Published in Mol Cell Biol on October 20, 2008
The pathophysiology of fragile X (and what it teaches us about synapses). Annu Rev Neurosci (2012) 2.16
FMR1: a gene with three faces. Biochim Biophys Acta (2009) 1.77
The unstable repeats--three evolving faces of neurological disease. Neuron (2013) 1.26
Fragile X syndrome: an update on developing treatment modalities. ACS Chem Neurosci (2011) 1.18
Identification of novel FMR1 variants by massively parallel sequencing in developmentally delayed males. Am J Med Genet A (2010) 1.16
The fate of the messenger is pre-determined: a new model for regulation of gene expression. Biochim Biophys Acta (2013) 1.08
MicroRNA-mediated mRNA translation activation in quiescent cells and oocytes involves recruitment of a nuclear microRNP. Sci Rep (2012) 1.06
Potential therapeutic interventions for fragile X syndrome. Trends Mol Med (2010) 1.05
A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response. Cell (2014) 1.04
The fragile X mental retardation protein in circadian rhythmicity and memory consolidation. Mol Neurobiol (2009) 0.99
Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin. PLoS One (2014) 0.94
Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2. PLoS One (2010) 0.94
Arginine methylation of RNA-binding proteins regulates cell function and differentiation. Mol Reprod Dev (2012) 0.94
MOV10 and FMRP regulate AGO2 association with microRNA recognition elements. Cell Rep (2014) 0.91
Therapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and Back. Neurotherapeutics (2015) 0.90
Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons. Neurobiol Dis (2009) 0.89
Murine leukemia virus uses NXF1 for nuclear export of spliced and unspliced viral transcripts. J Virol (2014) 0.89
Recombinant bacterial expression and purification of human fragile X mental retardation protein isoform 1. Protein Expr Purif (2010) 0.85
Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies. PLoS Genet (2013) 0.83
A novel fragile X syndrome mutation reveals a conserved role for the carboxy-terminus in FMRP localization and function. EMBO Mol Med (2015) 0.83
Increasing our understanding of human cognition through the study of Fragile X Syndrome. Dev Neurobiol (2013) 0.82
Fragile X mental retardation protein: A paradigm for translational control by RNA-binding proteins. Biochimie (2015) 0.81
A new regulatory function of the region proximal to the RGG box in the fragile X mental retardation protein. J Cell Sci (2011) 0.78
Zfrp8 forms a complex with fragile-X mental retardation protein and regulates its localization and function. Dev Biol (2016) 0.76
Identification and characterisation of Simiate, a novel protein linked to the fragile X syndrome. PLoS One (2013) 0.76
New X-chromosomal interactors of dFMRP regulate axonal and synaptic morphology of brain neurons in Drosophila melanogaster. Biotechnol Biotechnol Equip (2014) 0.75
FMRP: a new chapter with chromatin. Protein Cell (2014) 0.75
Splice form-dependent regulation of axonal arbor complexity by FMRP. Dev Neurobiol (2016) 0.75
Fragile X premutation in women: recognizing the health challenges beyond primary ovarian insufficiency. J Assist Reprod Genet (2016) 0.75
RNA Secondary Structure Modulates FMRP's Bi-Functional Role in the MicroRNA Pathway. Int J Mol Sci (2016) 0.75
The Atypical Dual Specificity Phosphatase HYVH1 Associates With Multiple Ribonucleoprotein Particles. J Biol Chem (2016) 0.75
Fragile X mental retardation protein recognizes a G quadruplex structure within the survival motor neuron domain containing 1 mRNA 5'-UTR. Mol Biosyst (2017) 0.75
A short amino acid sequence able to specify nuclear location. Cell (1984) 21.17
Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell (1991) 17.00
Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox. Cell (1991) 12.27
Nucleocytoplasmic transport: the soluble phase. Annu Rev Biochem (1998) 10.74
Sequence requirements for nuclear location of simian virus 40 large-T antigen. Nature (1984) 10.52
CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature (1997) 10.49
Exportin 1 (Crm1p) is an essential nuclear export factor. Cell (1997) 10.32
A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage. Cell (1982) 9.11
Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell (2001) 8.04
The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. EMBO J (2000) 7.54
Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome. Science (1991) 7.16
Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods (2002) 6.67
Evidence for a role of CRM1 in signal-mediated nuclear protein export. Science (1997) 6.60
Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell (2001) 6.50
Transport of proteins and RNAs in and out of the nucleus. Cell (1999) 6.02
AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2. Cell (2007) 5.87
TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. Mol Cell (1998) 5.85
