Functional subdomain in the ankyrin domain of tankyrase 1 required for poly(ADP-ribosyl)ation of TRF1 and telomere elongation.

PubWeight™: 0.97‹?› | Rank: Top 15%

🔗 View Article (PMC 350561)

Published in Mol Cell Biol on March 01, 2004

Authors

Hiroyuki Seimiya1, Yukiko Muramatsu, Susan Smith, Takashi Tsuruo

Author Affiliations

1: Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo 170-8455, Japan. hseimiya@jfcr.or.jp

Articles citing this

Tankyrase-targeted therapeutics: expanding opportunities in the PARP family. Nat Rev Drug Discov (2012) 1.62

Tankyrase polymerization is controlled by its sterile alpha motif and poly(ADP-ribose) polymerase domains. Mol Cell Biol (2004) 1.09

Tankyrases: structure, function and therapeutic implications in cancer. Curr Pharm Des (2014) 1.01

Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment. Proc Natl Acad Sci U S A (2012) 1.01

The telomeric PARP, tankyrases, as targets for cancer therapy. Br J Cancer (2006) 0.99

GDP-mannose-4,6-dehydratase is a cytosolic partner of tankyrase 1 that inhibits its poly(ADP-ribose) polymerase activity. Mol Cell Biol (2012) 0.86

Design and Discovery of 2-Arylquinazolin-4-ones as Potent and Selective Inhibitors of Tankyrases. ACS Med Chem Lett (2013) 0.82

Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling. Mol Aspects Med (2013) 0.81

Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs. PLoS Genet (2016) 0.80

Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation. Mol Cell Biol (2010) 0.79

Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling. Mol Cell (2016) 0.79

TRF1 ensures the centromeric function of Aurora-B and proper chromosome segregation. Mol Cell Biol (2014) 0.78

WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1. Nucleic Acids Res (2017) 0.75

Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells. PLoS One (2015) 0.75

Articles cited by this

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13

Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 28.20

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell (1985) 24.17

Extension of life-span by introduction of telomerase into normal human cells. Science (1998) 20.48

Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. Science (1996) 19.48

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell (1997) 13.34

Mammalian telomeres end in a large duplex loop. Cell (1999) 12.12

Switching and signaling at the telomere. Cell (2001) 11.25

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J (1992) 10.97

A survey of telomerase activity in human cancer. Eur J Cancer (1997) 10.84

TRF2 protects human telomeres from end-to-end fusions. Cell (1998) 10.13

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell (1989) 8.68

Control of telomere length by the human telomeric protein TRF1. Nature (1997) 7.62

Essential role of mouse telomerase in highly proliferative organs. Nature (1998) 7.23

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J Cell Biol (1991) 7.18

Structure and variability of human chromosome ends. Mol Cell Biol (1990) 6.18

The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell (2001) 5.98

Germline p16 mutations in familial melanoma. Nat Genet (1994) 5.59

POT1 as a terminal transducer of TRF1 telomere length control. Nature (2003) 5.43

Protection of mammalian telomeres. Oncogene (2002) 5.38

Cellular senescence: mitotic clock or culture shock? Cell (2000) 5.17

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science (1998) 4.95

A human telomeric protein. Science (1995) 4.77

Hypervariable ultra-long telomeres in mice. Nature (1990) 4.76

Senescence induced by altered telomere state, not telomere loss. Science (2002) 4.17

The ankyrin repeat: a diversity of interactions on a common structural framework. Trends Biochem Sci (1999) 4.14

The telomerase reverse transcriptase: components and regulation. Genes Dev (1998) 3.63

A simple and rapid method for generating a deletion by PCR. Nucleic Acids Res (1991) 3.20

