Published in J Am Chem Soc on April 21, 2004
Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase. Proc Natl Acad Sci U S A (2006) 2.37
Mechanisms and free energies of enzymatic reactions. Chem Rev (2006) 2.25
Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis. Proc Natl Acad Sci U S A (2005) 2.21
Multidimensional tunneling, recrossing, and the transmission coefficient for enzymatic reactions. Chem Rev (2006) 2.16
Hydrogen tunneling links protein dynamics to enzyme catalysis. Annu Rev Biochem (2013) 1.76
Taking Ockham's razor to enzyme dynamics and catalysis. Nat Chem (2012) 1.71
Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling. Philos Trans R Soc Lond B Biol Sci (2006) 1.64
Effects of a distal mutation on active site chemistry. Biochemistry (2006) 1.59
An integrated model for enzyme catalysis emerges from studies of hydrogen tunneling. Chem Phys Lett (2009) 1.51
Small temperature dependence of the kinetic isotope effect for the hydride transfer reaction catalyzed by Escherichia coli dihydrofolate reductase. J Phys Chem B (2005) 1.47
The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase. Philos Trans R Soc Lond B Biol Sci (2006) 1.39
Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction. J Am Chem Soc (2012) 1.37
Hydrogen donor-acceptor fluctuations from kinetic isotope effects: a phenomenological model. Biochemistry (2012) 1.28
Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis. Biochemistry (2008) 1.19
Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects. Proc Natl Acad Sci U S A (2007) 1.16
Hydrogen tunnelling in enzyme-catalysed H-transfer reactions: flavoprotein and quinoprotein systems. Philos Trans R Soc Lond B Biol Sci (2006) 1.15
Extension and limits of the network of coupled motions correlated to hydride transfer in dihydrofolate reductase. J Am Chem Soc (2014) 1.14
Nonperfect synchronization of reaction center rehybridization in the transition state of the hydride transfer catalyzed by dihydrofolate reductase. J Am Chem Soc (2005) 1.12
Connecting protein conformational dynamics with catalytic function as illustrated in dihydrofolate reductase. Biochemistry (2013) 1.12
Role of dynamics in enzyme catalysis: substantial versus semantic controversies. Acc Chem Res (2014) 1.11
Evidence that a 'dynamic knockout' in Escherichia coli dihydrofolate reductase does not affect the chemical step of catalysis. Nat Chem (2012) 1.08
Thymidylate synthase catalyzed H-transfers: two chapters in one tale. J Am Chem Soc (2010) 1.08
Tuning of the H-transfer coordinate in primitive versus well-evolved enzymes. Chemphyschem (2008) 1.07
A distal mutation perturbs dynamic amino acid networks in dihydrofolate reductase. Biochemistry (2013) 1.06
Examination of enzymatic H-tunneling through kinetics and dynamics. J Am Chem Soc (2009) 1.05
Protein mass-modulated effects in the catalytic mechanism of dihydrofolate reductase: beyond promoting vibrations. J Am Chem Soc (2014) 1.04
Isotope effects as probes for enzyme catalyzed hydrogen-transfer reactions. Molecules (2013) 1.03
Carbon-deuterium bonds as probes of dihydrofolate reductase. J Am Chem Soc (2008) 1.02
Triple isotopic labeling and kinetic isotope effects: exposing H-transfer steps in enzymatic systems. Biochemistry (2011) 1.01
Preservation of protein dynamics in dihydrofolate reductase evolution. J Biol Chem (2013) 1.01
Increased dynamic effects in a catalytically compromised variant of Escherichia coli dihydrofolate reductase. J Am Chem Soc (2013) 1.00
Coupling of protein motions and hydrogen transfer during catalysis by Escherichia coli dihydrofolate reductase. Biochem J (2006) 0.95
Temperature dependence of protein motions in a thermophilic dihydrofolate reductase and its relationship to catalytic efficiency. Proc Natl Acad Sci U S A (2010) 0.94
The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer. Chem Commun (Camb) (2010) 0.93
Kinetic isotope effects as a probe of hydrogen transfers to and from common enzymatic cofactors. Arch Biochem Biophys (2013) 0.92
Evolutionary aspects of enzyme dynamics. J Biol Chem (2014) 0.92
Escherichia coli dihydrofolate reductase catalyzed proton and hydride transfers: temporal order and the roles of Asp27 and Tyr100. Proc Natl Acad Sci U S A (2014) 0.90
Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. J Am Chem Soc (2013) 0.89
