Published in Biochem J on June 15, 2004
The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev (2006) 6.80
Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. Chem Rev (2008) 3.51
Chemical probes of endocannabinoid metabolism. Pharmacol Rev (2013) 1.68
Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain. J Biol Chem (2008) 1.60
Multiple functions of endocannabinoid signaling in the brain. Annu Rev Neurosci (2012) 1.60
Multiple pathways involved in the biosynthesis of anandamide. Neuropharmacology (2007) 1.59
Lipidomic analysis of endocannabinoid metabolism in biological samples. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 1.23
Why do cannabinoid receptors have more than one endogenous ligand? Philos Trans R Soc Lond B Biol Sci (2012) 1.17
Identification of N-acylphosphatidylserine molecules in eukaryotic cells. Biochemistry (2007) 1.17
Role and regulation of acylethanolamides in energy balance: focus on adipocytes and beta-cells. Br J Pharmacol (2007) 1.15
Peroxisome proliferator-activated receptor α mediates acute effects of palmitoylethanolamide on sensory neurons. J Neurosci (2012) 1.10
Endocannabinoids in the retina: from marijuana to neuroprotection. Prog Retin Eye Res (2008) 1.08
Oxidation of the endogenous cannabinoid arachidonoyl ethanolamide by the cytochrome P450 monooxygenases: physiological and pharmacological implications. Pharmacol Rev (2010) 1.05
Compartmentalization of endocannabinoids into lipid rafts in a dorsal root ganglion cell line. Br J Pharmacol (2007) 1.04
Critical enzymes involved in endocannabinoid metabolism. Protein Pept Lett (2007) 1.04
Endogenous cannabinoid signaling is required for voluntary exercise-induced enhancement of progenitor cell proliferation in the hippocampus. Hippocampus (2010) 1.03
A review of the interactions between alcohol and the endocannabinoid system: implications for alcohol dependence and future directions for research. Alcohol (2012) 1.02
Glucocorticoids shift arachidonic acid metabolism toward endocannabinoid synthesis: a non-genomic anti-inflammatory switch. Eur J Pharmacol (2008) 0.93
Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. Cell Mol Neurobiol (2006) 0.93
Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives. Recent Pat CNS Drug Discov (2012) 0.91
Neuropharmacology of the endocannabinoid signaling system-molecular mechanisms, biological actions and synaptic plasticity. Curr Neuropharmacol (2007) 0.90
Discovering novel brain lipids by liquid chromatography/tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 0.86
Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family. J Biol Chem (2012) 0.86
Endocannabinoid signalling in innate and adaptive immunity. Immunology (2015) 0.83
Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown. Neuropharmacology (2008) 0.83
Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain. Biochim Biophys Acta (2016) 0.82
ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system. Biochemistry (2015) 0.82
Regulation of endocannabinoid release by G proteins: a paracrine mechanism of G protein-coupled receptor action. Mol Cell Endocrinol (2011) 0.82
Roles for the endocannabinoid system in ethanol-motivated behavior. Prog Neuropsychopharmacol Biol Psychiatry (2015) 0.81
Cannabinoid receptor 1 signaling in embryo neurodevelopment. Birth Defects Res B Dev Reprod Toxicol (2012) 0.80
Capsaicin-sensitive primary sensory neurons in the mouse express N-Acyl phosphatidylethanolamine phospholipase D. Neuroscience (2009) 0.79
A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines. Nat Chem Biol (2016) 0.78
Anandamide produced by Ca(2+)-insensitive enzymes induces excitation in primary sensory neurons. Pflugers Arch (2013) 0.77
Site-specific and time-dependent activation of the endocannabinoid system after transection of long-range projections. PLoS One (2012) 0.77
Miscibility and phase behavior of N-acylethanolamine/diacylphosphatidylethanolamine binary mixtures of matched acyl chainlengths (N=14, 16). Biophys J (2007) 0.77
Endogenous molecules stimulating N-acylethanolamine-hydrolyzing acid amidase (NAAA). ACS Chem Neurosci (2012) 0.76
Alterations in the anandamide metabolism in the development of neuropathic pain. Biomed Res Int (2014) 0.76
