Published in Nature on January 27, 2005
Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry. Proc Natl Acad Sci U S A (2009) 4.13
Cellular lipidomics. EMBO J (2005) 3.01
Recent developments in parameter estimation and structure identification of biochemical and genomic systems. Math Biosci (2009) 2.58
Many ceramides. J Biol Chem (2011) 2.31
Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. Chem Rev (2011) 1.93
The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism. BMC Syst Biol (2008) 1.73
A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways. J Biol Chem (2010) 1.56
Flux balance analysis of mycolic acid pathway: targets for anti-tubercular drugs. PLoS Comput Biol (2005) 1.55
Membranes in balance: mechanisms of sphingolipid homeostasis. Mol Cell (2010) 1.52
The intricate side of systems biology. Proc Natl Acad Sci U S A (2006) 1.37
Role of sphingolipids in microbial pathogenesis. Infect Immun (2006) 1.27
Modulation of sphingolipid metabolism by the phosphatidylinositol-4-phosphate phosphatase Sac1p through regulation of phosphatidylinositol in Saccharomyces cerevisiae. J Biol Chem (2009) 1.20
Sphingolipidomics: a valuable tool for understanding the roles of sphingolipids in biology and disease. J Lipid Res (2008) 1.19
Mathematical modeling of pathogenicity of Cryptococcus neoformans. Mol Syst Biol (2008) 1.14
Bioinformatics and systems biology of the lipidome. Chem Rev (2011) 1.14
Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling. Mol Genet Genomics (2010) 1.07
Isc1 regulates sphingolipid metabolism in yeast mitochondria. Biochim Biophys Acta (2007) 1.06
Identifying quantitative operation principles in metabolic pathways: a systematic method for searching feasible enzyme activity patterns leading to cellular adaptive responses. BMC Bioinformatics (2009) 1.03
Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity. J Lipid Res (2009) 1.00
Revealing a signaling role of phytosphingosine-1-phosphate in yeast. Mol Syst Biol (2010) 0.98
Differential regulation of dihydroceramide desaturase by palmitate versus monounsaturated fatty acids: implications for insulin resistance. J Biol Chem (2011) 0.98
Sphingolipidomics: methods for the comprehensive analysis of sphingolipids. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 0.96
Computational systems analysis of dopamine metabolism. PLoS One (2008) 0.96
Interruption of inositol sphingolipid synthesis triggers Stt4p-dependent protein kinase C signaling. J Biol Chem (2010) 0.92
Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism. BMC Syst Biol (2011) 0.91
The yeast sphingolipid signaling landscape. Chem Phys Lipids (2013) 0.90
Pathway switching explains the sharp response characteristic of hypoxia response network. PLoS Comput Biol (2007) 0.90
Use of physiological constraints to identify quantitative design principles for gene expression in yeast adaptation to heat shock. BMC Bioinformatics (2006) 0.90
Cell wall integrity MAPK pathway is essential for lipid homeostasis. J Biol Chem (2008) 0.90
Canonical modeling of the multi-scale regulation of the heat stress response in yeast. Metabolites (2012) 0.88
Coordination of the dynamics of yeast sphingolipid metabolism during the diauxic shift. Theor Biol Med Model (2007) 0.87
A genome-scale metabolic model of the lipid-accumulating yeast Yarrowia lipolytica. BMC Syst Biol (2012) 0.86
Sphingolipid metabolic pathway: an overview of major roles played in human diseases. J Lipids (2013) 0.85
The response to inositol: regulation of glycerolipid metabolism and stress response signaling in yeast. Chem Phys Lipids (2014) 0.85
Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning. Acta Biomater (2014) 0.84
Mathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiae. PLoS One (2011) 0.84
Coordination of rapid sphingolipid responses to heat stress in yeast. PLoS Comput Biol (2013) 0.84
Computational analysis of determinants of dopamine (DA) dysfunction in DA nerve terminals. Synapse (2009) 0.83
Re-configuration of sphingolipid metabolism by oncogenic transformation. Biomolecules (2014) 0.83
Sphingolipids: the nexus between Gaucher disease and insulin resistance. Lipids Health Dis (2010) 0.82
Biological systems modeling and analysis: a biomolecular technique of the twenty-first century. J Biomol Tech (2006) 0.82
Biochemical systems analysis of signaling pathways to understand fungal pathogenicity. Methods Mol Biol (2011) 0.82
Finding pathway-modulating genes from a novel Ontology Fingerprint-derived gene network. Nucleic Acids Res (2014) 0.80
Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice. Hum Mol Genet (2013) 0.79
SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae. Genetics (2006) 0.79
A U-system approach for predicting metabolic behaviors and responses based on an alleged metabolic reaction network. BMC Syst Biol (2014) 0.79
Valproate Induces the Unfolded Protein Response by Increasing Ceramide Levels. J Biol Chem (2016) 0.78