Kinetic isotope effects on aromatic and benzylic hydroxylation by Chromobacterium violaceum phenylalanine hydroxylase as probes of chemical mechanism and reactivity. Biochemistry (2008) 0.86
Thermal adaptation of conformational dynamics in ribonuclease H. PLoS Comput Biol (2013) 0.86
Kinetic and chemical mechanism of the dihydrofolate reductase from Mycobacterium tuberculosis. Biochemistry (2010) 0.86
Are there dynamical effects in enzyme catalysis? Some thoughts concerning the enzymatic chemical step. Arch Biochem Biophys (2015) 0.86
Linking protein motion to enzyme catalysis. Molecules (2015) 0.86
Hydrogen tunneling in adenosylcobalamin-dependent glutamate mutase: evidence from intrinsic kinetic isotope effects measured by intramolecular competition. Biochemistry (2010) 0.85
Protein motions and the activation of the CH bond catalyzed by dihydrofolate reductase. Curr Opin Chem Biol (2014) 0.85
Relationship of femtosecond-picosecond dynamics to enzyme-catalyzed H-transfer. Top Curr Chem (2013) 0.85
Hydride transfer catalysed by Escherichia coli and Bacillus subtilis dihydrofolate reductase: coupled motions and distal mutations. Philos Trans R Soc Lond B Biol Sci (2006) 0.84
Comparative hydrogen-deuterium exchange for a mesophilic vs thermophilic dihydrofolate reductase at 25 °C: identification of a single active site region with enhanced flexibility in the mesophilic protein. Biochemistry (2011) 0.84
Experimental evidence for hydrogen tunneling when the isotopic arrhenius prefactor (A(H)/A(D)) is unity. J Am Chem Soc (2008) 0.84
An analysis of reaction pathways for proton tunnelling in methylamine dehydrogenase. Philos Trans R Soc Lond B Biol Sci (2006) 0.82
Different dynamical effects in mesophilic and hyperthermophilic dihydrofolate reductases. J Am Chem Soc (2014) 0.81
The importance of ensemble averaging in enzyme kinetics. Acc Chem Res (2014) 0.81
Structural and Kinetic Studies of Formate Dehydrogenase from Candida boidinii. Biochemistry (2016) 0.81
Microscale synthesis and kinetic isotope effect analysis of (4R)-[Ad-(14)C, 4-(2)H] NADPH and (4R)-[Ad-(3)H,4-(2)H] NADPH. J Labelled Comp Radiopharm (2009) 0.81
Hydride Transfer in DHFR by Transition Path Sampling, Kinetic Isotope Effects, and Heavy Enzyme Studies. Biochemistry (2015) 0.81
Protein motions during catalysis by dihydrofolate reductases. Philos Trans R Soc Lond B Biol Sci (2006) 0.80
Network of remote and local protein dynamics in dihydrofolate reductase catalysis. ACS Catal (2015) 0.79
Computational approach for ranking mutant enzymes according to catalytic reaction rates. J Phys Chem B (2009) 0.79
Evolution alters the enzymatic reaction coordinate of dihydrofolate reductase. J Phys Chem B (2014) 0.78
How Accurate Are Transition States from Simulations of Enzymatic Reactions? J Chem Theory Comput (2014) 0.77
Examinations of the Chemical Step in Enzyme Catalysis. Methods Enzymol (2016) 0.76
Synthesis of radiolabeled nicotinamide cofactors from labeled pyridines: versatile probes for enzyme kinetics. Anal Biochem (2012) 0.76
The Effect of Protein Mass Modulation on Human Dihydrofolate Reductase. Biochemistry (2016) 0.76
Carboxyl-terminal truncations alter the activity of the human α-galactosidase A. PLoS One (2015) 0.75
(13)C ENDOR Spectroscopy of Lipoxygenase-Substrate Complexes Reveals the Structural Basis for C-H Activation by Tunneling. J Am Chem Soc (2017) 0.75
Computational replication of the abnormal secondary kinetic isotope effects in a hydride transfer reaction in solution with a motion assisted H-tunneling model. J Org Chem (2014) 0.75
The mutational landscape of head and neck squamous cell carcinoma. Science (2011) 16.88
Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med (2013) 5.29
Randomized trial of oral teriflunomide for relapsing multiple sclerosis. N Engl J Med (2011) 4.93
Relating protein motion to catalysis. Annu Rev Biochem (2006) 4.50
The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell (2009) 4.47
The developmental dynamics of the maize leaf transcriptome. Nat Genet (2010) 4.02
Network of coupled promoting motions in enzyme catalysis. Proc Natl Acad Sci U S A (2002) 3.98
DNA polymerase fidelity: kinetics, structure, and checkpoints. Biochemistry (2004) 3.71
Allosteric regulation and catalysis emerge via a common route. Nat Chem Biol (2008) 3.62
A requirement for CARMA1 in TCR-induced NF-kappa B activation. Nat Immunol (2002) 3.38
Reference genome sequence of the model plant Setaria. Nat Biotechnol (2012) 3.21
