Published in COPD on February 01, 2010
Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med (2012) 5.54
Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med (2011) 4.75
GOLD 2011 disease severity classification in COPDGene: a prospective cohort study. Lancet Respir Med (2012) 3.98
Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology (2011) 3.30
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet (2013) 3.17
Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression. Nat Med (2012) 2.95
Comparison of spirometric thresholds in diagnosing smoking-related airflow obstruction. Thorax (2013) 2.88
The clinical features of the overlap between COPD and asthma. Respir Res (2011) 2.29
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med (2014) 2.28
The clinical and genetic features of COPD-asthma overlap syndrome. Eur Respir J (2014) 2.27
The chronic bronchitic phenotype of COPD: an analysis of the COPDGene Study. Chest (2011) 2.14
Distinct quantitative computed tomography emphysema patterns are associated with physiology and function in smokers. Am J Respir Crit Care Med (2013) 2.09
A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation. COPD (2012) 2.07
Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study. Am J Respir Crit Care Med (2011) 2.06
Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). Thorax (2013) 1.99
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet (2011) 1.98
Coronary artery and thoracic calcium on noncontrast thoracic CT scans: comparison of ungated and gated examinations in patients from the COPD Gene cohort. J Cardiovasc Comput Tomogr (2010) 1.91
Interstitial lung abnormalities and reduced exercise capacity. Am J Respir Crit Care Med (2012) 1.80
Clinical and radiographic predictors of GOLD-unclassified smokers in the COPDGene study. Am J Respir Crit Care Med (2011) 1.76
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 1.72
The association of adiponectin with computed tomography phenotypes in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 1.67
Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers. Am J Respir Crit Care Med (2013) 1.67
Gender differences of airway dimensions in anatomically matched sites on CT in smokers. COPD (2011) 1.66
Racial differences in quality of life in patients with COPD. Chest (2011) 1.64
Relationships between airflow obstruction and quantitative CT measurements of emphysema, air trapping, and airways in subjects with and without chronic obstructive pulmonary disease. AJR Am J Roentgenol (2013) 1.63
Clinical and Radiologic Disease in Smokers With Normal Spirometry. JAMA Intern Med (2015) 1.61
Association Between Interstitial Lung Abnormalities and All-Cause Mortality. JAMA (2016) 1.61
Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns. Am J Respir Crit Care Med (2014) 1.57
Registration-based lung mechanical analysis of chronic obstructive pulmonary disease (COPD) using a supervised machine learning framework. Acad Radiol (2013) 1.54
Reduced Bone Density and Vertebral Fractures in Smokers. Men and COPD Patients at Increased Risk. Ann Am Thorac Soc (2015) 1.54
Reduction of exacerbations by the PDE4 inhibitor roflumilast--the importance of defining different subsets of patients with COPD. Respir Res (2011) 1.52
Susceptibility to chronic mucus hypersecretion, a genome wide association study. PLoS One (2014) 1.52
Clinical and Immunological Factors in Emphysema Progression. Five-Year Prospective Longitudinal Exacerbation Study of Chronic Obstructive Pulmonary Disease (LES-COPD). Am J Respir Crit Care Med (2015) 1.50
β-Blockers are associated with a reduction in COPD exacerbations. Thorax (2015) 1.48
Phenotype of Spirometric Impairment in an Aging Population. Am J Respir Crit Care Med (2016) 1.48
Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema. Thorax (2014) 1.48
Quantitative computed tomography of the lungs and airways in healthy nonsmoking adults. Invest Radiol (2012) 1.41
Radiological correlates and clinical implications of the paradoxical lung function response to β₂ agonists: an observational study. Lancet Respir Med (2014) 1.41
Quantitative computed tomography in COPD: possibilities and limitations. Lung (2011) 1.35
Reference standard and statistical model for intersite and temporal comparisons of CT attenuation in a multicenter quantitative lung study. Med Phys (2012) 1.33
Computed tomographic measures of pulmonary vascular morphology in smokers and their clinical implications. Am J Respir Crit Care Med (2013) 1.33
CT-Definable Subtypes of Chronic Obstructive Pulmonary Disease: A Statement of the Fleischner Society. Radiology (2015) 1.24
The clinical impact of non-obstructive chronic bronchitis in current and former smokers. Respir Med (2013) 1.23
Quantitative computed tomography in chronic obstructive pulmonary disease. J Thorac Imaging (2013) 1.22
Genome-wide association study of smoking behaviours in patients with COPD. Thorax (2011) 1.18
Prediction of acute respiratory disease in current and former smokers with and without COPD. Chest (2014) 1.15
