Published in Am J Respir Crit Care Med on March 17, 2004
Progression of Airway Obstruction in Childhood Asthma | NCT00873873
Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol (2010) 2.27
Asthma: clinical expression and molecular mechanisms. J Allergy Clin Immunol (2010) 1.84
Sex dependence of airflow limitation and air trapping in children with severe asthma. J Allergy Clin Immunol (2011) 1.64
Management of severe asthma in children. Lancet (2010) 1.60
Genome-wide interrogation of longitudinal FEV1 in children with asthma. Am J Respir Crit Care Med (2014) 1.44
Advancing asthma care: the glass is only half full! J Allergy Clin Immunol (2011) 1.14
Pediatric asthma: a different disease. Proc Am Thorac Soc (2009) 1.08
Predictors of remitting, periodic, and persistent childhood asthma. J Allergy Clin Immunol (2010) 1.05
Phenotype of asthma-chronic obstructive pulmonary disease overlap syndrome. Korean J Intern Med (2015) 1.02
The course of persistent airflow limitation in subjects with and without asthma. Respir Med (2008) 1.01
Progressive airflow limitation is a feature of children with severe asthma. J Allergy Clin Immunol (2011) 0.93
Long-term outcomes of early-onset wheeze and asthma. J Allergy Clin Immunol (2012) 0.90
Leukotrienes and airway inflammation. Biochim Biophys Acta (2011) 0.88
Epidemiology of the origins of airflow limitation in asthma. Proc Am Thorac Soc (2009) 0.88
The irreversible component of persistent asthma. J Allergy Clin Immunol (2009) 0.86
Inhaled corticosteroids moderate lung function decline in adults with asthma. Thorax (2006) 0.85
Progress in the management of childhood asthma. Asia Pac Allergy (2012) 0.85
Serum Adiponectin is Associated with Adverse Outcomes of Asthma in Men but Not in Women. Front Pharmacol (2011) 0.84
Severe asthma in childhood: recent advances in phenotyping and pathogenesis. Curr Opin Allergy Clin Immunol (2012) 0.84
The persistence of allergen exposure favors pulmonary function decline in workers with allergic occupational asthma. Int Arch Occup Environ Health (2011) 0.79
Current guidelines for the management of asthma in young children. Allergy Asthma Immunol Res (2009) 0.78
Sex-related differences in pulmonary physiologic outcome measures in a high-risk birth cohort. J Allergy Clin Immunol (2015) 0.78
Childhood asthma: diagnosis and treatment. Scientifica (Cairo) (2012) 0.77
The Childhood Asthma Management Program (CAMP): Contributions to the Understanding of Therapy and the Natural History of Childhood Asthma. Curr Respir Care Rep (2012) 0.76
Risk Factors Associated with Irreversible Airway Obstruction in Asthma: A Systematic Review and Meta-Analysis. Biomed Res Int (2016) 0.76
Asthma worsenings: approaches to prevention and management from the Asthma Worsenings Working Group. Can Respir J (2009) 0.75
Progression of asthma: small steps and a long way to go. Am J Respir Crit Care Med (2004) 0.75
Pediatric asthma: guidelines-based care, omalizumab, and other potential biologic agents. Immunol Allergy Clin North Am (2014) 0.75
The WEB-based Asthma Control: an intriguing connection or a dangerous hazard? Asthma Res Pract (2015) 0.75
Pulmonary remodeling in asthma. F1000 Med Rep (2010) 0.75
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med (2009) 9.38
Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group. N Engl J Med (2000) 8.32
Genetic epidemiology of COPD (COPDGene) study design. COPD (2010) 7.67
Daily versus as-needed corticosteroids for mild persistent asthma. N Engl J Med (2005) 7.61
Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids. N Engl J Med (2010) 6.51
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol (2007) 6.33
Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med (2010) 6.19
Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med (2006) 6.10
Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children. N Engl J Med (2011) 5.61
Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial. Lancet (2011) 5.42
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (2004) 5.01
Characterization of within-subject responses to fluticasone and montelukast in childhood asthma. J Allergy Clin Immunol (2005) 4.50
Daily or intermittent budesonide in preschool children with recurrent wheezing. N Engl J Med (2011) 4.09
Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol (2010) 3.54
Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet (2010) 3.44
Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J Allergy Clin Immunol (2010) 3.22
Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children. J Allergy Clin Immunol (2003) 2.93
Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma. Am J Respir Crit Care Med (2007) 2.81
Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma. J Allergy Clin Immunol (2004) 2.80
Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial. J Allergy Clin Immunol (2006) 2.79
Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history. Am J Respir Crit Care Med (2008) 2.61
Forced expiratory flow between 25% and 75% of vital capacity and FEV1/forced vital capacity ratio in relation to clinical and physiological parameters in asthmatic children with normal FEV1 values. J Allergy Clin Immunol (2010) 2.61
Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing. J Allergy Clin Immunol (2008) 2.56
beta-Adrenergic receptor polymorphisms and response to salmeterol. Am J Respir Crit Care Med (2005) 2.45
Complement activation fragment Bb in early pregnancy and spontaneous preterm birth. Am J Obstet Gynecol (2008) 2.38
Systemic effect comparisons of six inhaled corticosteroid preparations. Am J Respir Crit Care Med (2002) 2.24
Refractory asthma: importance of bronchoscopy to identify phenotypes and direct therapy. Chest (2011) 2.19
A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation. COPD (2012) 2.07
Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis. Am J Respir Crit Care Med (2006) 2.05
Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthma. J Allergy Clin Immunol (2006) 2.02
Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes. Hum Mol Genet (2010) 1.89
Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids. J Allergy Clin Immunol (2005) 1.88
Effect of vitamin D and inhaled corticosteroid treatment on lung function in children. Am J Respir Crit Care Med (2012) 1.88
Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma. J Pediatr (2003) 1.87
The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial. J Allergy Clin Immunol (2007) 1.87
Association of body mass with pulmonary function in the Childhood Asthma Management Program (CAMP). Thorax (2003) 1.86
The Prevention of Early Asthma in Kids study: design, rationale and methods for the Childhood Asthma Research and Education network. Control Clin Trials (2004) 1.79
Clinical and radiographic predictors of GOLD-unclassified smokers in the COPDGene study. Am J Respir Crit Care Med (2011) 1.76
Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. Am J Respir Crit Care Med (2008) 1.73
Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents. J Pediatr (2009) 1.68
Gender differences of airway dimensions in anatomically matched sites on CT in smokers. COPD (2011) 1.66
Minimizing attrition in a long-term clinical trial of pediatric asthma. Ann Allergy Asthma Immunol (2003) 1.66
Racial differences in quality of life in patients with COPD. Chest (2011) 1.64
Asthma control, adiposity, and adipokines among inner-city adolescents. J Allergy Clin Immunol (2010) 1.63
First do no harm: managing antihistamine impairment in patients with allergic rhinitis. J Allergy Clin Immunol (2003) 1.55
Bronchodilation and bronchoconstriction: predictors of future lung function in childhood asthma. J Allergy Clin Immunol (2006) 1.54
Phenotypic predictors of long-term response to inhaled corticosteroid and leukotriene modifier therapies in pediatric asthma. J Allergy Clin Immunol (2009) 1.51
Decreased response to inhaled steroids in overweight and obese asthmatic children. J Allergy Clin Immunol (2011) 1.49
Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma. Am J Respir Crit Care Med (2006) 1.46
Mild to moderate asthma affects lung growth in children and adolescents. J Allergy Clin Immunol (2006) 1.44
Persistently high perinatal transmission of HIV: assessment of risk factors. Pediatr Infect Dis J (2014) 1.44
A comparison of the clinical characteristics of children and adults with severe asthma. Chest (2003) 1.42
Childhood asthma: new insights into management. J Allergy Clin Immunol (2002) 1.42