A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis. Science (2011) 3.19
Priming in systemic plant immunity. Science (2009) 3.11
Reversible compartmentalization of de novo purine biosynthetic complexes in living cells. Science (2008) 2.98
Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis. Clin Cancer Res (2004) 2.96
Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease. Blood (2009) 2.91
On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves. Proc Natl Acad Sci U S A (2012) 2.91
PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B. J Biol Chem (2002) 2.88
Surface sites for engineering allosteric control in proteins. Science (2008) 2.82
An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science (2007) 2.82
The relationship of eosinophilia to intravenous immunoglobulin treatment failure in Kawasaki disease. Pediatr Allergy Immunol (2007) 2.81
In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses. Nat Biotechnol (2009) 2.76
Design and evolution of new catalytic activity with an existing protein scaffold. Science (2006) 2.71
Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. FEBS Lett (2002) 2.66
Triple versus dual antiplatelet therapy in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Circulation (2009) 2.62
Inferring reputation promotes the evolution of cooperation in spatial social dilemma games. PLoS One (2012) 2.41
Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase. Proc Natl Acad Sci U S A (2006) 2.37
Potential markers that complement expression of CA125 in epithelial ovarian cancer. Gynecol Oncol (2005) 2.34
Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster. Proc Natl Acad Sci U S A (2002) 2.33
First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy. Cancer Discov (2012) 2.31
Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers. Cancer Discov (2013) 2.29
Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma. Am J Gastroenterol (2010) 2.20
Re-emerging superconductivity at 48 kelvin in iron chalcogenides. Nature (2012) 2.13
Coupling interactions of distal residues enhance dihydrofolate reductase catalysis: mutational effects on hydride transfer rates. Biochemistry (2002) 2.09
Low-molecular-weight heparin versus unfractionated heparin in acute ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention with drug-eluting stents. Am Heart J (2010) 2.09
Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase. Proc Natl Acad Sci U S A (2005) 2.05
Effects of estrogen depletion on angiogenesis in estrogen-receptor-positive breast carcinoma--an immunohistochemical study of vasohibin-1 and CD31 with correlation to pathobiological response of the patients in neoadjuvant aromatase inhibitor therapy. Expert Opin Ther Targets (2012) 2.00
Nucleation and growth of nanoparticles in the atmosphere. Chem Rev (2011) 1.99
Targeting Stat3 abrogates EGFR inhibitor resistance in cancer. Clin Cancer Res (2012) 1.89
Hepatic resection as a safe and effective treatment for hepatocellular carcinoma involving a single large tumor, multiple tumors, or macrovascular invasion. Medicine (Baltimore) (2015) 1.88
Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats. Gastroenterology (2011) 1.85
AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function. J Clin Invest (2013) 1.84
Bionanotechnology based on silica nanoparticles. Med Res Rev (2004) 1.81
Real-time observation of bacteriophage T4 gp41 helicase reveals an unwinding mechanism. Proc Natl Acad Sci U S A (2007) 1.76
The dynamic processivity of the T4 DNA polymerase during replication. Proc Natl Acad Sci U S A (2004) 1.76
Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes. Dev Cell (2012) 1.76
Hydrogen tunneling links protein dynamics to enzyme catalysis. Annu Rev Biochem (2013) 1.76
Setaria viridis: a model for C4 photosynthesis. Plant Cell (2010) 1.72
Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle. Biochemistry (2004) 1.72
Regulation of polymerase exchange between Poleta and Poldelta by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme. Proc Natl Acad Sci U S A (2008) 1.71
Conformation coupled enzyme catalysis: single-molecule and transient kinetics investigation of dihydrofolate reductase. Biochemistry (2005) 1.68
Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI). J Biol Chem (2005) 1.68
Coupling DNA unwinding activity with primer synthesis in the bacteriophage T4 primosome. Nat Chem Biol (2009) 1.68
