Published in J Neurosci on March 17, 2004
Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function. Neuron (2008) 6.26
Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron (2008) 3.97
Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron (2010) 3.96
A pilot open label, single dose trial of fenobam in adults with fragile X syndrome. J Med Genet (2009) 2.76
A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability. Nat Neurosci (2007) 2.54
A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome. Dev Cell (2008) 2.51
Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes. Genes Dev (2005) 2.38
The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development. Proc Natl Acad Sci U S A (2004) 2.34
The Arc of synaptic memory. Exp Brain Res (2009) 2.30
The pathophysiology of fragile X (and what it teaches us about synapses). Annu Rev Neurosci (2012) 2.16
Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors. Proc Natl Acad Sci U S A (2007) 2.10
The state of synapses in fragile X syndrome. Neuroscientist (2009) 2.07
Dicer-derived microRNAs are utilized by the fragile X mental retardation protein for assembly on target RNAs. J Biomed Biotechnol (2006) 2.02
Transport of Drosophila fragile X mental retardation protein-containing ribonucleoprotein granules by kinesin-1 and cytoplasmic dynein. Proc Natl Acad Sci U S A (2004) 1.99
Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses. Proc Natl Acad Sci U S A (2004) 1.97
Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles. Proc Natl Acad Sci U S A (2004) 1.96
RNA transport and local control of translation. Annu Rev Cell Dev Biol (2005) 1.96
Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR. J Neurosci (2007) 1.95
Fragile X protein FMRP is required for homeostatic plasticity and regulation of synaptic strength by retinoic acid. J Neurosci (2010) 1.92
S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade. J Biol Chem (2008) 1.87
Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons. J Neurosci (2006) 1.80
Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome. PLoS One (2011) 1.75
The fragile X mental retardation protein and group I metabotropic glutamate receptors regulate levels of mRNA granules in brain. Proc Natl Acad Sci U S A (2005) 1.74
Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome. Proc Natl Acad Sci U S A (2005) 1.70
Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome. J Neurosci (2010) 1.69
Dendritic mRNAs encode diversified functionalities in hippocampal pyramidal neurons. BMC Neurosci (2006) 1.66
Downregulation of tonic GABAergic inhibition in a mouse model of fragile X syndrome. Cereb Cortex (2008) 1.45
Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein. Neuron (2011) 1.38
Signals, synapses, and synthesis: how new proteins control plasticity. Front Neural Circuits (2009) 1.31
Mechanisms and cellular roles of local protein synthesis in mammalian cells. Curr Opin Cell Biol (2008) 1.31
Therapeutic strategies in fragile X syndrome: dysregulated mGluR signaling and beyond. Neuropsychopharmacology (2011) 1.30
mGluR-dependent long-term depression is associated with increased phosphorylation of S6 and synthesis of elongation factor 1A but remains expressed in S6K-deficient mice. Mol Cell Biol (2008) 1.30
Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2. J Neurosci (2011) 1.30
Fragile X syndrome and targeted treatment trials. Results Probl Cell Differ (2012) 1.27
The unstable repeats--three evolving faces of neurological disease. Neuron (2013) 1.26
Altered mRNA transport, docking, and protein translation in neurons lacking fragile X mental retardation protein. Proc Natl Acad Sci U S A (2010) 1.25
Metabotropic glutamate receptor 5 upregulation in children with autism is associated with underexpression of both Fragile X mental retardation protein and GABAA receptor beta 3 in adults with autism. Anat Rec (Hoboken) (2011) 1.24
Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translation. J Neurosci (2012) 1.23
Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structure. Development (2008) 1.21
Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression. J Neurosci (2012) 1.21
Mechanistic relationships between Drosophila fragile X mental retardation protein and metabotropic glutamate receptor A signaling. Mol Cell Neurosci (2008) 1.15
Fragile X mental retardation protein FMRP and the RNA export factor NXF2 associate with and destabilize Nxf1 mRNA in neuronal cells. Proc Natl Acad Sci U S A (2007) 1.15
Staufen1 regulation of protein synthesis-dependent long-term potentiation and synaptic function in hippocampal pyramidal cells. Mol Cell Biol (2008) 1.12
Fragile X mental retardation protein and synaptic plasticity. Mol Brain (2013) 1.12
Fragile X mental retardation protein FMRP binds mRNAs in the nucleus. Mol Cell Biol (2008) 1.11
Dynamic association of the fragile X mental retardation protein as a messenger ribonucleoprotein between microtubules and polyribosomes. Mol Biol Cell (2007) 1.10
Fragile X Mental Retardation Protein is Involved in Protein Synthesis-Dependent Collapse of Growth Cones Induced by Semaphorin-3A. Front Neural Circuits (2009) 1.08
The RNA binding and transport proteins staufen and fragile X mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axons. Neuroscience (2006) 1.08
Arginines of the RGG box regulate FMRP association with polyribosomes and mRNA. Hum Mol Genet (2010) 1.08
The FMRP regulon: from targets to disease convergence. Front Neurosci (2013) 1.07
Glycogen synthase kinase-3: a promising therapeutic target for fragile x syndrome. Front Mol Neurosci (2011) 1.05
The role of fragile X mental retardation protein in major mental disorders. Neuropharmacology (2010) 1.04
Regulation of molecular pathways in the Fragile X Syndrome: insights into Autism Spectrum Disorders. J Neurodev Disord (2011) 1.04
Channelopathies and dendritic dysfunction in fragile X syndrome. Brain Res Bull (2014) 1.02
Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice. PLoS One (2012) 1.01
Smaug1 mRNA-silencing foci respond to NMDA and modulate synapse formation. J Cell Biol (2011) 1.00
The fragile X mental retardation protein in circadian rhythmicity and memory consolidation. Mol Neurobiol (2009) 0.99
Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures. Neurobiol Dis (2013) 0.99
mRNA and protein expression for novel GABAA receptors θ and ρ2 are altered in schizophrenia and mood disorders; relevance to FMRP-mGluR5 signaling pathway. Transl Psychiatry (2013) 0.98
Fragile x syndrome and autism: from disease model to therapeutic targets. J Neurodev Disord (2009) 0.98
Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant. Psychopharmacology (Berl) (2012) 0.98
Characterization of potential outcome measures for future clinical trials in fragile X syndrome. J Autism Dev Disord (2008) 0.95
Impaired activity-dependent FMRP translation and enhanced mGluR-dependent LTD in Fragile X premutation mice. Hum Mol Genet (2012) 0.95
Limbic epileptogenesis in a mouse model of fragile X syndrome. Cereb Cortex (2008) 0.94
Matrix metalloproteinases and minocycline: therapeutic avenues for fragile X syndrome. Neural Plast (2012) 0.94
Neural circuit architecture defects in a Drosophila model of Fragile X syndrome are alleviated by minocycline treatment and genetic removal of matrix metalloproteinase. Dis Model Mech (2011) 0.94
The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis. Mol Biol Cell (2005) 0.93
Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan. Neuroscience (2012) 0.93
Synaptic activity regulated mRNA-silencing foci for the fine tuning of local protein synthesis at the synapse. Commun Integr Biol (2012) 0.92
A common susceptibility factor of both autism and epilepsy: functional deficiency of GABA A receptors. J Autism Dev Disord (2013) 0.92
FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control. Proc Natl Acad Sci U S A (2013) 0.91
Molecular mechanisms of cognitive and behavioral comorbidities of epilepsy in children. Epilepsia (2011) 0.91
Above genetics: lessons from cerebral development in autism. Transl Neurosci (2011) 0.90
The Role of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in Cognition. Front Neuroanat (2011) 0.90
