Published in J Biol Chem on February 16, 2006
Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol (2008) 3.62
Matricellular proteins in cardiac adaptation and disease. Physiol Rev (2012) 2.01
Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease? J Cell Commun Signal (2009) 2.00
Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. Circ Res (2010) 1.94
Reduced expression of connective tissue growth factor (CTGF/CCN2) mediates collagen loss in chronologically aged human skin. J Invest Dermatol (2009) 1.93
Connective tissue growth factor promotes fibrosis downstream of TGFbeta and IL-6 in chronic cardiac allograft rejection. Am J Transplant (2009) 1.59
Thrombospondin 1 is a key mediator of transforming growth factor β-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism. Fibrogenesis Tissue Repair (2011) 1.48
Retracted GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism. J Clin Invest (2008) 1.46
Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts. PLoS One (2017) 1.39
Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo. J Cell Commun Signal (2009) 1.33
CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis. PLoS One (2012) 1.33
The gene expression profile induced by Wnt 3a in NIH 3T3 fibroblasts. J Cell Commun Signal (2008) 1.21
FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype. Mol Biol Cell (2007) 1.19
Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK. J Cell Commun Signal (2007) 1.13
Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis. Biochim Biophys Acta (2013) 1.11
Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair. J Cell Sci (2012) 1.09
Yin and Yang: CCN3 inhibits the pro-fibrotic effects of CCN2. J Cell Commun Signal (2009) 1.09
Scar wars: is TGFbeta the phantom menace in scleroderma? Arthritis Res Ther (2006) 1.05
Periostin facilitates skin sclerosis via PI3K/Akt dependent mechanism in a mouse model of scleroderma. PLoS One (2012) 1.05
Connective tissue growth factor promoter activity in normal and wounded skin. Fibrogenesis Tissue Repair (2008) 1.05
Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2. J Biol Chem (2008) 1.04
The mechanism of TGF-β signaling during palate development. Oral Dis (2011) 1.04
Rac1 expression by fibroblasts is required for tissue repair in vivo. Am J Pathol (2009) 1.03
The immunology of fibrosis: innate and adaptive responses. Trends Immunol (2010) 1.01
Connective tissue growth factor/CCN2-null mouse embryonic fibroblasts retain intact transforming growth factor-beta responsiveness. Exp Cell Res (2007) 0.99
Molecular requirements for induction of CTGF expression by TGF-beta1 in primary osteoblasts. Bone (2008) 0.99
The molecular mechanism of hypertrophic scar. J Cell Commun Signal (2013) 0.97
Regulation of CCN2 mRNA expression and promoter activity in activated hepatic stellate cells. J Cell Commun Signal (2008) 0.97
JunB mediates enhancer/promoter activity of COL1A2 following TGF-beta induction. Nucleic Acids Res (2009) 0.93
Hypoxia in human trophoblasts stimulates the expression and secretion of connective tissue growth factor. Endocrinology (2008) 0.93
Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling. Mol Cell Biol (2015) 0.90
Towards an anti-fibrotic therapy for scleroderma: targeting myofibroblast differentiation and recruitment. Fibrogenesis Tissue Repair (2010) 0.90
New strategy to control cell migration and metastasis regulated by CCN2/CTGF. Cancer Cell Int (2014) 0.89
Cardiac stem cells with electrical stimulation improve ischaemic heart function through regulation of connective tissue growth factor and miR-378. Cardiovasc Res (2013) 0.89
Possible strategies for anti-fibrotic drug intervention in scleroderma. J Cell Commun Signal (2011) 0.89
Mechanisms of bronchopulmonary dysplasia. J Cell Commun Signal (2013) 0.88
CCN3: A novel function in vivo. J Cell Commun Signal (2008) 0.87
Cell surface receptors for CCN proteins. J Cell Commun Signal (2016) 0.86
Yin and Yang Part Deux: CCN5 inhibits the pro-fibrotic effects of CCN2. J Cell Commun Signal (2010) 0.85
CCN2 is required for recruitment of Sox2-expressing cells during cutaneous tissue repair. J Cell Commun Signal (2014) 0.85
CCN2 is not required for skin development. J Cell Commun Signal (2011) 0.82
Connective tissue growth factor modulates podocyte actin cytoskeleton and extracellular matrix synthesis and is induced in podocytes upon injury. Histochem Cell Biol (2011) 0.80
CCN2 modulates hair follicle cycling in mice. Mol Biol Cell (2013) 0.78
Ceramide inhibits CCN2 expression in fibroblasts. J Cell Commun Signal (2008) 0.78
Quantitative proteomics analysis of the effects of ionizing radiation in wild type and p53 K317R knock-in mouse thymocytes. Mol Cell Proteomics (2008) 0.78
The molecular basis of hypertrophic scars. Burns Trauma (2016) 0.78
AFAP1 Is a Novel Downstream Mediator of TGF-β1 for CCN2 Induction in Osteoblasts. PLoS One (2015) 0.78
EGCG blocks TGFβ1-induced CCN2 by suppressing JNK and p38 in buccal fibroblasts. Clin Oral Investig (2012) 0.78
CCN2: a bona fide target for anti-fibrotic drug intervention. J Cell Commun Signal (2011) 0.78
Tumour cells down-regulate CCN2 gene expression in co-cultured fibroblasts in a Smad7- and ERK-dependent manner. Cell Commun Signal (2013) 0.77
Increased fibroblast functionality on CNN2-loaded titania nanotubes. Int J Nanomedicine (2012) 0.77
Growth factor PDGF-BB stimulates cultured cardiomyocytes to synthesize the extracellular matrix component hyaluronan. PLoS One (2010) 0.77
Getting out of a sticky situation: targeting the myofibroblast in scleroderma. Open Rheumatol J (2012) 0.77
Cell-type-specific differentiation and molecular profiles in skin transplantation: implication of medical approach for genetic skin diseases. J Transplant (2011) 0.77
Loss of PPARγ expression by fibroblasts enhances dermal wound closure. Fibrogenesis Tissue Repair (2012) 0.77
Inhibitory effects of PPARγ ligands on TGF-β1-induced CTGF expression in cat corneal fibroblasts. Exp Eye Res (2015) 0.76
