Cytokines and fever.

Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection. Nat Immunol (2009) 2.80

Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions. J Proteome Res (2007) 2.61

A cascade of cytokines mediates mechanical inflammatory hypernociception in mice. Proc Natl Acad Sci U S A (2005) 2.53

New roles for interleukin-1 Beta in the mechanisms of epilepsy. Epilepsy Curr (2007) 1.50

Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise. Front Neuroendocrinol (2012) 1.35

Cytokines in radiobiological responses: a review. Radiat Res (2012) 1.29

Is maternal influenza or fever during pregnancy associated with autism or developmental delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) study. J Autism Dev Disord (2013) 1.25

Release of ATP in the central nervous system during systemic inflammation: real-time measurement in the hypothalamus of conscious rabbits. J Physiol (2007) 1.15

Cytokine and chemokine responses in serum and brain after single and repeated injections of lipopolysaccharide: multiplex quantification with path analysis. Brain Behav Immun (2011) 1.15

Brain mast cells link the immune system to anxiety-like behavior. Proc Natl Acad Sci U S A (2008) 1.12

Systemic inflammation exacerbates behavioral and histopathological consequences of isolated traumatic brain injury in rats. Exp Neurol (2008) 1.11

Cytokines and brain excitability. Front Neuroendocrinol (2011) 1.11

Pathogenic role for virus-specific CD4 T cells in mice with coronavirus-induced acute encephalitis. Am J Pathol (2006) 1.08

Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6. Proc Natl Acad Sci U S A (2013) 1.07

Spontaneous and influenza virus-induced sleep are altered in TNF-alpha double-receptor deficient mice. J Appl Physiol (1985) (2008) 1.07

Gaining entry to an uninflamed brain. Nat Immunol (2009) 1.03

Cortisol and inflammatory processes in ovarian cancer patients following primary treatment: relationships with depression, fatigue, and disability. Brain Behav Immun (2012) 1.03

Central and peripheral neuroimmune responses: hyporesponsiveness during pregnancy. J Physiol (2007) 1.02

Cytokine mRNA induction by interleukin-1beta or tumor necrosis factor alpha in vitro and in vivo. Brain Res (2008) 0.97

TNF-α and temporal changes in sleep architecture in mice exposed to sleep fragmentation. PLoS One (2012) 0.96

Transcriptomic analysis of the temporal host response to skin infestation with the ectoparasitic mite Psoroptes ovis. BMC Genomics (2010) 0.96

Limited dynamic range of immune response gene expression observed in healthy blood donors using RT-PCR. Mol Med (2006) 0.94

Circulating leptin mediates lipopolysaccharide-induced anorexia and fever in rats. J Physiol (2004) 0.94

The absence of typical pneumonia symptoms in a patient with rheumatoid arthritis during tocilizumab and steroid treatment. BMJ Case Rep (2012) 0.92

P2 receptor blockade attenuates fever and cytokine responses induced by lipopolysaccharide in rats. Br J Pharmacol (2005) 0.91

Peptide vaccination of mice immune to LCMV or vaccinia virus causes serious CD8 T cell-mediated, TNF-dependent immunopathology. J Clin Invest (2006) 0.89

Human lung innate immune cytokine response to adenovirus type 7. J Gen Virol (2010) 0.88

Pretreatment with recombinant human vascular endothelial growth factor reduces virus replication and inflammation in a perinatal lamb model of respiratory syncytial virus infection. Viral Immunol (2007) 0.88

Immune-to-brain signaling and central prostaglandin E2 synthesis in fasted rats with altered lipopolysaccharide-induced fever. Am J Physiol Regul Integr Comp Physiol (2008) 0.85

Neonatal programming of innate immune function. Am J Physiol Endocrinol Metab (2010) 0.84

Oligonol supplementation affects leukocyte and immune cell counts after heat loading in humans. Nutrients (2014) 0.82

Perinatal nutrition programs neuroimmune function long-term: mechanisms and implications. Front Neurosci (2013) 0.82

Suppression of the febrile response in late gestation: evidence, mechanisms and outcomes. J Neuroendocrinol (2008) 0.82

The TNF-alpha system: functional aspects in depression, narcolepsy and psychopharmacology. Curr Neuropharmacol (2008) 0.82

Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue. Cytokine (2010) 0.81

A large-scale immuno-epidemiological simulation of influenza A epidemics. BMC Public Health (2014) 0.79

Activation of kinin B1 receptor evokes hyperthermia through a vagal sensory mechanism in the rat. J Neuroinflammation (2012) 0.79

Postnatal programming of the innate immune response. Integr Comp Biol (2009) 0.79

Dissociation between sickness behavior and emotionality during lipopolysaccharide challenge in lymphocyte deficient Rag2(-/-) mice. Behav Brain Res (2014) 0.79

Early murine immune responses from endotracheal exposures to biotechnology-related Bacillus strains. Toxicol Environ Chem (2010) 0.79

Buying time-the immune system determinants of the incubation period to respiratory viruses. Viruses (2010) 0.78

Clinical chorioamnionitis at term V: umbilical cord plasma cytokine profile in the context of a systemic maternal inflammatory response. J Perinat Med (2016) 0.78

Postoperative fever: the potential relationship with prognosis in node negative breast cancer patients. PLoS One (2010) 0.77

Clinical chorioamnionitis at term IV: the maternal plasma cytokine profile. J Perinat Med (2016) 0.77

TTF-1 action on the transcriptional regulation of cyclooxygenase-2 gene in the rat brain. PLoS One (2011) 0.77

Antioxidant Effect of Spirulina (Arthrospira) maxima on Chronic Inflammation Induced by Freund's Complete Adjuvant in Rats. J Med Food (2015) 0.76

Tissue-Specific Induction of Mouse ZIP8 and ZIP14 Divalent Cation/Bicarbonate Symporters by, and Cytokine Response to, Inflammatory Signals. Int J Toxicol (2014) 0.76

Spotlight on sirukumab for the treatment of rheumatoid arthritis: the evidence to date. Drug Des Devel Ther (2016) 0.75

Intensive serial biomarker profiling for the prediction of neutropenic Fever in patients with hematologic malignancies undergoing chemotherapy: a pilot study. Hematol Rep (2014) 0.75

Paclitaxel inhibits the hyper-activation of spleen cells by lipopolysaccharide and induces cell death. J Vet Sci (2016) 0.75

Duration of red blood cell storage and inflammatory marker generation. Blood Transfus (2017) 0.75

Clozapine Associated with Autoimmune Reaction, Fever and Low Level Cardiotoxicity - A Case Report. In Vivo (2017) 0.75

The anti-inflammatory and immunomodulatory potential of braylin: Pharmacological properties and mechanisms by in silico, in vitro and in vivo approaches. PLoS One (2017) 0.75

Lifetime Modulation of the Pain System via Neuroimmune and Neuroendocrine Interactions. Front Immunol (2017) 0.75

Inflammatory index and treatment of brain abscess. Nagoya J Med Sci (2012) 0.75

Can cycles of chills and fever resolve bipolar disorder mania? BMJ Case Rep (2014) 0.75

Prognostic value of fever grade combined with neutrophil percentage in hepatocellular carcinoma patients presenting fever as the initial manifestation. Onco Targets Ther (2016) 0.75

Lipoic Acid Exerts Antioxidant and Anti-inflammatory Effects in Response to Heat Shock in C2C12 Myotubes. Inflammation (2016) 0.75

The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway. EMBO Rep (2002) 4.76

The role of inflammation in epilepsy. Nat Rev Neurol (2010) 3.89

Transgenic mice with a reduced core body temperature have an increased life span. Science (2006) 3.37

Interleukin-1beta contributes to the generation of experimental febrile seizures. Ann Neurol (2005) 2.90

A blood based 12-miRNA signature of Alzheimer disease patients. Genome Biol (2013) 1.99

A specific role for NR2A-containing NMDA receptors in the maintenance of parvalbumin and GAD67 immunoreactivity in cultured interneurons. J Neurosci (2006) 1.93

Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients. Diabetes (2006) 1.89

A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration. J Neurosci (2010) 1.80

Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity. Proc Natl Acad Sci U S A (2008) 1.64

A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta. Brain (2008) 1.64

MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics. Proc Natl Acad Sci U S A (2006) 1.61

IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures. Brain Behav Immun (2011) 1.57

The promise of single-cell sequencing. Nat Methods (2014) 1.51

Analysis of the gene expression profile activated by the CC chemokine ligand 5/RANTES and by lipopolysaccharide in human monocytes. J Immunol (2002) 1.42

Neuropeptides: opportunities for drug discovery. Lancet Neurol (2003) 1.41

Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency. Proc Natl Acad Sci U S A (2007) 1.40

Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist. J Neurotrauma (2002) 1.40

Anticonvulsant activity of a nonpeptide galanin receptor agonist. Proc Natl Acad Sci U S A (2002) 1.29

Single cell transcriptomics of hypothalamic warm sensitive neurons that control core body temperature and fever response Signaling asymmetry and an extension of chemical neuroanatomy. Pharmacol Ther (2010) 1.27

Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochem Pharmacol (2002) 1.21

Analyzing the validity of GalR1 and GalR2 antibodies using knockout mice. Naunyn Schmiedebergs Arch Pharmacol (2009) 1.20

Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity. J Neurochem (2005) 1.18

Insulin causes hyperthermia by direct inhibition of warm-sensitive neurons. Diabetes (2009) 1.16

Ceramide mediates the rapid phase of febrile response to IL-1beta. Proc Natl Acad Sci U S A (2006) 1.16

Galanin and its receptors in neurological disorders. Neuromolecular Med (2005) 1.14

Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in the dentate gyrus. Eur J Neurosci (2004) 1.10

The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal. Proc Natl Acad Sci U S A (2003) 1.07

IL-1beta induces a MyD88-dependent and ceramide-mediated activation of Src in anterior hypothalamic neurons. J Neurochem (2006) 1.06

The brain galanin receptors: targets for novel antidepressant drugs. CNS Neurol Disord Drug Targets (2007) 1.04

Neuropeptide expression in rats exposed to chronic mild stresses. Psychopharmacology (Berl) (2004) 1.02

High-throughput FRET assay yields allosteric SERCA activators. J Biomol Screen (2012) 1.01

A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc Natl Acad Sci U S A (2005) 0.99

Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5. J Pharmacol Exp Ther (2003) 0.98

G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice. J Clin Invest (2012) 0.97

Neuropeptides and neuropeptide receptors: drug targets, and peptide and non-peptide ligands: a tribute to Prof. Dieter Seebach. Chem Biodivers (2012) 0.97

Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour. Eur J Neurosci (2006) 0.97

Galanin receptor ligands. Neuropeptides (2005) 0.96

Galanin receptors and ligands. Front Endocrinol (Lausanne) (2012) 0.96

Metabolic characterization of a mouse deficient in all known leptin receptor isoforms. Cell Mol Neurobiol (2009) 0.95

Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests. Neuropeptides (2008) 0.95

Therapeutic potential of new antiinflammatory drugs. Epilepsia (2011) 0.95

GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models. Proc Natl Acad Sci U S A (2010) 0.95

Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance. Swiss Med Wkly (2008) 0.95

Effect of interleukin-18 on mouse core body temperature. Am J Physiol Regul Integr Comp Physiol (2002) 0.95

Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes. Neuropeptides (2005) 0.95

Night eating and obesity in the EP3R-deficient mouse. Proc Natl Acad Sci U S A (2007) 0.94

Evaluation of transportan 10 in PEI mediated plasmid delivery assay. J Control Release (2005) 0.93

Effects of chronic overexpression of interleukin-1 receptor antagonist in a model of permanent focal cerebral ischemia in mouse. Acta Neuropathol (2004) 0.91

Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors. J Biol Chem (2011) 0.91

Blunted neurogenesis and gliosis due to transgenic overexpression of human soluble IL-1ra in the mouse. Eur J Neurosci (2008) 0.91

Impaired long term memory consolidation in transgenic mice overexpressing the human soluble form of IL-1ra in the brain. J Neuroimmunol (2009) 0.91

Prostaglandin E2-increased thermosensitivity of anterior hypothalamic neurons is associated with depressed inhibition. Proc Natl Acad Sci U S A (2004) 0.90

Serotonergic neuron regulation informed by in vivo single-cell transcriptomics. FASEB J (2013) 0.89

