Published in Nature on August 02, 2001
Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell (2007) 6.02
Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol (2010) 5.88
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev (2003) 4.40
Cell cycle regulation of DNA replication. Annu Rev Genet (2007) 3.80
Causes and consequences of replication stress. Nat Cell Biol (2014) 3.70
Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev (2003) 3.59
Replication fork stalling at natural impediments. Microbiol Mol Biol Rev (2007) 3.47
Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases. Proc Natl Acad Sci U S A (2007) 3.44
Comparative genomics and molecular dynamics of DNA repeats in eukaryotes. Microbiol Mol Biol Rev (2008) 3.35
Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication. Nat Cell Biol (2006) 3.22
DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1. EMBO J (2003) 3.15
Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. Proc Natl Acad Sci U S A (2004) 3.12
Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork. Genes Dev (2005) 3.07
PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination. EMBO J (2009) 2.99
Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase. Genes Dev (2005) 2.91
Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia coli. Mol Cell (2009) 2.74
The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores. Cell (2011) 2.65
The mechanism of Mus81-Mms4 cleavage site selection distinguishes it from the homologous endonuclease Rad1-Rad10. Mol Cell Biol (2003) 2.59
Swi1 and Swi3 are components of a replication fork protection complex in fission yeast. Mol Cell Biol (2004) 2.55
The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. Mol Cell Biol (2007) 2.54
Regulation of replication timing in fission yeast. EMBO J (2001) 2.49
ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase. Genes Dev (2002) 2.40
Replication in hydroxyurea: it's a matter of time. Mol Cell Biol (2007) 2.35
DNA replication origins fire stochastically in fission yeast. Mol Biol Cell (2005) 2.35
Identification of protein complexes required for efficient sister chromatid cohesion. Mol Biol Cell (2004) 2.34
The Mcm complex: unwinding the mechanism of a replicative helicase. Microbiol Mol Biol Rev (2009) 2.29
Inviability of a DNA2 deletion mutant is due to the DNA damage checkpoint. Cell Cycle (2011) 2.25
ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks. EMBO J (2006) 2.25
Remodeling of DNA replication structures by the branch point translocase FANCM. Proc Natl Acad Sci U S A (2008) 2.20
Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1. Mol Cell Biol (2003) 2.19
Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations. Genes Dev (2005) 2.17
Replication fork reversal and the maintenance of genome stability. Nucleic Acids Res (2009) 2.06
Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase. Mol Cell Biol (2006) 2.05
Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein. Genes Dev (2003) 2.03
Elg1 forms an alternative RFC complex important for DNA replication and genome integrity. EMBO J (2003) 2.03
Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation. Nature (2010) 2.03
The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation. Mol Cell Biol (2004) 2.01
Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2002) 1.97
ATR: a master conductor of cellular responses to DNA replication stress. Trends Biochem Sci (2010) 1.96
Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans. EMBO J (2005) 1.94
Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance. EMBO J (2004) 1.94
Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall. Mol Cell (2014) 1.90
Cycles of chromosome instability are associated with a fragile site and are increased by defects in DNA replication and checkpoint controls in yeast. Genes Dev (2005) 1.89
Replication protein A (RPA) phosphorylation prevents RPA association with replication centers. Mol Cell Biol (2004) 1.89
Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX. Nat Struct Mol Biol (2010) 1.87
Damage-induced phosphorylation of Sld3 is important to block late origin firing. Nature (2010) 1.86
Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest. Mol Cell Biol (2006) 1.85
UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization. Proc Natl Acad Sci U S A (2001) 1.83
Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner. Cancer Res (2010) 1.82
Checkpoint activation regulates mutagenic translesion synthesis. Genes Dev (2003) 1.81
Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks. Genes Dev (2008) 1.80
Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication. Nucleic Acids Res (2011) 1.78
Saccharomyces cerevisiae Rrm3p DNA helicase promotes genome integrity by preventing replication fork stalling: viability of rrm3 cells requires the intra-S-phase checkpoint and fork restart activities. Mol Cell Biol (2004) 1.78
