Published in Nat Rev Mol Cell Biol on May 01, 2002
Cellular and molecular mechanisms of fibrosis. J Pathol (2008) 14.01
The myofibroblast: one function, multiple origins. Am J Pathol (2007) 8.64
Microenvironmental regulation of tumor progression and metastasis. Nat Med (2013) 8.37
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest (2007) 6.56
Bone marrow-derived progenitor cells in pulmonary fibrosis. J Clin Invest (2004) 5.97
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Nat Cell Biol (2010) 5.84
Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix. J Cell Biol (2007) 5.60
miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med (2010) 4.71
The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'? PLoS One (2008) 4.52
NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury. Nat Med (2009) 4.05
ECM remodeling in hypertensive heart disease. J Clin Invest (2007) 4.03
Cardiac fibroblast: the renaissance cell. Circ Res (2009) 4.01
Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration. Development (2011) 3.97
The immune system and cardiac repair. Pharmacol Res (2008) 3.42
Focal adhesion size controls tension-dependent recruitment of alpha-smooth muscle actin to stress fibers. J Cell Biol (2006) 3.37
Pulmonary fibrosis: pathogenesis, etiology and regulation. Mucosal Immunol (2009) 3.13
Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. J Cell Biol (2010) 2.96
Myocardial remodeling after infarction: the role of myofibroblasts. Nat Rev Cardiol (2009) 2.93
An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Dev Cell (2014) 2.89
The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction. J Mol Cell Cardiol (2009) 2.80
Periostin is essential for cardiac healing after acute myocardial infarction. J Exp Med (2008) 2.68
The role of endothelial-to-mesenchymal transition in cancer progression. Br J Cancer (2008) 2.67
Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β. J Clin Invest (2010) 2.64
Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells. Cancer Res (2010) 2.42
In situ elasticity modulation with dynamic substrates to direct cell phenotype. Biomaterials (2009) 2.41
The effect of matrix density on the regulation of 3-D capillary morphogenesis. Biophys J (2007) 2.37
The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration. J Cell Biol (2012) 2.34
Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT? J Cell Biochem (2007) 2.32
Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. Mol Biol Cell (2004) 2.29
Oxidative stress in pulmonary fibrosis: a possible role for redox modulatory therapy. Am J Respir Crit Care Med (2005) 2.29
Cancer associated fibroblasts: the dark side of the coin. Am J Cancer Res (2011) 2.26
TGF-β1-containing exosomes from injured epithelial cells activate fibroblasts to initiate tissue regenerative responses and fibrosis. J Am Soc Nephrol (2012) 2.24
Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts. Cell Signal (2006) 2.22
Myofibroblast and endothelial cell proliferation during murine myocardial infarct repair. Am J Pathol (2003) 2.22
Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases. Kidney Int (2011) 2.15
Activation of the pro-survival phosphatidylinositol 3-kinase/AKT pathway by transforming growth factor-beta1 in mesenchymal cells is mediated by p38 MAPK-dependent induction of an autocrine growth factor. J Biol Chem (2003) 2.12
Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am J Pathol (2006) 2.10
Fibroblast heterogeneity in the cancer wound. J Exp Med (2014) 2.09
Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase. Proc Natl Acad Sci U S A (2004) 2.02
Matricellular proteins in cardiac adaptation and disease. Physiol Rev (2012) 2.01
Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction. Circ Res (2010) 2.00
A transgenic mouse model of inducible macrophage depletion: effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes. Am J Pathol (2009) 1.99
Portal fibroblasts: Underappreciated mediators of biliary fibrosis. Hepatology (2010) 1.97
The pathogenesis of cardiac fibrosis. Cell Mol Life Sci (2013) 1.96
Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. Circ Res (2010) 1.94
Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol (2014) 1.94
Modulation of prosurvival signaling in fibroblasts by a protein kinase inhibitor protects against fibrotic tissue injury. Am J Pathol (2005) 1.93
Modulation of fibroblast morphology and adhesion during collagen matrix remodeling. Mol Biol Cell (2002) 1.92
Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues. Proc Natl Acad Sci U S A (2009) 1.89
The myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine. J Cell Mol Med (2007) 1.88
Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors. Mol Cell Biol (2006) 1.87
Cancer associated fibroblasts (CAFs) in tumor microenvironment. Front Biosci (Landmark Ed) (2010) 1.87
Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J Clin Invest (2014) 1.82
Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis. Arthritis Res Ther (2005) 1.81
Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis. J Clin Invest (2013) 1.81
Microtubule function in fibroblast spreading is modulated according to the tension state of cell-matrix interactions. Proc Natl Acad Sci U S A (2007) 1.80
NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts. J Am Soc Nephrol (2009) 1.80
A key role for NOX4 in epithelial cell death during development of lung fibrosis. Antioxid Redox Signal (2011) 1.79
Characterization of valvular interstitial cell function in three dimensional matrix metalloproteinase degradable PEG hydrogels. Biomaterials (2009) 1.77
Fibroblasts and myofibroblasts in renal fibrosis. Int J Exp Pathol (2011) 1.76
Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation. Cardiovasc Res (2010) 1.74
The myofibroblast matrix: implications for tissue repair and fibrosis. J Pathol (2013) 1.73
Connective tissue fibroblasts and Tcf4 regulate myogenesis. Development (2011) 1.72
Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts. Mol Biol Cell (2003) 1.70
Hepatic stellate cells require a stiff environment for myofibroblastic differentiation. Am J Physiol Gastrointest Liver Physiol (2011) 1.70
Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation. J Cell Biol (2014) 1.70
Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing. Am J Pathol (2006) 1.70
Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction. Am J Respir Cell Mol Biol (2012) 1.67
Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization. Mol Biol Cell (2005) 1.65
Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease. Fibrogenesis Tissue Repair (2012) 1.65
TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation. Circ Res (2010) 1.65
Origin of axial prestretch and residual stress in arteries. Biomech Model Mechanobiol (2009) 1.64
Dynamic reciprocity in the wound microenvironment. Wound Repair Regen (2011) 1.62
The precarious state of the liver after a Fontan operation: summary of a multidisciplinary symposium. Pediatr Cardiol (2012) 1.62
Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury. J Pharmacol Exp Ther (2014) 1.61
Dendritic fibroblasts in three-dimensional collagen matrices. Mol Biol Cell (2003) 1.61
Mechanical properties of cellularly responsive hydrogels and their experimental determination. Adv Mater (2010) 1.60
"Hypoxia-induced down-regulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression". J Transl Med (2010) 1.59
Fibroblast mechanics in 3D collagen matrices. Adv Drug Deliv Rev (2007) 1.58
Silk film biomaterials for cornea tissue engineering. Biomaterials (2008) 1.58
Biomechanical regulation of blood vessel growth during tissue vascularization. Nat Med (2009) 1.58
Myofibroblast development is characterized by specific cell-cell adherens junctions. Mol Biol Cell (2004) 1.56
The origin of interstitial myofibroblasts in chronic kidney disease. Pediatr Nephrol (2011) 1.55
Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential. Am J Pathol (2009) 1.55
The differential regulation of cell motile activity through matrix stiffness and porosity in three dimensional collagen matrices. Biomaterials (2010) 1.54