Automated telecommunication to obtain longitudinal follow-up in a multicenter cross-sectional COPD study. COPD (2012) 1.15
Clinical and computed tomographic predictors of chronic bronchitis in COPD: a cross sectional analysis of the COPDGene study. Respir Res (2014) 1.14
Early identification of small airways disease on lung cancer screening CT: comparison of current air trapping measures. Lung (2012) 1.14
Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2013) 1.12
Clinical and radiographic correlates of hypoxemia and oxygen therapy in the COPDGene study. Respir Med (2011) 1.12
Telomerase mutations in smokers with severe emphysema. J Clin Invest (2014) 1.11
Genetics of sputum gene expression in chronic obstructive pulmonary disease. PLoS One (2011) 1.11
Epidemiology, radiology, and genetics of nicotine dependence in COPD. Respir Res (2011) 1.10
Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs. Nat Immunol (2016) 1.09
Chronic obstructive pulmonary disease: lobe-based visual assessment of volumetric CT by Using standard images--comparison with quantitative CT and pulmonary function test in the COPDGene study. Radiology (2012) 1.07
Autoimmunity in chronic obstructive pulmonary disease: clinical and experimental evidence. Expert Rev Clin Immunol (2012) 1.07
Association between Functional Small Airway Disease and FEV1 Decline in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2016) 1.07
Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene. Respir Res (2014) 1.06
Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort. Chest (2011) 1.03
Association between airway caliber changes with lung inflation and emphysema assessed by volumetric CT scan in subjects with COPD. Chest (2011) 1.03
A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes. Am J Respir Crit Care Med (2015) 1.02
Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD. Respir Res (2013) 1.00
The Swedish CArdioPulmonary BioImage Study: objectives and design. J Intern Med (2015) 0.98
The chronic bronchitis phenotype in chronic obstructive pulmonary disease: features and implications. Curr Opin Pulm Med (2015) 0.98
Effect of emphysema on CT scan measures of airway dimensions in smokers. Chest (2013) 0.97
The effect of iterative reconstruction on computed tomography assessment of emphysema, air trapping and airway dimensions. Eur Radiol (2012) 0.97
Family history is a risk factor for COPD. Chest (2011) 0.96
Computed tomographic measures of airway morphology in smokers and never-smoking normals. J Appl Physiol (1985) (2014) 0.95
Plasma sphingolipids associated with chronic obstructive pulmonary disease phenotypes. Am J Respir Crit Care Med (2015) 0.95
Parametric response mapping as an indicator of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant (2014) 0.95
Racial differences in CT phenotypes in COPD. COPD (2013) 0.95
Automated texture-based quantification of centrilobular nodularity and centrilobular emphysema in chest CT images. Acad Radiol (2012) 0.94
Sinogram Affirmed Iterative Reconstruction (SAFIRE) versus weighted filtered back projection (WFBP) effects on quantitative measure in the COPDGene 2 test object. Med Phys (2014) 0.94
Pulmonary artery enlargement is associated with right ventricular dysfunction and loss of blood volume in small pulmonary vessels in chronic obstructive pulmonary disease. Circ Cardiovasc Imaging (2015) 0.93
Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report. COPD (2011) 0.93
FEV(1)/FEV(6) to diagnose airflow obstruction. Comparisons with computed tomography and morbidity indices. Ann Am Thorac Soc (2014) 0.93
Assessment of two immunodepletion methods: off-target effects and variations in immunodepletion efficiency may confound plasma proteomics. J Proteome Res (2012) 0.93
Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus. BMC Pulm Med (2014) 0.93
Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility. Hum Genet (2013) 0.92
Early chronic obstructive pulmonary disease: definition, assessment, and prevention. Lancet (2015) 0.92
Novel outcomes and end points: biomarkers in chronic obstructive pulmonary disease clinical trials. Proc Am Thorac Soc (2011) 0.92
Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2016) 0.92
Generative Method to Discover Genetically Driven Image Biomarkers. Inf Process Med Imaging (2015) 0.91
Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence. Transl Psychiatry (2015) 0.90
Pathophysiology and clinical implications of pulmonary arterial enlargement in COPD. Int J Chron Obstruct Pulmon Dis (2013) 0.90
Association between occupational exposure and lung function, respiratory symptoms, and high-resolution computed tomography imaging in COPDGene. Am J Respir Crit Care Med (2014) 0.89
A simplified score to quantify comorbidity in COPD. PLoS One (2014) 0.89
Pulmonary function reduction in diabetes with and without chronic obstructive pulmonary disease. Diabetes Care (2013) 0.89
Detailed analysis of the density change on chest CT of COPD using non-rigid registration of inspiration/expiration CT scans. Eur Radiol (2014) 0.89
Genes and chronic obstructive pulmonary disease. Med Clin North Am (2012) 0.88