Replication fork barriers: pausing for a break or stalling for time? EMBO Rep (2007) 1.78
Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation. Cell (2009) 1.78
Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation. Genes Dev (2007) 1.75
Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. EMBO J (2004) 1.75
Identification of SMARCAL1 as a component of the DNA damage response. J Biol Chem (2009) 1.74
The yeast Sgs1 helicase is differentially required for genomic and ribosomal DNA replication. EMBO J (2003) 1.74
Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex. Mol Cell Biol (2006) 1.73
Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus. J Cell Sci (2004) 1.72
ATR phosphorylates SMARCAL1 to prevent replication fork collapse. Genes Dev (2013) 1.70
Mrc1 and Tof1 regulate DNA replication forks in different ways during normal S phase. Mol Biol Cell (2007) 1.70
Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage. EMBO J (2004) 1.66
An overview of Cdk1-controlled targets and processes. Cell Div (2010) 1.66
Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells. J Cell Biol (2015) 1.65
Mrc1 and Srs2 are major actors in the regulation of spontaneous crossover. EMBO J (2006) 1.65
Chk1-dependent S-M checkpoint delay in vertebrate cells is linked to maintenance of viable replication structures. Mol Cell Biol (2005) 1.63
Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories. J Cell Biol (2010) 1.63
Histone deposition protein Asf1 maintains DNA replisome integrity and interacts with replication factor C. Genes Dev (2005) 1.62
Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress. Genes Dev (2005) 1.60
dNTP pools determine fork progression and origin usage under replication stress. EMBO J (2012) 1.58
ATR and H2AX cooperate in maintaining genome stability under replication stress. J Biol Chem (2008) 1.55
An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing. Proc Natl Acad Sci U S A (2002) 1.55
Temporal separation of replication and recombination requires the intra-S checkpoint. J Cell Biol (2005) 1.54
Y-family DNA polymerases respond to DNA damage-independent inhibition of replication fork progression. EMBO J (2006) 1.53
Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes. Genetics (2002) 1.51
Tracking of controlled Escherichia coli replication fork stalling and restart at repressor-bound DNA in vivo. EMBO J (2006) 1.51
NuA4 subunit Yng2 function in intra-S-phase DNA damage response. Mol Cell Biol (2002) 1.51
Disruption of mechanisms that prevent rereplication triggers a DNA damage response. Mol Cell Biol (2005) 1.51
Smc5/6 is required for repair at collapsed replication forks. Mol Cell Biol (2006) 1.51
Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1. Genes Dev (2006) 1.51
Differential regulation of homologous recombination at DNA breaks and replication forks by the Mrc1 branch of the S-phase checkpoint. EMBO J (2009) 1.50
Replication checkpoint kinase Cds1 regulates recombinational repair protein Rad60. Mol Cell Biol (2003) 1.50
DNA damage response: three levels of DNA repair regulation. Cold Spring Harb Perspect Biol (2013) 1.48
Histone H2AX is integral to hypoxia-driven neovascularization. Nat Med (2009) 1.48
The histone chaperone Asf1 at the crossroads of chromatin and DNA checkpoint pathways. Chromosoma (2006) 1.48
Replication origin plasticity, Taylor-made: inhibition vs recruitment of origins under conditions of replication stress. Chromosoma (2007) 1.47
A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-free DNA repair. Genetics (2005) 1.46
Set1 is required for meiotic S-phase onset, double-strand break formation and middle gene expression. EMBO J (2004) 1.46
A proteome-wide analysis of kinase-substrate network in the DNA damage response. J Biol Chem (2010) 1.46
Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress. J Cell Sci (2009) 1.44
DNA polymerase epsilon: a polymerase of unusual size (and complexity). Prog Nucleic Acid Res Mol Biol (2008) 1.44
Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling. Mol Cell Biol (2003) 1.42
An FHA domain-mediated protein interaction network of Rad53 reveals its role in polarized cell growth. J Cell Biol (2006) 1.40
Genome-wide replication profiles of S-phase checkpoint mutants reveal fragile sites in yeast. EMBO J (2006) 1.40
Genetic interaction of RAD53 protein kinase with histones is important for DNA replication. Cell Cycle (2010) 1.40
The essential kinase ATR: ensuring faithful duplication of a challenging genome. Nat Rev Mol Cell Biol (2017) 1.38
Roles of Chk1 in cell biology and cancer therapy. Int J Cancer (2013) 1.37
The F-box protein Dia2 overcomes replication impedance to promote genome stability in Saccharomyces cerevisiae. Genetics (2006) 1.33
Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes Dev (1996) 4.98
Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase. EMBO J (1999) 4.64
Isolation of a circular derivative of yeast chromosome III: implications for the mechanism of mating type interconversion. Cell (1979) 4.01
Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest. Mol Cell (2001) 3.74
DNA replication fork pause sites dependent on transcription. Science (1996) 3.43
Yeast chromosome replication and segregation. Microbiol Rev (1988) 3.40
Close association of a DNA replication origin and an ARS element on chromosome III of the yeast, Saccharomyces cerevisiae. Nucleic Acids Res (1988) 3.21
DNA polymerase I gene of Saccharomyces cerevisiae: nucleotide sequence, mapping of a temperature-sensitive mutation, and protein homology with other DNA polymerases. Proc Natl Acad Sci U S A (1988) 2.97
Complex formation by positive and negative translational regulators of GCN4. Mol Cell Biol (1991) 2.79
The B subunit of the DNA polymerase alpha-primase complex in Saccharomyces cerevisiae executes an essential function at the initial stage of DNA replication. Mol Cell Biol (1994) 2.75
Time of replication of ARS elements along yeast chromosome III. Mol Cell Biol (1989) 2.74
Evidence suggesting that the ARS elements associated with silencers of the yeast mating-type locus HML do not function as chromosomal DNA replication origins. Mol Cell Biol (1991) 2.56
Saccharomyces cerevisiae cdc2 mutants fail to replicate approximately one-third of their nuclear genome. Mol Cell Biol (1983) 2.56
The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast. EMBO J (1997) 2.48
Mutational analysis of the consensus sequence of a replication origin from yeast chromosome III. Mol Cell Biol (1990) 2.44
The yeast DNA polymerase I transcript is regulated in both the mitotic cell cycle and in meiosis and is also induced after DNA damage. Nucleic Acids Res (1987) 2.38
A yeast replication origin consists of multiple copies of a small conserved sequence. Cell (1988) 2.36
Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation. Genes Dev (1997) 2.34
Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p. EMBO J (1998) 2.34
DNA damage checkpoint in budding yeast. EMBO J (1998) 2.25
Completion of replication map of Saccharomyces cerevisiae chromosome III. Mol Biol Cell (2001) 2.23
Srs2 DNA helicase is involved in checkpoint response and its regulation requires a functional Mec1-dependent pathway and Cdk1 activity. EMBO J (2000) 2.15
Mitochondrial DNA synthesis in cell cycle mutants of Saccharomyces cerevisiae. Cell (1975) 2.09
Replication forks pause at yeast centromeres. Mol Cell Biol (1992) 2.07
DNA sequence analysis of ARS elements from chromosome III of Saccharomyces cerevisiae: identification of a new conserved sequence. Nucleic Acids Res (1986) 2.03
Domain B of ARS307 contains two functional elements and contributes to chromosomal replication origin function. Mol Cell Biol (1994) 1.97
The ARS consensus sequence is required for chromosomal origin function in Saccharomyces cerevisiae. Mol Cell Biol (1992) 1.95
Nucleotide sequence characterization of Ty 1-17, a class II transposon from yeast. Nucleic Acids Res (1985) 1.94
Expression of the yeast DNA primase gene, PRI1, is regulated within the mitotic cell cycle and in meiosis. Mol Gen Genet (1990) 1.85
Cell cycle-dependent phosphorylation and dephosphorylation of the yeast DNA polymerase alpha-primase B subunit. Mol Cell Biol (1995) 1.77
DNA damage checkpoints and DNA replication controls in Saccharomyces cerevisiae. Mutat Res (2000) 1.76
Localization of a DNA replication origin and termination zone on chromosome III of Saccharomyces cerevisiae. Mol Cell Biol (1992) 1.72
Meiosis-specific formation of joint DNA molecules containing sequences from homologous chromosomes. Cell (1994) 1.72
Replication factor A is required in vivo for DNA replication, repair, and recombination. Mol Cell Biol (1994) 1.70
The ARS309 chromosomal replicator of Saccharomyces cerevisiae depends on an exceptional ARS consensus sequence. Proc Natl Acad Sci U S A (1997) 1.70
The effect on chromosome stability of deleting replication origins. Mol Cell Biol (1993) 1.62
Yeast pip3/mec3 mutants fail to delay entry into S phase and to slow DNA replication in response to DNA damage, and they define a functional link between Mec3 and DNA primase. Mol Cell Biol (1996) 1.61
Replication of yeast chromosomal DNA. Nature (1974) 1.59
A single essential gene, PRI2, encodes the large subunit of DNA primase in Saccharomyces cerevisiae. Mol Cell Biol (1989) 1.56
Isolation and characterization of yeast ring chromosome III by a method applicable to other circular DNAs. Gene (1982) 1.56
A replication map of a 61-kb circular derivative of Saccharomyces cerevisiae chromosome III. Mol Biol Cell (1992) 1.55
A role for DNA primase in coupling DNA replication to DNA damage response. EMBO J (1997) 1.48