No effect of an oleoylethanolamide-related phospholipid on satiety and energy intake: a randomised controlled trial of phosphatidylethanolamine. Lipids Health Dis (2008) 0.76
Anandamide levels fluctuate in the bovine oviduct during the oestrous cycle. PLoS One (2013) 0.76
Characterization of N-acyl phosphatidylethanolamine-specific phospholipase-D isoforms in the nematode Caenorhabditis elegans. PLoS One (2014) 0.75
Lipidomic Analysis of Endocannabinoid Signaling: Targeted Metabolite Identification and Quantification. Neural Plast (2015) 0.75
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science (1992) 16.31
The emerging role of lysophosphatidic acid in cancer. Nat Rev Cancer (2003) 6.70
Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature (1994) 5.70
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J Cell Biol (2002) 5.52
Control of pain initiation by endogenous cannabinoids. Nature (1998) 4.73
The expanding superfamily of phospholipase A(2) enzymes: classification and characterization. Biochim Biophys Acta (2000) 4.62
Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature (2003) 4.60
Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. J Biol Chem (2002) 3.53
An anorexic lipid mediator regulated by feeding. Nature (2001) 2.94
Phospholipase A2 enzymes. Prostaglandins Other Lipid Mediat (2002) 2.92
Molecular characterization of a phospholipase D generating anandamide and its congeners. J Biol Chem (2003) 2.75
Dog and rat pancreatic phospholipases A2: complete amino acid sequences deduced from complementary DNAs. J Biochem (1986) 2.36
The palmitoylethanolamide family: a new class of anti-inflammatory agents? Curr Med Chem (2002) 1.92
Phospholipase A2. J Biochem (2002) 1.82
N-acylated glycerophospholipids and their derivatives. Prog Lipid Res (1990) 1.77
Fas-induced arachidonic acid release is mediated by Ca2+-independent phospholipase A2 but not cytosolic phospholipase A2, which undergoes proteolytic inactivation. J Biol Chem (1998) 1.57
Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance. Prostaglandins Leukot Essent Fatty Acids (2002) 1.48
Anandamide receptors. Prostaglandins Leukot Essent Fatty Acids (2002) 1.46
Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide. Eur J Pharmacol (2001) 1.45
'Endocannabinoids' and other fatty acid derivatives with cannabimimetic properties: biochemistry and possible physiopathological relevance. Biochim Biophys Acta (1998) 1.43
Functional coupling between various phospholipase A2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways. J Biol Chem (1999) 1.36
Occurrence and postmortem generation of anandamide and other long-chain N-acylethanolamines in mammalian brain. FEBS Lett (1995) 1.31
Transacylase-mediated and phosphodiesterase-mediated synthesis of N-arachidonoylethanolamine, an endogenous cannabinoid-receptor ligand, in rat brain microsomes. Comparison with synthesis from free arachidonic acid and ethanolamine. Eur J Biochem (1996) 1.30
Pathways and mechanisms of N-acylethanolamine biosynthesis: can anandamide be generated selectively? Chem Phys Lipids (2000) 1.28
N-Acylethanolamine accumulation in infarcted myocardium. Biochem Biophys Res Commun (1979) 1.27
Autotaxin, tumor motility-stimulating exophosphodiesterase. Adv Enzyme Regul (1997) 1.20
Metabolism of N-acylethanolamine phospholipids by a mammalian phosphodiesterase of the phospholipase D type. J Biol Chem (1983) 1.20
N-Acylethanolamines and precursor phospholipids - relation to cell injury. Chem Phys Lipids (2000) 1.15
Catabolism of N-acylethanolamine phospholipids by dog brain preparations. J Neurochem (1984) 1.05
Endocannabinoids and fatty acid amides in cancer, inflammation and related disorders. Chem Phys Lipids (2000) 1.04
Accumulation of various N-acylethanolamines including N-arachidonoylethanolamine (anandamide) in cadmium chloride-administered rat testis. Arch Biochem Biophys (1998) 0.99
Binding, degradation and apoptotic activity of stearoylethanolamide in rat C6 glioma cells. Biochem J (2002) 0.99
Glutamate stimulates the formation of N-acylphosphatidylethanolamine and N-acylethanolamine in cortical neurons in culture. Biochim Biophys Acta (1995) 0.99
Type II secretory phospholipase A2 associated with cell surfaces via C-terminal heparin-binding lysine residues augments stimulus-initiated delayed prostaglandin generation. J Biol Chem (1996) 0.99
