Published in Science on June 22, 2007
Platforms for antibiotic discovery. Nat Rev Drug Discov (2013) 3.66
Aminoacyl tRNA synthetases and their connections to disease. Proc Natl Acad Sci U S A (2008) 2.41
Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin. Cell Host Microbe (2012) 2.05
Aminoacyl-tRNA synthetases in medicine and disease. EMBO Mol Med (2013) 1.67
Structural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase. Nat Struct Mol Biol (2012) 1.51
CP1-dependent partitioning of pretransfer and posttransfer editing in leucyl-tRNA synthetase. Proc Natl Acad Sci U S A (2008) 1.45
Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA. Nature (2013) 1.45
Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor. Chem Biol (2015) 1.42
Antibiotics and bacterial resistance in the 21st century. Perspect Medicin Chem (2014) 1.41
Boron mimetics: 1,2-dihydro-1,2-azaborines bind inside a nonpolar cavity of T4 lysozyme. Angew Chem Int Ed Engl (2009) 1.35
Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization. J Med Chem (2012) 1.35
Antifungal drug development: challenges, unmet clinical needs, and new approaches. Cold Spring Harb Perspect Med (2014) 1.31
Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria. Antimicrob Agents Chemother (2013) 1.27
tRNA-dependent pre-transfer editing by prokaryotic leucyl-tRNA synthetase. J Biol Chem (2009) 1.25
A survey of yeast genomic assays for drug and target discovery. Pharmacol Ther (2010) 1.18
The balance between pre- and post-transfer editing in tRNA synthetases. FEBS Lett (2010) 1.14
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase. Nature (2012) 1.13
Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase. Nucleic Acids Res (2010) 1.11
Partitioning of tRNA-dependent editing between pre- and post-transfer pathways in class I aminoacyl-tRNA synthetases. J Biol Chem (2010) 1.11
Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model. Proc Natl Acad Sci U S A (2010) 1.10
DNA polymerases and aminoacyl-tRNA synthetases: shared mechanisms for ensuring the fidelity of gene expression. Biochemistry (2008) 1.04
Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis. Antimicrob Agents Chemother (2010) 1.04
Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections. Antimicrob Agents Chemother (2014) 1.02
The physiological target for LeuRS translational quality control is norvaline. EMBO J (2014) 1.00
Kinetic partitioning between synthetic and editing pathways in class I aminoacyl-tRNA synthetases occurs at both pre-transfer and post-transfer hydrolytic steps. J Biol Chem (2012) 1.00
Characterization of two seryl-tRNA synthetases in albomycin-producing Streptomyces sp. strain ATCC 700974. Antimicrob Agents Chemother (2009) 0.99
Mechanism of Action of ME1111, a Novel Antifungal Agent for Topical Treatment of Onychomycosis. Antimicrob Agents Chemother (2015) 0.98
In vitro assays for the determination of aminoacyl-tRNA synthetase editing activity. Methods (2008) 0.98
A genomic glimpse of aminoacyl-tRNA synthetases in malaria parasite Plasmodium falciparum. BMC Genomics (2009) 0.97
Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition. Nucleic Acids Res (2013) 0.97
Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase. Sci Rep (2013) 0.93
Functional segregation of a predicted "hinge" site within the beta-strand linkers of Escherichia coli leucyl-tRNA synthetase. Biochemistry (2008) 0.93
Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor. Sci Rep (2016) 0.92
Five conditions commonly used to down-regulate tor complex 1 generate different physiological situations exhibiting distinct requirements and outcomes. J Biol Chem (2013) 0.91
Defects in transient tRNA translocation bypass tRNA synthetase quality control mechanisms. J Biol Chem (2009) 0.91
Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo. Proc Natl Acad Sci U S A (2014) 0.91