Formation of nanoparticles of blue haze enhanced by anthropogenic pollution. Proc Natl Acad Sci U S A (2009) 1.67
CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. J Biol Chem (2002) 1.66
Decompressive hemicraniectomy in malignant middle cerebral artery infarct: a randomized controlled trial enrolling patients up to 80 years old. Neurocrit Care (2012) 1.65
DelPhi: a comprehensive suite for DelPhi software and associated resources. BMC Biophys (2012) 1.64
Risk of MDM2 SNP309 alone or in combination with the p53 codon 72 polymorphism in acute myeloid leukemia. Leuk Res (2009) 1.64
Correlation of pandemic (H1N1) 2009 viral load with disease severity and prolonged viral shedding in children. Emerg Infect Dis (2010) 1.64
An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene. Nature (2009) 1.62
Idiopathic bilateral optic atrophy in the rhesus macaque. Invest Ophthalmol Vis Sci (2005) 1.62
Molecular surveillance of Cryptosporidium spp., Giardia duodenalis, and Enterocytozoon bieneusi by genotyping and subtyping parasites in wastewater. PLoS Negl Trop Dis (2012) 1.60
Flexibility, diversity, and cooperativity: pillars of enzyme catalysis. Biochemistry (2011) 1.60
High-affinity peptide against MT1-MMP for in vivo tumor imaging. J Control Release (2011) 1.59
Effects of a distal mutation on active site chemistry. Biochemistry (2006) 1.59
Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model. PLoS One (2013) 1.56
Preclinical characteristics of the hepatitis C virus NS3/4A protease inhibitor ITMN-191 (R7227). Antimicrob Agents Chemother (2008) 1.56
Mechanistic studies of a flavin-dependent thymidylate synthase. Biochemistry (2004) 1.55
Aberrant expression of TSC2 gene in the newly diagnosed acute leukemia. Leuk Res (2009) 1.52
Vibrationally enhanced hydrogen tunneling in the Escherichia coli thymidylate synthase catalyzed reaction. Biochemistry (2004) 1.49
High-responsivity graphene/InAs nanowire heterojunction near-infrared photodetectors with distinct photocurrent on/off ratios. Small (2014) 1.49
Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease. J Am Soc Nephrol (2013) 1.49
Coupled motions in enzyme catalysis. Curr Opin Chem Biol (2010) 1.49
Tourniquet device for hemorrhage control during cesarean section of complete placenta previa pregnancies. J Obstet Gynaecol Res (2013) 1.48
Toll-like receptor 9 activation of signal transducer and activator of transcription 3 constrains its agonist-based immunotherapy. Cancer Res (2009) 1.46
Therapeutic potential of adipose-derived stem cells-based micro-tissues in a rat model of postprostatectomy erectile dysfunction. J Sex Med (2014) 1.44
Energy dependence of response of new high sensitivity radiochromic films for megavoltage and kilovoltage radiation energies. Med Phys (2005) 1.44
BCL-xL is a target gene regulated by hypoxia-inducible factor-1{alpha}. J Biol Chem (2009) 1.43
Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics. Proc Natl Acad Sci U S A (2002) 1.43
Rare cell isolation and analysis in microfluidics. Lab Chip (2014) 1.42
Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells. J Biol Chem (2010) 1.42
Placement of 125I implants with the da Vinci robotic system after video-assisted thoracoscopic wedge resection: a feasibility study. Int J Radiat Oncol Biol Phys (2004) 1.42
Requirement of Gab2 for mast cell development and KitL/c-Kit signaling. Blood (2002) 1.41
Induction of interleukin 2 expression in the liver for the treatment of H22 hepatoma in mice. Dig Liver Dis (2012) 1.41
DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet? PLoS One (2011) 1.39
Multidisciplinary optimization of a butterfly valve. ISA Trans (2009) 1.39
The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase. Philos Trans R Soc Lond B Biol Sci (2006) 1.39
HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling. J Cereb Blood Flow Metab (2010) 1.39
Induction docetaxel, cisplatin, and cetuximab followed by concurrent radiotherapy, cisplatin, and cetuximab and maintenance cetuximab in patients with locally advanced head and neck cancer. J Clin Oncol (2010) 1.37
Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction. J Am Chem Soc (2012) 1.37
Toll-like receptor 4 involvement in hepatic ischemia/reperfusion injury in mice. Hepatobiliary Pancreat Dis Int (2004) 1.37
Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2. J Biol Chem (2010) 1.36
Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers. Cancer Res (2003) 1.35