Published in J Biol Chem on June 11, 1999
Membrane transporters in drug development. Nat Rev Drug Discov (2010) 8.56
Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch (2003) 3.33
Impact of OATP transporters on pharmacokinetics. Br J Pharmacol (2009) 2.97
Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol Rev (2010) 2.97
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. J Clin Oncol (2009) 2.20
Targeted disruption of murine organic anion-transporting polypeptide 1b2 (Oatp1b2/Slco1b2) significantly alters disposition of prototypical drug substrates pravastatin and rifampin. Mol Pharmacol (2008) 2.11
Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition. Circulation (2016) 1.87
Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia. Hum Mol Genet (2009) 1.87
OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies. Br J Pharmacol (2012) 1.74
Pharmacogenomics of human OATP transporters. Naunyn Schmiedebergs Arch Pharmacol (2006) 1.71
The expression and function of organic anion transporting polypeptides in normal tissues and in cancer. Annu Rev Pharmacol Toxicol (2011) 1.41
Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A (2004) 1.27
PharmGKB summary: methotrexate pathway. Pharmacogenet Genomics (2011) 1.27
Interactions of green tea catechins with organic anion-transporting polypeptides. Drug Metab Dispos (2011) 1.24
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation. PLoS Genet (2012) 1.23
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. J Med Chem (2012) 1.18
Elucidating rifampin's inducing and inhibiting effects on glyburide pharmacokinetics and blood glucose in healthy volunteers: unmasking the differential effects of enzyme induction and transporter inhibition for a drug and its primary metabolite. Clin Pharmacol Ther (2008) 1.14
The SLCO (former SLC21) superfamily of transporters. Mol Aspects Med (2013) 1.12
Amino acid residues in transmembrane domain 10 of organic anion transporting polypeptide 1B3 are critical for cholecystokinin octapeptide transport. Biochemistry (2008) 1.11
Active efflux across the blood-brain barrier: role of the solute carrier family. NeuroRx (2005) 1.11
In vitro and in silico strategies to identify OATP1B1 inhibitors and predict clinical drug-drug interactions. Pharm Res (2011) 1.01
Targeted drug delivery to treat pain and cerebral hypoxia. Pharmacol Rev (2013) 1.01
Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res (2013) 0.97
Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. Curr Chem Genomics (2010) 0.96
Role of transmembrane domain 10 for the function of organic anion transporting polypeptide 1B1. Protein Sci (2009) 0.95
Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X. Biochem J (2000) 0.95
The intestinal absorption of folates. Annu Rev Physiol (2014) 0.94
Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins. Naunyn Schmiedebergs Arch Pharmacol (2003) 0.94
Several conserved positively charged amino acids in OATP1B1 are involved in binding or translocation of different substrates. J Membr Biol (2010) 0.91
PharmGKB very important pharmacogene: SLCO1B1. Pharmacogenet Genomics (2010) 0.90
Contribution of tumoral and host solute carriers to clinical drug response. Drug Resist Updat (2012) 0.90
Stable expression and functional characterization of a Na+-taurocholate cotransporting green fluorescent protein in human hepatoblastoma HepG2 cells. Cytotechnology (2000) 0.90
Pharmacogenetics of SLCO1B1: haplotypes, htSNPs and hepatic expression in three distinct Asian populations. Eur J Clin Pharmacol (2007) 0.87
Mechanism of polybrominated diphenyl ether uptake into the liver: PBDE congeners are substrates of human hepatic OATP transporters. Toxicol Sci (2010) 0.87
Regulation of bile acid and cholesterol metabolism by PPARs. PPAR Res (2009) 0.86
Peroxisome proliferator-activated receptor alpha activates cyclooxygenase-2 gene transcription through bile acid transport in human colorectal cancer cell lines. J Gastroenterol (2008) 0.85
Cloning and expression of SLC10A4, a putative organic anion transport protein. World J Gastroenterol (2006) 0.84
Intracellular 'boosting' of darunavir using known transport inhibitors in primary PBMC. Br J Clin Pharmacol (2009) 0.83
Identification, Ki determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17beta-glucuronide transport. Pharmacol Res (2009) 0.83
Hepatocellular transport proteins and their role in liver disease. World J Gastroenterol (2001) 0.82
