Published in J Biol Chem on March 02, 2004
Roles for the type III TGF-beta receptor in human cancer. Cell Signal (2010) 1.50
Alternative splicing of TGF-betas and their high-affinity receptors T beta RI, T beta RII and T beta RIII (betaglycan) reveal new variants in human prostatic cells. BMC Genomics (2007) 0.96
TGFβRIIb mutations trigger aortic aneurysm pathogenesis by altering transforming growth factor β2 signal transduction. Circ Cardiovasc Genet (2012) 0.86
The type III TGF-β receptor betaglycan transmembrane-cytoplasmic domain fragment is stable after ectodomain cleavage and is a substrate of the intramembrane protease γ-secretase. Biochim Biophys Acta (2010) 0.81
Abnormal expression of TGF-beta type II receptor isoforms contributes to acute myeloid leukemia. Oncotarget (2016) 0.75
Development and characterization of human monoclonal antibodies that neutralize multiple TGFβ isoforms. MAbs (2015) 0.75
Multiple soluble TGF-β receptors in addition to soluble endoglin are elevated in preeclamptic serum and they synergistically inhibit TGF-β signalling. J Clin Endocrinol Metab (2017) 0.75
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet (2006) 8.32
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol (2007) 8.08
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet (2009) 4.84
Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med (2013) 4.14
Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest (2007) 4.09
Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nat Med (2013) 2.48
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. J Biol Chem (2005) 2.07
A comparison of muscle thin filament models obtained from electron microscopy reconstructions and low-angle X-ray fibre diagrams from non-overlap muscle. J Struct Biol (2006) 2.02
Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice. Hepatology (2011) 2.02
Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood (2008) 2.01
Mechanisms of anemia in CKD. J Am Soc Nephrol (2012) 1.91
DRAGON, a bone morphogenetic protein co-receptor. J Biol Chem (2005) 1.89
Divergent roles of Smad3 and PI3-kinase in murine adriamycin nephropathy indicate distinct mechanisms of proteinuria and fibrogenesis. Kidney Int (2012) 1.66
DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties. J Neurosci (2004) 1.64
The biology of activin: recent advances in structure, regulation and function. J Endocrinol (2009) 1.64
Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats. Blood (2011) 1.63
FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults. Proc Natl Acad Sci U S A (2007) 1.55
Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation. Am J Hematol (2012) 1.52
Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis. Gastroenterology (2009) 1.51
Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. J Clin Invest (2009) 1.48
Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J Biol Chem (2007) 1.45
Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD. Am J Kidney Dis (2010) 1.43
BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. Genes Dev (2004) 1.40
Statement of concern about a commercial assay used to measure soluble hemojuvelin in humans. Am J Nephrol (2012) 1.31
The liver: conductor of systemic iron balance. Blood (2013) 1.30
BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice. Gastroenterology (2010) 1.22
The RGM/DRAGON family of BMP co-receptors. Cytokine Growth Factor Rev (2009) 1.21
Regulation of TMPRSS6 by BMP6 and iron in human cells and mice. Blood (2011) 1.19
Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment. Biol Cell (2006) 1.14
Evidence for a role of transforming growth factor (TGF)-beta1 in the induction of postglomerular albuminuria in diabetic nephropathy: amelioration by soluble TGF-beta type II receptor. Diabetes (2007) 1.11
Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages. J Immunol (2010) 1.08
Emerging roles for the TGFbeta family in pancreatic beta-cell homeostasis. Trends Endocrinol Metab (2010) 1.05
The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease. Inflamm Bowel Dis (2011) 1.05
The molecular pathogenesis of hereditary hemochromatosis. Semin Liver Dis (2011) 1.03
Direct concentration and viability measurement of yeast in corn mash using a novel imaging cytometry method. J Ind Microbiol Biotechnol (2010) 1.03
