Published in Proc Natl Acad Sci U S A on March 01, 2004
Membrane transporters in drug development. Nat Rev Drug Discov (2010) 8.56
Impact of OATP transporters on pharmacokinetics. Br J Pharmacol (2009) 2.97
Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol Rev (2010) 2.97
OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies. Br J Pharmacol (2012) 1.74
Pharmacogenomics of human OATP transporters. Naunyn Schmiedebergs Arch Pharmacol (2006) 1.71
SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation. J Am Soc Nephrol (2009) 1.70
The expression and function of organic anion transporting polypeptides in normal tissues and in cancer. Annu Rev Pharmacol Toxicol (2011) 1.41
The SLCO (former SLC21) superfamily of transporters. Mol Aspects Med (2013) 1.12
Drug transporters, the blood-testis barrier, and spermatogenesis. J Endocrinol (2010) 1.05
Targeted drug delivery to treat pain and cerebral hypoxia. Pharmacol Rev (2013) 1.01
Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys. Drug Metab Dispos (2009) 0.99
Tumor-specific expression of organic anion-transporting polypeptides: transporters as novel targets for cancer therapy. J Drug Deliv (2013) 0.98
Activation of protein kinase Czeta increases OAT1 (SLC22A6)- and OAT3 (SLC22A8)-mediated transport. J Biol Chem (2008) 0.96
Cyanobacterial cyclopeptides as lead compounds to novel targeted cancer drugs. Mar Drugs (2010) 0.96
Contribution of tumoral and host solute carriers to clinical drug response. Drug Resist Updat (2012) 0.90
Integrative assessment of chlorine-induced acute lung injury in mice. Am J Respir Cell Mol Biol (2012) 0.89
Transporters at CNS barrier sites: obstacles or opportunities for drug delivery? Curr Pharm Des (2014) 0.88
Assessment of the role of renal organic anion transporters in drug-induced nephrotoxicity. Toxins (Basel) (2010) 0.88
Endothelin-1 reduces p-glycoprotein transport activity in an in vitro model of human adult blood-brain barrier. Cell Mol Neurobiol (2008) 0.87
Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain. Am J Hypertens (2009) 0.85
Endogenous ouabain: a link between sodium intake and hypertension. Curr Hypertens Rep (2011) 0.85
Roles of rat renal organic anion transporters in transporting perfluorinated carboxylates with different chain lengths. Toxicol Sci (2009) 0.85
Human organic anion transporters function as a high-capacity transporter for p-cresyl sulfate, a uremic toxin. Clin Exp Nephrol (2013) 0.83
Identification, Ki determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17beta-glucuronide transport. Pharmacol Res (2009) 0.83
Molecular mechanism of ochratoxin a transport in the kidney. Toxins (Basel) (2010) 0.83
Podocyte expression of membrane transporters involved in puromycin aminonucleoside-mediated injury. PLoS One (2013) 0.80
Metabolomic profiling of the autosomal dominant polycystic kidney disease rat model. Clin Exp Nephrol (2011) 0.80
Localization and functional characterization of the rat Oatp4c1 transporter in an in vitro cell system and rat tissues. PLoS One (2012) 0.80
Abc3-mediated efflux of an endogenous digoxin-like steroidal glycoside by Magnaporthe oryzae is necessary for host invasion during blast disease. PLoS Pathog (2012) 0.79
Change in mRNA Expression after Atenolol, a Beta-adrenergic Receptor Antagonist and Association with Pharmacological Response. Arch Drug Inf (2009) 0.79
Uptake carriers and oncology drug safety. Drug Metab Dispos (2013) 0.79
Endogenous ouabain in renal Na(+) handling and related diseases. Biochim Biophys Acta (2010) 0.79
Transporter function and cyclic AMP turnover in normal colonic mucosa from patients with and without colorectal neoplasia. BMC Gastroenterol (2012) 0.78
Transport of organic anions and cations in murine embryonic kidney development and in serially-reaggregated engineered kidneys. Sci Rep (2015) 0.78
Endogenous cardiotonic steroids in kidney failure: a review and an hypothesis. Adv Chronic Kidney Dis (2015) 0.78
Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer Therapy. AAPS J (2015) 0.78
Genome-wide association study revealed genomic regions related to white/red earlobe color trait in the Rhode Island Red chickens. BMC Genet (2016) 0.78
Renal drug transporters and their significance in drug-drug interactions. Acta Pharm Sin B (2016) 0.77
Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regulation of GATA3. PLoS One (2013) 0.77
Proximal tubule cell hypothesis for cardiorenal syndrome in diabetes. Int J Nephrol (2010) 0.77
