Published in Science on November 09, 2001
Mechanisms of polycomb gene silencing: knowns and unknowns. Nat Rev Mol Cell Biol (2009) 9.29
Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol Cell Biol (2004) 6.55
Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins. Genes Dev (2006) 5.03
Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference. Cell (2006) 3.76
The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. Annu Rev Biochem (2012) 3.61
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc Natl Acad Sci U S A (2005) 3.37
CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing. Development (2009) 3.34
Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations. J Clin Invest (2006) 3.27
The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. Mol Cell Biol (2002) 3.13
A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory. Cell (2009) 2.74
Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. Mol Cell Biol (2003) 2.70
Trithorax group proteins: switching genes on and keeping them active. Nat Rev Mol Cell Biol (2011) 2.56
The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins. EMBO Rep (2004) 2.36
Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression. Genes Dev (2006) 2.20
Alternative epigenetic chromatin states of polycomb target genes. PLoS Genet (2010) 2.15
Inheritance of Polycomb-dependent chromosomal interactions in Drosophila. Genes Dev (2003) 2.07
From genetics to epigenetics: the tale of Polycomb group and trithorax group genes. Chromosome Res (2006) 2.04
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis. Cancer Cell (2011) 2.01
Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins. Nat Rev Cancer (2010) 1.93
A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc development. Genes Dev (2002) 1.85
ASH1, a Drosophila trithorax group protein, is required for methylation of lysine 4 residues on histone H3. Proc Natl Acad Sci U S A (2003) 1.84
The Drosophila BRM complex facilitates global transcription by RNA polymerase II. EMBO J (2002) 1.78
Drosophila Kismet regulates histone H3 lysine 27 methylation and early elongation by RNA polymerase II. PLoS Genet (2008) 1.75
The COMPASS family of H3K4 methylases in Drosophila. Mol Cell Biol (2011) 1.54
The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity. Development (2008) 1.54
Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor. Genes Dev (2003) 1.47
Comparative analysis of SET domain proteins in maize and Arabidopsis reveals multiple duplications preceding the divergence of monocots and dicots. Plant Physiol (2003) 1.47
Native and recombinant polycomb group complexes establish a selective block to template accessibility to repress transcription in vitro. Mol Cell Biol (2002) 1.47
Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription. EMBO J (2011) 1.44
Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins. Proc Natl Acad Sci U S A (2007) 1.41
CBP binding outside of promoters and enhancers in Drosophila melanogaster. Epigenetics Chromatin (2015) 1.41
Plant SET domain-containing proteins: structure, function and regulation. Biochim Biophys Acta (2007) 1.36
The highly similar Arabidopsis homologs of trithorax ATX1 and ATX2 encode proteins with divergent biochemical functions. Plant Cell (2008) 1.35
ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia. Br J Cancer (2004) 1.34
Trithorax requires Hsp90 for maintenance of active chromatin at sites of gene expression. Proc Natl Acad Sci U S A (2009) 1.31
A view of nuclear Polycomb bodies. Curr Opin Genet Dev (2011) 1.31
Chromatin inheritance upon Zeste-mediated Brahma recruitment at a minimal cellular memory module. EMBO J (2004) 1.25
A role for Set1/MLL-related components in epigenetic regulation of the Caenorhabditis elegans germ line. PLoS Genet (2011) 1.22
The Arabidopsis homologs of trithorax (ATX1) and enhancer of zeste (CLF) establish 'bivalent chromatin marks' at the silent AGAMOUS locus. Nucleic Acids Res (2007) 1.20
Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27. Mol Cell Biol (2012) 1.20
A polycomb group protein is retained at specific sites on chromatin in mitosis. PLoS Genet (2012) 1.19
Proteogenomic characterization and mapping of nucleosomes decoded by Brd and HP1 proteins. Genome Biol (2012) 1.18
Functional dissection of the ash2 and ash1 transcriptomes provides insights into the transcriptional basis of wing phenotypes and reveals conserved protein interactions. Genome Biol (2007) 1.18
Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human. FEBS J (2010) 1.12
