Tankyrase promotes telomere elongation in human cells.

PubWeight™: 2.67‹?› | Rank: Top 1%

🔗 View Article (PMID 11069113)

Published in Curr Biol on October 19, 2000

Authors

S Smith1, T de Lange

Author Affiliations

1: The Rockefeller University, New York, New York 10021, USA.

Articles citing this

TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres. Genes Dev (2003) 2.27

Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol Cell Biol (2002) 2.25

Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. Mol Cell Biol (2002) 2.22

Telomere length homeostasis. Chromosoma (2006) 2.12

A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. Proc Natl Acad Sci U S A (2006) 2.04

Natural and pharmacological regulation of telomerase. Nucleic Acids Res (2002) 1.92

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development. PLoS One (2008) 1.86

Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase). Biochem J (2002) 1.79

Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing. Mol Cell Biol (2002) 1.69

Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol Cell Biol (2003) 1.69

DNA-PKcs is critical for telomere capping. Proc Natl Acad Sci U S A (2001) 1.64

Tankyrase-targeted therapeutics: expanding opportunities in the PARP family. Nat Rev Drug Discov (2012) 1.62

Telomere protection by TPP1/POT1 requires tethering to TIN2. Mol Cell (2011) 1.62

Rap1 affects the length and heterogeneity of human telomeres. Mol Biol Cell (2003) 1.59

The telosome/shelterin complex and its functions. Genome Biol (2008) 1.57

The association of telomere length and genetic variation in telomere biology genes. Hum Mutat (2010) 1.53

NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis. Biochem J (2005) 1.53

Telomere-bound TRF1 and TRF2 stall the replication fork at telomeric repeats. Nucleic Acids Res (2004) 1.53

Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells. Cancer Cell (2015) 1.52

Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling. PLoS One (2011) 1.46

Protein requirements for sister telomere association in human cells. EMBO J (2007) 1.45

Tankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit growth defects but have normal telomere length and capping. Mol Cell Biol (2006) 1.45

Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells. J Cell Biol (2009) 1.43

Characterization of oxidative guanine damage and repair in mammalian telomeres. PLoS Genet (2010) 1.41

Mammalian meiotic telomeres: protein composition and redistribution in relation to nuclear pores. Mol Biol Cell (2000) 1.39

Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert. Proc Natl Acad Sci U S A (2002) 1.38

Genetic variants in telomere-maintaining genes and skin cancer risk. Hum Genet (2010) 1.38

Comparison between TRF2 and TRF1 of their telomeric DNA-bound structures and DNA-binding activities. Protein Sci (2005) 1.36

DNA damage-induced phosphorylation of the human telomere-associated protein TRF2. Proc Natl Acad Sci U S A (2005) 1.24

Pot1 and cell cycle progression cooperate in telomere length regulation. Nat Struct Mol Biol (2007) 1.23

Interaction between Poly(ADP-ribose) and NuMA contributes to mitotic spindle pole assembly. Mol Biol Cell (2009) 1.20

Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-deficient mice and primary cells despite increased chromosomal instability. J Cell Biol (2001) 1.19

Clickable NAD analogues for labeling substrate proteins of poly(ADP-ribose) polymerases. J Am Chem Soc (2010) 1.18

Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice. Mol Cell Biol (2006) 1.13

Sister telomeres rendered dysfunctional by persistent cohesion are fused by NHEJ. J Cell Biol (2009) 1.11

Vertebrate tankyrase domain structure and sterile alpha motif (SAM)-mediated multimerization. Biochem J (2003) 1.10

Tankyrase polymerization is controlled by its sterile alpha motif and poly(ADP-ribose) polymerase domains. Mol Cell Biol (2004) 1.09

PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres. Mol Biol Cell (2006) 1.07

Inhibition of Epstein-Barr virus OriP function by tankyrase, a telomere-associated poly-ADP ribose polymerase that binds and modifies EBNA1. J Virol (2005) 1.06

Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics. Acta Pharmacol Sin (2010) 1.06

Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1. Nucleic Acids Res (2008) 1.06

Poly-ADP-ribose polymerase: machinery for nuclear processes. Mol Aspects Med (2013) 1.06

Deletion of Ogg1 DNA glycosylase results in telomere base damage and length alteration in yeast. EMBO J (2009) 1.04

Shelterin complex and associated factors at human telomeres. Nucleus (2011) 1.04

The paralogous genes RADICAL-INDUCED CELL DEATH1 and SIMILAR TO RCD ONE1 have partially redundant functions during Arabidopsis development. Plant Physiol (2009) 1.02