The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. EMBO J (2001) 5.69
Regulating gene expression through RNA nuclear retention. Cell (2005) 5.58
Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1. Nature (2005) 5.29
FMR1 protein: conserved RNP family domains and selective RNA binding. Science (1993) 4.77
The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation. Nat Genet (1993) 4.57
Dynamic nuclear pore complexes: life on the edge. Cell (2006) 4.53
DNA methylation represses FMR-1 transcription in fragile X syndrome. Hum Mol Genet (1992) 4.22
REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. RNA (2000) 4.10
The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein. Cell (1993) 4.10
Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm. Mol Cell (2000) 3.86
Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo. Methods (2002) 3.73
FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association. Mol Cell (1997) 3.71
SR splicing factors serve as adapter proteins for TAP-dependent mRNA export. Mol Cell (2003) 3.61
RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice. Neuron (2003) 3.58
A point mutation in the FMR-1 gene associated with fragile X mental retardation. Nat Genet (1993) 3.58
The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif. EMBO J (2001) 3.42
The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences. Genes Dev (1999) 3.24
Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression. Hum Mol Genet (2002) 3.17
REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus. Proc Natl Acad Sci U S A (2001) 3.10
Nucleocytoplasmic transport enters the atomic age. Curr Opin Cell Biol (2001) 3.06
Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome. Cell (1994) 3.01
Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes. J Neurosci (1997) 2.93
TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus. EMBO J (1999) 2.83
SRprises along a messenger's journey. Mol Cell (2005) 2.81
Polarization of both major body axes in Drosophila by gurken-torpedo signalling. Nature (1995) 2.73
RNA and microRNAs in fragile X mental retardation. Nat Cell Biol (2004) 2.63
Metabotropic glutamate receptor activation regulates fragile x mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses. J Neurosci (2004) 2.59
The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals. Hum Mol Genet (1996) 2.49
Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes. Genes Dev (2005) 2.38
Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them. Mol Cell Biol (1996) 2.26
Dissection of a nuclear localization signal. J Biol Chem (2001) 2.20
Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex. Mol Cell Biol (1999) 2.13
Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport. Curr Biol (2001) 1.97
Human and murine FMR-1: alternative splicing and translational initiation downstream of the CGG-repeat. Nat Genet (1993) 1.95
Alternative splicing of exon 14 determines nuclear or cytoplasmic localisation of fmr1 protein isoforms. Hum Mol Genet (1996) 1.74
Transcription, translation and fragile X syndrome. Curr Opin Genet Dev (2006) 1.72
An intron with a constitutive transport element is retained in a Tap messenger RNA. Nature (2006) 1.65
A nuclear role for the Fragile X mental retardation protein. EMBO J (1996) 1.54
FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues. Biochem Biophys Res Commun (2006) 1.54
Tap and NXT promote translation of unspliced mRNA. Genes Dev (2003) 1.48
Transport of fragile X mental retardation protein via granules in neurites of PC12 cells. Mol Cell Biol (2002) 1.42
High resolution methylation analysis of the FMR1 gene trinucleotide repeat region in fragile X syndrome. Hum Mol Genet (1993) 1.42
The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules. Hum Mol Genet (2007) 1.36
Different targets for the fragile X-related proteins revealed by their distinct nuclear localizations. Hum Mol Genet (1999) 1.35
Small bristles, the Drosophila ortholog of NXF-1, is essential for mRNA export throughout development. RNA (2001) 1.32
The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer. Nucleic Acids Res (2008) 1.32
Fragile X mental retardation protein (FMRP) binds specifically to the brain cytoplasmic RNAs BC1/BC200 via a novel RNA-binding motif. J Biol Chem (2005) 1.32
Fine structure of the human FMR1 gene. Hum Mol Genet (1993) 1.30
Dissecting FMR1, the protein responsible for fragile X syndrome, in its structural and functional domains. RNA (1999) 1.26
A novel family of nuclear transport receptors mediates the export of messenger RNA to the cytoplasm. Eur J Cell Biol (2002) 1.24
Lampbrush chromosomes and associated bodies: new insights into principles of nuclear structure and function. Chromosome Res (2002) 1.21
The nuclear connection in RNA transport and localization. Trends Cell Biol (2002) 1.20
hnRNP A2 and hnRNP L bind the 3'UTR of glucose transporter 1 mRNA and exist as a complex in vivo. Biochem Biophys Res Commun (1999) 1.19