Retinoid signaling and neurogenin2 function are coupled for the specification of spinal motor neurons through a chromatin modifier CBP. Neuron (2009) 1.11
Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1. J Clin Invest (2002) 1.07
Inner workings and regulatory inputs that control Polycomb repressive complex 2. Chromosoma (2012) 1.07
dSet1 is the main H3K4 di- and tri-methyltransferase throughout Drosophila development. Genetics (2011) 1.05
The DNA-binding Polycomb-group protein Pleiohomeotic maintains both active and repressed transcriptional states through a single site. Development (2008) 1.03
CREB binding protein functions during successive stages of eye development in Drosophila. Genetics (2004) 1.03
Drosophila ptip is essential for anterior/posterior patterning in development and interacts with the PcG and trxG pathways. Development (2009) 1.01
Stepwise histone modifications are mediated by multiple enzymes that rapidly associate with nascent DNA during replication. Nat Commun (2013) 1.01
The trithorax group and Pc group proteins are differentially involved in heterochromatin formation in Drosophila. Chromosoma (2007) 0.99
A chromatin link to caste identity in the carpenter ant Camponotus floridanus. Genome Res (2012) 0.99
Trithorax monomethylates histone H3K4 and interacts directly with CBP to promote H3K27 acetylation and antagonize Polycomb silencing. Development (2014) 0.97
The nuclear organization of Polycomb/Trithorax group response elements in larval tissues of Drosophila melanogaster. Chromosome Res (2008) 0.97
The Drosophila SNR1 (SNF5/INI1) subunit directs essential developmental functions of the Brahma chromatin remodeling complex. Mol Cell Biol (2003) 0.96
Role of chromatin states in transcriptional memory. Biochim Biophys Acta (2009) 0.94
Trithorax interacts with type 1 serine/threonine protein phosphatase in Drosophila. EMBO Rep (2003) 0.93
Functional role of CREB-binding protein in the circadian clock system of Drosophila melanogaster. Mol Cell Biol (2007) 0.91
Phosphatidylinositol 5-phosphate links dehydration stress to the activity of ARABIDOPSIS TRITHORAX-LIKE factor ATX1. PLoS One (2010) 0.90
A genetic screen identifies putative targets and binding partners of CREB-binding protein in the developing Drosophila eye. Genetics (2005) 0.89
The Arabidopsis chromatin modifier ATX1, the myotubularin-like AtMTM and the response to drought. Plant Signal Behav (2009) 0.89
dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX. Biochem J (2006) 0.89
The trithorax group proteins Kismet and ASH1 promote H3K36 dimethylation to counteract Polycomb group repression in Drosophila. Development (2013) 0.87
Trithorax group protein Oryza sativa Trithorax1 controls flowering time in rice via interaction with early heading date3. Plant Physiol (2014) 0.86
The cis-regulatory code of Hox function in Drosophila. EMBO J (2012) 0.83
Corto and DSP1 interact and bind to a maintenance element of the Scr Hox gene: understanding the role of Enhancers of trithorax and Polycomb. BMC Biol (2006) 0.83
Proper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeleton. Dev Growth Differ (2008) 0.82
The role of menin in hematopoiesis. Adv Exp Med Biol (2009) 0.82
Phenotypic Plasticity through Transcriptional Regulation of the Evolutionary Hotspot Gene tan in Drosophila melanogaster. PLoS Genet (2016) 0.81
Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory. Elife (2016) 0.81
Transcriptional regulation by trithorax-group proteins. Cold Spring Harb Perspect Biol (2014) 0.81
Regulation by polycomb and trithorax group proteins in Arabidopsis. Arabidopsis Book (2010) 0.80
The Arabidopsis thaliana SET-domain-containing protein ASHH1/SDG26 interacts with itself and with distinct histone lysine methyltransferases. J Plant Res (2012) 0.79
Epigenetic transcriptional memory. Curr Genet (2016) 0.78
Gene silencing and Polycomb group proteins: an overview of their structure, mechanisms and phylogenetics. OMICS (2013) 0.77
Heterochromatin-mediated gene silencing is not affected by Drosophila CBP activity. J Hered (2009) 0.76
Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain. Proc Natl Acad Sci U S A (2016) 0.76
A phylogenetic survey of myotubularin genes of eukaryotes: distribution, protein structure, evolution, and gene expression. BMC Evol Biol (2010) 0.76
Polycomb and trithorax opposition in development and disease. Wiley Interdiscip Rev Dev Biol (2016) 0.76
Slow Chromatin Dynamics Allow Polycomb Target Genes to Filter Fluctuations in Transcription Factor Activity. Cell Syst (2017) 0.75
Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70. Epigenetics Chromatin (2017) 0.75