Cannabinoid receptor-inactive N-acylethanolamines and other fatty acid amides: metabolism and function. Prostaglandins Leukot Essent Fatty Acids (2002) 0.99
Marked activation of the N-acylphosphatidylethanolamine-hydrolyzing phosphodiesterase by divalent cations. Biochim Biophys Acta (2001) 0.93
Identification of a cellular protein that functionally interacts with the C2 domain of cytosolic phospholipase A(2)alpha. J Biol Chem (2000) 0.92
Cloning and characterization of novel mouse and human secretory phospholipase A(2)s. J Biol Chem (1999) 0.91
N-acylphosphatidylethanolamine-hydrolysing phospholipase D lacks the ability to transphosphatidylate. FEBS Lett (1999) 0.87
A rapid phospholipase D assay using zirconium precipitation of anionic substrate phospholipids: application to n-acylethanolamine formation in vitro. J Lipid Res (2000) 0.85
Presence of pancreatic-type phospholipase A2 mRNA in rat gastric mucosa and lung. Biochim Biophys Acta (1989) 0.84
Activation of N-acylethanolamine-releasing phospholipase D by polyamines. Chem Phys Lipids (2002) 0.81
Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab (2006) 3.34
The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J Clin Invest (2002) 3.21
The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell (2013) 3.19
Phospholipase A2 enzymes. Prostaglandins Other Lipid Mediat (2002) 2.92
Molecular characterization of a phospholipase D generating anandamide and its congeners. J Biol Chem (2003) 2.75
Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase. J Biol Chem (2005) 1.83
Phospholipase A2. J Biochem (2002) 1.82
Kinetic scaffolding mediated by a phospholipase C-beta and Gq signaling complex. Science (2010) 1.78
Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae. Nature (2005) 1.76
Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol Cell Biol (2003) 1.75
Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. J Biol Chem (2002) 1.74
Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. J Biol Chem (2003) 1.69
Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1. J Biol Chem (2004) 1.65
Prostaglandin E synthase. Prostaglandins Other Lipid Mediat (2002) 1.65
Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway. Prog Lipid Res (2004) 1.60
Prostaglandin E synthase: a novel drug target for inflammation and cancer. Curr Pharm Des (2006) 1.54
Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis. J Biol Chem (2003) 1.47
Enzymological studies on the biosynthesis of N-acylethanolamines. Biochim Biophys Acta (2010) 1.38
Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria. J Exp Med (2009) 1.36
Yeast sphingolipids: metabolism and biology. Biochim Biophys Acta (2002) 1.31
The N-acylethanolamine-hydrolyzing acid amidase (NAAA). Chem Biodivers (2007) 1.31
RalA functions as an indispensable signal mediator for the nutrient-sensing system. J Biol Chem (2008) 1.28
Discovery and characterization of a Ca2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners. J Biol Chem (2006) 1.26
The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation. Hepatology (2009) 1.26
Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction. J Biol Chem (2006) 1.25
S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species. Cardiovasc Res (2009) 1.25
Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function. Nat Med (2012) 1.23
Coupling between cyclooxygenases and terminal prostanoid synthases. Biochem Biophys Res Commun (2005) 1.22
Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis. J Biochem Mol Biol (2005) 1.21
Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation. Mol Biol Cell (2006) 1.21
Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis. J Biol Chem (2008) 1.19
Activation and localization of inositol phosphosphingolipid phospholipase C, Isc1p, to the mitochondria during growth of Saccharomyces cerevisiae. J Biol Chem (2003) 1.19
Biosynthetic pathways of the endocannabinoid anandamide. Chem Biodivers (2007) 1.18
N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA). Prog Lipid Res (2010) 1.17
Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system. Biochim Biophys Acta (2008) 1.16
Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action. Diabetes (2010) 1.14
Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models. Biochimie (2010) 1.14