A reference dataset for deformable image registration spatial accuracy evaluation using the COPDgene study archive. Phys Med Biol (2013) 0.88
The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes. Respir Res (2014) 0.88
Phenotype of Normal Spirometry in an Aging Population. Am J Respir Crit Care Med (2015) 0.88
Improved pulmonary nodule classification utilizing quantitative lung parenchyma features. J Med Imaging (Bellingham) (2015) 0.87
Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: a cohort study. BMC Pulm Med (2016) 0.87
Prevalence and global initiative for chronic obstructive lung disease group distribution of chronic obstructive pulmonary disease detected by preoperative pulmonary function test. PLoS One (2015) 0.87
Comparison of acute respiratory events between asthma-COPD overlap syndrome and COPD patients: a population-based cohort study. Medicine (Baltimore) (2015) 0.87
Analysis of Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome Defined on the Basis of Bronchodilator Response and Degree of Emphysema. Ann Am Thorac Soc (2016) 0.87
Characterizing functional lung heterogeneity in COPD using reference equations for CT scan-measured lobar volumes. Chest (2013) 0.86
Global burden of COPD: risk factors, prevalence, and future trends. Lancet (2007) 9.50
Chronic obstructive pulmonary disease surveillance--United States, 1971-2000. MMWR Surveill Summ (2002) 7.07
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93
Genomic screening and replication using the same data set in family-based association testing. Nat Genet (2005) 5.44
Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. Am J Respir Crit Care Med (1998) 3.83
A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78
Developing COPD: a 25 year follow up study of the general population. Thorax (2006) 3.72
Deaths: final data for 1999. Natl Vital Stat Rep (2001) 3.52
State of the Art. A structural and functional assessment of the lung via multidetector-row computed tomography: phenotyping chronic obstructive pulmonary disease. Proc Am Thorac Soc (2006) 2.60
Phenotypes of chronic obstructive pulmonary disease. COPD (2007) 2.33
Siblings of patients with severe chronic obstructive pulmonary disease have a significant risk of airflow obstruction. Am J Respir Crit Care Med (2001) 2.11
Genetic association analysis of functional impairment in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2006) 1.98
Genetic determinants of emphysema distribution in the national emphysema treatment trial. Am J Respir Crit Care Med (2007) 1.94
Familial prevalence of chronic obstructive pulmonary disease in a matched pair study. Am J Med (1977) 1.63
Heritability of longitudinal change in lung function. The Framingham study. Am J Respir Crit Care Med (2001) 1.60
Risk factors in chronic obstructive pulmonary disease (COPD). Am J Epidemiol (1977) 1.50
Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery. Respir Res (2007) 1.27
Exacerbations in chronic obstructive pulmonary disease: do they contribute to disease progression? Proc Am Thorac Soc (2007) 1.22
An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med (2011) 22.39
Azithromycin for prevention of exacerbations of COPD. N Engl J Med (2011) 8.66
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med (2009) 7.17
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93
Recommendations for the management of subsolid pulmonary nodules detected at CT: a statement from the Fleischner Society. Radiology (2012) 6.92
An official American Thoracic Society/European Respiratory Society statement: Update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med (2013) 6.82
Acute exacerbations of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2007) 6.71
Sensitive detection of chromosomal segments of distinct ancestry in admixed populations. PLoS Genet (2009) 6.36
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol (2007) 6.33
Changes in forced expiratory volume in 1 second over time in COPD. N Engl J Med (2011) 5.69
Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol (2004) 5.57
Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med (2012) 5.54
Genomic screening and replication using the same data set in family-based association testing. Nat Genet (2005) 5.44
Cleft lip and palate: understanding genetic and environmental influences. Nat Rev Genet (2011) 5.41
Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res (2010) 5.17
Pulmonary Rehabilitation: Joint ACCP/AACVPR Evidence-Based Clinical Practice Guidelines. Chest (2007) 5.01
Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med (2011) 4.75
PBAT: tools for family-based association studies. Am J Hum Genet (2004) 4.68
An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med (2013) 4.49
The PhenX Toolkit: get the most from your measures. Am J Epidemiol (2011) 4.19
Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med (2010) 4.19
Variants of DENND1B associated with asthma in children. N Engl J Med (2009) 4.18
GOLD 2011 disease severity classification in COPDGene: a prospective cohort study. Lancet Respir Med (2012) 3.98