Fragile X mental retardation protein FMRP and the RNA export factor NXF2 associate with and destabilize Nxf1 mRNA in neuronal cells. Proc Natl Acad Sci U S A (2007) 1.15
The Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron. Genes Dev (2006) 1.11
Binding and internalization of fluorescent opioid peptide conjugates in living cells. Mol Pharmacol (2000) 1.10
The N-terminus of the fragile X mental retardation protein contains a novel domain involved in dimerization and RNA binding. Biochemistry (2003) 1.07
Identification and characterization of the methyl arginines in the fragile X mental retardation protein Fmrp. Hum Mol Genet (2005) 1.07
The fragile X mental retardation protein interacts with a distinct mRNA nuclear export factor NXF2. RNA (2006) 0.99
Identification and characterization of the mouse nuclear export factor (Nxf) family members. Nucleic Acids Res (2005) 0.98
The molecular basis of fragile X syndrome. Cold Spring Harb Symp Quant Biol (1996) 0.94
Analysis of domains affecting intracellular localization of the FMRP protein. Neurobiol Dis (1997) 0.94
Characterisation of Fmrp in zebrafish: evolutionary dynamics of the fmr1 gene. Dev Genes Evol (2005) 0.92
Two members of the Fxr gene family, Fmr1 and Fxr1, are differentially expressed in Xenopus tropicalis. Int J Dev Biol (2005) 0.90
Fragile X mental retardation protein controls trailer hitch expression and cleavage furrow formation in Drosophila embryos. Proc Natl Acad Sci U S A (2006) 0.90
Splicing-independent recruitment of spliceosomal small nuclear RNPs to nascent RNA polymerase II transcripts. J Cell Biol (2007) 0.89
The tripartite motif of nuclear factor 7 is required for its association with transcriptional units. Mol Cell Biol (2007) 0.89
Formation of a Tap/NXF1 homotypic complex is mediated through the amino-terminal domain of Tap and enhances interaction with nucleoporins. Mol Biol Cell (2007) 0.86
Mutations in tap uncouple RNA export activity from translocation through the nuclear pore complex. Mol Biol Cell (2005) 0.84
Development and characterization of antibodies that immunoprecipitate the FMR1 protein. Methods Mol Biol (2003) 0.79
Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nat Neurosci (2004) 4.69
FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A. J Neurosci (2007) 2.02
S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade. J Biol Chem (2008) 1.87
Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile x syndrome. Am J Hum Genet (2002) 1.59
The assembly of a spliceosomal small nuclear ribonucleoprotein particle. Nucleic Acids Res (2008) 1.34
Phosphorylation of FMRP inhibits association with Dicer. RNA (2009) 1.16
The dynamic landscape of the cell nucleus. Mol Reprod Dev (2010) 1.11
Arginines of the RGG box regulate FMRP association with polyribosomes and mRNA. Hum Mol Genet (2010) 1.08
Identification and characterization of the methyl arginines in the fragile X mental retardation protein Fmrp. Hum Mol Genet (2005) 1.07
Arginine methylation of RNA-binding proteins regulates cell function and differentiation. Mol Reprod Dev (2012) 0.94
Fragile X protein family member FXR1P is regulated by microRNAs. RNA (2010) 0.92
Splicing-independent recruitment of spliceosomal small nuclear RNPs to nascent RNA polymerase II transcripts. J Cell Biol (2007) 0.89
Translation regulation of mRNAs by the fragile X family of proteins through the microRNA pathway. RNA Biol (2009) 0.89
The tripartite motif of nuclear factor 7 is required for its association with transcriptional units. Mol Cell Biol (2007) 0.89
Live images of RNA polymerase II transcription units. Chromosome Res (2008) 0.84
Fragile X mental retardation protein: past, present and future. Curr Protein Pept Sci (2012) 0.83
Facioscapulohumeral muscular dystrophy region gene 1 is a dynamic RNA-associated and actin-bundling protein. J Mol Biol (2011) 0.82
Novel domains in the hnRNP G/RBMX protein with distinct roles in RNA binding and targeting nascent transcripts. Nucleus (2011) 0.81
Lampbrush chromosomes enable study of cohesin dynamics. Chromosome Res (2009) 0.80
Distribution of XCAP-E and XCAP-D2 in the Xenopus oocyte nucleus. Chromosome Res (2003) 0.80
Exploring the zebra finch Taeniopygia guttata as a novel animal model for the speech-language deficit of fragile X syndrome. Results Probl Cell Differ (2012) 0.78
A new regulatory function of the region proximal to the RGG box in the fragile X mental retardation protein. J Cell Sci (2011) 0.78
Association of modified cytosines and the methylated DNA-binding protein MeCP2 with distinctive structural domains of lampbrush chromatin. Chromosome Res (2012) 0.76
Fragile X family members have important and non-overlapping functions. Biomol Concepts (2011) 0.76
The recruitment of the U5 snRNP to nascent transcripts requires internal loop 1 of U5 snRNA. Chromosome Res (2012) 0.75