Published in Nature on December 13, 2006
Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Cell (2009) 5.56
Cell cycle regulation of DNA replication. Annu Rev Genet (2007) 3.80
How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells? Genes Dev (2010) 2.88
The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4. Nature (2010) 2.50
Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases. Cell (2011) 2.40
The Mcm complex: unwinding the mechanism of a replicative helicase. Microbiol Mol Biol Rev (2009) 2.29
Regulation of the replication cycle: conserved and diverse regulatory systems for DnaA and oriC. Nat Rev Microbiol (2010) 2.27
Control of cell cycle transcription during G1 and S phases. Nat Rev Mol Cell Biol (2013) 2.17
Regulated eukaryotic DNA replication origin firing with purified proteins. Nature (2015) 2.07
Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. Cell (2010) 2.06
Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation. Nature (2010) 2.03
Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast. EMBO J (2011) 1.94
Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. Proc Natl Acad Sci U S A (2009) 1.88
CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast. Genes Dev (2010) 1.86
Damage-induced phosphorylation of Sld3 is important to block late origin firing. Nature (2010) 1.86
Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7. Mol Cell (2010) 1.83
Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation. Genes Dev (2009) 1.76
The ubiquitin-proteasome system of Saccharomyces cerevisiae. Genetics (2012) 1.73
Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly. Genes Dev (2010) 1.71
ATR autophosphorylation as a molecular switch for checkpoint activation. Mol Cell (2011) 1.70
Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast. Genes Dev (2008) 1.68
An overview of Cdk1-controlled targets and processes. Cell Div (2010) 1.66
BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol Cell (2010) 1.65
Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase. J Biol Chem (2008) 1.61
MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication. EMBO J (2009) 1.60
Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci U S A (2008) 1.58
Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint. Mol Cell Biol (2008) 1.54
Regulating DNA replication in eukarya. Cold Spring Harb Perspect Biol (2013) 1.52
Reduced expression of GINS complex members induces hallmarks of pre-malignancy in primary untransformed human cells. Cell Cycle (2009) 1.49
The eukaryotic leading and lagging strand DNA polymerases are loaded onto primer-ends via separate mechanisms but have comparable processivity in the presence of PCNA. Nucleic Acids Res (2007) 1.49
A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Genes Dev (2010) 1.47
TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint. EMBO J (2010) 1.46
Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis. Proc Natl Acad Sci U S A (2012) 1.44
DNA polymerase epsilon: a polymerase of unusual size (and complexity). Prog Nucleic Acid Res Mol Biol (2008) 1.44
A new MCM modification cycle regulates DNA replication initiation. Nat Struct Mol Biol (2016) 1.42
Quality control in the initiation of eukaryotic DNA replication. Philos Trans R Soc Lond B Biol Sci (2011) 1.40
Genetic interaction of RAD53 protein kinase with histones is important for DNA replication. Cell Cycle (2010) 1.40
A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA. Genes Dev (2014) 1.40
DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome. Elife (2014) 1.40
MDC1 collaborates with TopBP1 in DNA replication checkpoint control. J Cell Biol (2011) 1.40
GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication. Nat Cell Biol (2010) 1.39
Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication. J Cell Biol (2011) 1.37
The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication. Nucleic Acids Res (2009) 1.35
Cdc7-Drf1 kinase links chromosome cohesion to the initiation of DNA replication in Xenopus egg extracts. Genes Dev (2008) 1.34
A quantitative model for cyclin-dependent kinase control of the cell cycle: revisited. Philos Trans R Soc Lond B Biol Sci (2011) 1.33
Helicase activation and establishment of replication forks at chromosomal origins of replication. Cold Spring Harb Perspect Biol (2013) 1.32
A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1. DNA Repair (Amst) (2009) 1.29
Mechanisms for initiating cellular DNA replication. Annu Rev Biochem (2013) 1.28
Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment. EMBO J (2011) 1.28
Quantitative proteomics reveals the basis for the biochemical specificity of the cell-cycle machinery. Mol Cell (2011) 1.27
Helicase loading at chromosomal origins of replication. Cold Spring Harb Perspect Biol (2013) 1.26
Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases. EMBO J (2011) 1.25
Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex. Genes Dev (2014) 1.25
A dynamic stochastic model for DNA replication initiation in early embryos. PLoS One (2008) 1.24
Regulation of the initiation step of DNA replication by cyclin-dependent kinases. Chromosoma (2010) 1.24
Genomic instability in cancer. Cold Spring Harb Perspect Biol (2013) 1.23
DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9. Nature (2012) 1.22
Defining replication origin efficiency using DNA fiber assays. Chromosome Res (2010) 1.21
Dbf4-Cdc7 phosphorylation of Mcm2 is required for cell growth. J Biol Chem (2009) 1.20
Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels. J Cell Biol (2010) 1.20
Domain architecture and biochemical characterization of vertebrate Mcm10. J Biol Chem (2007) 1.19
Tetrapyrrole signal as a cell-cycle coordinator from organelle to nuclear DNA replication in plant cells. Proc Natl Acad Sci U S A (2009) 1.18
The role of CDK in the initiation step of DNA replication in eukaryotes. Cell Div (2007) 1.18
MRC1-dependent scaling of the budding yeast DNA replication timing program. Genome Res (2010) 1.18
Embryonic onset of late replication requires Cdc25 down-regulation. Genes Dev (2012) 1.17
Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components. EMBO J (2012) 1.15
Structural basis for DNA binding by replication initiator Mcm10. Structure (2008) 1.14