New agents for the treatment of drug-resistant Mycobacterium tuberculosis. Adv Drug Deliv Rev (2016) 0.90
Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase. Nat Commun (2015) 0.90
Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor. Sci Rep (2015) 0.90
Evolutionary basis for the coupled-domain motions in Thermus thermophilus leucyl-tRNA synthetase. J Biol Chem (2009) 0.88
Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Giardia intestinalis Trophozoites. Antimicrob Agents Chemother (2015) 0.87
ATPsite: sequence-based prediction of ATP-binding residues. Proteome Sci (2011) 0.86
Ring Structure and Aromatic Substituent Effects on the pK a of the Benzoxaborole Pharmacophore. ACS Med Chem Lett (2011) 0.86
Regulation of angiogenesis by aminoacyl-tRNA synthetases. Int J Mol Sci (2014) 0.86
Discovery of novel benzoxaborole-based potent antitrypanosomal agents. ACS Med Chem Lett (2010) 0.85
Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase. Nat Commun (2013) 0.85
Crucial role of the C-terminal domain of Mycobacterium tuberculosis leucyl-tRNA synthetase in aminoacylation and editing. Nucleic Acids Res (2012) 0.85
tRNA synthetase: tRNA aminoacylation and beyond. Wiley Interdiscip Rev RNA (2014) 0.84
In silico discovery of aminoacyl-tRNA synthetase inhibitors. Int J Mol Sci (2014) 0.83
Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design. Nucleic Acids Res (2010) 0.82
Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase. Antimicrob Agents Chemother (2016) 0.82
The tRNA Elbow in Structure, Recognition and Evolution. Life (Basel) (2016) 0.81
Mechanisms of action for 2-phenylethanol isolated from Kloeckera apiculata in control of Penicillium molds of citrus fruits. BMC Microbiol (2014) 0.81
Branched peptide boronic acids (BPBAs): a novel mode of binding towards RNA. Chem Commun (Camb) (2013) 0.81
Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design. Mol Biochem Parasitol (2013) 0.81
Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review. Curr Top Med Chem (2014) 0.79
Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase. Antimicrob Agents Chemother (2016) 0.79
Metalloid compounds as drugs. Res Pharm Sci (2013) 0.78
Scalable, Metal- and Additive-Free, Photoinduced Borylation of Haloarenes and Quaternary Arylammonium Salts. J Am Chem Soc (2016) 0.78
A Polymorphism in leuS Confers Reduced Susceptibility to GSK2251052 in a Clinical Isolate of Staphylococcus aureus. Antimicrob Agents Chemother (2016) 0.78
Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase. Antimicrob Agents Chemother (2016) 0.78
Benzoxaborole antimalarial agents. Part 4. Discovery of potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles. J Med Chem (2015) 0.78
A glycine hinge for tRNA-dependent translocation of editing substrates to prevent errors by leucyl-tRNA synthetase. FEBS Lett (2009) 0.78
tRNAs as antibiotic targets. Int J Mol Sci (2014) 0.78
Emergence and evolution. Top Curr Chem (2014) 0.78
Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode Classification. Life (Basel) (2015) 0.78
The tRNA A76 Hydroxyl Groups Control Partitioning of the tRNA-dependent Pre- and Post-transfer Editing Pathways in Class I tRNA Synthetase. J Biol Chem (2015) 0.77
HIV-1 drug discovery: targeting folded RNA structures with branched peptides. Org Biomol Chem (2015) 0.77
A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens. Acta Crystallogr D Biol Crystallogr (2015) 0.77
Hybrid phenylthiazole and 1,3,5-triazine target cytosolic leucyl-tRNA synthetase for antifungal action as revealed by molecular docking studies. In Silico Pharmacol (2013) 0.77
The Yin and Yang of tRNA: proper binding of acceptor end determines the catalytic balance of editing and aminoacylation. Nucleic Acids Res (2013) 0.77
Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome. PLoS Negl Trop Dis (2015) 0.77