Trafficking and other regulatory mechanisms for organic anion transporting polypeptides and organic anion transporters that modulate cellular drug and xenobiotic influx and that are dysregulated in disease. Br J Pharmacol (2017) 0.75
Structure and function of thyroid hormone plasma membrane transporters. Eur Thyroid J (2014) 0.75
Delineating the role of various factors in renal disposition of digoxin through application of physiologically-based kidney model to renal impairment populations. J Pharmacol Exp Ther (2017) 0.75
Unmasking the Role of Uptake Transporters for Digoxin Uptake Across the Barriers of the Central Nervous System in Rat. J Cent Nerv Syst Dis (2017) 0.75
Comparative bioinformatics, temporal and spatial expression analyses of Ixodes scapularis organic anion transporting polypeptides. Ticks Tick Borne Dis (2014) 0.75
Xenobiotic transporters and kidney injury. Adv Drug Deliv Rev (2017) 0.75
Renal Drug Transporters and Drug Interactions. Clin Pharmacokinet (2017) 0.75
Effect of Liver Disease on Hepatic Transporter Expression and Function. J Pharm Sci (2017) 0.75
A simple method for displaying the hydropathic character of a protein. J Mol Biol (1982) 150.65
TreeView: an application to display phylogenetic trees on personal computers. Comput Appl Biosci (1996) 56.57
Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J (1982) 38.14
The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med (1997) 10.68
The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta (2003) 2.53
LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology (2001) 2.02
Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem (1999) 1.87
Endogenous cardiac glycosides, a new class of steroid hormones. Eur J Biochem (2002) 1.51
Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters. J Pharm Sci (2001) 1.48
Cellular and molecular aspects of drug transport in the kidney. Kidney Int (2000) 1.41
Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1). J Pharmacol Exp Ther (1992) 1.35
Immunologic distribution of an organic anion transport protein in rat liver and kidney. Am J Physiol (1996) 1.22
Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2. J Biol Chem (1998) 1.20
Thyroid hormone transporters: recent advances. Trends Endocrinol Metab (2002) 1.20
Depletion of CD8 positive cells in nephrotoxic serum nephritis of WKY rats. Kidney Int (1992) 1.17
Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Mol Pharmacol (2001) 1.14
Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology (2001) 1.13
Thyroid hormone transport by the heterodimeric human system L amino acid transporter. Endocrinology (2001) 1.12
Gender differences in expression of organic cation transporter OCT2 in rat kidney. FEBS Lett (1999) 1.11
Identification of thyroid hormone transporters. Biochem Biophys Res Commun (1999) 1.00
Expression of MDR1 (multidrug resistance) gene and its protein in normal human kidney. Nephron (1997) 1.00
Clinical pharmacokinetic significance of the renal tubular secretion of digoxin. Clin Pharmacokinet (1987) 0.99
Renal Na+/H+ exchanger isoforms and their regulation by thyroid hormone. Am J Physiol (1996) 0.98
Tissue expression, ontogeny, and inducibility of rat organic anion transporting polypeptide 4. J Pharmacol Exp Ther (2002) 0.95
Physiologically based pharmacokinetics of digoxin in mdr1a knockout mice. J Pharm Sci (1999) 0.94
The metabolism of tritiated digoxin in renal insufficiency in dogs and man. J Pharmacol Exp Ther (1966) 0.92
Identification and characterization of novel rat and human gonad-specific organic anion transporters. Mol Endocrinol (2003) 0.91
Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney. J Biol Chem (1996) 0.91
Two apical multidrug transporters, P-gp and MRP2, are differently altered in chronic renal failure. Am J Physiol Renal Physiol (2001) 0.91
Contribution of sodium taurocholate co-transporting polypeptide to the uptake of its possible substrates into rat hepatocytes. J Pharmacol Exp Ther (1998) 0.89
Multispecific substrate recognition of kidney-specific organic anion transporters OAT-K1 and OAT-K2. J Pharmacol Exp Ther (2001) 0.86
mRNA distribution and membrane localization of the OAT-K1 organic anion transporter in rat renal tubules. FEBS Lett (1997) 0.84
A model for the prediction of digoxin-drug interactions at the renal tubular cell level. Ther Drug Monit (1998) 0.84
The type I iodothyronine 5'-deiodinase messenger ribonucleic acid is localized to the S3 segment of the rat kidney proximal tubule. Endocrinology (1993) 0.83
Organic anion transporter oatp2-mediated interaction between digoxin and amiodarone in the rat liver. Pharm Res (2002) 0.82