Prereplicative complexes assembled in vitro support origin-dependent and independent DNA replication. EMBO J (2014) 1.14
Regulation of DNA replication during development. Development (2012) 1.13
Chromosome Duplication in Saccharomyces cerevisiae. Genetics (2016) 1.11
Interplay between S-cyclin-dependent kinase and Dbf4-dependent kinase in controlling DNA replication through phosphorylation of yeast Mcm4 N-terminal domain. Mol Biol Cell (2008) 1.11
Protein phosphatase 1 recruitment by Rif1 regulates DNA replication origin firing by counteracting DDK activity. Cell Rep (2014) 1.11
Drosophila homologue of the Rothmund-Thomson syndrome gene: essential function in DNA replication during development. Dev Biol (2008) 1.10
Multiple functions for Mcm2-7 ATPase motifs during replication initiation. Mol Cell (2014) 1.09
Origin plasticity during budding yeast DNA replication in vitro. EMBO J (2014) 1.08
Structural changes in Mcm5 protein bypass Cdc7-Dbf4 function and reduce replication origin efficiency in Saccharomyces cerevisiae. Mol Cell Biol (2007) 1.08
Cell biology: a switch for S phase. Nature (2007) 1.08
The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation. Mol Cell Biol (2010) 1.07
Phosphorylation of MCM3 on Ser-112 regulates its incorporation into the MCM2-7 complex. Proc Natl Acad Sci U S A (2008) 1.06
Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control. J Biol Chem (2010) 1.06
Differences in the DNA replication of unicellular eukaryotes and metazoans: known unknowns. EMBO Rep (2010) 1.04
Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated. Chromosoma (2014) 1.03
Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation. Mol Syst Biol (2009) 1.01
Preventing DNA over-replication: a Cdk perspective. Cell Div (2008) 1.01
A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication. Genes Dev (2014) 1.01
GINS and Sld3 compete with one another for Mcm2-7 and Cdc45 binding. J Biol Chem (2011) 1.00
CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast. Mol Biol Cell (2011) 1.00
The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress. Mol Biol Cell (2009) 1.00
Sld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast. EMBO J (2011) 1.00
The Cdc45·Mcm2-7·GINS protein complex in trypanosomes regulates DNA replication and interacts with two Orc1-like proteins in the origin recognition complex. J Biol Chem (2011) 1.00
Once in a lifetime: strategies for preventing re-replication in prokaryotic and eukaryotic cells. EMBO Rep (2008) 1.00
Sld2 binds to origin single-stranded DNA and stimulates DNA annealing. Nucleic Acids Res (2010) 0.99
The replication initiation protein Sld2 regulates helicase assembly. J Biol Chem (2013) 0.99
Physical interactions between Mcm10, DNA, and DNA polymerase alpha. J Biol Chem (2009) 0.99
Loading and activation of DNA replicative helicases: the key step of initiation of DNA replication. Genes Cells (2013) 0.98
New insights into replisome fluidity during chromosome replication. Trends Biochem Sci (2012) 0.98
Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation. EMBO J (2016) 0.97
Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress. J Biol Chem (2013) 0.96
Structure and evolutionary origins of the CMG complex. Chromosoma (2013) 0.96
Retracted The Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly. J Biol Chem (2014) 0.96
Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Cell (2009) 5.56
A central role for DNA replication forks in checkpoint activation and response. Mol Cell (2003) 4.15
CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Cell (2005) 3.29
Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase. Nat Cell Biol (2002) 3.12
ATPase-dependent quality control of DNA replication origin licensing. Nature (2013) 2.72
Eukaryotic DNA replication control: lock and load, then fire. Curr Opin Cell Biol (2009) 2.45
Visualization of altered replication dynamics after DNA damage in human cells. J Biol Chem (2004) 2.41
Break dosage, cell cycle stage and DNA replication influence DNA double strand break response. EMBO J (2008) 2.21
Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation. Nature (2010) 2.03
Homology explains the functional similarities of Treslin/Ticrr and Sld3. Curr Biol (2010) 1.94
Role of DNA replication proteins in double-strand break-induced recombination in Saccharomyces cerevisiae. Mol Cell Biol (2004) 1.87
Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks. Genes Dev (2008) 1.80
Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation. Genes Dev (2002) 1.78
DNA replication as a target of the DNA damage checkpoint. DNA Repair (Amst) (2009) 1.76
Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans. Curr Biol (2011) 1.54
Topoisomerase II inactivation prevents the completion of DNA replication in budding yeast. Mol Cell (2008) 1.54
Regulating DNA replication in eukarya. Cold Spring Harb Perspect Biol (2013) 1.52
Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control. Nature (2004) 1.39
Activation of the replicative DNA helicase: breaking up is hard to do. Curr Opin Cell Biol (2012) 1.28
Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment. EMBO J (2011) 1.28
Reconstitution of an efficient thymidine salvage pathway in Saccharomyces cerevisiae. Nucleic Acids Res (2003) 1.23
Factors affecting the diversity of DNA replication licensing control in eukaryotes. Curr Biol (2009) 1.18
Prereplicative complexes assembled in vitro support origin-dependent and independent DNA replication. EMBO J (2014) 1.14
Mechanisms involved in regulating DNA replication origins during the cell cycle and in response to DNA damage. Philos Trans R Soc Lond B Biol Sci (2004) 1.09
Controlling DNA replication origins in response to DNA damage - inhibit globally, activate locally. J Cell Sci (2013) 1.07
Global effects of DNA replication and DNA replication origin activity on eukaryotic gene expression. Mol Syst Biol (2009) 1.04
Identification of a heteromeric complex that promotes DNA replication origin firing in human cells. Science (2013) 0.98
Lessons in how to hold a fork. Nat Struct Biol (2003) 0.92
Replication timing: the early bird catches the worm. Curr Biol (2012) 0.91
Pre-replicative complex assembly with purified proteins. Methods (2012) 0.77