Novel and unique domains in aminoacyl-tRNA synthetases from human fungal pathogens Aspergillus niger, Candida albicans and Cryptococcus neoformans. BMC Genomics (2014) 0.76
Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis. EMBO Mol Med (2017) 0.76
Repurposing strategies for tropical disease drug discovery. Bioorg Med Chem Lett (2016) 0.76
Molecular recognition with boronic acids-applications in chemical biology. J Chem Biol (2013) 0.76
Degenerate Connective Polypeptide 1 (CP1) Domain from Human Mitochondrial Leucyl-tRNA Synthetase. J Biol Chem (2015) 0.76
Spotlight on tavaborole for the treatment of onychomycosis. Drug Des Devel Ther (2015) 0.76
A paradigm shift for the amino acid editing mechanism of human cytoplasmic leucyl-tRNA synthetase. Biochemistry (2009) 0.76
Structural characterization of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent. Nat Commun (2016) 0.75
A human leucyl-tRNA synthetase as an anticancer target. Onco Targets Ther (2015) 0.75
Application of Nail Polish During Topical Management of Onychomycosis: Are Data Available to Guide the Clinician About What to Tell Their Patients? J Clin Aesthet Dermatol (2016) 0.75
Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and Schistosomiasis. PLoS Negl Trop Dis (2016) 0.75
Molecular trigger for pre-transfer editing pathway in Valyl-tRNA synthetase: a molecular dynamics simulation study. J Mol Model (2010) 0.75
Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts. Biochimie (2017) 0.75
Universal pathway for posttransfer editing reactions: insights from the crystal structure of TtPheRS with puromycin. Proc Natl Acad Sci U S A (2015) 0.75
Characterization of benzoxaborole-based antifungal resistance mutations demonstrates that editing depends on electrostatic stabilization of the leucyl-tRNA synthetase editing cap. FEBS Lett (2011) 0.75
Organocatalytic, enantioselective synthesis of benzoxaboroles via Wittig/oxa-Michael reaction Cascade of α-formyl boronic acids. Chem Sci (2017) 0.75
5-Fluoro-1,3-dihydro-2,1-benzoxaborol-1-ol. Acta Crystallogr Sect E Struct Rep Online (2011) 0.75
New conjugates of polyene macrolide amphotericin B with benzoxaboroles: synthesis and properties. J Antibiot (Tokyo) (2016) 0.75
A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue. Nat Commun (2017) 0.75
Clone and functional analysis of Seryl-tRNA synthetase and Tyrosyl-tRNA synthetase from silkworm, Bombyx mori. Sci Rep (2017) 0.75
A Divalent Protecting Group for Benzoxaboroles. RSC Adv (2013) 0.75
Reversing resistance: The next generation antibacterials. Indian J Pharmacol (2015) 0.75
Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction. Nat Commun (2017) 0.75
The versatility of boron in biological target engagement. Nat Chem (2017) 0.75
Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target. PLoS Negl Trop Dis (2017) 0.75
The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit. Nature (2009) 5.06
Rapid and sequential movement of individual chromosomal loci to specific subcellular locations during bacterial DNA replication. Proc Natl Acad Sci U S A (2004) 4.64
MreB actin-mediated segregation of a specific region of a bacterial chromosome. Cell (2005) 4.63
Relating protein motion to catalysis. Annu Rev Biochem (2006) 4.50
MipZ, a spatial regulator coordinating chromosome segregation with cell division in Caulobacter. Cell (2006) 4.45
The structural basis for cap binding by influenza virus polymerase subunit PB2. Nat Struct Mol Biol (2008) 4.33
Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA. Cell (2011) 4.11
An actin-like gene can determine cell polarity in bacteria. Proc Natl Acad Sci U S A (2004) 4.00
Network of coupled promoting motions in enzyme catalysis. Proc Natl Acad Sci U S A (2002) 3.98
DNA polymerase fidelity: kinetics, structure, and checkpoints. Biochemistry (2004) 3.71
