Published in J Biol Chem on January 25, 2005
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet (2009) 4.84
Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest (2007) 4.09
Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood (2008) 2.01
Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formation. Dev Cell (2010) 1.97
The extracellular regulation of bone morphogenetic protein signaling. Development (2009) 1.69
Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis. Blood (2010) 1.63
Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site. Blood Cells Mol Dis (2007) 1.40
Trophoblast differentiation defect in human embryonic stem cells lacking PIG-A and GPI-anchored cell-surface proteins. Cell Stem Cell (2008) 1.32
BMP signaling in vascular development and disease. Cytokine Growth Factor Rev (2010) 1.26
Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression. J Biol Chem (2009) 1.24
The RGM/DRAGON family of BMP co-receptors. Cytokine Growth Factor Rev (2009) 1.21
Repulsive guidance molecule-A (RGM-A) inhibits leukocyte migration and mitigates inflammation. Proc Natl Acad Sci U S A (2011) 1.15
TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation. Bone Res (2015) 1.12
RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. J Exp Med (2014) 1.09
Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages. J Immunol (2010) 1.08
Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane. J Biol Chem (2008) 1.06
Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo. Blood (2014) 1.03
Role of RGM coreceptors in bone morphogenetic protein signaling. J Mol Signal (2007) 1.01
Molecular biology, genetics and biochemistry of the repulsive guidance molecule family. Biochem J (2009) 1.00
Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis. Front Pharmacol (2014) 1.00
Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells. J Am Soc Nephrol (2010) 0.98
MicroRNA gene expression signatures in the developing neural tube. Birth Defects Res A Clin Mol Teratol (2011) 0.98
Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation. Circ Res (2016) 0.98
Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression. J Biol Chem (2010) 0.96
Bone morphogenetic protein-2/4 signalling pathway components are expressed in the human thymus and inhibit early T-cell development. Immunology (2007) 0.95
Digital gene expression tag profiling of bat digits provides robust candidates contributing to wing formation. BMC Genomics (2010) 0.93
Localization and action of Dragon (repulsive guidance molecule b), a novel bone morphogenetic protein coreceptor, throughout the reproductive axis. Endocrinology (2005) 0.93
The role of repulsive guidance molecules in the embryonic and adult vertebrate central nervous system. Philos Trans R Soc Lond B Biol Sci (2006) 0.92
Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS One (2012) 0.91
The genetic regulation of the terminating phase of liver regeneration. Comp Hepatol (2012) 0.91
Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein. Nat Struct Mol Biol (2015) 0.90
The BMP coreceptor RGMb promotes while the endogenous BMP antagonist noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling. J Neurosci (2011) 0.90
Variants in several genomic regions associated with asperger disorder. Autism Res (2010) 0.89
Bone Morphogenetic Protein functions as a context-dependent angiogenic cue in vertebrates. Semin Cell Dev Biol (2011) 0.88
Molecular evolution of hemojuvelin and the repulsive guidance molecule family. J Mol Evol (2007) 0.88
The RGM protein DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis elegans. Development (2010) 0.87
Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis. Dev Biol (2011) 0.87
SMAD versus non-SMAD signaling is determined by lateral mobility of bone morphogenetic protein (BMP) receptors. J Biol Chem (2012) 0.87
Overexpression of repulsive guidance molecule (RGM) a induces cell death through Neogenin in early vertebrate development. J Mol Histol (2007) 0.86
Stimulating neuroregeneration as a therapeutic drug approach for traumatic brain injury. Br J Pharmacol (2009) 0.84
Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signaling. Mol Reprod Dev (2013) 0.82
Novel roles of the chemorepellent axon guidance molecule RGMa in cell migration and adhesion. Mol Cell Biol (2012) 0.82
Proteomic analysis and molecular modelling characterize the iron-regulatory protein haemojuvelin/repulsive guidance molecule c. Biochem J (2013) 0.81
GDF-5 can act as a context-dependent BMP-2 antagonist. BMC Biol (2015) 0.81
BMP signaling in axon regeneration. Curr Opin Neurobiol (2014) 0.80
Dragon (repulsive guidance molecule RGMb) inhibits E-cadherin expression and induces apoptosis in renal tubular epithelial cells. J Biol Chem (2013) 0.80
Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy. Cell Mol Life Sci (2012) 0.80
Generation of glycosylphosphatidylinositol anchor protein-deficient blood cells from human induced pluripotent stem cells. Stem Cells Transl Med (2013) 0.79
The neogenin/DCC homolog UNC-40 promotes BMP signaling via the RGM protein DRAG-1 in C. elegans. Development (2013) 0.79