Fluorescence-based assays for the assessment of drug interaction with the human transporters OATP1B1 and OATP1B3. Anal Biochem (2010) 0.82
Role of solute carriers in response to anticancer drugs. Mol Cell Ther (2014) 0.81
Inhibition of the organic anion-transporting polypeptide 1B1 by quercetin: an in vitro and in vivo assessment. Br J Clin Pharmacol (2012) 0.80
Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene. J Gastroenterol (2006) 0.80
Hepatic organic anion transporting polypeptide transporter and thyroid hormone receptor interplay determines cholesterol and glucose homeostasis. Hepatology (2011) 0.80
Effect of CYP2C9 and SLCO1B1 polymorphisms on the pharmacokinetics and pharmacodynamics of nateglinide in healthy Chinese male volunteers. Eur J Clin Pharmacol (2012) 0.79
Uptake carriers and oncology drug safety. Drug Metab Dispos (2013) 0.79
Non-synonymous polymorphisms in the human SLCO1B1 gene: an in vitro analysis of SNP c.1929A>C. Mol Genet Genomics (2007) 0.79
Interaction of three regiospecific amino acid residues is required for OATP1B1 gain of OATP1B3 substrate specificity. Mol Pharm (2012) 0.79
Expression and function of thyroid hormone transporters in the microvillous plasma membrane of human term placental syncytiotrophoblast. Endocrinology (2012) 0.79
Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer Therapy. AAPS J (2015) 0.78
Role of UDP-glucuronosyltransferase (UGT) 2B2 in metabolism of triiodothyronine: effect of microsomal enzyme inducers in Sprague Dawley and UGT2B2-deficient Fischer 344 rats. Toxicol Sci (2010) 0.77
Molecular cloning and functional characterization of a rainbow trout liver Oatp. Toxicol Appl Pharmacol (2014) 0.77
Cloning/characterization of the canine organic anion transporting polypeptide 1b4 (Oatp1b4) and classification of the canine OATP/SLCO members. Comp Biochem Physiol C Toxicol Pharmacol (2010) 0.76
The effect of breast cancer resistance protein, multidrug resistant protein 1, and organic anion-transporting polypeptide 1B3 on the antitumor efficacy of the lipophilic camptothecin 7-t-butyldimethylsilyl-10-hydroxycamptothecin (AR-67) in vitro. Drug Metab Dispos (2013) 0.76
Disruption of thyroid hormone homeostasis in Ugt1a-deficient Gunn rats by microsomal enzyme inducers is not due to enhanced thyroxine glucuronidation. Toxicol Appl Pharmacol (2010) 0.76
Comparative bioinformatics, temporal and spatial expression analyses of Ixodes scapularis organic anion transporting polypeptides. Ticks Tick Borne Dis (2014) 0.75
Down-regulation of OATP1B proteins correlates with hyperbilirubinemia in advanced cholestasis. Int J Clin Exp Pathol (2015) 0.75
Clinical validity of new genetic biomarkers of irinotecan neutropenia: an independent replication study. Pharmacogenomics J (2015) 0.75
Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty Acid. Biomol Ther (Seoul) (2015) 0.75
Pharmacogenomics in type 2 diabetes: oral antidiabetic drugs. Pharmacogenomics J (2016) 0.75
Use of gadoxetate disodium for functional MRI based on its unique molecular mechanism. Br J Radiol (2015) 0.75
The influence of herbal medicine ursolic acid on the uptake of rosuvastatin mediated by OATP1B1*1a and *5. Eur J Drug Metab Pharmacokinet (2014) 0.75
SLCO1B1*5 polymorphism (rs4149056) is associated with chemotherapy-induced amenorrhea in premenopausal women with breast cancer: a prospective cohort study. BMC Cancer (2016) 0.75
Preference of Conjugated Bile Acids over Unconjugated Bile Acids as Substrates for OATP1B1 and OATP1B3. PLoS One (2017) 0.75
The transcriptional landscape of the mammalian genome. Science (2005) 37.63
Antisense transcription in the mammalian transcriptome. Science (2005) 15.69
Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution. Nature (2000) 9.44
Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci U S A (1991) 8.04
Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor. Nature (1986) 7.73
Peroral endoscopic myotomy (POEM) for esophageal achalasia. Endoscopy (2010) 7.10
Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases. Proc Natl Acad Sci U S A (1994) 6.96
Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin. Nature (1989) 5.86
Plaque assay of neonatal calf diarrhea virus and the neutralizing antibody in human sera. J Clin Microbiol (1977) 5.01
A standard reference frame for the description of nucleic acid base-pair geometry. J Mol Biol (2001) 4.29
Clinically mild encephalitis/encephalopathy with a reversible splenial lesion. Neurology (2004) 4.24
