Published in Proc Natl Acad Sci U S A on February 20, 2004
Mechanisms of sudden cardiac death. J Clin Invest (2005) 2.90
Connective tissue growth factor promotes fibrosis downstream of TGFbeta and IL-6 in chronic cardiac allograft rejection. Am J Transplant (2009) 1.59
Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel. J Clin Invest (2007) 1.53
Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo. Proc Natl Acad Sci U S A (2006) 1.48
Neural modulation of cardiac arrhythmias and sudden cardiac death. Heart Rhythm (2006) 1.42
Myocyte-restricted focal adhesion kinase deletion attenuates pressure overload-induced hypertrophy. Circ Res (2006) 1.34
Restoration of podocyte structure and improvement of chronic renal disease in transgenic mice overexpressing renin. PLoS One (2009) 1.14
Critical role for IL-6 in hypertrophy and fibrosis in chronic cardiac allograft rejection. Am J Transplant (2009) 1.13
Regression of pressure-induced left ventricular hypertrophy is characterized by a distinct gene expression profile. J Thorac Cardiovasc Surg (2009) 1.09
G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection. J Mol Endocrinol (2013) 0.92
Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males. Proc Natl Acad Sci U S A (2007) 0.92
Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules. Am J Physiol Heart Circ Physiol (2011) 0.88
The renin angiotensin system and the metabolic syndrome. Open Hypertens J (2010) 0.86
Transgenic mice overexpressing Renin exhibit glucose intolerance and diet-genotype interactions. Front Endocrinol (Lausanne) (2013) 0.85
Loss of receptor activity-modifying protein 3 exacerbates cardiac hypertrophy and transition to heart failure in a sex-dependent manner. J Mol Cell Cardiol (2011) 0.83
Chronic Activation of the Renin-Angiotensin System Induces Lung Fibrosis. Sci Rep (2015) 0.77
A novel mouse model of advanced diabetic kidney disease. PLoS One (2014) 0.77
Activation of the Renin-Angiotensin System Promotes Colitis Development. Sci Rep (2016) 0.75
Inhibition of CaMKII does not attenuate cardiac hypertrophy in mice with dysfunctional ryanodine receptor. PLoS One (2014) 0.75
Genetic variations involved in sudden cardiac death and their associations and interactions. Heart Fail Rev (2016) 0.75
Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol (2003) 6.99
FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell (2003) 4.68
An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice. Genes Dev (1987) 4.48
A noninvasive computerized tail-cuff system for measuring blood pressure in mice. Hypertension (1995) 4.08
Prospective study of heart rate variability and mortality in chronic heart failure: results of the United Kingdom heart failure evaluation and assessment of risk trial (UK-heart). Circulation (1998) 3.99
A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia. Cell (2001) 3.13
Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proc Natl Acad Sci U S A (1997) 2.99
Single-copy transgenic mice with chosen-site integration. Proc Natl Acad Sci U S A (1996) 2.84
Adrenomedullin, a multifunctional regulatory peptide. Endocr Rev (2000) 2.52
TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II. J Clin Invest (2002) 2.35
Regulation of Ca2+ signaling in transgenic mouse cardiac myocytes overexpressing calsequestrin. J Clin Invest (1998) 2.29
Induction of cardiac fibrosis by transforming growth factor-beta(1). Mol Genet Metab (2000) 2.24
Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titration. Proc Natl Acad Sci U S A (2002) 2.08
Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice. J Clin Invest (2001) 2.03
Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy. Physiol Genomics (2001) 1.98
Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene. Proc Natl Acad Sci U S A (2001) 1.85
Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy. Proc Natl Acad Sci U S A (2000) 1.82
Modified moving average analysis of T-wave alternans to predict ventricular fibrillation with high accuracy. J Appl Physiol (1985) (2002) 1.79
Genomic circuits and the integrative biology of cardiac diseases. Nature (2000) 1.70
Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure. Physiol Genomics (2002) 1.57
Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression. J Biol Chem (1999) 1.56
Modifier genes for hypertrophic cardiomyopathy. Curr Opin Cardiol (2002) 1.47