Genome-wide association study of short-acting β2-agonists. A novel genome-wide significant locus on chromosome 2 near ASB3. Am J Respir Crit Care Med (2015) 1.42
Quantitative computed tomography of the lungs and airways in healthy nonsmoking adults. Invest Radiol (2012) 1.41
A trial of clarithromycin for the treatment of suboptimally controlled asthma. J Allergy Clin Immunol (2010) 1.39
Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. J Allergy Clin Immunol (2009) 1.38
Clinical predictors and outcomes of consistent bronchodilator response in the childhood asthma management program. J Allergy Clin Immunol (2008) 1.36
Importance of the personal endotoxin cloud in school-age children with asthma. J Allergy Clin Immunol (2005) 1.33
Factors associated with asthma exacerbations during a long-term clinical trial of controller medications in children. J Allergy Clin Immunol (2008) 1.28
The Aerocrine exhaled nitric oxide monitoring system NIOX is cleared by the US Food and Drug Administration for monitoring therapy in asthma. J Allergy Clin Immunol (2004) 1.26
Nocturnal awakening caused by asthma in children with mild-to-moderate asthma in the childhood asthma management program. J Allergy Clin Immunol (2002) 1.25
Patient characteristics associated with improved outcomes with use of an inhaled corticosteroid in preschool children at risk for asthma. J Allergy Clin Immunol (2009) 1.21
Alternative complement pathway activation fragment Bb in early pregnancy as a predictor of preeclampsia. Am J Obstet Gynecol (2008) 1.17
Statin and statin-fibrate use was significantly associated with increased myositis risk in a managed care population. J Clin Epidemiol (2007) 1.16
Disease severity, scratching, and sleep quality in patients with atopic dermatitis. J Am Acad Dermatol (2008) 1.15
Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. J Allergy Clin Immunol (2013) 1.15
Extended red blood cell antigen matching for transfusions in sickle cell disease: a review of a 14-year experience from a single center (CME). Transfusion (2011) 1.14
Key findings and clinical implications from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. J Allergy Clin Immunol (2012) 1.14
Community-associated methicillin-resistant Staphylococcus aureus in pediatric patients. Emerg Infect Dis (2005) 1.13
Baseline characteristics of patients enrolled in EXCELS: a cohort study. Ann Allergy Asthma Immunol (2009) 1.13
Development and validation of the Composite Asthma Severity Index--an outcome measure for use in children and adolescents. J Allergy Clin Immunol (2012) 1.12
Predictors of symptoms are different from predictors of severe exacerbations from asthma in children. Chest (2011) 1.10
Epidemiology, radiology, and genetics of nicotine dependence in COPD. Respir Res (2011) 1.10
Hygiene hypothesis: fact or fiction? J Allergy Clin Immunol (2003) 1.09
Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene. PLoS Genet (2012) 1.09
Prevalence and correlates of household exposures to tobacco smoke and pets in children with asthma. J Pediatr (2002) 1.08
Montelukast for respiratory syncytial virus bronchiolitis: significant effect or provocative findings? Am J Respir Crit Care Med (2003) 1.08
IgG antibodies produced during subcutaneous allergen immunotherapy mediate inhibition of basophil activation via a mechanism involving both FcgammaRIIA and FcgammaRIIB. Immunol Lett (2009) 1.08
Screening of single-donor apheresis platelets for bacterial contamination: the PASSPORT study results. Transfusion (2009) 1.07
Quantitative computed tomography detects peripheral airway disease in asthmatic children. Pediatr Pulmonol (2005) 1.07
Recent asthma exacerbations predict future exacerbations in children with severe or difficult-to-treat asthma. J Allergy Clin Immunol (2009) 1.06
Predictors of remitting, periodic, and persistent childhood asthma. J Allergy Clin Immunol (2010) 1.05
Oral food challenges in children with a diagnosis of food allergy. J Pediatr (2010) 1.03
Early elevations of the complement activation fragment C3a and adverse pregnancy outcomes. Obstet Gynecol (2011) 1.03
Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma. J Allergy Clin Immunol (2010) 1.02
Inhaled corticosteroids: past lessons and future issues. J Allergy Clin Immunol (2003) 1.02