Tankyrases: structure, function and therapeutic implications in cancer. Curr Pharm Des (2014) 1.01

POT1 association with TRF2 regulates telomere length. Mol Cell Biol (2009) 1.01

Review of poly (ADP-ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases. Crit Rev Eukaryot Gene Expr (2014) 0.99

The telomeric PARP, tankyrases, as targets for cancer therapy. Br J Cancer (2006) 0.99

Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs. Aging (Albany NY) (2010) 0.98

Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo. Mol Cell Biol (2004) 0.97

The substrates of Plk1, beyond the functions in mitosis. Protein Cell (2010) 0.97

Functional subdomain in the ankyrin domain of tankyrase 1 required for poly(ADP-ribosyl)ation of TRF1 and telomere elongation. Mol Cell Biol (2004) 0.97

Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1. J Biol Chem (2009) 0.96

Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation. J Biol Chem (2010) 0.96

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. PLoS One (2010) 0.92

New PARP targets for cancer therapy. Nat Rev Cancer (2014) 0.91

Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.90

Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma. Oncotarget (2013) 0.89

Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4. PLoS One (2013) 0.88

Telomerase activity in B-cell non-Hodgkin lymphomas is regulated by hTERT transcription and correlated with telomere-binding protein expression but uncoupled from proliferation. Br J Cancer (2003) 0.88

Cell-cycle-dependent Xenopus TRF1 recruitment to telomere chromatin regulated by Polo-like kinase. EMBO J (2006) 0.87

Telomere-regulating genes and the telomere interactome in familial cancers. Mol Cancer Res (2014) 0.87

TIN2 stability is regulated by the E3 ligase Siah2. Mol Cell Biol (2011) 0.87

Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation. Cell Death Differ (2011) 0.87

Herpes simplex virus requires poly(ADP-ribose) polymerase activity for efficient replication and induces extracellular signal-related kinase-dependent phosphorylation and ICP0-dependent nuclear localization of tankyrase 1. J Virol (2011) 0.86

GDP-mannose-4,6-dehydratase is a cytosolic partner of tankyrase 1 that inhibits its poly(ADP-ribose) polymerase activity. Mol Cell Biol (2012) 0.86

Fanconi anemia protein FANCD2 inhibits TRF1 polyADP-ribosylation through tankyrase1-dependent manner. Genome Integr (2011) 0.85

SA1 binds directly to DNA through its unique AT-hook to promote sister chromatid cohesion at telomeres. J Cell Sci (2013) 0.84

Function, replication and structure of the mammalian telomere. Cytotechnology (2004) 0.84

Poly (ADP-ribose) polymerase 3 (PARP3), a potential repressor of telomerase activity. J Exp Clin Cancer Res (2014) 0.82

Regulation of mitosis by poly(ADP-ribosyl)ation. Biochem J (2005) 0.82

Chromatin structure in telomere dynamics. Front Oncol (2013) 0.82

TRF1 and TRF2 differentially modulate Rad51-mediated telomeric and nontelomeric displacement loop formation in vitro. Biochemistry (2014) 0.81

Analysis of poly(ADP-Ribose) polymerases in Arabidopsis telomere biology. PLoS One (2014) 0.81

Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling. Mol Aspects Med (2013) 0.81

A role for sister telomere cohesion in telomere elongation by telomerase. Cell Cycle (2012) 0.81

The Drosophila tankyrase regulates Wg signaling depending on the concentration of Daxin. Cell Signal (2014) 0.80

Chemical proteomics reveals ADP-ribosylation of small GTPases during oxidative stress. Nat Chem Biol (2017) 0.79

Altered mRNA expression of telomere-associated genes in monoclonal gammopathy of undetermined significance and multiple myeloma. Mol Med (2010) 0.79

PARP-1 and YY1 are important novel regulators of CXCL12 gene transcription in rat pancreatic beta cells. PLoS One (2013) 0.79

The telomere protein tankyrase 1 regulates DNA damage responses at telomeres. Aging (Albany NY) (2010) 0.79

PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage. Nucleic Acids Res (2015) 0.79

ADP-ribosylation: activation, recognition, and removal. Mol Cells (2014) 0.78

Zinc deficiency or excess within the physiological range increases genome instability and cytotoxicity, respectively, in human oral keratinocyte cells. Genes Nutr (2011) 0.77

Heregulin, a new regulator of telomere length in human cells. Oncotarget (2015) 0.77

Structural insights into SAM domain-mediated tankyrase oligomerization. Protein Sci (2016) 0.77

Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology. Philos Trans R Soc Lond B Biol Sci (2002) 0.77

