Published in J Control Release on January 26, 2005
Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics. Br J Pharmacol (2009) 2.99
Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA. Mol Ther Nucleic Acids (2012) 0.95
Recent developments in peptide-based nucleic acid delivery. Int J Mol Sci (2008) 0.92
Peptide-mediated cellular delivery of oligonucleotide-based therapeutics in vitro: quantitative evaluation of overall efficacy employing easy to handle reporter systems. Curr Pharm Des (2008) 0.91
Cell penetrating peptides in the delivery of biopharmaceuticals. Biomolecules (2012) 0.88
Applications of cell-penetrating peptides for tumor targeting and future cancer therapies. Pharmaceuticals (Basel) (2012) 0.87
Structure analysis and conformational transitions of the cell penetrating peptide transportan 10 in the membrane-bound state. PLoS One (2014) 0.84
Degradable polyethylenimine derivate coupled to a bifunctional peptide R13 as a new gene-delivery vector. Int J Nanomedicine (2012) 0.83
Bifunctional chimeric fusion proteins engineered for DNA delivery: optimization of the protein to DNA ratio. Biochim Biophys Acta (2009) 0.82
Cell-Penetrating Peptides-Mechanisms of Cellular Uptake and Generation of Delivery Systems. Pharmaceuticals (Basel) (2010) 0.81
An unusual cell penetrating peptide identified using a plasmid display-based functional selection platform. ACS Chem Biol (2011) 0.80
Peptide-ligand binding modeling of siRNA with cell-penetrating peptides. Biomed Res Int (2014) 0.78
The Role of Cell-Penetrating Peptide and Transferrin on Enhanced Delivery of Drug to Brain. Int J Mol Sci (2016) 0.78
Transfecting the hard-to-transfect lymphoma/leukemia cells using a simple cationic polymer nanocomplex. J Control Release (2012) 0.76
siRNA Delivery by Stimuli-Sensitive Nanocarriers. Curr Pharm Des (2015) 0.76
Identification of cell-penetrating peptides that are bactericidal to Neisseria meningitidis and prevent inflammatory responses upon infection. Antimicrob Agents Chemother (2013) 0.75
The role of inflammation in epilepsy. Nat Rev Neurol (2010) 3.89
Transgenic mice with a reduced core body temperature have an increased life span. Science (2006) 3.37
Interleukin-1beta contributes to the generation of experimental febrile seizures. Ann Neurol (2005) 2.90
Cell-penetrating peptides: mechanism and kinetics of cargo delivery. Adv Drug Deliv Rev (2005) 2.80
Mechanisms of cellular uptake of cell-penetrating peptides. J Biophys (2011) 2.34
Characterization of the physical interaction of Gli proteins with SUFU proteins. J Biol Chem (2002) 2.29
Immunoprecipitation of mRNA-protein complexes. Nat Protoc (2006) 2.21
A blood based 12-miRNA signature of Alzheimer disease patients. Genome Biol (2013) 1.99
A specific role for NR2A-containing NMDA receptors in the maintenance of parvalbumin and GAD67 immunoreactivity in cultured interneurons. J Neurosci (2006) 1.93
The use of cell-penetrating peptides as a tool for gene regulation. Drug Discov Today (2004) 1.90
Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients. Diabetes (2006) 1.89
Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site. Gene (2004) 1.82
Cytokines and fever. Front Biosci (2004) 1.78
Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity. Proc Natl Acad Sci U S A (2008) 1.64
A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta. Brain (2008) 1.64
Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice. Mov Disord (2014) 1.63
MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics. Proc Natl Acad Sci U S A (2006) 1.61
Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. J Biol Chem (2002) 1.60
Characterization of bioactive cell penetrating peptides from human cytochrome c: protein mimicry and the development of a novel apoptogenic agent. Chem Biol (2010) 1.58
IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures. Brain Behav Immun (2011) 1.57
The promise of single-cell sequencing. Nat Methods (2014) 1.51
Mechanism of the cell-penetrating peptide transportan 10 permeation of lipid bilayers. Biophys J (2007) 1.50
Cell-penetrating peptides: mechanisms and applications. Curr Pharm Des (2005) 1.50
Hedgehog signalling: how to get from Smo to Ci and Gli. Trends Cell Biol (2006) 1.46
Cell-penetrating peptides as vectors for peptide, protein and oligonucleotide delivery. Curr Opin Pharmacol (2006) 1.45
The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor. J Exp Med (2003) 1.44
Analysis of the gene expression profile activated by the CC chemokine ligand 5/RANTES and by lipopolysaccharide in human monocytes. J Immunol (2002) 1.42
Neuropeptides: opportunities for drug discovery. Lancet Neurol (2003) 1.41
Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist. J Neurotrauma (2002) 1.40
Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency. Proc Natl Acad Sci U S A (2007) 1.40
Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo. Nucleic Acids Res (2011) 1.35
Cell-penetrating peptides: a comparative membrane toxicity study. Anal Biochem (2005) 1.30
Anticonvulsant activity of a nonpeptide galanin receptor agonist. Proc Natl Acad Sci U S A (2002) 1.29
A brief introduction to cell-penetrating peptides. J Mol Recognit (2003) 1.29
Single cell transcriptomics of hypothalamic warm sensitive neurons that control core body temperature and fever response Signaling asymmetry and an extension of chemical neuroanatomy. Pharmacol Ther (2010) 1.27
Global sampling of plant roots expands the described molecular diversity of arbuscular mycorrhizal fungi. Mycorrhiza (2013) 1.26
Cell-penetrating peptides--a brief introduction. Biochim Biophys Acta (2006) 1.24
Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochem Pharmacol (2002) 1.21
Cargo-dependent cytotoxicity and delivery efficacy of cell-penetrating peptides: a comparative study. Biochem J (2007) 1.20
Classes and prediction of cell-penetrating peptides. Methods Mol Biol (2011) 1.20
Analyzing the validity of GalR1 and GalR2 antibodies using knockout mice. Naunyn Schmiedebergs Arch Pharmacol (2009) 1.20
Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: The effects of subtype-selective agonists and the role of G-protein-mediated signaling. J Pharmacol Exp Ther (2006) 1.19
Communities of arbuscular mycorrhizal fungi detected in forest soil are spatially heterogeneous but do not vary throughout the growing season. PLoS One (2012) 1.19
Protein cargo delivery properties of cell-penetrating peptides. A comparative study. Bioconjug Chem (2004) 1.18
Predicting cell-penetrating peptides. Adv Drug Deliv Rev (2007) 1.18
Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity. J Neurochem (2005) 1.18
Efficient intracellular delivery of nucleic acid pharmaceuticals using cell-penetrating peptides. Acc Chem Res (2011) 1.18
Insulin causes hyperthermia by direct inhibition of warm-sensitive neurons. Diabetes (2009) 1.16
Ceramide mediates the rapid phase of febrile response to IL-1beta. Proc Natl Acad Sci U S A (2006) 1.16
Induction of splice correction by cell-penetrating peptide nucleic acids. J Gene Med (2006) 1.14
Galanin and its receptors in neurological disorders. Neuromolecular Med (2005) 1.14
Secondary structure of cell-penetrating peptides controls membrane interaction and insertion. Biochim Biophys Acta (2010) 1.13
Cell entry and antimicrobial properties of eukaryotic cell-penetrating peptides. FASEB J (2003) 1.12
Galanin protects against behavioral and neurochemical correlates of opiate reward. Neuropsychopharmacology (2007) 1.11
A stearylated CPP for delivery of splice correcting oligonucleotides using a non-covalent co-incubation strategy. J Control Release (2008) 1.10
Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in the dentate gyrus. Eur J Neurosci (2004) 1.10
Insights into the cellular trafficking of splice redirecting oligonucleotides complexed with chemically modified cell-penetrating peptides. J Control Release (2011) 1.09
Knockdown of L calcium channel subtypes: differential effects in neuropathic pain. J Neurosci (2010) 1.09
The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal. Proc Natl Acad Sci U S A (2003) 1.07
Characterization of the vaginal micro- and mycobiome in asymptomatic reproductive-age Estonian women. PLoS One (2013) 1.07
Design of a tumor-homing cell-penetrating peptide. Bioconjug Chem (2007) 1.06
Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway. Exp Cell Res (2009) 1.06
Cell transduction pathways of transportans. Bioconjug Chem (2005) 1.06
Plant species richness belowground: higher richness and new patterns revealed by next-generation sequencing. Mol Ecol (2011) 1.06
In vitro uptake and stability study of pVEC and its all-D analog. Biol Chem (2003) 1.06
IL-1beta induces a MyD88-dependent and ceramide-mediated activation of Src in anterior hypothalamic neurons. J Neurochem (2006) 1.06
The brain galanin receptors: targets for novel antidepressant drugs. CNS Neurol Disord Drug Targets (2007) 1.04
Neuropeptide expression in rats exposed to chronic mild stresses. Psychopharmacology (Berl) (2004) 1.02
Delivery of nucleic acids with a stearylated (RxR)4 peptide using a non-covalent co-incubation strategy. J Control Release (2009) 1.01
A novel cell-penetrating peptide, M918, for efficient delivery of proteins and peptide nucleic acids. Mol Ther (2007) 1.01
High-throughput FRET assay yields allosteric SERCA activators. J Biomol Screen (2012) 1.01
A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc Natl Acad Sci U S A (2005) 0.99
A specific role for the TFIID subunit TAF4 and RanBPM in neural progenitor differentiation. Mol Cell Neurosci (2005) 0.98
Elucidating cell-penetrating peptide mechanisms of action for membrane interaction, cellular uptake, and translocation utilizing the hydrophobic counter-anion pyrenebutyrate. Biochim Biophys Acta (2009) 0.98
Distinct uptake routes of cell-penetrating peptide conjugates. Bioconjug Chem (2008) 0.98
Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5. J Pharmacol Exp Ther (2003) 0.98
G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice. J Clin Invest (2012) 0.97
Neuropeptides and neuropeptide receptors: drug targets, and peptide and non-peptide ligands: a tribute to Prof. Dieter Seebach. Chem Biodivers (2012) 0.97
Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour. Eur J Neurosci (2006) 0.97
Galanin receptor ligands. Neuropeptides (2005) 0.96
Chemically modified cell-penetrating peptides for the delivery of nucleic acids. Expert Opin Drug Deliv (2009) 0.96
Galanin receptors and ligands. Front Endocrinol (Lausanne) (2012) 0.96
Studying the uptake of cell-penetrating peptides. Nat Protoc (2006) 0.96
Mitochondria-cytoskeleton interaction: distribution of β-tubulins in cardiomyocytes and HL-1 cells. Biochim Biophys Acta (2011) 0.96
Analysis of in vitro toxicity of five cell-penetrating peptides by metabolic profiling. Toxicology (2009) 0.95
Two novel targeting peptide degrading proteases, PrePs, in mitochondria and chloroplasts, so similar and still different. J Mol Biol (2005) 0.95
Metabolic characterization of a mouse deficient in all known leptin receptor isoforms. Cell Mol Neurobiol (2009) 0.95
Effect of interleukin-18 on mouse core body temperature. Am J Physiol Regul Integr Comp Physiol (2002) 0.95
Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests. Neuropeptides (2008) 0.95
Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance. Swiss Med Wkly (2008) 0.95
N-terminal peptides from unprocessed prion proteins enter cells by macropinocytosis. Biochem Biophys Res Commun (2006) 0.95