and gastric cancer patients. PLoS One (2011) 1.01
Thiamin status of patients treated with drug combinations containing 5-fluorouracil. Eur J Cancer (1980) 1.01
Thiamine transporter gene expression and exogenous thiamine modulate the expression of genes involved in drug and prostaglandin metabolism in breast cancer cells. Mol Cancer Res (2004) 1.00
Quantitative detection of tumor M2-pyruvate kinase in plasma of patients with lung cancer in comparison to other lung diseases. Cancer Detect Prev (2000) 1.00
Effects of 5-fluorouracil on the thiamin status of adult female rats. Chemotherapy (1979) 0.98
Overexpression of transketolase-like gene 1 is associated with cell proliferation in uterine cervix cancer. J Exp Clin Cancer Res (2009) 0.98
Thiamine deficiency in patients with B-chronic lymphocytic leukaemia: a pilot study. Postgrad Med J (2001) 0.97
Retracted Overexpression of transketolase protein TKTL1 is associated with occurrence and progression in nasopharyngeal carcinoma: a potential therapeutic target in nasopharyngeal carcinoma. Cancer Biol Ther (2008) 0.95
Dichloroacetate shifts the metabolism from glycolysis to glucose oxidation and exhibits synergistic growth inhibition with cisplatin in HeLa cells. Int J Oncol (2010) 0.94
Expression of Transketolase like gene 1 (TKTL1) predicts disease-free survival in patients with locally advanced rectal cancer receiving neoadjuvant chemoradiotherapy. BMC Cancer (2011) 0.93
Antioxidant properties of thiamine. Bull Exp Biol Med (2000) 0.93
Promoter hypermethylation mediates downregulation of thiamine receptor SLC19A3 in gastric cancer. Tumour Biol (2009) 0.92
Oxidant stress and B vitamins status in patients with non-small cell lung cancer. Nutr Cancer (2007) 0.92
Thiamine deficiency decreases steady-state transketolase and pyruvate dehydrogenase but not alpha-ketoglutarate dehydrogenase mRNA levels in three human cell types. J Nutr (1998) 0.92
Emerging role of thiamine therapy for prevention and treatment of early-stage diabetic nephropathy. Diabetes Obes Metab (2011) 0.91
Thiamine homeostasis in neuroblastoma cells. Neurochem Int (1995) 0.91
Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target. Int J Oncol (2012) 0.91
Dual system of intestinal thiamine transport in humans. J Lab Clin Med (1982) 0.91
Up-regulation of vitamin B1 homeostasis genes in breast cancer. J Nutr Biochem (2013) 0.89