Signaling in cell differentiation and morphogenesis. Cold Spring Harb Perspect Biol (2012) 0.78
Dragon (RGMb) induces oxaliplatin resistance in colon cancer cells. Oncotarget (2016) 0.78
Spatiotemporal expression of repulsive guidance molecules (RGMs) and their receptor neogenin in the mouse brain. PLoS One (2013) 0.78
RGM co-receptors add complexity to BMP signaling. Nat Struct Mol Biol (2015) 0.77
Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-α, and IL-1β. Am J Physiol Endocrinol Metab (2014) 0.77
Study on expression of lncRNA RGMB-AS1 and repulsive guidance molecule b in non-small cell lung cancer. Diagn Pathol (2015) 0.76
Repulsive guidance molecule B inhibits metastasis and is associated with decreased mortality in non-small cell lung cancer. Oncotarget (2016) 0.76
Antagonism of activin by activin chimeras. Vitam Horm (2011) 0.75
RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling. Trends Cell Biol (2016) 0.75
Dragon (repulsive guidance molecule b, RGMb) is a novel gene that promotes colorectal cancer growth. Oncotarget (2015) 0.75
A transmembrane protein EIG121L is required for epidermal differentiation during early embryonic development. J Biol Chem (2010) 0.75
Crystallization and preliminary X-ray analysis of the complex of the first von Willebrand type C domain bound to bone morphogenetic protein 2. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.75
Bone Morphogenetic Protein 4 Signalling in Neural Stem and Progenitor Cells during Development and after Injury. Stem Cells Int (2016) 0.75
Regulators and effectors of bone morphogenetic protein signalling in the cardiovascular system. J Physiol (2015) 0.75
Therapeutic Potential for Bone Morphogenetic Protein 4 in Human Malignant Glioma. Neoplasia (2017) 0.75
MuSK is a BMP co-receptor that shapes BMP responses and calcium signaling in muscle cells. Sci Signal (2016) 0.75
Biochemical and Cellular Analysis Reveals Ligand Binding Specificities, a Molecular Basis for Ligand Recognition, and Membrane Association-dependent Activities of Cripto-1 and Cryptic. J Biol Chem (2017) 0.75
BST2 Mediates Osteoblast Differentiation via the BMP2 Signaling Pathway in Human Alveolar-Derived Bone Marrow Stromal Cells. PLoS One (2016) 0.75
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature (2010) 16.12
HMDB: the Human Metabolome Database. Nucleic Acids Res (2007) 13.38
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med (2003) 12.94
WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell (2005) 8.86
In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science (2002) 8.80
TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron (2006) 8.57
Persistent postsurgical pain: risk factors and prevention. Lancet (2006) 8.46
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet (2006) 8.32
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol (2007) 8.08
The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nat Med (2007) 7.59
Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain (2009) 7.11
Effects of body size and hypertension treatments on cardiovascular event rates: subanalysis of the ACCOMPLISH randomised controlled trial. Lancet (2012) 6.69
Enhanced nitrogen deposition over China. Nature (2013) 5.49
The neuropathic pain triad: neurons, immune cells and glia. Nat Neurosci (2007) 5.38
Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci (2009) 5.00
A functionally characterized test set of human induced pluripotent stem cells. Nat Biotechnol (2011) 4.95
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet (2009) 4.84
Central sensitization and LTP: do pain and memory share similar mechanisms? Trends Neurosci (2003) 4.69
Neisseria gonorrhoeae treatment failure and susceptibility to cefixime in Toronto, Canada. JAMA (2013) 4.69
Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell (2011) 4.65
The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell (2010) 4.49
p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron (2002) 4.27
Developmental fluoride neurotoxicity: a systematic review and meta-analysis. Environ Health Perspect (2012) 4.15
Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med (2013) 4.14
Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis. Science (2011) 4.13
Visualization of membrane protein domains by cryo-electron microscopy of dengue virus. Nat Struct Biol (2003) 4.11
Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest (2007) 4.09
Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc Natl Acad Sci U S A (2007) 4.05
Nitrogen deposition and its ecological impact in China: an overview. Environ Pollut (2010) 4.03
Molecular signature of human embryonic stem cells and its comparison with the mouse. Dev Biol (2003) 3.95
Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada. PLoS Med (2010) 3.85
Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function. Cancer Res (2006) 3.83
One-year health care costs associated with delirium in the elderly population. Arch Intern Med (2008) 3.82
p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J Neurosci (2003) 3.72
MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res (2009) 3.57