The PILATUS 1M detector. J Synchrotron Radiat (2006) 4.16
A candidate for a new serotype of human rotavirus. J Virol (1985) 4.09
Cross-contamination potential with dental equipment. Lancet (1992) 3.55
Clinical characteristics of clear cell carcinoma of the ovary: a distinct histologic type with poor prognosis and resistance to platinum-based chemotherapy. Cancer (2000) 3.46
A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature (1999) 3.40
A new form of amyloid protein associated with chronic hemodialysis was identified as beta 2-microglobulin. Biochem Biophys Res Commun (1985) 3.40
Bacterial genomic reorganization upon DNA replication. Science (2001) 3.25
Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase. Nat Genet (1999) 3.17
Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Oncogene (2007) 3.11
A novel transgenic technique that allows specific marking of the neural crest cell lineage in mice. Dev Biol (1999) 3.11
Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF). Biochem Biophys Res Commun (1989) 3.09
Development of an MRI-compatible needle insertion manipulator for stereotactic neurosurgery. J Image Guid Surg (1995) 3.07
Visualization of neurogenesis in the central nervous system using nestin promoter-GFP transgenic mice. Neuroreport (2000) 3.04
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet (1999) 2.81
Experimental investigation of geologically produced antineutrinos with KamLAND. Nature (2005) 2.75
Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature (2002) 2.71
Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent protein kinase. J Biol Chem (1985) 2.55
A novel mode of DNA recognition by a beta-sheet revealed by the solution structure of the GCC-box binding domain in complex with DNA. EMBO J (1998) 2.48
Spectrodensitometric determination of trichothecene mycotoxins with 4-(p-nitrobenzyl)pyridine on silica gel thin-layer chromatograms. J Chromatogr (1979) 2.38
Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium. Circ Res (2005) 2.38
Tracheostomy can fatally exacerbate sleep-disordered breathing in multiple system atrophy. Neurology (2007) 2.37
Mutually exclusive expression of odorant receptor transgenes. Nat Neurosci (2000) 2.36
Intraductal papillary mucinous tumors of the pancreas comprise 2 clinical subtypes: differences in clinical characteristics and surgical management. Arch Surg (1999) 2.33
Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism. Hum Mol Genet (1999) 2.32
Physiological role of silent receptors of atrial natriuretic factor. Science (1987) 2.31
Altered cochlear fibrocytes in a mouse model of DFN3 nonsyndromic deafness. Science (1999) 2.25
Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation. Leukemia (2009) 2.24
'SPKK' motifs prefer to bind to DNA at A/T-rich sites. EMBO J (1989) 2.24
Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites. Biochem Biophys Res Commun (1997) 2.22
Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy. Int J Radiat Oncol Biol Phys (1999) 2.19
Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor. Nature (1989) 2.17
Polycystin-L is a calcium-regulated cation channel permeable to calcium ions. Nature (1999) 2.17
Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducers. Proc Natl Acad Sci U S A (2006) 2.15
Telaprevir-based triple therapy for chronic hepatitis C patients with advanced fibrosis: a prospective clinical study. Aliment Pharmacol Ther (2013) 2.13
Genomic organization of the S locus: Identification and characterization of genes in SLG/SRK region of S(9) haplotype of Brassica campestris (syn. rapa). Genetics (1999) 2.12
Catheter ablation in patients with multiple and unstable ventricular tachycardias after myocardial infarction: short ablation lines guided by reentry circuit isthmuses and sinus rhythm mapping. Circulation (2001) 2.12
Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line. J Biol Chem (1997) 2.10
Proline-directed and non-proline-directed phosphorylation of PHF-tau. J Biol Chem (1995) 2.09
Varying grades of epithelial atypia in the pancreatic ducts of humans. Classification based on morphometry and multivariate analysis and correlated with positive reactions of carcinoembryonic antigen. Arch Pathol Lab Med (1994) 2.06
Cloning and characterization of the cDNAs for human and rabbit interleukin-1 precursor. Nucleic Acids Res (1985) 2.06
Changes in antibody avidity after virus infections: detection by an immunosorbent assay in which a mild protein-denaturing agent is employed. J Clin Microbiol (1984) 2.03
LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology (2001) 2.02
Prenatal DNA diagnosis of a single-gene disorder from maternal plasma. Lancet (2000) 2.01
Analysis of platelet abnormalities in uremia with and without Glanzmann's thrombasthenia. Nephron (1994) 2.00
Solitary fibrous tumour: significance of p53 and CD34 immunoreactivity in its malignant transformation. Histopathology (1998) 2.00
Evidence that errors made by DNA polymerase alpha are corrected by DNA polymerase delta. Curr Biol (2006) 1.98
The chromosomal gene structure and two mRNAs for human granulocyte colony-stimulating factor. EMBO J (1986) 1.98
DNA binding of PhoB and its interaction with RNA polymerase. J Mol Biol (1996) 1.97
Relation between use of health check ups starting in middle age and demand for inpatient care by elderly people in Japan. BMJ (1991) 1.96
Complete nucleotide sequence of the gene for human interleukin 1 alpha. Nucleic Acids Res (1986) 1.95
A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization. J Biochem (1995) 1.92
The time of occurrence of liver metastasis in carcinoma of the pancreas. Int J Pancreatol (1995) 1.90
Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain. J Biol Chem (1992) 1.89
Prokaryotic DNA polymerase I: evolution, structure, and "base flipping" mechanism for nucleotide selection. J Mol Biol (2001) 1.88
Isolation of human rotaviruses with a distinct RNA electrophoretic pattern from Indonesia. Microbiol Immunol (1984) 1.87
NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel. Br J Cancer (2005) 1.87
ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun (1991) 1.85
Polypeptides of bovine rotavirus. J Gen Virol (1979) 1.85
Promotion of parallel DNA quadruplexes by a yeast telomere binding protein: a circular dichroism study. Proc Natl Acad Sci U S A (1994) 1.83
Scavenging effects of tea catechins and their derivatives on 1,1-diphenyl-2-picrylhydrazyl radical. Free Radic Biol Med (1996) 1.82
Transposable element in fish. Nature (1996) 1.80
Aneurysms at nonbranching sites in the surpaclinoid portion of the internal carotid artery: internal carotid artery trunk aneurysms. Neurosurgery (2000) 1.80
Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay. Cancer Res (2000) 1.79
Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors. J Biol Chem (1994) 1.78
Pulmonary leiomyosarcoma extending into left atrium or pulmonary trunk: complete resection with cardiopulmonary bypass. J Thorac Cardiovasc Surg (1998) 1.77
Pathological findings at the site of conduction block in multifocal motor neuropathy. Ann Neurol (1993) 1.75
Striking sequence similarity in inter- and intra-specific comparisons of class I SLG alleles from Brassica oleracea and Brassica campestris: implications for the evolution and recognition mechanism. Proc Natl Acad Sci U S A (1997) 1.75
Randomized clinical trial of external stent drainage of the pancreatic duct to reduce postoperative pancreatic fistula after pancreaticojejunostomy. Br J Surg (2012) 1.75
The 5' upstream region of mPer1 gene contains two promoters and is responsible for circadian oscillation. Curr Biol (2000) 1.74
Biochemical characterization of the Wilson disease protein and functional expression in the yeast Saccharomyces cerevisiae. J Biol Chem (1997) 1.72
Semisynthetic -lactam antibiotics. 2. Synthesis and properties of D- and L- -sulfobenzylpenicillins. J Med Chem (1972) 1.70
An optical spectrum of the afterglow of a gamma-ray burst at a redshift of z = 6.295. Nature (2006) 1.70
Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res (2000) 1.70
Why do phospholipid polymers reduce protein adsorption? J Biomed Mater Res (1998) 1.70
Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination. Cell (1998) 1.69
Increased expression of S100A4, a metastasis-associated gene, in human colorectal adenocarcinomas. Clin Cancer Res (1997) 1.68
Clear cell carcinoma of the ovary: a retrospective multicentre experience of 254 patients with complete surgical staging. Br J Cancer (2006) 1.67
Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium. Proc Natl Acad Sci U S A (2000) 1.67
Hypoxic brain damage: cortical laminar necrosis and delayed changes in white matter at sequential MR imaging. Radiology (1993) 1.65
Development of the polymer micelle carrier system for doxorubicin. J Control Release (2001) 1.64
Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels. Biochem Biophys Res Commun (2000) 1.64