Human telomeres are attached to the nuclear matrix. EMBO J (1992) 3.08

Tankyrase promotes telomere elongation in human cells. Curr Biol (2000) 2.67

TRF1 is a dimer and bends telomeric DNA. EMBO J (1997) 2.64

TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres. Genes Dev (2003) 2.27

Crystal structure of a 12 ANK repeat stack from human ankyrinR. EMBO J (2002) 2.27

Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. Mol Cell Biol (2002) 2.22

TRF1 binds a bipartite telomeric site with extreme spatial flexibility. EMBO J (1999) 2.20

The world according to PARP. Trends Biochem Sci (2001) 2.18

Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2. Mol Cell (2001) 1.93

Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles. J Biol Chem (2000) 1.93

Cell cycle dependent localization of the telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes. J Cell Sci (1999) 1.88

Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase). Biochem J (2002) 1.79

Mutations associated with familial melanoma impair p16INK4 function. Nat Genet (1995) 1.69

The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). J Biol Chem (2002) 1.57

Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner. J Biol Chem (2002) 1.54

The membrane-binding domain of ankyrin contains four independently folded subdomains, each comprised of six ankyrin repeats. J Biol Chem (1993) 1.46

TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. J Biol Chem (2001) 1.44

Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14. J Biol Chem (2001) 1.38

Defective folding of mutant p16(INK4) proteins encoded by tumor-derived alleles. J Biol Chem (1996) 1.24

TRF1, a mammalian telomeric protein. Trends Genet (1997) 1.10

Vertebrate tankyrase domain structure and sterile alpha motif (SAM)-mediated multimerization. Biochem J (2003) 1.10

Structure of the cyclin-dependent kinase inhibitor p19Ink4d. Nature (1997) 1.05

Articles by these authors

Resolution of sister telomere association is required for progression through mitosis. Science (2004) 3.13

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release. Circ Res (2002) 3.01

Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function. Nat Cell Biol (2004) 2.63

A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2. Curr Biol (2004) 2.45

Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow. J Cell Biol (2003) 2.40

Effect on tumor cells of blocking survival response to glucose deprivation. J Natl Cancer Inst (2004) 2.30

TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres. Genes Dev (2003) 2.27

Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. Mol Cell Biol (2002) 2.22

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. Cancer Res (2008) 2.20

A randomized, placebo-controlled, double-masked clinical trial of etanercept for the treatment of uveitis associated with juvenile idiopathic arthritis. Arthritis Rheum (2005) 2.20

Effect of antibiotic prescribing on antibiotic resistance in individual children in primary care: prospective cohort study. BMJ (2007) 2.19

Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. J Biol Chem (2002) 2.17

Tankyrase function at telomeres, spindle poles, and beyond. Biochimie (2007) 2.12

Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression. Proc Natl Acad Sci U S A (2011) 2.10

How long does it take for epilepsy to become intractable? A prospective investigation. Ann Neurol (2006) 2.09

Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide. Cancer Res (2003) 2.04

Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics. Cancer Cell (2005) 1.96

C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance. Mol Cancer Ther (2002) 1.95

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development. PLoS One (2008) 1.86

mRNA decay factor AUF1 maintains normal aging, telomere maintenance, and suppression of senescence by activation of telomerase transcription. Mol Cell (2012) 1.86

Binding and phosphorylation of par-4 by akt is essential for cancer cell survival. Mol Cell (2005) 1.82

Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production. Brain Res (2005) 1.76

Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks. EMBO Rep (2009) 1.69

Integrating medical management with diabetes self-management training: a randomized control trial of the Diabetes Outpatient Intensive Treatment program. Diabetes Care (2003) 1.68

Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors. J Biol Chem (2003) 1.67

Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Cancer Res (2005) 1.65

Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization. J Biol Chem (2003) 1.59

Alteration in copy numbers of genes as a mechanism for acquired drug resistance. Cancer Res (2004) 1.58

The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). J Biol Chem (2002) 1.57

Trauma resuscitation errors and computer-assisted decision support. Arch Surg (2011) 1.57

Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition. Mol Cell Biol (2005) 1.56