A global optimisation method for robust affine registration of brain images. Med Image Anal (2001) 27.87
Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging (2001) 25.22
Entropic elasticity of lambda-phage DNA. Science (1994) 15.40
A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science (1995) 15.20
The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell (1996) 15.19
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun (1999) 14.25
Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci U S A (1982) 11.15
CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature (1997) 10.49
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol (2000) 9.85
Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ (1995) 9.26
Large-scale temporal gene expression mapping of central nervous system development. Proc Natl Acad Sci U S A (1998) 9.06
Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science (1984) 8.80
Fused transcript of abl and bcr genes in chronic myelogenous leukaemia. Nature (1985) 8.32
Involvement of the bcl-2 gene in human follicular lymphoma. Science (1985) 8.19
Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun (2005) 7.50
Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation (2000) 6.96
The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science (1985) 6.63
Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group. N Engl J Med (1996) 6.01
Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature (1984) 5.85
Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations: a statement for healthcare professionals from the American Heart Association and the American College of Cardiology. Circulation (1999) 5.62
Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci U S A (1986) 5.54
The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell (1992) 5.39
Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation (2000) 5.36
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes (2001) 5.18
Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell (1991) 4.98
Nucleotide sequence of cloned cDNA of human c-myc oncogene. Nature (1983) 4.83
A cyclic nucleotide-gated conductance in olfactory receptor cilia. Nature (1987) 4.81
The DNA sequence and analysis of human chromosome 6. Nature (2003) 4.75
STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J (1999) 4.55
Chromosomal location of the genes for human immunoglobulin heavy chains. Proc Natl Acad Sci U S A (1979) 4.52
Clinical application of transvenous mitral commissurotomy by a new balloon catheter. J Thorac Cardiovasc Surg (1984) 4.45
Production of antibodies against influenza virus by somatic cell hybrids between mouse myeloma and primed spleen cells. Proc Natl Acad Sci U S A (1977) 4.30
Abdominal fat: standardized technique for measurement at CT. Radiology (1999) 4.25
MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma. Oncogene (2008) 4.11
MicroRNA deregulation in human thyroid papillary carcinomas. Endocr Relat Cancer (2006) 4.11
Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses. Blood (1998) 4.07
Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. J Exp Med (1997) 4.06
miR-15a and miR-16-1 in cancer: discovery, function and future perspectives. Cell Death Differ (2009) 3.94
Transcriptionally active c-myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia. Proc Natl Acad Sci U S A (1983) 3.90
Role of subunits of 60 to 70S avian tumor virus ribonucleic acid in its template activity for the viral deoxyribonucleic acid polymerase. J Virol (1972) 3.88
Systematic implementation of an advance directive program in nursing homes: a randomized controlled trial. JAMA (2000) 3.87
Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas. Science (1983) 3.82
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities. Clin Genet (1975) 3.81
Translocation of an immunoglobulin kappa locus to a region 3' of an unrearranged c-myc oncogene enhances c-myc transcription. Proc Natl Acad Sci U S A (1983) 3.75
Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. Biochem Biophys Res Commun (1984) 3.70
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci U S A (2000) 3.69
Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation. Science (1984) 3.64
Complementarity between Rous sarcoma virus (RSV) RNA and the in vitro-synthesized DNA of the virus-associated DNA polymerase. Virology (1970) 3.61
Evidence for 30-40S RNA as precursor of the 60-70S RNA of Rous sarcoma virus. Proc Natl Acad Sci U S A (1973) 3.61
Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene. Cell (1986) 3.59
