Mechanisms involved in regulating DNA replication origins during the cell cycle and in response to DNA damage.

PubWeight™: 1.09‹?› | Rank: Top 10%

🔗 View Article (PMC 1693309)

Published in Philos Trans R Soc Lond B Biol Sci on January 29, 2004

Authors

Anne Early1, Lucy S Drury, John F X Diffley

Author Affiliations

1: Cancer Research UK, London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms EN6 3LD, UK.

Articles citing this

Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication. Nat Cell Biol (2006) 3.22

DNA replication timing of the human beta-globin domain is controlled by histone modification at the origin. Genes Dev (2008) 1.89

SeqA blocking of DnaA-oriC interactions ensures staged assembly of the E. coli pre-RC. Mol Cell (2006) 1.46

RNA-dependent recruitment of the origin recognition complex. EMBO J (2008) 1.37

H2A.Z functions to regulate progression through the cell cycle. Mol Cell Biol (2006) 1.27

Condensin function at centromere chromatin facilitates proper kinetochore tension and ensures correct mitotic segregation of sister chromatids. Genes Cells (2007) 1.09

Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p. BMC Biol (2007) 1.05

Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation. Genetics (2008) 1.04

Epstein-Barr virus episome stability is coupled to a delay in replication timing. J Virol (2008) 1.02

Catalytic-site mutations in the MYST family histone Acetyltransferase Esa1. Genetics (2008) 0.95

New roles for cyclin E in megakaryocytic polyploidization. J Biol Chem (2010) 0.95

Phosphorylation of MCM3 protein by cyclin E/cyclin-dependent kinase 2 (Cdk2) regulates its function in cell cycle. J Biol Chem (2011) 0.89

One-hit wonders of genomic instability. Cell Div (2010) 0.81

Regulation of Epstein-Barr virus origin of plasmid replication (OriP) by the S-phase checkpoint kinase Chk2. J Virol (2010) 0.81

On the detection of functionally coherent groups of protein domains with an extension to protein annotation. BMC Bioinformatics (2007) 0.78

Articles cited by this

DNA replication in eukaryotic cells. Annu Rev Biochem (2001) 13.39

AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Genome Res (1999) 11.30

Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. Genes Dev (1997) 8.35

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science (1997) 8.00

An essential G1 function for cyclin-like proteins in yeast. Cell (1989) 7.43

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature (2001) 7.31

The DNA replication checkpoint response stabilizes stalled replication forks. Nature (2001) 7.04

Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature (2001) 6.55

A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature (1998) 6.47

Two steps in the assembly of complexes at yeast replication origins in vivo. Cell (1994) 6.42

The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5. Cell (1991) 6.36

Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclins. J Cell Biol (1993) 6.28

Uninterrupted MCM2-7 function required for DNA replication fork progression. Science (2000) 6.27

A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage. Cell (1995) 6.00

Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast. EMBO J (1993) 5.80

CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae. Genes Dev (1993) 5.62

Yeast Hct1 is a regulator of Clb2 cyclin proteolysis. Cell (1997) 5.55

Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc Natl Acad Sci U S A (1997) 5.51

CLB5: a novel B cyclin from budding yeast with a role in S phase. Genes Dev (1992) 5.23

A family of cyclin homologs that control the G1 phase in yeast. Proc Natl Acad Sci U S A (1989) 5.09

DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae. Mol Cell Biol (1988) 5.08

Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex. Science (1998) 4.57

Regulation of DNA-replication origins during cell-cycle progression. Nature (1998) 4.52

The Cdt1 protein is required to license DNA for replication in fission yeast. Nature (2000) 4.46

Heat-inducible degron: a method for constructing temperature-sensitive mutants. Science (1994) 4.42

Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae. EMBO J (1995) 4.40

Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants. Genes Dev (1997) 4.27

S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state. Curr Biol (1995) 4.20

Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair. Nature (2002) 4.18

A central role for DNA replication forks in checkpoint activation and response. Mol Cell (2003) 4.15

NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. EMBO J (1999) 4.14

Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms. Nature (2001) 3.98

Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr Biol (1999) 3.96

Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase. Mol Cell (2000) 3.80

Histone acetylation regulates the time of replication origin firing. Mol Cell (2002) 3.67

Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin. Science (1998) 3.63

Esa1p is an essential histone acetyltransferase required for cell cycle progression. Mol Cell Biol (1999) 3.57

Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase. Mol Cell Biol (2000) 3.52

The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast. EMBO J (1997) 3.35

A novel Mcm1-dependent element in the SWI4, CLN3, CDC6, and CDC47 promoters activates M/G1-specific transcription. Genes Dev (1997) 3.28

XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis. Nature (2000) 3.25

ESA1 is a histone acetyltransferase that is essential for growth in yeast. Proc Natl Acad Sci U S A (1998) 3.19

Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase. Nat Cell Biol (2002) 3.12

Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication. Proc Natl Acad Sci U S A (1999) 2.96

The B subunit of the DNA polymerase alpha-primase complex in Saccharomyces cerevisiae executes an essential function at the initial stage of DNA replication. Mol Cell Biol (1994) 2.75

Initiating DNA synthesis: from recruiting to activating the MCM complex. J Cell Sci (2001) 2.66

Sensing and responding to DNA damage. Curr Opin Genet Dev (2000) 2.63

Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders. Mol Cell (1998) 2.49

The transcription factor Swi5 regulates expression of the cyclin kinase inhibitor p40SIC1. Mol Cell Biol (1996) 2.49

G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus. Nat Cell Biol (1999) 2.39

SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities. Mol Biol Cell (1997) 2.38

Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins. BMC Biochem (2001) 2.36

Is the MCM2-7 complex the eukaryotic DNA replication fork helicase? Curr Opin Genet Dev (2001) 2.28

Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7. Curr Biol (2000) 2.23

Activation of dormant origins of DNA replication in budding yeast. Genes Dev (1999) 2.17

Phosphorylation controls timing of Cdc6p destruction: A biochemical analysis. Mol Biol Cell (1999) 2.07

The cyclin-dependent kinase Cdc28p regulates distinct modes of Cdc6p proteolysis during the budding yeast cell cycle. Curr Biol (2000) 1.98

Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation. Genes Dev (2002) 1.78

Cell cycle-dependent phosphorylation and dephosphorylation of the yeast DNA polymerase alpha-primase B subunit. Mol Cell Biol (1995) 1.77

CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis. Mol Cell (2000) 1.69

A new pair of B-type cyclins from Saccharomyces cerevisiae that function early in the cell cycle. EMBO J (1993) 1.59

MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint. Mol Biol Cell (2001) 1.58

Evidence for a Cdc6p-independent mitotic resetting event involving DNA polymerase alpha. EMBO J (1998) 1.45

Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis. EMBO J (2001) 1.24

The stability of the Cdc6 protein is regulated by cyclin-dependent kinase/cyclin B complexes in Saccharomyces cerevisiae. J Biol Chem (2000) 1.10

DNA synthesis control in yeast: an evolutionarily conserved mechanism for regulating DNA synthesis genes? Bioessays (1992) 1.10

Articles by these authors

Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Cell (2009) 5.56

Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature (2006) 4.94

A central role for DNA replication forks in checkpoint activation and response. Mol Cell (2003) 4.15

CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Cell (2005) 3.29

Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase. Nat Cell Biol (2002) 3.12

ATPase-dependent quality control of DNA replication origin licensing. Nature (2013) 2.72

Eukaryotic DNA replication control: lock and load, then fire. Curr Opin Cell Biol (2009) 2.45

Visualization of altered replication dynamics after DNA damage in human cells. J Biol Chem (2004) 2.41

Break dosage, cell cycle stage and DNA replication influence DNA double strand break response. EMBO J (2008) 2.21

Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation. Nature (2010) 2.03

Homology explains the functional similarities of Treslin/Ticrr and Sld3. Curr Biol (2010) 1.94

Role of DNA replication proteins in double-strand break-induced recombination in Saccharomyces cerevisiae. Mol Cell Biol (2004) 1.87

Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks. Genes Dev (2008) 1.80

Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation. Genes Dev (2002) 1.78

DNA replication as a target of the DNA damage checkpoint. DNA Repair (Amst) (2009) 1.76

Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans. Curr Biol (2011) 1.54

Topoisomerase II inactivation prevents the completion of DNA replication in budding yeast. Mol Cell (2008) 1.54

Regulating DNA replication in eukarya. Cold Spring Harb Perspect Biol (2013) 1.52

Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control. Nature (2004) 1.39

Activation of the replicative DNA helicase: breaking up is hard to do. Curr Opin Cell Biol (2012) 1.28

Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment. EMBO J (2011) 1.28

Reconstitution of an efficient thymidine salvage pathway in Saccharomyces cerevisiae. Nucleic Acids Res (2003) 1.23

Factors affecting the diversity of DNA replication licensing control in eukaryotes. Curr Biol (2009) 1.18

Prereplicative complexes assembled in vitro support origin-dependent and independent DNA replication. EMBO J (2014) 1.14

Controlling DNA replication origins in response to DNA damage - inhibit globally, activate locally. J Cell Sci (2013) 1.07

Global effects of DNA replication and DNA replication origin activity on eukaryotic gene expression. Mol Syst Biol (2009) 1.04

Identification of a heteromeric complex that promotes DNA replication origin firing in human cells. Science (2013) 0.98

Lessons in how to hold a fork. Nat Struct Biol (2003) 0.92

Replication timing: the early bird catches the worm. Curr Biol (2012) 0.91

Pre-replicative complex assembly with purified proteins. Methods (2012) 0.77