The development of cortical columns: role of Fragile X mental retardation protein. J Physiol (2009) 0.89
Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons. Neurobiol Dis (2009) 0.89
Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders. Prog Neurobiol (2015) 0.89
Resolution of spatial and temporal visual attention in infants with fragile X syndrome. Brain (2011) 0.89
The fragile X mental retardation protein developmentally regulates the strength and fidelity of calcium signaling in Drosophila mushroom body neurons. Neurobiol Dis (2010) 0.89
Early continuous inhibition of group 1 mGlu signaling partially rescues dendritic spine abnormalities in the Fmr1 knockout mouse model for fragile X syndrome. Psychopharmacology (Berl) (2010) 0.89
Modeling fragile X syndrome in the Fmr1 knockout mouse. Intractable Rare Dis Res (2014) 0.88
The gene encoding the fragile X RNA-binding protein is controlled by nuclear respiratory factor 2 and the CREB family of transcription factors. Nucleic Acids Res (2006) 0.87
Neurobiology of autism gene products: towards pathogenesis and drug targets. Psychopharmacology (Berl) (2014) 0.86
Neuronal activation increases the density of eukaryotic translation initiation factor 4E mRNA clusters in dendrites of cultured hippocampal neurons. Exp Mol Med (2009) 0.86
Identifying large-scale brain networks in fragile X syndrome. JAMA Psychiatry (2013) 0.86
Group I metabotropic glutamate receptor-mediated gene transcription and implications for synaptic plasticity and diseases. Front Pharmacol (2012) 0.86
Ca2+/calmodulin-dependent protein kinase IV links group I metabotropic glutamate receptors to fragile X mental retardation protein in cingulate cortex. J Biol Chem (2009) 0.85
RNA exodus to Israel: RNA controlling function in the far reaches of the neuron. Workshop on RNA control on neuronal function. EMBO Rep (2006) 0.84
The Relationship between Dendritic Branch Dynamics and CPEB-Labeled RNP Granules Captured in Vivo. Front Neural Circuits (2009) 0.83
Protein methylation and stress granules: posttranslational remodeler or innocent bystander? Mol Biol Int (2011) 0.83
Activity-dependent FMRP requirements in development of the neural circuitry of learning and memory. Development (2015) 0.83
Increasing our understanding of human cognition through the study of Fragile X Syndrome. Dev Neurobiol (2013) 0.82
Cell-Type Specific Channelopathies in the Prefrontal Cortex of the fmr1-/y Mouse Model of Fragile X Syndrome(1,2,3). eNeuro (2015) 0.81
A 'learning platform' approach to outcome measurement in fragile X syndrome: a preliminary psychometric study. J Intellect Disabil Res (2012) 0.81
Comprehensive motor testing in Fmr1-KO mice exposes temporal defects in oromotor coordination. Behav Neurosci (2011) 0.81
Olfactory discrimination learning in mice lacking the fragile X mental retardation protein. Neurobiol Learn Mem (2008) 0.80
Fragile X syndrome: (What's) lost in translation? Proc Natl Acad Sci U S A (2004) 0.80
Local protein synthesis in axonal growth cones: what is next? Cell Adh Migr (2007) 0.80
Fragile X mental retardation protein controls ion channel expression and activity. J Physiol (2016) 0.80
In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders. Neural Plast (2015) 0.79
Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1. Nature (2005) 5.29
SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN. Hum Mol Genet (2005) 5.23
Neuronal RNA granules: movers and makers. Neuron (2006) 3.44
Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome. J Neurosci (2007) 3.31
An essential role for beta-actin mRNA localization and translation in Ca2+-dependent growth cone guidance. Nat Neurosci (2006) 3.30
Extracellular stimuli specifically regulate localized levels of individual neuronal mRNAs. J Cell Biol (2007) 2.54
A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome. Dev Cell (2008) 2.51
Plastin 3 is a protective modifier of autosomal recessive spinal muscular atrophy. Science (2008) 2.51
Activity-dependent trafficking and dynamic localization of zipcode binding protein 1 and beta-actin mRNA in dendrites and spines of hippocampal neurons. J Neurosci (2003) 2.34