Dynamics of the Heat Stress Response of Ceramides with Different Fatty-Acyl Chain Lengths in Baker's Yeast. PLoS Comput Biol (2015) 0.78
Quantitative analysis of cellular metabolic dissipative, self-organized structures. Int J Mol Sci (2010) 0.78
Computational modeling of sphingolipid metabolism. BMC Syst Biol (2015) 0.78
Dynamics of Positional Enrichment: Theoretical Development and Application to Carbon Labeling in Zymomonas mobilis. Biochem Eng J (2008) 0.77
Loss of hydroxyl groups from the ceramide moiety can modify the lateral diffusion of membrane proteins in S. cerevisiae. J Lipid Res (2014) 0.77
Reverse engineering biomolecular systems using -omic data: challenges, progress and opportunities. Brief Bioinform (2012) 0.77
Analysis of the Involvement of Different Ceramide Variants in the Response to Hydroxyurea Stress in Baker's Yeast. PLoS One (2016) 0.77
Role of Inositol Phosphosphingolipid Phospholipase C1, the Yeast Homolog of Neutral Sphingomyelinases in DNA Damage Response and Diseases. J Lipids (2015) 0.75
Computational Modeling of Lipid Metabolism in Yeast. Front Mol Biosci (2016) 0.75
Differential network analysis with multiply imputed lipidomic data. PLoS One (2015) 0.75
Regulation of very-long acyl chain ceramide synthesis by Acyl-CoA binding protein. J Biol Chem (2017) 0.75
Harnessing the power of yeast to elucidate the role of sphingolipids in metabolic and signaling processes pertinent to psychiatric disorders. Clin Lipidol (2014) 0.75
Trifunctional lipid probes for comprehensive studies of single lipid species in living cells. Proc Natl Acad Sci U S A (2017) 0.75
Activation of protein kinase C-mitogen-activated protein kinase signaling in response to inositol starvation triggers Sir2p-dependent telomeric silencing in yeast. J Biol Chem (2013) 0.75
Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer (2004) 5.63
Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Methods (2006) 4.31
Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab (2006) 3.34
Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. Nature (2007) 3.13
The complex life of simple sphingolipids. EMBO Rep (2004) 3.10
EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res (2004) 2.78
Bioactive sphingolipids: metabolism and function. J Lipid Res (2008) 2.73
Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta (2002) 2.69
Recent developments in parameter estimation and structure identification of biochemical and genomic systems. Math Biosci (2009) 2.58
An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol (2010) 2.33
De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J Biol Chem (2002) 2.24
The sphingolipid salvage pathway in ceramide metabolism and signaling. Cell Signal (2007) 2.16
PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J Biol Chem (2002) 2.11
The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J (2003) 2.10
Acid and neutral sphingomyelinases: roles and mechanisms of regulation. Biochem Cell Biol (2004) 2.06
Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. Am J Physiol Endocrinol Metab (2009) 2.00
Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes (2006) 1.91
Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem (2004) 1.84
Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase. J Biol Chem (2005) 1.83
Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J (2005) 1.83
Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. FASEB J (2009) 1.82
Role for sphingosine kinase 1 in colon carcinogenesis. FASEB J (2008) 1.78
Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2. J Biol Chem (2003) 1.76
Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. J Biol Chem (2003) 1.75
Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. J Biol Chem (2002) 1.74
Blood sphingolipidomics in healthy humans: impact of sample collection methodology. J Lipid Res (2010) 1.72
A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. FASEB J (2008) 1.71
Parameter estimation in biochemical systems models with alternating regression. Theor Biol Med Model (2006) 1.69
Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans. J Clin Invest (2003) 1.66
The extended family of neutral sphingomyelinases. Biochemistry (2006) 1.63
Roles and regulation of secretory and lysosomal acid sphingomyelinase. Cell Signal (2009) 1.62
Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem (2005) 1.61
Identification of metabolic system parameters using global optimization methods. Theor Biol Med Model (2006) 1.59
Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis. FASEB J (2005) 1.57
Ceramide synthases at the centre of sphingolipid metabolism and biology. Biochem J (2012) 1.57
Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. FASEB J (2008) 1.56
Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1. J Biol Chem (2008) 1.55
Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. Mol Cancer Ther (2007) 1.55
Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. J Biol Chem (2004) 1.52
Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation. J Biol Chem (2007) 1.49
Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. J Biol Chem (2003) 1.47
System estimation from metabolic time-series data. Bioinformatics (2008) 1.43
Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity. J Biol Chem (2006) 1.43
Sphingomyelin metabolism at the plasma membrane: implications for bioactive sphingolipids. FEBS Lett (2009) 1.43
The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans. J Biol Chem (2004) 1.42
Mechanistic simulations of inflammation: current state and future prospects. Math Biosci (2008) 1.40
BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome. J Biol Chem (2003) 1.39
Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. J Biol Chem (2007) 1.38
Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis. Cell Res (2007) 1.38
Neural-network-based parameter estimation in S-system models of biological networks. Genome Inform (2003) 1.37
Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway. J Cell Biol (2008) 1.35
The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Mol Pharmacol (2005) 1.33
Translational aspects of sphingolipid metabolism. Trends Mol Med (2007) 1.31
Yeast sphingolipids: metabolism and biology. Biochim Biophys Acta (2002) 1.31
Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses. Neuromolecular Med (2010) 1.30
Sphingolipids function as downstream effectors of a fungal PAQR. Mol Pharmacol (2008) 1.30
A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria. Biochem J (2005) 1.28
Automated smoother for the numerical decoupling of dynamics models. BMC Bioinformatics (2007) 1.27
The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy. Cancer Biol Ther (2007) 1.27
Discovery and characterization of a Ca2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners. J Biol Chem (2006) 1.26
The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation. Hepatology (2009) 1.26
Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits. Hum Mol Genet (2010) 1.25
S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species. Cardiovasc Res (2009) 1.25
Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes. J Clin Invest (2012) 1.25
Biosynthesis of anandamide and N-palmitoylethanolamine by sequential actions of phospholipase A2 and lysophospholipase D. Biochem J (2004) 1.25
Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. J Biol Chem (2005) 1.24
Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. J Pharmacol Exp Ther (2006) 1.24
Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis. J Biol Chem (2007) 1.24
Tailoring structure-function and targeting properties of ceramides by site-specific cationization. Bioorg Med Chem (2006) 1.24
Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem (2003) 1.24
Positively charged ceramide is a potent inducer of mitochondrial permeabilization. J Biol Chem (2005) 1.23
Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function. Nat Med (2012) 1.23
Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism. J Lipid Res (2010) 1.23
AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. J Lipid Res (2009) 1.23
Priming nonlinear searches for pathway identification. Theor Biol Med Model (2004) 1.22
Golgi fragmentation is associated with ceramide-induced cellular effects. Mol Biol Cell (2005) 1.21
Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells. Exp Cell Res (2004) 1.21
The structural requirements for ceramide activation of serine-threonine protein phosphatases. J Lipid Res (2003) 1.21
Mitochondria and ceramide: intertwined roles in regulation of apoptosis. Adv Enzyme Regul (2002) 1.21
Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization. J Biol Chem (2007) 1.21
Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids. Bioorg Med Chem (2007) 1.20
Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy. Mol Ther (2007) 1.20
Bioactive sphingolipids in the modulation of the inflammatory response. Pharmacol Ther (2006) 1.20
Modulation of sphingolipid metabolism by the phosphatidylinositol-4-phosphate phosphatase Sac1p through regulation of phosphatidylinositol in Saccharomyces cerevisiae. J Biol Chem (2009) 1.20
Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metab (2013) 1.19
Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes. FEBS Lett (2002) 1.19
Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation. J Biol Chem (2010) 1.19
Activation and localization of inositol phosphosphingolipid phospholipase C, Isc1p, to the mitochondria during growth of Saccharomyces cerevisiae. J Biol Chem (2003) 1.19
Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. Mol Ther (2008) 1.19
Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells. Cancer Chemother Pharmacol (2007) 1.18
Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. J Biol Chem (2004) 1.18
Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. J Biol Chem (2006) 1.18
Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells. Mol Pharmacol (2008) 1.18
Plant sphingolipids: decoding the enigma of the Sphinx. New Phytol (2009) 1.17