Collagen fibril flow and tissue translocation coupled to fibroblast migration in 3D collagen matrices. Mol Biol Cell (2008) 1.54
Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction. J Cell Biochem (2010) 1.53
High perfusion pressure accelerates renal injury in salt-sensitive hypertension. J Am Soc Nephrol (2008) 1.50
The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals. Proc Natl Acad Sci U S A (2008) 1.49
In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts. Nat Methods (2009) 1.48
Thrombospondin 1 is a key mediator of transforming growth factor β-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism. Fibrogenesis Tissue Repair (2011) 1.48
Fibrosis in connective tissue disease: the role of the myofibroblast and fibroblast-epithelial cell interactions. Arthritis Res Ther (2007) 1.47
Whole animal knockout of smooth muscle alpha-actin does not alter excisional wound healing or the fibroblast-to-myofibroblast transition. Wound Repair Regen (2012) 1.47
Tenascin-C regulates recruitment of myofibroblasts during tissue repair after myocardial injury. Am J Pathol (2005) 1.46
The role of the myofibroblast in tumor stroma remodeling. Cell Adh Migr (2012) 1.46
The extracellular matrix: an active or passive player in fibrosis? Am J Physiol Gastrointest Liver Physiol (2011) 1.46
Filamentous network mechanics and active contractility determine cell and tissue shape. Biophys J (2008) 1.44
Mesenchymal-endothelial transition contributes to cardiac neovascularization. Nature (2014) 1.44
Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms. Exp Cell Res (2010) 1.43
The myofibroblast: one function, multiple origins. Am J Pathol (2007) 8.64
Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix. J Cell Biol (2007) 5.60
Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol (2007) 5.22
Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. Am J Pathol (2012) 4.13
Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome. Circulation (2007) 3.77
Tissue repair, contraction, and the myofibroblast. Wound Repair Regen (2005) 3.70
Neuronal competition and selection during memory formation. Science (2007) 3.48
Focal adhesion size controls tension-dependent recruitment of alpha-smooth muscle actin to stress fibers. J Cell Biol (2006) 3.37
The stroma reaction myofibroblast: a key player in the control of tumor cell behavior. Int J Dev Biol (2004) 3.34
Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship. Eur J Cell Biol (2008) 2.74
Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma. Mol Cell (2009) 2.50
Mechanisms of force generation and transmission by myofibroblasts. Curr Opin Biotechnol (2003) 2.43
Normal and pathologic soft tissue remodeling: role of the myofibroblast, with special emphasis on liver and kidney fibrosis. Lab Invest (2003) 2.27
Smooth muscle cell plasticity: fact or fiction? Circ Res (2012) 2.18
Arterial smooth muscle cell heterogeneity: implications for atherosclerosis and restenosis development. Arterioscler Thromb Vasc Biol (2003) 2.17
Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro. J Cell Sci (2005) 2.07
Endogenous angiotensin II induces atherosclerotic plaque vulnerability and elicits a Th1 response in ApoE-/- mice. Hypertension (2004) 1.89
The clinical use of various blood compartments for cytomegalovirus (CMV) DNA quantitation in transplant recipients with CMV disease. Transplantation (2002) 1.86
The NH2-terminal peptide of alpha-smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo. J Cell Biol (2002) 1.82
Selective reactivation of human herpesvirus 6 variant a occurs in critically ill immunocompetent hosts. J Infect Dis (2001) 1.81
A key role for NOX4 in epithelial cell death during development of lung fibrosis. Antioxid Redox Signal (2011) 1.79
Relationship between Toll-like receptor 2 polymorphism and cytomegalovirus disease after liver transplantation. Clin Infect Dis (2007) 1.75
The myofibroblast matrix: implications for tissue repair and fibrosis. J Pathol (2013) 1.73