Active transport of the survival motor neuron protein and the role of exon-7 in cytoplasmic localization. J Neurosci (2003) 2.28
Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation, and mGluR signaling. Mol Cell (2011) 2.27
Survival motor neuron function in motor axons is independent of functions required for small nuclear ribonucleoprotein biogenesis. J Neurosci (2006) 2.11
Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors. Proc Natl Acad Sci U S A (2007) 2.10
Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis. Nature (2012) 2.08
FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A. J Neurosci (2007) 2.02
Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome. J Neurosci (2010) 1.89
Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses. Mol Cell Neurosci (2006) 1.88
S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade. J Biol Chem (2008) 1.87
Local RNA translation at the synapse and in disease. J Neurosci (2011) 1.83
Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons. J Neurosci (2006) 1.80
A predominantly nuclear protein affecting cytoplasmic localization of beta-actin mRNA in fibroblasts and neurons. J Cell Biol (2002) 1.77
Localization of a beta-actin messenger ribonucleoprotein complex with zipcode-binding protein modulates the density of dendritic filopodia and filopodial synapses. J Neurosci (2003) 1.74
Transgenic mice lacking NMDAR-dependent LTD exhibit deficits in behavioral flexibility. Neuron (2008) 1.74
Activity bidirectionally regulates AMPA receptor mRNA abundance in dendrites of hippocampal neurons. J Neurosci (2006) 1.60
Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacity. EMBO J (2011) 1.49
NMDA receptor activation potentiates inhibitory transmission through GABA receptor-associated protein-dependent exocytosis of GABA(A) receptors. J Neurosci (2007) 1.46
Characterization of the role of microtubule-associated protein 1B in metabotropic glutamate receptor-mediated endocytosis of AMPA receptors in hippocampus. J Neurosci (2007) 1.42
Long-term plasticity at inhibitory synapses. Curr Opin Neurobiol (2011) 1.41
Single molecule-sensitive probes for imaging RNA in live cells. Nat Methods (2009) 1.40
Netrin-1-induced local β-actin synthesis and growth cone guidance requires zipcode binding protein 1. J Neurosci (2011) 1.32
Therapeutic strategies in fragile X syndrome: dysregulated mGluR signaling and beyond. Neuropsychopharmacology (2011) 1.30
Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2. J Neurosci (2011) 1.30
Phosphorylation of zipcode binding protein 1 is required for brain-derived neurotrophic factor signaling of local beta-actin synthesis and growth cone turning. J Neurosci (2010) 1.29
Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex. Mol Cell (2012) 1.29
Axonal Localization of transgene mRNA in mature PNS and CNS neurons. J Neurosci (2011) 1.28
Spinal muscular atrophy: the role of SMN in axonal mRNA regulation. Brain Res (2012) 1.26
The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth. Hum Mol Genet (2012) 1.25
The survival of motor neuron (SMN) protein interacts with the mRNA-binding protein HuD and regulates localization of poly(A) mRNA in primary motor neuron axons. J Neurosci (2011) 1.25
Selective translocation of Ca2+/calmodulin protein kinase IIalpha (CaMKIIalpha) to inhibitory synapses. Proc Natl Acad Sci U S A (2010) 1.24
Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translation. J Neurosci (2012) 1.23
GAP-43 mRNA in growth cones is associated with HuD and ribosomes. J Neurobiol (2004) 1.21
Cooperative roles of BDNF expression in neurons and Schwann cells are modulated by exercise to facilitate nerve regeneration. J Neurosci (2012) 1.19
Spinal muscular atrophy and a model for survival of motor neuron protein function in axonal ribonucleoprotein complexes. Results Probl Cell Differ (2009) 1.17
Imaging mRNA movement from transcription sites to translation sites. Semin Cell Dev Biol (2007) 1.17
Making and breaking synapses through local mRNA regulation. Curr Opin Genet Dev (2011) 1.17