Tracheal Aspirate Levels of the Matricellular Protein SPARC Predict Development of Bronchopulmonary Dysplasia. PLoS One (2015) 0.76
Quantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation. PLoS One (2017) 0.75
CCN2: a mechanosignaling sensor modulating integrin-dependent connective tissue remodeling in fibroblasts? J Cell Commun Signal (2013) 0.75
Assembly of the prothrombinase complex on the surface of human foreskin fibroblasts: Implications for connective tissue growth factor. Thromb Res (2011) 0.75
Inhibition of CTGF ameliorates peritoneal fibrosis through suppression of fibroblast and myofibroblast accumulation and angiogenesis. Sci Rep (2017) 0.75
Genome-wide insertional mutagenesis of Arabidopsis thaliana. Science (2003) 39.19
Bosentan therapy for pulmonary arterial hypertension. N Engl J Med (2002) 11.18
TGF-beta signaling and the fibrotic response. FASEB J (2004) 9.81
All in the CCN family: essential matricellular signaling modulators emerge from the bunker. J Cell Sci (2006) 5.18
Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development (2003) 4.31
Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse. Nat Med (2003) 4.03
Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development (2004) 3.46
A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma. Arthritis Rheum (2006) 3.45
Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles. Proc Natl Acad Sci U S A (2004) 3.34
Interstitial lung disease in systemic sclerosis: a simple staging system. Am J Respir Crit Care Med (2008) 3.19
Histopathologic subsets of fibrosing alveolitis in patients with systemic sclerosis and their relationship to outcome. Am J Respir Crit Care Med (2002) 3.06
A polymorphism in the CTGF promoter region associated with systemic sclerosis. N Engl J Med (2007) 2.95
Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci U S A (2005) 2.82
Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. Arthritis Rheum (2007) 2.80
Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis. J Biol Chem (2003) 2.63
The bone marrow functionally contributes to liver fibrosis. Gastroenterology (2006) 2.52
Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy? Matrix Biol (2002) 2.45
Effects of propofol and ketamine as combined anesthesia for electroconvulsive therapy in patients with depressive disorder. J ECT (2012) 2.43
Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev (2008) 2.40
Autoregulation of neurogenesis by GDF11. Neuron (2003) 2.40
Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts. J Biol Chem (2003) 2.35
Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial. Ann Rheum Dis (2010) 2.30
Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. Mol Biol Cell (2004) 2.29
BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development (2009) 2.21
Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in systemic sclerosis or sarcoidosis. Thorax (2013) 2.17
Role of N-terminal brain natriuretic peptide (N-TproBNP) in scleroderma-associated pulmonary arterial hypertension. Eur Heart J (2006) 2.16
Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice. Gastroenterology (2009) 2.06
Efficacy of the specific endothelin a receptor antagonist zibotentan (ZD4054) in colorectal cancer: a preclinical study. Mol Cancer Ther (2013) 2.05
GDF11 controls the timing of progenitor cell competence in developing retina. Science (2005) 2.04
BMP signaling is required for septation of the outflow tract of the mammalian heart. Development (2003) 1.95
Multiple functions of BMPs in chondrogenesis. J Cell Biochem (2004) 1.92
Inducible lineage-specific deletion of TbetaRII in fibroblasts defines a pivotal regulatory role during adult skin wound healing. J Invest Dermatol (2008) 1.92
Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors. Mol Cell Biol (2006) 1.87
CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell (2004) 1.83
Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis. Arthritis Res Ther (2005) 1.81
The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology. Biochem Cell Biol (2003) 1.80
CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC. Kidney Int (2002) 1.77
An essential role for resident fibroblasts in experimental lung fibrosis is defined by lineage-specific deletion of high-affinity type II transforming growth factor β receptor. Am J Respir Crit Care Med (2010) 1.76
Cell mixing at a neural crest-mesoderm boundary and deficient ephrin-Eph signaling in the pathogenesis of craniosynostosis. Hum Mol Genet (2006) 1.74
Mechanisms and consequences of fibrosis in systemic sclerosis. Nat Clin Pract Rheumatol (2006) 1.73
Flexibility and diversity in consultant careers. Clin Med (2002) 1.71
Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing. Am J Pathol (2006) 1.70
Ligand-dependent genetic recombination in fibroblasts : a potentially powerful technique for investigating gene function in fibrosis. Am J Pathol (2002) 1.68
Pleuroparenchymal fibroelastosis: a spectrum of histopathological and imaging phenotypes. Eur Respir J (2012) 1.67
Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen. Arthritis Rheum (2009) 1.65
Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. Arthritis Rheum (2010) 1.64
Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway. FASEB J (2002) 1.64
RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis. J Biol Chem (2005) 1.64
BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways. Development (2006) 1.59
CCN2 is necessary for the function of mouse embryonic fibroblasts. Exp Cell Res (2006) 1.57
Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts. Respir Res (2004) 1.55
RhoA/ROCK signaling regulates chondrogenesis in a context-dependent manner. J Biol Chem (2006) 1.55
High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1. Mol Biol Cell (2011) 1.55
CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes. J Biochem (2008) 1.55