Genes directly controlled by CtrA, a master regulator of the Caulobacter cell cycle. Proc Natl Acad Sci U S A (2002) 3.70
Allosteric regulation and catalysis emerge via a common route. Nat Chem Biol (2008) 3.62
The three-dimensional architecture of a bacterial genome and its alteration by genetic perturbation. Mol Cell (2011) 3.61
Super-resolution imaging in live Caulobacter crescentus cells using photoswitchable EYFP. Nat Methods (2008) 3.21
Single molecules of the bacterial actin MreB undergo directed treadmilling motion in Caulobacter crescentus. Proc Natl Acad Sci U S A (2006) 3.19
A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis. Science (2011) 3.19
A polymeric protein anchors the chromosomal origin/ParB complex at a bacterial cell pole. Cell (2008) 3.15
Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit. Nat Struct Mol Biol (2007) 3.13
Reversible compartmentalization of de novo purine biosynthetic complexes in living cells. Science (2008) 2.98
On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves. Proc Natl Acad Sci U S A (2012) 2.91
A spindle-like apparatus guides bacterial chromosome segregation. Nat Cell Biol (2010) 2.85
Surface sites for engineering allosteric control in proteins. Science (2008) 2.82
Design and evolution of new catalytic activity with an existing protein scaffold. Science (2006) 2.71
Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion. Nat Struct Biol (2003) 2.71
The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. Nat Struct Mol Biol (2004) 2.65
Improved surface temperature prediction for the coming decade from a global climate model. Science (2007) 2.65
Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit. PLoS Pathog (2008) 2.60
High-throughput identification of transcription start sites, conserved promoter motifs and predicted regulons. Nat Biotechnol (2007) 2.57
Codon usage between genomes is constrained by genome-wide mutational processes. Proc Natl Acad Sci U S A (2004) 2.56
A comprehensive set of plasmids for vanillate- and xylose-inducible gene expression in Caulobacter crescentus. Nucleic Acids Res (2007) 2.48
Structural and mechanistic basis of pre- and posttransfer editing by leucyl-tRNA synthetase. Mol Cell (2003) 2.41
Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase. Proc Natl Acad Sci U S A (2006) 2.37
A bacterial cell-cycle regulatory network operating in time and space. Science (2003) 2.33
Tunneling and coupled motion in the Escherichia coli dihydrofolate reductase catalysis. J Am Chem Soc (2004) 2.21
Oscillating global regulators control the genetic circuit driving a bacterial cell cycle. Science (2004) 2.20
An open letter to Elias Zerhouni. Science (2005) 2.19
The structure of the human adenovirus 2 penton. Mol Cell (2005) 2.17
A phospho-signaling pathway controls the localization and activity of a protease complex critical for bacterial cell cycle progression. Proc Natl Acad Sci U S A (2006) 2.16
The essential genome of a bacterium. Mol Syst Biol (2011) 2.14
Bacterial chromosome organization and segregation. Cold Spring Harb Perspect Biol (2010) 2.11
Caulobacter requires a dedicated mechanism to initiate chromosome segregation. Proc Natl Acad Sci U S A (2008) 2.10
Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex. EMBO J (2002) 2.10
Coupling interactions of distal residues enhance dihydrofolate reductase catalysis: mutational effects on hydride transfer rates. Biochemistry (2002) 2.09
A quasi-atomic model of human adenovirus type 5 capsid. EMBO J (2005) 2.09
Class I tyrosyl-tRNA synthetase has a class II mode of cognate tRNA recognition. EMBO J (2002) 2.09
A dynamically localized protease complex and a polar specificity factor control a cell cycle master regulator. Cell (2006) 2.07
Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase. Proc Natl Acad Sci U S A (2005) 2.05