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1. J Biol Chem (2002) 1.55

NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis. Biochem J (2005) 1.53

Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation. Cancer Res (2009) 1.53

Telomere length influences cancer cell differentiation in vivo. Mol Cell Biol (2013) 1.52

Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer. Proc Natl Acad Sci U S A (2004) 1.49

The platelet aggregation-inducing factor aggrus/podoplanin promotes pulmonary metastasis. Am J Pathol (2007) 1.46

Protein requirements for sister telomere association in human cells. EMBO J (2007) 1.45

Tankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit growth defects but have normal telomere length and capping. Mol Cell Biol (2006) 1.45

Enhanced expression of Aggrus (T1alpha/podoplanin), a platelet-aggregation-inducing factor in lung squamous cell carcinoma. Tumour Biol (2005) 1.45

Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells. J Cell Biol (2009) 1.43

Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine). Oncogene (2002) 1.42

Increased nerve and blood vessel ingrowth associated with proteoglycan depletion in an ovine anular lesion model of experimental disc degeneration. Spine (Phila Pa 1976) (2002) 1.39

Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways. J Cell Physiol (2007) 1.39

Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839). Hum Mol Genet (2004) 1.35

Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization. Int J Cancer (2002) 1.29

Involvement of 3-phosphoinositide-dependent protein kinase-1 in the MEK/MAPK signal transduction pathway. J Biol Chem (2004) 1.29

Identification of ATF-3, caveolin-1, DLC-1, and NM23-H2 as putative antitumorigenic, progesterone-regulated genes for ovarian cancer cells by gene profiling. Oncogene (2005) 1.27

Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B. J Biol Chem (2002) 1.26

Breast cancer resistance protein exports sulfated estrogens but not free estrogens. Mol Pharmacol (2003) 1.26

Cullin 3 promotes proteasomal degradation of the topoisomerase I-DNA covalent complex. Cancer Res (2004) 1.25

Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo. Cancer Res (2003) 1.24

p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target. J Natl Cancer Inst (2005) 1.23

A role for heterochromatin protein 1γ at human telomeres. Genes Dev (2011) 1.22

B1 integrin/Fak/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms. Apoptosis (2008) 1.22

Functional sialylated O-glycan to platelet aggregation on Aggrus (T1alpha/Podoplanin) molecules expressed in Chinese hamster ovary cells. J Biol Chem (2004) 1.20

Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors. Oncogene (2004) 1.20

Telomere shortening and growth inhibition of human cancer cells by novel synthetic telomerase inhibitors MST-312, MST-295, and MST-1991. Mol Cancer Ther (2002) 1.13

Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1. J Cell Biochem (2009) 1.13

Freud-1/Aki1, a novel PDK1-interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling. Mol Cell Biol (2008) 1.13

Modulation of heat-shock protein 27 (Hsp27) anti-apoptotic activity by methylglyoxal modification. J Biol Chem (2002) 1.13

PRMT5, a novel TRAIL receptor-binding protein, inhibits TRAIL-induced apoptosis via nuclear factor-kappaB activation. Mol Cancer Res (2009) 1.12

Human intestinal epithelial cell survival and anoikis. Differentiation state-distinct regulation and roles of protein kinase B/Akt isoforms. J Biol Chem (2004) 1.12

Sister telomeres rendered dysfunctional by persistent cohesion are fused by NHEJ. J Cell Biol (2009) 1.11

Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3. J Biol Chem (2002) 1.10

Comparative spatial and temporal localisation of perlecan, aggrecan and type I, II and IV collagen in the ovine meniscus: an ageing study. Histochem Cell Biol (2005) 1.08

Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions. Am J Pathol (2008) 1.08

3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling. J Biol Chem (2005) 1.07

Burns caused by steam inhalation for respiratory tract infections in children. BMJ (2004) 1.07

Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer. Cancer Res (2002) 1.07

Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma. Acta Neuropathol (2006) 1.06