Neural induction, the default model and embryonic stem cells. Nat Rev Neurosci (2002) 3.53
Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell (2009) 3.50
The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. J Clin Invest (2006) 3.49
V1 spinal neurons regulate the speed of vertebrate locomotor outputs. Nature (2006) 3.45
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med (2006) 3.38
Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma. Hepatology (2010) 3.37
Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord. J Neurosci (2002) 3.32
Vaccine potential of the Neisseria meningitidis 2086 lipoprotein. Infect Immun (2004) 3.29
The flavivirus precursor membrane-envelope protein complex: structure and maturation. Science (2008) 3.26
Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Nature (2007) 3.23
Balancing BMP signaling through integrated inputs into the Smad1 linker. Mol Cell (2007) 3.23
Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci (2002) 3.21
Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells. Nature (2012) 3.09
The miR-430/427/302 family controls mesendodermal fate specification via species-specific target selection. Dev Cell (2009) 3.01
Transient receptor potential channels: targeting pain at the source. Nat Rev Drug Discov (2009) 2.88
The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell (2012) 2.84
Crystal structure of a Rad51 filament. Nat Struct Mol Biol (2004) 2.83
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci (2007) 2.78
Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice. J Clin Invest (2008) 2.69
Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron (2010) 2.69
Mycobacterial catalase-peroxidase is a tissue antigen and target of the adaptive immune response in systemic sarcoidosis. J Exp Med (2005) 2.69
Proposed diagnostic criteria for internet addiction. Addiction (2010) 2.68
Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression. Genome Res (2009) 2.64
A chart-based method for identification of delirium: validation compared with interviewer ratings using the confusion assessment method. J Am Geriatr Soc (2005) 2.63
Recombinant vascular endothelial growth factor 121 attenuates hypertension and improves kidney damage in a rat model of preeclampsia. Hypertension (2007) 2.62
Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host. PLoS Pathog (2009) 2.62
Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron (2006) 2.60
ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. J Neurosci (2002) 2.60
Person-to-person transmission of severe fever with thrombocytopenia syndrome bunyavirus through blood contact. Clin Infect Dis (2011) 2.59
Activity-independent homeostasis in rhythmically active neurons. Neuron (2003) 2.57
Bacteria activate sensory neurons that modulate pain and inflammation. Nature (2013) 2.56
Can we conquer pain? Nat Neurosci (2002) 2.56
Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines. Cardiovasc Res (2009) 2.54
Surgical field fire during a repair of bronchoesophageal fistula. Anesth Analg (2005) 2.54
Delirium in the intensive care unit: occurrence and clinical course in older patients. J Am Geriatr Soc (2003) 2.53
Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). Genes Dev (2010) 2.53
Clinical progress and risk factors for death in severe fever with thrombocytopenia syndrome patients. J Infect Dis (2012) 2.49
Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nat Med (2013) 2.48
CutDB: a proteolytic event database. Nucleic Acids Res (2006) 2.41
Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain (2010) 2.41
ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regeneration. J Neurosci (2007) 2.40
Epigenetic regulation of SOX9 by the NF-κB signaling pathway in pancreatic cancer stem cells. Stem Cells (2013) 2.40
Chromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange. Nat Struct Mol Biol (2012) 2.37
A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell (2010) 2.37
Survival prediction of gastric cancer by a seven-microRNA signature. Gut (2009) 2.37
Nociceptors are interleukin-1beta sensors. J Neurosci (2008) 2.26
Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat Med (2012) 2.25
FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. EMBO J (2004) 2.24
SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood (2008) 2.19
BACE1 regulates voltage-gated sodium channels and neuronal activity. Nat Cell Biol (2007) 2.18
Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury. J Neurosci (2005) 2.16
Flexible DNA bending in HU-DNA cocrystal structures. EMBO J (2003) 2.15
Retracted MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts. J Biol Chem (2007) 2.14
A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell (2013) 2.14
Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells. Mol Cell Biol (2007) 2.14
Quality of Australian clinical guidelines and relevance to the care of older people with multiple comorbid conditions. Med J Aust (2008) 2.11
Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron (2012) 2.11
Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression. Genome Res (2012) 2.10