Trypanosoma brucei TIF2 and TRF Suppress VSG Switching Using Overlapping and Independent Mechanisms. PLoS One (2016) 0.76

Parp3 negatively regulates immunoglobulin class switch recombination. PLoS Genet (2015) 0.76

The 68-kDa telomeric repeat binding factor 1 (TRF1)-associated protein (TAP68) interacts with and recruits TRF1 to the spindle pole during mitosis. J Biol Chem (2014) 0.76

Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage. Nucleic Acids Res (2017) 0.75

Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals. BMC Biol (2016) 0.75

ERCC1 and telomere status in breast tumours treated with neoadjuvant chemotherapy and their association with patient prognosis. J Pathol Clin Res (2016) 0.75

Macrocyclized extended peptides: Inhibiting the substrate-recognition domain of tankyrase. J Am Chem Soc (2017) 0.75

Regulation of Telomere Length Requires a Conserved N-Terminal Domain of Rif2 in Saccharomyces cerevisiae. Genetics (2015) 0.75

Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9. Mol Cell (2017) 0.75

Articles by these authors

Mammalian telomeres end in a large duplex loop. Cell (1999) 12.12

TRF2 protects human telomeres from end-to-end fusions. Cell (1998) 10.13

Control of telomere length by the human telomeric protein TRF1. Nature (1997) 7.62

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science (1999) 5.89

Definition of regions in human c-myc that are involved in transformation and nuclear localization. Mol Cell Biol (1987) 5.67

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet (1997) 4.95

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science (1998) 4.95

A human telomeric protein. Science (1995) 4.77

Control of human telomere length by TRF1 and TRF2. Mol Cell Biol (2000) 4.54

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat Genet (2000) 4.30

Identification of human Rap1: implications for telomere evolution. Cell (2000) 4.06

Telomerase activity in normal and malignant hematopoietic cells. Proc Natl Acad Sci U S A (1995) 3.79

T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang. EMBO J (2001) 3.28

TRF1 is a dimer and bends telomeric DNA. EMBO J (1997) 2.64

Withdrawal time as a quality indicator for colonoscopy - a nationwide analysis. Endoscopy (2012) 2.25

TRF1 binds a bipartite telomeric site with extreme spatial flexibility. EMBO J (1999) 2.20

Unusual chromatin in human telomeres. Mol Cell Biol (1994) 2.19

Stringent sequence requirements for the formation of human telomeres. Proc Natl Acad Sci U S A (1994) 2.16

A mammalian factor that binds telomeric TTAGGG repeats in vitro. Mol Cell Biol (1992) 2.04

Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2. Mol Cell (2001) 1.93

t-loops at trypanosome telomeres. EMBO J (2001) 1.91

Cell cycle dependent localization of the telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes. J Cell Sci (1999) 1.88

Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex. J Cell Biol (1996) 1.75

TRF1 promotes parallel pairing of telomeric tracts in vitro. J Mol Biol (1998) 1.73

A map of the distal region of the long arm of human chromosome 21 constructed by radiation hybrid mapping and pulsed-field gel electrophoresis. Genomics (1991) 1.55

Ku binds telomeric DNA in vitro. J Biol Chem (1999) 1.55

Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domains. Hum Mol Genet (1997) 1.48

Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation. Mol Cell Biol (1996) 1.44

Mammalian meiotic telomeres: protein composition and redistribution in relation to nuclear pores. Mol Biol Cell (2000) 1.39

Telomeric structure in cells with chromosome end associations. Chromosoma (1993) 1.34

The control of variant surface antigen synthesis in trypanosomes. Eur J Biochem (1983) 1.32

A Xenopus egg factor with DNA-binding properties characteristic of terminus-specific telomeric proteins. Genes Dev (1993) 1.25

TRF1, a mammalian telomeric protein. Trends Genet (1997) 1.10

Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages. Exp Cell Res (2006) 1.09

NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains. J Mol Biol (2001) 1.05

Ending up with the right partner. Nature (1998) 1.03

Coincident multiple activations of the same surface antigen gene in Trypanosoma brucei. J Mol Biol (1987) 0.89

Incontinence after colonoscopy--an unrecognized and preventable problem. A cross-sectional study from the Gastronet quality assurance program. Endoscopy (2012) 0.82

Energy requirement for maintenance of the transmembrane potassium gradient in Klebsiella aerogenes NCTC 418: a continuous culture study. Arch Microbiol (1979) 0.79

Chromosomal mapping of the tankyrase gene in human and mouse. Genomics (1999) 0.78

The role of ferritin in developing primary bean leaves under various light conditions. Planta (1981) 0.75