Development and characterization of a model of liver metastasis using human colon cancer HCT-116 cells. Biol Pharm Bull (2007) 1.05

Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis. Blood (2008) 1.05

Human intestinal epithelial crypt cell survival and death: Complex modulations of Bcl-2 homologs by Fak, PI3-K/Akt-1, MEK/Erk, and p38 signaling pathways. J Cell Physiol (2004) 1.05

Cellular FLIP inhibits beta-catenin ubiquitylation and enhances Wnt signaling. Mol Cell Biol (2004) 1.04

Spatial and temporal localization of transforming growth factor-beta, fibroblast growth factor-2, and osteonectin, and identification of cells expressing alpha-smooth muscle actin in the injured anulus fibrosus: implications for extracellular matrix repair. Spine (Phila Pa 1976) (2002) 1.03

p27Kip1 localization depends on the tumor suppressor protein tuberin. Hum Mol Genet (2007) 1.02

A novel endoplasmic reticulum export signal: proline at the +2-position from the signal peptide cleavage site. J Biol Chem (2009) 1.01

Dofequidar fumarate (MS-209) in combination with cyclophosphamide, doxorubicin, and fluorouracil for patients with advanced or recurrent breast cancer. J Clin Oncol (2006) 1.01

Randomized controlled trial to assess the short-term effectiveness of tailored web- and text-based facilitation of smoking cessation in primary care (iQuit in practice). Addiction (2014) 1.01

Topotecan inhibits VEGF- and bFGF-induced vascular endothelial cell migration via downregulation of the PI3K-Akt signaling pathway. Int J Cancer (2002) 1.01

The structure, location, and function of perlecan, a prominent pericellular proteoglycan of fetal, postnatal, and mature hyaline cartilages. J Biol Chem (2006) 1.01

Hypoxia up-regulates glyceraldehyde-3-phosphate dehydrogenase in mouse brain capillary endothelial cells: involvement of Na+/Ca2+ exchanger. Biochim Biophys Acta (2003) 1.00

Transforming growth factor-beta1 upregulates the tight junction and P-glycoprotein of brain microvascular endothelial cells. Cell Mol Neurobiol (2004) 1.00

IL12RB2 and ABCA1 genes are associated with susceptibility to radiation dermatitis. Clin Cancer Res (2008) 0.99

Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide. Cancer Sci (2009) 0.99

Mitochondrial aggregation precedes cytochrome c release from mitochondria during apoptosis. Oncogene (2003) 0.99

Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation. J Biol Chem (2007) 0.98

Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment. J Pharmacol Exp Ther (2002) 0.97

Estrone and 17beta-estradiol reverse breast cancer resistance protein-mediated multidrug resistance. Jpn J Cancer Res (2002) 0.97

Dofequidar fumarate sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export. Cancer Sci (2009) 0.97

Mitochondria regulate the unfolded protein response leading to cancer cell survival under glucose deprivation conditions. Cancer Sci (2010) 0.96

Defects of the apoptotic pathway as therapeutic target against cancer. Drug Resist Updat (2005) 0.96

Differentiation of lymphatic endothelial cells from embryonic stem cells on OP9 stromal cells. Arterioscler Thromb Vasc Biol (2006) 0.95

Transforming growth factor-beta induces expression of receptor activator of NF-kappa B ligand in vascular endothelial cells derived from bone. J Biol Chem (2002) 0.95

Involvement of FKHR-dependent TRADD expression in chemotherapeutic drug-induced apoptosis. Mol Cell Biol (2002) 0.95

Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing. Wound Repair Regen (2005) 0.95

Involvement of mitochondrial aggregation in arsenic trioxide (As2O3)-induced apoptosis in human glioblastoma cells. Cancer Sci (2005) 0.94

Adult genital surgery for intersex: a solution to what problem? J Health Psychol (2005) 0.94