Idiopathic nonspecific interstitial pneumonia: report of an American Thoracic Society project. Am J Respir Crit Care Med (2008) 3.97
MMP12, lung function, and COPD in high-risk populations. N Engl J Med (2009) 3.96
An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 3.92
A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78
Predictors of mortality in patients with emphysema and severe airflow obstruction. Am J Respir Crit Care Med (2006) 3.71
Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 3.70
Detectable clonal mosaicism from birth to old age and its relationship to cancer. Nat Genet (2012) 3.68
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet (2011) 3.68
A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics (2003) 3.52
Simvastatin for the prevention of exacerbations in moderate-to-severe COPD. N Engl J Med (2014) 3.51
The Gene, Environment Association Studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions. Genet Epidemiol (2010) 3.48
Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet (2010) 3.44
Six-minute-walk test in chronic obstructive pulmonary disease: minimal clinically important difference for death or hospitalization. Am J Respir Crit Care Med (2012) 3.44
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet (2009) 3.41
On the replication of genetic associations: timing can be everything! Am J Hum Genet (2008) 3.32
Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology (2011) 3.30
BUILD-3: a randomized, controlled trial of bosentan in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2011) 3.23
Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J Allergy Clin Immunol (2010) 3.22
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet (2013) 3.17
The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations. Am J Respir Crit Care Med (2007) 2.91
Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J Appl Physiol (1985) (2007) 2.83
Sex differences in severe pulmonary emphysema. Am J Respir Crit Care Med (2007) 2.77
Brief report: airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: early injury or initiating site of autoimmunity? Arthritis Rheum (2011) 2.74
Predictors of rehospitalization and death after a severe exacerbation of COPD. Chest (2007) 2.67
Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35. Am J Hum Genet (2004) 2.65
Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med (2004) 2.62
A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol (2009) 2.53
Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One (2012) 2.52
Effect of type 1 diabetes on the gender difference in coronary artery calcification: a role for insulin resistance? The Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study. Diabetes (2003) 2.51
Baseline characteristics of participants in the randomized national lung screening trial. J Natl Cancer Inst (2010) 2.50
Superoxide dismutases in the lung and human lung diseases. Am J Respir Crit Care Med (2003) 2.49
Progression of coronary artery calcium predicts all-cause mortality. JACC Cardiovasc Imaging (2010) 2.48
The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet (2005) 2.46
Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med (2003) 2.39
Complement activation fragment Bb in early pregnancy and spontaneous preterm birth. Am J Obstet Gynecol (2008) 2.38
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet (2007) 2.35
The clinical features of the overlap between COPD and asthma. Respir Res (2011) 2.29
Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med (2004) 2.24
Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum. J Allergy Clin Immunol (2009) 2.20
The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet (2004) 2.19
Refractory asthma: importance of bronchoscopy to identify phenotypes and direct therapy. Chest (2011) 2.19
Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet (2003) 2.18
The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol (2011) 2.16
Radiologic findings are strongly associated with a pathologic diagnosis of usual interstitial pneumonia. Chest (2003) 2.16
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. Nat Genet (2012) 2.15
Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease. Thorax (2012) 2.15
A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. Stat Appl Genet Mol Biol (2004) 2.15
Clarification of the risk of chronic obstructive pulmonary disease in α1-antitrypsin deficiency PiMZ heterozygotes. Am J Respir Crit Care Med (2014) 2.14
Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet (2004) 2.14
Progression of asthma measured by lung function in the childhood asthma management program. Am J Respir Crit Care Med (2004) 2.12
Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. Am J Respir Crit Care Med (2009) 2.10
Distinct quantitative computed tomography emphysema patterns are associated with physiology and function in smokers. Am J Respir Crit Care Med (2013) 2.09
Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Am J Respir Cell Mol Biol (2005) 2.08
A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation. COPD (2012) 2.07