Effects of long 5' leader sequences on initiation by eukaryotic ribosomes in vitro. Gene Expr (1991) 1.39
Genetic modifier loci affecting survival and cardiac function in murine dilated cardiomyopathy. Circulation (2002) 1.21
A genetically clamped renin transgene for the induction of hypertension. Proc Natl Acad Sci U S A (2002) 1.15
Angiotensin II and the pathophysiology of cardiovascular remodeling. Am J Cardiol (2001) 0.98
Development and application of a biological peptide pump for the study of the in vivo actions of angiotensin peptides. Am J Hypertens (2001) 0.86
QT dispersion has no prognostic value in patients with symptomatic heart failure: an ELITE II substudy. Pacing Clin Electrophysiol (2003) 0.84
Heart size-independent analysis of myocardial function in murine pressure overload hypertrophy. Am J Physiol Heart Circ Physiol (2002) 0.84
Modulation of gene expression in transgenic mouse hearts overexpressing calsequestrin. Cell Calcium (2002) 0.83
Cardiac hypertrophy and failure: lessons learned from genetically engineered mice. Acta Physiol Scand (2001) 0.83
Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association. Circulation (2004) 13.07
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A (2006) 4.10
Mouse models of diabetic nephropathy. J Am Soc Nephrol (2009) 3.74
Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. Circ Res (2004) 2.98
Prostacyclin protects against elevated blood pressure and cardiac fibrosis. Cell Metab (2005) 2.82
Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. J Clin Invest (2005) 2.59
Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened. Dev Cell (2004) 2.52
Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science (2002) 2.45
Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction. J Clin Invest (2006) 2.33
An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. Proc Natl Acad Sci U S A (2005) 2.18
Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titration. Proc Natl Acad Sci U S A (2002) 2.08
Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. J Clin Invest (2006) 1.92
Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma. J Clin Invest (2004) 1.91
Lymphocyte responses exacerbate angiotensin II-dependent hypertension. Am J Physiol Regul Integr Comp Physiol (2010) 1.76
Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension. Am J Physiol Renal Physiol (2008) 1.71
Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type. J Am Soc Nephrol (2004) 1.71
Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase. Hypertension (2007) 1.70
TRPC1 channels are critical for hypertrophic signaling in the heart. Circ Res (2009) 1.64
Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption. Hypertension (2006) 1.62
Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury. Kidney Int (2012) 1.60
Impaired T cell function in RANTES-deficient mice. Clin Immunol (2002) 1.60
β-arrestin1-biased β1-adrenergic receptor signaling regulates microRNA processing. Circ Res (2013) 1.59
Role for thromboxane receptors in angiotensin-II-induced hypertension. Hypertension (2004) 1.57
Analysis of the incidence and clinical effect of the heterotopic ossification in a single-level cervical artificial disc replacement. Spine J (2010) 1.55
Endothelial dysfunction: associations with exposure to ambient fine particles in diabetic individuals. Environ Health Perspect (2008) 1.53
Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel. J Clin Invest (2007) 1.53
Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction. Proc Natl Acad Sci U S A (2010) 1.51
Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo. Proc Natl Acad Sci U S A (2006) 1.48
Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure. J Clin Invest (2003) 1.47
Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor. Proc Natl Acad Sci U S A (2004) 1.45
Tnni3k modifies disease progression in murine models of cardiomyopathy. PLoS Genet (2009) 1.44
Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance. J Biol Chem (2003) 1.43
Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy. Am J Physiol Heart Circ Physiol (2004) 1.41
Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure. J Hypertens (2012) 1.41
Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis. J Clin Invest (2009) 1.41
Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo. Mol Endocrinol (2003) 1.40
Increased energy expenditure, dietary fat wasting, and resistance to diet-induced obesity in mice lacking renin. Cell Metab (2007) 1.39
Hidden Transection of Follicular Unit Extraction in Donor Site. Dermatol Surg (2016) 1.39
Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors. J Clin Invest (2006) 1.38
Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene. Mol Cell Biol (2006) 1.35
Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury. Proc Natl Acad Sci U S A (2007) 1.30
Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in mice. Am J Pathol (2007) 1.29
Three-dimensional diffusion tensor microscopy of fixed mouse hearts. Magn Reson Med (2004) 1.28
Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice. Proc Natl Acad Sci U S A (2010) 1.26
Coarse particulate matter (PM2.5-10) affects heart rate variability, blood lipids, and circulating eosinophils in adults with asthma. Environ Health Perspect (2007) 1.22
Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice. J Clin Invest (2006) 1.22
Kidney cysts, pancreatic cysts, and biliary disease in a mouse model of autosomal recessive polycystic kidney disease. Pediatr Nephrol (2008) 1.22
RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice. Proc Natl Acad Sci U S A (2009) 1.21
Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling. Am J Physiol Heart Circ Physiol (2006) 1.19
Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment. Mol Cell Biol (2007) 1.18
Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age. J Biol Chem (2007) 1.18
Peripherally induced resiniferatoxin analgesia. Pain (2003) 1.17
Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol (2009) 1.17
Posttranscriptional compensation for heterozygous disruption of the kidney-specific NaK2Cl cotransporter gene. J Am Soc Nephrol (2002) 1.16
Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice. Endocrinology (2005) 1.16
A genetically clamped renin transgene for the induction of hypertension. Proc Natl Acad Sci U S A (2002) 1.15
β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury. Am J Physiol Heart Circ Physiol (2012) 1.15
Restoration of podocyte structure and improvement of chronic renal disease in transgenic mice overexpressing renin. PLoS One (2009) 1.14
Targeted disruption of hsp70.1 sensitizes to osmotic stress. EMBO Rep (2002) 1.13
A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation. Proc Natl Acad Sci U S A (2006) 1.13
Risk factors of sagittal decompensation after long posterior instrumentation and fusion for degenerative lumbar scoliosis. Spine (Phila Pa 1976) (2010) 1.12
Kidney function in mice lacking aldosterone. Am J Physiol Renal Physiol (2005) 1.11
A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy. Proc Natl Acad Sci U S A (2011) 1.10
Npr1-regulated gene pathways contributing to cardiac hypertrophy and fibrosis. J Mol Endocrinol (2007) 1.06
Diabetic kidney disease in FVB/NJ Akita mice: temporal pattern of kidney injury and urinary nephrin excretion. PLoS One (2012) 1.06
Natriuretic peptide receptor A mediates renal sodium excretory responses to blood volume expansion. Am J Physiol Renal Physiol (2003) 1.05
eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype. J Am Soc Nephrol (2012) 1.05
The kallikrein-kinin system in health and in diseases of the kidney. Kidney Int (2009) 1.04
Cardiac micro-computed tomography for morphological and functional phenotyping of muscle LIM protein null mice. Mol Imaging (2007) 1.03
Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy. Proc Natl Acad Sci U S A (2010) 1.03
Tissue-specific regulation of ACE/ACE2 and AT1/AT2 receptor gene expression by oestrogen in apolipoprotein E/oestrogen receptor-alpha knock-out mice. Exp Physiol (2008) 1.03
A role for the thromboxane receptor in L-NAME hypertension. Am J Physiol Renal Physiol (2008) 1.02
Genotype/age interactions on aggressive behavior in gonadally intact estrogen receptor beta knockout (betaERKO) male mice. Horm Behav (2002) 1.02
Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group VI: revascularization in diabetic patients. Circulation (2002) 1.01
Altering the expression in mice of genes by modifying their 3' regions. Dev Cell (2004) 1.00
Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro. Proc Natl Acad Sci U S A (2005) 1.00