Biology of endocannabinoid synthesis system. Prostaglandins Other Lipid Mediat (2008) 1.14
Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae. Biochem J (2006) 1.13
Involvement of N-acylethanolamine-hydrolyzing acid amidase in the degradation of anandamide and other N-acylethanolamines in macrophages. Biochim Biophys Acta (2005) 1.12
Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-beta-lactamase family. J Biol Chem (2006) 1.12
The tumor suppressor gene H-Rev107 functions as a novel Ca2+-independent cytosolic phospholipase A1/2 of the thiol hydrolase type. J Lipid Res (2008) 1.10
Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. Biochim Biophys Acta (2009) 1.09
Apparent diffusion coefficient in pancreatic cancer: characterization and histopathological correlations. J Magn Reson Imaging (2008) 1.08
Transcriptional regulation of the membrane-associated prostaglandin E2 synthase gene. Essential role of the transcription factor Egr-1. J Biol Chem (2002) 1.08
Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators. J Exp Med (2013) 1.08
Diverse cellular localizations of secretory phospholipase A2 enzymes in several human tissues. Biochim Biophys Acta (2005) 1.08
Expression of secretory phospholipase A2s in human atherosclerosis development. Atherosclerosis (2007) 1.07
LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells. Cardiovasc Res (2009) 1.07
Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. Nat Immunol (2013) 1.06
Mammalian cells stably overexpressing N-acylphosphatidylethanolamine-hydrolysing phospholipase D exhibit significantly decreased levels of N-acylphosphatidylethanolamines. Biochem J (2005) 1.06
Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice. J Clin Invest (2010) 1.06
N-cyclohexanecarbonylpentadecylamine: a selective inhibitor of the acid amidase hydrolysing N-acylethanolamines, as a tool to distinguish acid amidase from fatty acid amide hydrolase. Biochem J (2004) 1.05
Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A(2). J Biol Chem (2005) 1.05
Metabolism of endocannabinoids and related N-acylethanolamines: canonical and alternative pathways. FEBS J (2013) 1.05
Retracted Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice. J Clin Invest (2010) 1.05
Secretory phospholipase A2. Biol Pharm Bull (2004) 1.05
Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII). J Biol Chem (2003) 1.04
S1P(2), the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice. Cancer Res (2010) 1.03
The phosphatidylglycerol/cardiolipin biosynthetic pathway is required for the activation of inositol phosphosphingolipid phospholipase C, Isc1p, during growth of Saccharomyces cerevisiae. J Biol Chem (2004) 1.03
Rat islet culture in serum-free medium containing silk protein sericin. J Hepatobiliary Pancreat Surg (2009) 1.03
Roles for sphingolipid biosynthesis in mediation of specific programs of the heat stress response determined through gene expression profiling. J Biol Chem (2003) 1.03
Small RNA transcriptomes of two types of exosomes in human whole saliva determined by next generation sequencing. Biol Pharm Bull (2013) 1.03
Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal. Biochem Biophys Res Commun (2007) 1.03
Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation. Biochem Pharmacol (2011) 1.01
Expression of secretory phospholipase A2 enzymes in lungs of humans with pneumonia and their potential prostaglandin-synthetic function in human lung-derived cells. Biochem J (2005) 1.00
Arachidonate release and eicosanoid generation by group IIE phospholipase A(2). Biochem Biophys Res Commun (2002) 1.00
N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation. J Biol Chem (2005) 1.00
Induction of distinct sets of secretory phospholipase A(2) in rodents during inflammation. Biochim Biophys Acta (2003) 1.00
Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind Hyde. Am J Cancer Res (2011) 0.99
Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2. J Biol Chem (2005) 0.99
Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol. Biofactors (2010) 0.98
Expression of messenger RNA for prostaglandin E receptor subtypes EP4/EP2 and cyclooxygenase isozymes in mouse periovulatory follicles and oviducts during superovulation. Biol Reprod (2003) 0.97