Published in EMBO Rep on March 19, 2004
Mechanisms of polycomb gene silencing: knowns and unknowns. Nat Rev Mol Cell Biol (2009) 9.29
Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins. Genes Dev (2006) 5.03
Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference. Cell (2006) 3.76
Intergenic transcription through a polycomb group response element counteracts silencing. Genes Dev (2005) 3.50
CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing. Development (2009) 3.34
Silencing chromatin: comparing modes and mechanisms. Nat Rev Genet (2011) 2.86
H3K36 methylation antagonizes PRC2-mediated H3K27 methylation. J Biol Chem (2011) 2.63
Advances in early kidney specification, development and patterning. Development (2009) 2.62
Trithorax group proteins: switching genes on and keeping them active. Nat Rev Mol Cell Biol (2011) 2.56
Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains. Cell (2011) 2.30
Histone H3 lysine 4 (H3K4) methylation in development and differentiation. Dev Biol (2009) 2.24
The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Dev Cell (2007) 2.20
Alternative epigenetic chromatin states of polycomb target genes. PLoS Genet (2010) 2.15
Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Genes Dev (2012) 2.04
p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation. Nat Struct Mol Biol (2007) 2.03
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands. Elife (2012) 1.99
Drosophila Kismet regulates histone H3 lysine 27 methylation and early elongation by RNA polymerase II. PLoS Genet (2008) 1.75
ARABIDOPSIS TRITHORAX1 dynamically regulates FLOWERING LOCUS C activation via histone 3 lysine 4 trimethylation. Plant Cell (2008) 1.66
Polycomb preferentially targets stalled promoters of coding and noncoding transcripts. Genome Res (2010) 1.63
The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis. Epigenetics Chromatin (2009) 1.59
RNA at the steering wheel. Genome Biol (2006) 1.57
Antagonism between MES-4 and Polycomb repressive complex 2 promotes appropriate gene expression in C. elegans germ cells. Cell Rep (2012) 1.56
Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence. PLoS One (2009) 1.48
Increased apoptosis and skewed differentiation in mouse embryonic stem cells lacking the histone methyltransferase Mll2. Mol Biol Cell (2007) 1.48
Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance. Proc Natl Acad Sci U S A (2009) 1.45
Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins. Proc Natl Acad Sci U S A (2007) 1.41
Molecular integration of wingless, decapentaplegic, and autoregulatory inputs into Distalless during Drosophila leg development. Dev Cell (2008) 1.40
Monovalent and unpoised status of most genes in undifferentiated cell-enriched Drosophila testis. Genome Biol (2010) 1.38
Regulation of transcription in plants: mechanisms controlling developmental switches. Nat Rev Genet (2010) 1.38
Trithorax requires Hsp90 for maintenance of active chromatin at sites of gene expression. Proc Natl Acad Sci U S A (2009) 1.31
A view of nuclear Polycomb bodies. Curr Opin Genet Dev (2011) 1.31
A mono-allelic bivalent chromatin domain controls tissue-specific imprinting at Grb10. EMBO J (2008) 1.27
Chromatin sampling--an emerging perspective on targeting polycomb repressor proteins. PLoS Genet (2013) 1.23
The Arabidopsis homologs of trithorax (ATX1) and enhancer of zeste (CLF) establish 'bivalent chromatin marks' at the silent AGAMOUS locus. Nucleic Acids Res (2007) 1.20
Transcriptional silencing by polycomb-group proteins. Cold Spring Harb Perspect Biol (2014) 1.19
Functional dissection of the ash2 and ash1 transcriptomes provides insights into the transcriptional basis of wing phenotypes and reveals conserved protein interactions. Genome Biol (2007) 1.18
Regulating a master regulator: establishing tissue-specific gene expression in skeletal muscle. Epigenetics (2010) 1.17
The SAND domain protein ULTRAPETALA1 acts as a trithorax group factor to regulate cell fate in plants. Genes Dev (2009) 1.17
Mitotic bookmarking of formerly active genes: keeping epigenetic memories from fading. Cell Cycle (2009) 1.15
The MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset. Nucleic Acids Res (2011) 1.13
Polycomb repressive complex 2-dependent and -independent functions of Jarid2 in transcriptional regulation in Drosophila. Mol Cell Biol (2012) 1.10
Hsp90 affecting chromatin remodeling might explain transgenerational epigenetic inheritance in Drosophila. Curr Genomics (2008) 1.09
Inner workings and regulatory inputs that control Polycomb repressive complex 2. Chromosoma (2012) 1.07
Monomethyl histone H3 lysine 4 as an epigenetic mark for silenced euchromatin in Chlamydomonas. Plant Cell (2005) 1.06