The fragile X syndrome: from molecular genetics to neurobiology. Ment Retard Dev Disabil Res Rev (2004) 1.13
Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans. Proc Natl Acad Sci U S A (2011) 1.11
Dynamic association of the fragile X mental retardation protein as a messenger ribonucleoprotein between microtubules and polyribosomes. Mol Biol Cell (2007) 1.10
Fragile X Mental Retardation Protein is Involved in Protein Synthesis-Dependent Collapse of Growth Cones Induced by Semaphorin-3A. Front Neural Circuits (2009) 1.08
The COPI vesicle complex binds and moves with survival motor neuron within axons. Hum Mol Genet (2011) 1.08
Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination. PLoS One (2012) 1.05
Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology. Nat Med (2013) 1.04
High-efficiency transfection of cultured primary motor neurons to study protein localization, trafficking, and function. Mol Neurodegener (2010) 1.02
CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion. Mol Cell Biol (2010) 1.01
G-protein-mediated inhibition of the Trp channel TRPM1 requires the Gβγ dimer. Proc Natl Acad Sci U S A (2012) 1.00
Experience-induced Arc/Arg3.1 primes CA1 pyramidal neurons for metabotropic glutamate receptor-dependent long-term synaptic depression. Neuron (2013) 1.00
Automated 4D analysis of dendritic spine morphology: applications to stimulus-induced spine remodeling and pharmacological rescue in a disease model. Mol Brain (2011) 0.98
Activity-dependent synaptic plasticity in retinal ganglion cells. J Neurosci (2007) 0.97
Excess protein synthesis in FXS patient lymphoblastoid cells can be rescued with a p110β-selective inhibitor. Mol Med (2012) 0.96
Negative regulation of RhoA translation and signaling by hnRNP-Q1 affects cellular morphogenesis. Mol Biol Cell (2012) 0.94
mRNA localization: an orchestration of assembly, traffic and synthesis. Traffic (2012) 0.94
A boost in microRNAs shapes up the neuron. EMBO J (2009) 0.93
Identification of axon-enriched microRNAs localized to growth cones of cortical neurons. Dev Neurobiol (2013) 0.93
State-dependent AMPA receptor trafficking in the mammalian retina. J Neurosci (2006) 0.92
RACK1 is a ribosome scaffold protein for β-actin mRNA/ZBP1 complex. PLoS One (2012) 0.91
Dendritic GluN2A synthesis mediates activity-induced NMDA receptor insertion. J Neurosci (2013) 0.90
QNQKE targeting motif for the SMN-Gemin multiprotein complexin neurons. J Neurosci Res (2007) 0.90
Therapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and Back. Neurotherapeutics (2015) 0.90
FMRP interacts with G-quadruplex structures in the 3'-UTR of its dendritic target Shank1 mRNA. RNA Biol (2014) 0.89
MeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons. PLoS One (2013) 0.87
High-resolution fluorescence in situ hybridization to detect mRNAs in neuronal compartments in vitro and in vivo. Methods Mol Biol (2011) 0.86
Regulation of zipcode binding protein 1 transport dynamics in axons by myosin Va. J Neurosci (2012) 0.86
Regulation of chemotropic guidance of nerve growth cones by microRNA. Mol Brain (2011) 0.85
Reducing glutamate signaling pays off in fragile X. Nat Med (2008) 0.85
mGluR and NMDAR activation internalize distinct populations of AMPARs. Mol Cell Neurosci (2011) 0.84
Light-induced plasticity of synaptic AMPA receptor composition in retinal ganglion cells. Neuron (2012) 0.83
Poly(A) RNA-binding proteins and polyadenosine RNA: new members and novel functions. Wiley Interdiscip Rev RNA (2014) 0.83
The ups and downs of translation-dependent plasticity. Neuron (2008) 0.83
AMPAR exocytosis through NO modulation of PICK1. Neuropharmacology (2007) 0.79
Spatial organization of AMPAR subtypes in ON RGCs. J Neurosci (2014) 0.77
Fragile balance: RNA editing tunes the synapse. Nat Neurosci (2011) 0.77
Molecular mechanisms underlying activity-dependent AMPA receptor cycling in retinal ganglion cells. Mol Cell Neurosci (2013) 0.76
Genes, brain, and behavior: development gone awry in autism? A report on the 23rd Annual International Symposium of the Center for the Study of Gene Structure and Function. Ann N Y Acad Sci (2010) 0.75