Novel image cytometric method for detection of physiological and metabolic changes in Saccharomyces cerevisiae. J Ind Microbiol Biotechnol (2012) 1.01
The role of follistatin domains in follistatin biological action. Mol Endocrinol (2003) 1.01
Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway. Am J Physiol Cell Physiol (2005) 1.01
Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity. Circulation (2014) 0.99
Functional role of the NPxxY motif in internalization of the type 2 vasopressin receptor in LLC-PK1 cells. Am J Physiol Cell Physiol (2003) 0.99
Follicular arrest in polycystic ovary syndrome is associated with deficient inhibin A and B biosynthesis. J Clin Endocrinol Metab (2005) 0.99
Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells. J Am Soc Nephrol (2010) 0.98
Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe. Gastroenterology (2011) 0.98
Reconstitution and analysis of soluble inhibin and activin receptor complexes in a cell-free system. J Biol Chem (2004) 0.95
Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-beta-induced nuclear accumulation. Am J Physiol Cell Physiol (2003) 0.95
Follistatin-related protein and follistatin differentially neutralize endogenous vs. exogenous activin. Endocrinology (2002) 0.95
The iron cycle in chronic kidney disease (CKD): from genetics and experimental models to CKD patients. Nephrol Dial Transplant (2013) 0.93
Altered hepatic BMP signaling pathway in human HFE hemochromatosis. Blood Cells Mol Dis (2010) 0.93
Localization and action of Dragon (repulsive guidance molecule b), a novel bone morphogenetic protein coreceptor, throughout the reproductive axis. Endocrinology (2005) 0.93
Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent. PLoS One (2012) 0.91
Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS One (2012) 0.91
The BMP coreceptor RGMb promotes while the endogenous BMP antagonist noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling. J Neurosci (2011) 0.90
BMP antagonists enhance myogenic differentiation and ameliorate the dystrophic phenotype in a DMD mouse model. Neurobiol Dis (2010) 0.89
Leptin and soluble leptin receptor in follicular fluid. J Assist Reprod Genet (2003) 0.89
A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats. Nephrol Dial Transplant (2013) 0.88
A novel validated enzyme-linked immunosorbent assay to quantify soluble hemojuvelin in mouse serum. Haematologica (2012) 0.88
Heparin and activin-binding determinants in follistatin and FSTL3. Endocrinology (2004) 0.88
Effects of the renal medullary pH and ionic environment on vasopressin binding and signaling. Kidney Int (2008) 0.88
Automated quantification of budding Saccharomyces cerevisiae using a novel image cytometry method. J Ind Microbiol Biotechnol (2013) 0.87
A novel method for kinetic measurements of rare cell proliferation using Cellometer image-based cytometry. J Immunol Methods (2012) 0.87
Differential actions of follistatin and follistatin-like 3. Mol Cell Endocrinol (2004) 0.87
Differential synthesis and action of TGFß superfamily ligands in mouse and rat islets. Islets (2011) 0.87
Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R. Am J Physiol Renal Physiol (2007) 0.86
Follistatin regulates germ cell nest breakdown and primordial follicle formation. Endocrinology (2010) 0.85
Ovarian brain-derived neurotrophic factor is present in follicular fluid from normally cycling women. Fertil Steril (2003) 0.85
Regulation of endometrial adenocarcinoma cell proliferation by Activin-A and its modulation by 17beta-estradiol. Mol Cell Endocrinol (2002) 0.82
Exogenous BMP7 corrects plasma iron overload and bone loss in Bmp6-/- mice. Int Orthop (2014) 0.81
Dragon (repulsive guidance molecule RGMb) inhibits E-cadherin expression and induces apoptosis in renal tubular epithelial cells. J Biol Chem (2013) 0.80
BMP signaling modulates hepcidin expression in zebrafish embryos independent of hemojuvelin. PLoS One (2011) 0.79
The soluble transforming growth factor-beta receptor: advantages and applications. Int J Biochem Cell Biol (2008) 0.79
Hepcidin regulation in the anemia of inflammation. Curr Opin Hematol (2016) 0.79
Increased activin bioavailability enhances hepatic insulin sensitivity while inducing hepatic steatosis in male mice. Endocrinology (2013) 0.78
Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor β (TGFβ) signaling is essential for testicular aging and regulating testis size. Endocrinology (2013) 0.78