Enhanced hippocampal noradrenaline and serotonin release in galanin-overexpressing mice after repeated forced swimming test. Proc Natl Acad Sci U S A (2003) 0.89

Reversal of obesity and insulin resistance by a non-peptidic glucagon-like peptide-1 receptor agonist in diet-induced obese mice. PLoS One (2010) 0.89

Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide. J Immunol (2012) 0.89

Advancements on phenotypic and functional characterization of non-antigen-specific CD8+CD28- regulatory T cells. Hum Immunol (2008) 0.89

A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests. Neurosci Lett (2006) 0.88

Systemic galnon, a low-molecular weight galanin receptor agonist, reduces heat hyperalgesia in rats with nerve injury. Eur J Pharmacol (2003) 0.88

TLR2 is required for the altered transcription of p75NGF receptors in gram positive infection. Neurochem Res (2006) 0.87

Hypothalamic and dietary control of temperature-mediated longevity. Ageing Res Rev (2009) 0.87

Galanin overexpressing transgenic mice. Neuropeptides (2002) 0.86

Galnon--a low-molecular weight ligand of the galanin receptors. Neuropeptides (2005) 0.86

Transgenic overexpression of interleukin-1 receptor antagonist in the CNS influences behaviour, serum corticosterone and brain monoamines. Brain Behav Immun (2005) 0.86

Distribution and differential regulation of galanin receptor subtypes in rat brain: effects of seizure activity. Neuropeptides (2005) 0.85

Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of GalR2. Bioorg Med Chem Lett (2011) 0.84

AdipoR1 and 2 are expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyperthermic effects of adiponectin. Brain Res (2011) 0.84

Important pharmacophores for binding to galanin receptor 2. Neuropeptides (2005) 0.84

Homodimerization and internalization of galanin type 1 receptor in living CHO cells. Neuropeptides (2005) 0.83

Synthesis of galmic: a nonpeptide galanin receptor agonist. Proc Natl Acad Sci U S A (2004) 0.83

Regulation of feeding by galnon. Neuropeptides (2004) 0.83

Multiple interaction sites of galnon trigger its biological effects. Neuropeptides (2005) 0.82

Downregulation of GPR83 in the hypothalamic preoptic area reduces core body temperature and elevates circulating levels of adiponectin. Metabolism (2012) 0.82

Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue. Cytokine (2010) 0.81

Novel isoforms of the TFIID subunit TAF4 modulate nuclear receptor-mediated transcriptional activity. Biochem Biophys Res Commun (2004) 0.81

Effects of galnon, a non-peptide galanin-receptor agonist, on insulin release from rat pancreatic islets. Biochem Biophys Res Commun (2005) 0.81

Galanin alters GABAergic neurotransmission in the dorsal raphe nucleus. Neurochem Res (2007) 0.80

Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala. Addict Biol (2011) 0.79

Impairment of memory consolidation by galanin correlates with in vivo inhibition of both LTP and CREB phosphorylation. Neurobiol Learn Mem (2009) 0.79

Morphological and behavioral changes induced by transgenic overexpression of interleukin-1ra in the brain. J Neurosci Res (2010) 0.78

Age-related impairments of synaptic plasticity in the lateral perforant path input to the dentate gyrus of galanin overexpressing mice. Neuropeptides (2005) 0.78

It all happens between Toll receptors and caspase 1. Proc Natl Acad Sci U S A (2007) 0.78

Targeting of antisense PNA oligomers to human galanin receptor type 1 mRNA. Neuropeptides (2004) 0.78

Synthesis of cell-penetrating peptide-PNA constructs. Methods Mol Biol (2002) 0.78

Novel systemically active galanin receptor 2 ligands in depression-like behavior. J Neurochem (2013) 0.77

Why is the New York Times writing so much about Alzheimer's disease therapies? ScientificWorldJournal (2010) 0.77

High frequency of TNF alleles -238A and -376A in individuals from northern Sardinia. Cytokine (2004) 0.76

Molecular characterization of the ligand binding site of the human galanin receptor type 2, identifying subtype selective interactions. J Neurochem (2007) 0.76

Choices in neuroscience careers. Nat Rev Neurosci (2008) 0.75