Transverse motion of spin-labeled 3,3',5-triiodo-L-thyronine in phospholipid bilayers. Biochem Biophys Res Commun (1985) 0.82
Calcimimetic NPS R-568 prevents parathyroid hyperplasia in rats with severe secondary hyperparathyroidism. Kidney Int (2000) 0.82
Gender difference in the urinary excretion of organic anions in rats. J Pharmacol Exp Ther (2002) 0.80
Interaction of digoxin with antihypertensive drugs via MDR1. Life Sci (2002) 0.79
Renal handling and effects of [3H]digoxin and interactions with quinidine in the avian kidney. Acta Physiol Scand (1986) 0.77
Olmesartan for the delay or prevention of microalbuminuria in type 2 diabetes. N Engl J Med (2011) 11.11
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009). Hypertens Res (2009) 5.24
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014). Hypertens Res (2014) 4.83
Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci U S A (2003) 4.03
IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J Immunol (2005) 3.02
Modification of the Modification of Diet in Renal Disease (MDRD) Study equation for Japan. Am J Kidney Dis (2007) 2.74
An expert consensus statement on use of adrenal vein sampling for the subtyping of primary aldosteronism. Hypertension (2013) 2.72
Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient. Clin Exp Nephrol (2007) 2.58
Characterization of small solid tumors in the pancreas: the value of contrast-enhanced harmonic endoscopic ultrasonography. Am J Gastroenterol (2011) 2.49
Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma. Endocr Relat Cancer (2014) 2.45
Target blood pressure for treatment of isolated systolic hypertension in the elderly: valsartan in elderly isolated systolic hypertension study. Hypertension (2010) 2.37
Characteristics of printing company workers newly diagnosed with occupational cholangiocarcinoma. J Hepatobiliary Pancreat Sci (2014) 2.22
Estimation of glomerular filtration rate by the MDRD study equation modified for Japanese patients with chronic kidney disease. Clin Exp Nephrol (2007) 2.20
Increased expression of HIP/PAP and regenerating gene III in human inflammatory bowel disease and a murine bacterial reconstitution model. Inflamm Bowel Dis (2003) 2.09
Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol (2007) 2.05
Hemoglobin is expressed by mesangial cells and reduces oxidant stress. J Am Soc Nephrol (2008) 1.99
Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1. Drug Metab Pharmacokinet (2005) 1.96
Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J Am Soc Nephrol (2002) 1.85
CENP-C is involved in chromosome segregation, mitotic checkpoint function, and kinetochore assembly. Mol Biol Cell (2007) 1.85
Prevention of cardiovascular events with calcium channel blocker-based combination therapies in patients with hypertension: a randomized controlled trial. J Hypertens (2011) 1.75
Mutations in the serine protease inhibitor Kazal Type 1 (SPINK1) gene in Japanese patients with pancreatitis. Pancreatology (2005) 1.74
An inward rectifier K(+) channel at the basolateral membrane of the mouse distal convoluted tubule: similarities with Kir4-Kir5.1 heteromeric channels. J Physiol (2002) 1.71
SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation. J Am Soc Nephrol (2009) 1.70
Localization of aldosterone-producing adrenocortical adenomas: significance of adrenal venous sampling. Hypertens Res (2007) 1.68
CENP-O class proteins form a stable complex and are required for proper kinetochore function. Mol Biol Cell (2007) 1.68
Progressive graft fibrosis and donor-specific human leukocyte antigen antibodies in pediatric late liver allografts. Liver Transpl (2012) 1.67
COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis. Proc Natl Acad Sci U S A (2009) 1.67
Guidelines for the diagnosis and treatment of primary aldosteronism--the Japan Endocrine Society 2009. Endocr J (2011) 1.67
Combinations of olmesartan and a calcium channel blocker or a diuretic in elderly hypertensive patients: a randomized, controlled trial. J Hypertens (2014) 1.56
18-oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primary aldosteronism. J Clin Endocrinol Metab (2011) 1.54
Cutting balloon angioplasty of resistant renal artery stenosis caused by fibromuscular dysplasia. J Vasc Surg (2005) 1.53
Keap1 degradation by autophagy for the maintenance of redox homeostasis. Proc Natl Acad Sci U S A (2012) 1.53
Mutation of the Mg2+ transporter SLC41A1 results in a nephronophthisis-like phenotype. J Am Soc Nephrol (2013) 1.52
Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family). J Pharmacol Exp Ther (2006) 1.52
Pulse pressure amplification, arterial stiffness, and peripheral wave reflection determine pulsatile flow waveform of the femoral artery. Hypertension (2010) 1.52
Prevention of transition from incipient to overt nephropathy with telmisartan in patients with type 2 diabetes. Diabetes Care (2007) 1.50
All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta. J Leukoc Biol (2011) 1.50
Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain. J Nutr (2010) 1.47
Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor. Genes Dev (2003) 1.47
Tacrolimus therapy as an alternative to thiopurines for maintaining remission in patients with refractory ulcerative colitis. J Clin Gastroenterol (2011) 1.47
Kidney dysfunction as a risk factor for first symptomatic stroke events in a general Japanese population--the Ohasama study. Nephrol Dial Transplant (2007) 1.47
Laparoscopic simultaneous bilateral adrenalectomy: assessment of feasibility and potential indications. Int J Urol (2011) 1.46
Crucial roles of Brn1 in distal tubule formation and function in mouse kidney. Development (2003) 1.44
The constitutive centromere component CENP-50 is required for recovery from spindle damage. Mol Cell Biol (2005) 1.44
Cerebrospinal fluid concentration of gefitinib and erlotinib in patients with non-small cell lung cancer. Cancer Chemother Pharmacol (2012) 1.43
Effects of dual blockade of the renin-angiotensin system on renal and cardiovascular outcomes in type 2 diabetes with overt nephropathy and hypertension in the ORIENT: a post-hoc analysis (ORIENT-Hypertension). Hypertens Res (2013) 1.42
Angiotensin II type 1 receptor blockers reduce urinary oxidative stress markers in hypertensive diabetic nephropathy. Hypertension (2006) 1.41
A decline in glomerular filtration rate rather than renal arterial stenotic lesions, per se, predicts cardiovascular-renal events in type 2 diabetic patients. Circ J (2013) 1.40
The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer. Dig Dis Sci (2008) 1.40
To stimulate or not to stimulate: is adrenocorticotrophic hormone testing necessary, or not? J Hypertens (2007) 1.39
Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1. Am J Physiol Cell Physiol (2008) 1.38
Central pulse pressure links microalbuminuria with plasma B-type natriuretic peptide elevation: causal implication for cardiorenal syndrome in hypertension. J Hypertens (2014) 1.37
RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation. Neoplasia (2012) 1.36
Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas. Gut (2010) 1.35
Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity. Biochem Pharmacol (2007) 1.35
IL-28 elicits antitumor responses against murine fibrosarcoma. J Immunol (2007) 1.35
Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells. Int J Cancer (2008) 1.35
Central pulse pressure and aortic stiffness determine renal hemodynamics: pathophysiological implication for microalbuminuria in hypertension. Hypertension (2011) 1.35
C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation. Pharmacogenetics (2002) 1.33
Strain vessel hypothesis: a viewpoint for linkage of albuminuria and cerebro-cardiovascular risk. Hypertens Res (2009) 1.32
Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2). Pharm Res (2007) 1.32
Maternal riboflavin deficiency, resulting in transient neonatal-onset glutaric aciduria Type 2, is caused by a microdeletion in the riboflavin transporter gene GPR172B. Hum Mutat (2011) 1.31
Assembly of two distinct dimers and higher-order oligomers from full-length tau. Eur J Neurosci (2007) 1.31
Gd-EOB-DTPA-enhanced magnetic resonance images of hepatocellular carcinoma: correlation with histological grading and portal blood flow. Eur Radiol (2010) 1.31
Plasticity of renal erythropoietin-producing cells governs fibrosis. J Am Soc Nephrol (2013) 1.30
Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells. Biochem Biophys Res Commun (2010) 1.28
Association between tubular toxicity of cisplatin and expression of organic cation transporter rOCT2 (Slc22a2) in the rat. Biochem Pharmacol (2005) 1.28
Enhanced superoxide production in renal outer medulla of Dahl salt-sensitive rats reduces nitric oxide tubular-vascular cross-talk. Hypertension (2007) 1.27
Sitagliptin, a dipeptidyl peptidase-4 inhibitor, decreases systolic blood pressure in Japanese hypertensive patients with type 2 diabetes. Tohoku J Exp Med (2011) 1.26
Metabolomic profiling of uremic solutes in CKD patients. Hypertens Res (2010) 1.26