Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.

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Published in Mol Biol Cell on March 26, 2004

Authors

Xu Shi-Wen1, Yunliang Chen, Christopher P Denton, Mark Eastwood, Elisabetta A Renzoni, George Bou-Gharios, Jeremy D Pearson, Michael Dashwood, Roland M du Bois, Carol M Black, Andrew Leask, David J Abraham

Author Affiliations

1: Centre for Rheumatology, Royal Free and University College Medical School, London NW3 2PF, United Kingdom.

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