A number of different nuclear genes for the small subunit of RuBPCase are transcribed in petunia. Nucleic Acids Res (1983) 3.56
Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a C lambda locus in Burkitt. Proc Natl Acad Sci U S A (1983) 3.53
Immunochemical structure of hepatitis B e antigen in the serum. J Immunol (1983) 3.50
Transcriptional activation of the translocated c-myc oncogene in burkitt lymphoma. Proc Natl Acad Sci U S A (1983) 3.46
Assignment of the genes for human lambda immunoglobulin chains to chromosome 22. Nature (1981) 3.43
Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome. Nature (1991) 3.43
Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo. J Cell Biol (1999) 3.43
Differential expression of the normal and of the translocated human c-myc oncogenes in B cells. Proc Natl Acad Sci U S A (1983) 3.43
Differential expression of the translocated and the untranslocated c-myc oncogene in Burkitt lymphoma. Science (1983) 3.40
Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion. Science (1998) 3.39
Translocation of immunoglobulin VH genes in Burkitt lymphoma. Proc Natl Acad Sci U S A (1982) 3.30
Specific microRNAs are downregulated in human thyroid anaplastic carcinomas. Oncogene (2007) 3.29
Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (1998) 3.23
Leukaemia disease genes: large-scale cloning and pathway predictions. Nat Genet (1999) 3.19
Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy. Proc Natl Acad Sci U S A (1993) 3.16
Inactivation of Bcl-2 by phosphorylation. Proc Natl Acad Sci U S A (1995) 3.13
The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. Am J Respir Crit Care Med (1996) 3.10
The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. Cancer Res (1995) 3.04
The next ten years of health spending: what does the future hold? The Health Expenditures Projection Team. Health Aff (Millwood) (1998) 3.04
Stigmatization of AIDS patients by physicians. Am J Public Health (1987) 3.03
microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer. Oncogene (2011) 3.02
Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat Med (1996) 3.02
Use of polymerase chain reaction for diagnosis of picornavirus infection in subjects with and without respiratory symptoms. J Clin Microbiol (1993) 3.01
p53 Mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res (1993) 2.99
Nucleotide sequence analysis of the transforming region and large terminal redundancies of Moloney murine sarcoma virus. Proc Natl Acad Sci U S A (1980) 2.93
Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11;14) chromosome translocation. Nature (1985) 2.91
Yeast KEX2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases. Biochem Biophys Res Commun (1988) 2.89
Respiratory epithelial cell invasion by group B streptococci. Infect Immun (1992) 2.86
A randomised controlled trial of stress reduction for hypertension in older African Americans. Hypertension (1995) 2.85
TOPS: an internet-based system to prevent healthy subjects from over-volunteering for clinical trials. Eur J Clin Pharmacol (2012) 2.80
MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia. Oncogene (2007) 2.79
Assessment of the efficacy and effectiveness of influenza vaccines in healthy children: systematic review. Lancet (2005) 2.78
Health spending growth up in 1999; faster growth expected in the future. Health Aff (Millwood) (2001) 2.77
Two-step glutamate dehydrogenase antigen real-time polymerase chain reaction assay for detection of toxigenic Clostridium difficile. J Hosp Infect (2009) 2.76
Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet (2001) 2.76
Reduction of serum uric acid by hormone replacement therapy in postmenopausal women with hyperuricaemia. Lancet (1999) 2.71
Comparison of CT scan muscle measurements and isokinetic trunk strength in postoperative patients. Spine (Phila Pa 1976) (1989) 2.70
Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax. Oncogene (1997) 2.69
The action of substances allied to 4:4'-diaminodiphenylsulphone in streptococcal and other infections in mice. Biochem J (1938) 2.69
DNA sequence of the rat growth hormone gene: location of the 5' terminus of the growth hormone mRNA and identification of an internal transposon-like element. Nucleic Acids Res (1981) 2.67
Determining the common medical presenting problems to an accident and emergency department. Arch Dis Child (2001) 2.67
Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. Genes Dev (2000) 2.65
TRF1 is a dimer and bends telomeric DNA. EMBO J (1997) 2.64
Assignment of the T-antigen gene of simian virus 40 to human chromosome C-7. Proc Natl Acad Sci U S A (1973) 2.63