Beta and gamma-cytoplasmic actins display distinct distribution and functional diversity. J Cell Sci (2009) 1.72
Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts. Mol Biol Cell (2003) 1.70
A large population of 'Lyman-break' galaxies in a protocluster at redshift z approximately 4.1. Nature (2004) 1.59
A rapid fabricated living dermal equivalent for skin tissue engineering: an in vivo evaluation in an acute wound model. Tissue Eng Part A (2011) 1.58
The mechanical memory of lung myofibroblasts. Integr Biol (Camb) (2012) 1.50
Guiding cell migration in 3D: a collagen matrix with graded directional stiffness. Cell Motil Cytoskeleton (2009) 1.49
Clinical significance of pretransplant chromosomally integrated human herpesvirus-6 in liver transplant recipients. Transplantation (2011) 1.47
The role of the myofibroblast in tumor stroma remodeling. Cell Adh Migr (2012) 1.46
Fibrosis: recent advances in myofibroblast biology and new therapeutic perspectives. F1000 Biol Rep (2010) 1.41
Cell-matrix and cell-cell contacts of myofibroblasts: role in connective tissue remodeling. Thromb Haemost (2003) 1.41
Evidence of an intracellular reservoir in the nasal mucosa of patients with recurrent Staphylococcus aureus rhinosinusitis. J Infect Dis (2005) 1.39
Biomedical research publication system. Science (2004) 1.39
The single-molecule mechanics of the latent TGF-β1 complex. Curr Biol (2011) 1.37
MR perfusion and diffusion in acute ischemic stroke: human gray and white matter have different thresholds for infarction. J Cereb Blood Flow Metab (2005) 1.25
Isoform-specific regulation of the actin-organizing protein palladin during TGF-beta1-induced myofibroblast differentiation. J Invest Dermatol (2006) 1.24
Cellular retinol-binding protein-1 expression and modulation during in vivo and in vitro myofibroblastic differentiation of rat hepatic stellate cells and portal fibroblasts. Lab Invest (2002) 1.23
Intimal smooth muscle cells of porcine and human coronary artery express S100A4, a marker of the rhomboid phenotype in vitro. Circ Res (2007) 1.23
Wound-healing defect of CD18(-/-) mice due to a decrease in TGF-beta1 and myofibroblast differentiation. EMBO J (2005) 1.22
Acquisition and performance of goal-directed instrumental actions depends on ERK signaling in distinct regions of dorsal striatum in rats. J Neurosci (2010) 1.22
Plastic compressed collagen as a biomimetic substrate for human limbal epithelial cell culture. Biomaterials (2010) 1.21
Aging, smooth muscle cells and vascular pathobiology: implications for atherosclerosis. Atherosclerosis (2006) 1.17
Tumor cell invasion is promoted by interstitial flow-induced matrix priming by stromal fibroblasts. Cancer Res (2011) 1.16
Myofibroblast communication is controlled by intercellular mechanical coupling. J Cell Sci (2008) 1.16
Contraction of myofibroblasts in granulation tissue is dependent on Rho/Rho kinase/myosin light chain phosphatase activity. Wound Repair Regen (2006) 1.15
Dissecting the roles of endothelin, TGF-beta and GM-CSF on myofibroblast differentiation by keratinocytes. Thromb Haemost (2004) 1.15
The pathogenesis of hepatitis C virus is influenced by cytomegalovirus. Clin Infect Dis (2002) 1.13
Myofibroblast-mediated adventitial remodeling: an underestimated player in arterial pathology. Arterioscler Thromb Vasc Biol (2011) 1.13
Regulation of myofibroblast activities: calcium pulls some strings behind the scene. Exp Cell Res (2010) 1.13
The covalent attachment of adhesion molecules to silicone membranes for cell stretching applications. Biomaterials (2008) 1.12
Pathological situations characterized by altered actin isoform expression. J Pathol (2004) 1.10
A new lock-step mechanism of matrix remodelling based on subcellular contractile events. J Cell Sci (2010) 1.10
Parvovirus B19 infection after transplantation: a review of 98 cases. Clin Infect Dis (2006) 1.09
Phenotypic modulation of intima and media smooth muscle cells in fatal cases of coronary artery lesion. Arterioscler Thromb Vasc Biol (2005) 1.09