dSet1 is the main H3K4 di- and tri-methyltransferase throughout Drosophila development. Genetics (2011) 1.05
Insulators target active genes to transcription factories and polycomb-repressed genes to polycomb bodies. PLoS Genet (2013) 1.03
Targeted deficiency of the transcriptional activator Hnf1alpha alters subnuclear positioning of its genomic targets. PLoS Genet (2008) 0.99
The nuclear organization of Polycomb/Trithorax group response elements in larval tissues of Drosophila melanogaster. Chromosome Res (2008) 0.97
Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines. Mol Cancer (2010) 0.96
Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression. PLoS One (2011) 0.95
A novel human polycomb binding site acts as a functional polycomb response element in Drosophila. PLoS One (2012) 0.93
EMBRYONIC FLOWER1 and ULTRAPETALA1 Act Antagonistically on Arabidopsis Development and Stress Response. Plant Physiol (2013) 0.91
Inactivation of intergenic enhancers by EBNA3A initiates and maintains polycomb signatures across a chromatin domain encoding CXCL10 and CXCL9. PLoS Pathog (2013) 0.90
Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila. Genome Biol (2008) 0.90
R loops regulate promoter-proximal chromatin architecture and cellular differentiation. Nat Struct Mol Biol (2015) 0.88
Psip1/Ledgf p75 restrains Hox gene expression by recruiting both trithorax and polycomb group proteins. Nucleic Acids Res (2014) 0.87
The trithorax group proteins Kismet and ASH1 promote H3K36 dimethylation to counteract Polycomb group repression in Drosophila. Development (2013) 0.87
The histone H3-K27 demethylase Utx regulates HOX gene expression in Drosophila in a temporally restricted manner. Development (2013) 0.86
Coordinated regulation of Myc trans-activation targets by Polycomb and the Trithorax group protein Ash1. BMC Mol Biol (2007) 0.85
Quantitative in vivo analysis of chromatin binding of Polycomb and Trithorax group proteins reveals retention of ASH1 on mitotic chromatin. Nucleic Acids Res (2013) 0.85
Histone H2A ubiquitination inhibits the enzymatic activity of H3 lysine 36 methyltransferases. J Biol Chem (2013) 0.83
Proper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeleton. Dev Growth Differ (2008) 0.82
Regulation of cellular chromatin state: insights from quiescence and differentiation. Organogenesis (2010) 0.82
An Evolutionary Conserved Epigenetic Mark of Polycomb Response Elements Implemented by Trx/MLL/COMPASS. Mol Cell (2016) 0.81
Establishment of a Developmental Compartment Requires Interactions between Three Synergistic Cis-regulatory Modules. PLoS Genet (2015) 0.81
Transcriptional regulation by trithorax-group proteins. Cold Spring Harb Perspect Biol (2014) 0.81
The genetics and epigenetics of kidney development. Semin Nephrol (2013) 0.80
Identification and Validation of a Putative Polycomb Responsive Element in the Human Genome. PLoS One (2013) 0.80
Epigenetics in kidney development and renal disease. Transl Res (2014) 0.80
Dual functionality of cis-regulatory elements as developmental enhancers and Polycomb response elements. Genes Dev (2017) 0.79
The BET protein FSH functionally interacts with ASH1 to orchestrate global gene activity in Drosophila. Genome Biol (2013) 0.79
Interdependence of PRC1 and PRC2 for recruitment to Polycomb Response Elements. Nucleic Acids Res (2016) 0.78
An interactive network of long non-coding RNAs facilitates the Drosophila sex determination decision. Biochim Biophys Acta (2014) 0.78
Histone methyltransferase Ash1L mediates activity-dependent repression of neurexin-1α. Sci Rep (2016) 0.76
The Histone Methyltransferase Gene Absent, Small, or Homeotic Discs-1 Like Is Required for Normal Hox Gene Expression and Fertility in Mice. Biol Reprod (2015) 0.75
Polycomb-dependent nucleolus localization of Jumonji/Jarid2 during Drosophila spermatogenesis. Spermatogenesis (2016) 0.75
An Ash1-Like Protein MoKMT2H Null Mutant Is Delayed for Conidium Germination and Pathogenesis in Magnaporthe oryzae. Biomed Res Int (2016) 0.75
Recognition of methylated peptides by Drosophila melanogaster polycomb chromodomain. J Proteome Res (2013) 0.75
Drosophila poised enhancers are generated during tissue patterning with the help of repression. Genome Res (2016) 0.75
dBRWD3 Regulates Tissue Overgrowth and Ectopic Gene Expression Caused by Polycomb Group Mutations. PLoS Genet (2016) 0.75
Slow Chromatin Dynamics Allow Polycomb Target Genes to Filter Fluctuations in Transcription Factor Activity. Cell Syst (2017) 0.75
Systems biology meets chromatin function: a report on the Fourth Elmau Conference on Nuclear Organization. Chromosome Res (2007) 0.75
Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science (2002) 24.31
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev (2002) 13.08
Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell (2002) 13.05
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell (2002) 12.28
Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. Mol Cell (2003) 11.78
MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol Cell (2002) 8.17
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev (2003) 7.91
Stabilization of chromatin structure by PRC1, a Polycomb complex. Cell (1999) 6.90
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol Cell (2002) 6.72
Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev (2003) 5.77
Reconstitution of a functional core polycomb repressive complex. Mol Cell (2001) 4.39
Retracted Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1. Nature (2002) 4.18
A Drosophila Polycomb group complex includes Zeste and dTAFII proteins. Nature (2001) 3.90
Mechanisms of transcriptional memory. Nat Rev Mol Cell Biol (2001) 3.56
Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products. Development (1992) 3.47
Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes. Curr Opin Genet Dev (2002) 3.25
Altered distributions of Ultrabithorax transcripts in extra sex combs mutant embryos of Drosophila. EMBO J (1985) 3.08
The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains. Proc Natl Acad Sci U S A (1990) 2.85
Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. Proc Natl Acad Sci U S A (1999) 2.76
Polycomb group proteins and heritable silencing of Drosophila Hox genes. Development (2001) 2.67
Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene. Science (2001) 2.61
Trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each. Development (1993) 1.92
ASH1, a Drosophila trithorax group protein, is required for methylation of lysine 4 residues on histone H3. Proc Natl Acad Sci U S A (2003) 1.84
The Drosophila brahma complex is an essential coactivator for the trithorax group protein zeste. Genes Dev (2000) 1.79
Trans-regulation of thoracic homeotic selector genes of the Antennapedia and bithorax complexes by the trithorax group genes: absent, small, and homeotic discs 1 and 2. Mech Dev (1995) 1.66
The Drosophila trithorax protein is a coactivator required to prevent re-establishment of polycomb silencing. Development (2002) 1.45
Differential expression of bithorax complex genes in the absence of the extra sex combs and trithorax genes. Nature (2014) 1.08
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature (2010) 5.23
Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins. Genes Dev (2006) 5.03
A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities. Genes Dev (2006) 3.49
Essential role of the glycosyltransferase sxc/Ogt in polycomb repression. Science (2009) 3.44
Histone methylation by PRC2 is inhibited by active chromatin marks. Mol Cell (2011) 3.14
Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes. EMBO J (2007) 2.49
Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila. Dev Cell (2008) 2.41
A histone mutant reproduces the phenotype caused by loss of histone-modifying factor Polycomb. Science (2013) 2.31
Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex. Mol Cell (2008) 2.09
Nucleosome binding and histone methyltransferase activity of Drosophila PRC2. EMBO Rep (2005) 1.95
A genetic screen identifies novel polycomb group genes in Drosophila. Genetics (2007) 1.60
Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt. EMBO J (2009) 1.42
Analysis of a polycomb group protein defines regions that link repressive activity on nucleosomal templates to in vivo function. Mol Cell Biol (2005) 1.36
Structural and functional analyses of methyl-lysine binding by the malignant brain tumour repeat protein Sex comb on midleg. EMBO Rep (2007) 1.36
General transcriptional silencing by a Polycomb response element in Drosophila. Development (2004) 1.15
The role of the histone H2A ubiquitinase Sce in Polycomb repression. Development (2011) 1.14
Molecular and genetic analysis of the Polycomb group gene Sex combs extra/Ring in Drosophila. Mech Dev (2003) 1.05
The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. Nat Cell Biol (2011) 1.05
Structure of an atypical Tudor domain in the Drosophila Polycomblike protein. Protein Sci (2010) 0.94
Histone H2A monoubiquitination and Polycomb repression: the missing pieces of the puzzle. Fly (Austin) (2012) 0.88
The histone H3-K27 demethylase Utx regulates HOX gene expression in Drosophila in a temporally restricted manner. Development (2013) 0.86
Structural basis for targeting the chromatin repressor Sfmbt to Polycomb response elements. Genes Dev (2013) 0.85