Evidence for a Cdc6p-independent mitotic resetting event involving DNA polymerase alpha. EMBO J (1998) 1.45
The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast. Nucleic Acids Res (1996) 1.41
Guanine nucleotide exchange factor for eukaryotic translation initiation factor 2 in Saccharomyces cerevisiae: interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3. Mol Cell Biol (1993) 1.39
Method and parameters for genetic transformation of Streptococcus sanguis Challis. Res Microbiol (1991) 1.38
The mitotic stability of deletion derivatives of chromosome III in yeast. Proc Natl Acad Sci U S A (1986) 1.38
Polypeptide structure of DNA primase from a yeast DNA polymerase-primase complex. J Biol Chem (1985) 1.36
Nucleotide sequence and characterization of temperature-sensitive pol1 mutants of Saccharomyces cerevisiae. Gene (1990) 1.35
A 'hot-spot' for Ty transposition on the left arm of yeast chromosome III. Nucleic Acids Res (1986) 1.34
RAD51-independent break-induced replication to repair a broken chromosome depends on a distant enhancer site. Genes Dev (2001) 1.32
Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways. Int J Cancer (2001) 1.31
Mutations in the gene encoding the 34 kDa subunit of yeast replication protein A cause defective S phase progression. J Mol Biol (1995) 1.30
The Saccharomyces recombination protein Tid1p is required for adaptation from G2/M arrest induced by a double-strand break. Curr Biol (2001) 1.28
Chromosomal DNA replication initiates at the same origins in meiosis and mitosis. Mol Cell Biol (1994) 1.28
Yeast DNA polymerase--DNA primase complex; cloning of PRI 1, a single essential gene related to DNA primase activity. EMBO J (1987) 1.27
Identification of the yeast DNA polymerase I gene with antibody probes. Curr Genet (1985) 1.25
Production of petites by cell cycle mutants of Saccharomyces cerevisiae defective in DNA synthesis. Mol Gen Genet (1979) 1.25
Genetic mapping of the Saccharomyces cerevisiae DNA polymerase I gene and characterization of a pol1 temperature-sensitive mutant altered in DNA primase-polymerase complex stability. Mol Gen Genet (1988) 1.23
Affinity labeling of the active center and ribonucleoside triphosphate binding site of yeast DNA primase. J Biol Chem (1989) 1.22
Mcm1 regulates donor preference controlled by the recombination enhancer in Saccharomyces mating-type switching. Genes Dev (1998) 1.21
Polymorphisms on the right arm of yeast chromosome III associated with Ty transposition and recombination events. Nucleic Acids Res (1987) 1.21
Arrest, adaptation, and recovery following a chromosome double-strand break in Saccharomyces cerevisiae. Cold Spring Harb Symp Quant Biol (2000) 1.19
The DNA polymerase alpha-primase complex couples DNA replication, cell-cycle progression and DNA-damage response. Trends Biochem Sci (1997) 1.17
DNA polymerase I and DNA primase complex in yeast. J Biol Chem (1984) 1.17
A physical comparison of chromosome III in six strains of Saccharomyces cerevisiae. Yeast (1994) 1.14
Two compound replication origins in Saccharomyces cerevisiae contain redundant origin recognition complex binding sites. Mol Cell Biol (2001) 1.14
Yeast chromosomal DNA: size, structure, and replication. Cold Spring Harb Symp Quant Biol (1974) 1.14
Sequence organization and expression of a yeast plasmid DNA. Gene (1977) 1.14
Structure of DNA in DNA replication mutants of yeast. Nature (1974) 1.13
De novo synthesis of budding yeast DNA polymerase alpha and POL1 transcription at the G1/S boundary are not required for entrance into S phase. Proc Natl Acad Sci U S A (1993) 1.12
Mutations in conserved yeast DNA primase domains impair DNA replication in vivo. Proc Natl Acad Sci U S A (1991) 1.12
Purification and characterization of a new DNA polymerase from budding yeast Saccharomyces cerevisiae. A probable homolog of mammalian DNA polymerase beta. J Biol Chem (1993) 1.11
Conditional mutations in the yeast DNA primase genes affect different aspects of DNA metabolism and interactions in the DNA polymerase alpha-primase complex. Genetics (1993) 1.11
The isolated 48,000-dalton subunit of yeast DNA primase is sufficient for RNA primer synthesis. J Biol Chem (1993) 1.10
Time of synthesis for ribosomal ribonucleic acid in Physarum. Biochemistry (1973) 1.09
Evolutionary conservation of DNA polymerase beta structure. Proc Natl Acad Sci U S A (1982) 1.06
Control of DNA synthesis genes in budding yeast: involvement of the transcriptional modulator MOT1 in the expression of the DNA polymerase alpha gene. Chromosoma (1992) 1.05
The secondary alcohol metabolite of doxorubicin irreversibly inactivates aconitase/iron regulatory protein-1 in cytosolic fractions from human myocardium. FASEB J (1998) 1.03
Role of homologous recombination in trabectedin-induced DNA damage. Eur J Cancer (2008) 1.03