Expression and function of alpha-smooth muscle actin during embryonic-stem-cell-derived cardiomyocyte differentiation. J Cell Sci (2006) 1.08
A longitudinal molecular surveillance study of human polyomavirus viremia in heart, kidney, liver, and pancreas transplant patients. J Infect Dis (2005) 1.05
γ-Actin regulates cell migration and modulates the ROCK signaling pathway. FASEB J (2011) 1.05
Dietary cholesterol withdrawal reduces vascular inflammation and induces coronary plaque stabilization in miniature pigs. Cardiovasc Res (2002) 1.05
Asp1424Asn MYH9 mutation results in an unstable protein responsible for the phenotypes in May-Hegglin anomaly/Fechtner syndrome. Blood (2003) 1.04
Blood pressure, cardiac, and renal responses to salt and deoxycorticosterone acetate in mice: role of Renin genes. J Am Soc Nephrol (2002) 1.04
Correlation of alpha-skeletal actin expression, ventricular fibrosis and heart function with the degree of pressure overload cardiac hypertrophy in rats. Exp Physiol (2006) 1.04
Heterogeneity of smooth muscle cell populations cultured from pig coronary artery. Arterioscler Thromb Vasc Biol (2002) 1.03
Cellular retinol-binding protein-1 expression in normal and fibrotic/cirrhotic human liver: different patterns of expression in hepatic stellate cells and (myo)fibroblast subpopulations. J Hepatol (2004) 1.03
Alpha-actin isoform distribution in normal and failing human heart: a morphological, morphometric, and biochemical study. J Pathol (2003) 1.03
The use of injectable forms of fibrin and fibronectin to support axonal ingrowth after spinal cord injury. Biomaterials (2010) 1.03
Spectrum of early-onset and late-onset bacteremias after liver transplantation: implications for management. Liver Transpl (2011) 1.02
Lkb1 is required for TGFbeta-mediated myofibroblast differentiation. J Cell Sci (2008) 1.01
Nonactivated versus thrombin-activated platelets on wound healing and fibroblast-to-myofibroblast differentiation in vivo and in vitro. Plast Reconstr Surg (2012) 1.01
Re-expression of alpha skeletal actin as a marker for dedifferentiation in cardiac pathologies. J Cell Mol Med (2009) 1.01
Modulation of actin isoform expression before the transition from experimental compensated pressure-overload cardiac hypertrophy to decompensation. Am J Physiol Heart Circ Physiol (2009) 1.00
Hypoxia impairs skin myofibroblast differentiation and function. J Invest Dermatol (2010) 0.99
The early surface cell response to flexor tendon injury. J Hand Surg Am (2003) 0.99
Biochemical evidence for interaction between smoothelin and filamentous actin. Exp Cell Res (2004) 0.98
Evidence for sequential utilization of fibronectin, vitronectin, and collagen during fibroblast-mediated collagen contraction. Wound Repair Regen (2002) 0.98
Effect of cell density on osteoblastic differentiation and matrix degradation of biomimetic dense collagen scaffolds. Biomacromolecules (2007) 0.98
Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β. Hum Mol Genet (2013) 0.97
Myofibroblasts work best under stress. J Bodyw Mov Ther (2008) 0.97
The N-terminal Ac-EEED sequence plays a role in alpha-smooth-muscle actin incorporation into stress fibers. J Cell Sci (2005) 0.96
Homozygosity for the toll-like receptor 2 R753Q single-nucleotide polymorphism is a risk factor for cytomegalovirus disease after liver transplantation. J Infect Dis (2012) 0.96
Neural tissue engineering: a self-organizing collagen guidance conduit. Tissue Eng (2005) 0.95
In situ monitoring of tendon structural changes by elastic scattering spectroscopy: correlation with changes in collagen fibril diameter and crimp. Tissue Eng (2006) 0.95
Cells lacking β-actin are genetically reprogrammed and maintain conditional migratory capacity. Mol Cell Proteomics (2012) 0.95
Cellular retinol-binding protein-1 in hepatocellular carcinoma correlates with beta-catenin, Ki-67 index, and patient survival. Hepatology (2003) 0.95
Intermediate filament protein synemin is present in human reactive and malignant astrocytes and associates with ruffled membranes in astrocytoma cells. Glia (2005) 0.95