Two independent spiral structures control cell shape in Caulobacter. Proc Natl Acad Sci U S A (2005) 2.03
Getting organized--how bacterial cells move proteins and DNA. Nat Rev Microbiol (2008) 2.01
A membrane metalloprotease participates in the sequential degradation of a Caulobacter polarity determinant. Mol Microbiol (2005) 1.93
Influenza A virus polymerase: structural insights into replication and host adaptation mechanisms. J Biol Chem (2010) 1.89
The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer-editing conformation. Nat Struct Mol Biol (2005) 1.87
Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis. J Med Chem (2006) 1.85
Nucleoproteins and nucleocapsids of negative-strand RNA viruses. Curr Opin Microbiol (2011) 1.84
Real-time observation of bacteriophage T4 gp41 helicase reveals an unwinding mechanism. Proc Natl Acad Sci U S A (2007) 1.76
The dynamic processivity of the T4 DNA polymerase during replication. Proc Natl Acad Sci U S A (2004) 1.76
Identification of a localization factor for the polar positioning of bacterial structural and regulatory proteins. Proc Natl Acad Sci U S A (2002) 1.73
Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap-dependent transcription. PLoS Pathog (2010) 1.73
Small non-coding RNAs in Caulobacter crescentus. Mol Microbiol (2008) 1.72
Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle. Biochemistry (2004) 1.72
Temporal and spatial regulation in prokaryotic cell cycle progression and development. Annu Rev Biochem (2003) 1.71
DnaA coordinates replication initiation and cell cycle transcription in Caulobacter crescentus. Mol Microbiol (2005) 1.71
Regulation of polymerase exchange between Poleta and Poldelta by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme. Proc Natl Acad Sci U S A (2008) 1.71
A DNA methylation ratchet governs progression through a bacterial cell cycle. Proc Natl Acad Sci U S A (2007) 1.70
Conformation coupled enzyme catalysis: single-molecule and transient kinetics investigation of dihydrofolate reductase. Biochemistry (2005) 1.68
DNA methylation affects the cell cycle transcription of the CtrA global regulator in Caulobacter. EMBO J (2002) 1.68
Coupling DNA unwinding activity with primer synthesis in the bacteriophage T4 primosome. Nat Chem Biol (2009) 1.68
Fluorescence bleaching reveals asymmetric compartment formation prior to cell division in Caulobacter. Proc Natl Acad Sci U S A (2003) 1.66
Assembly of the Caulobacter cell division machine. Mol Microbiol (2011) 1.66
SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis. PLoS Negl Trop Dis (2011) 1.66
Three-dimensional model for the isolated recombinant influenza virus polymerase heterotrimer. Nucleic Acids Res (2007) 1.62
Chromosome organization and segregation in bacteria. J Struct Biol (2006) 1.62
Superresolution imaging of targeted proteins in fixed and living cells using photoactivatable organic fluorophores. J Am Chem Soc (2010) 1.61
Crystal structure of species D adenovirus fiber knobs and their sialic acid binding sites. J Virol (2004) 1.60
Flexibility, diversity, and cooperativity: pillars of enzyme catalysis. Biochemistry (2011) 1.60
Dynamic localization of proteins and DNA during a bacterial cell cycle. Nat Rev Mol Cell Biol (2002) 1.59
Effects of a distal mutation on active site chemistry. Biochemistry (2006) 1.59
Systems biology of Caulobacter. Annu Rev Genet (2007) 1.58
DnaA couples DNA replication and the expression of two cell cycle master regulators. EMBO J (2006) 1.56
MicroRNA-183 regulates Ezrin expression in lung cancer cells. FEBS Lett (2008) 1.56
Caulobacter PopZ forms a polar subdomain dictating sequential changes in pole composition and function. Mol Microbiol (2010) 1.56
A signal transduction protein cues proteolytic events critical to Caulobacter cell cycle progression. Proc Natl Acad Sci U S A (2002) 1.55
Structural insights into the Slit-Robo complex. Proc Natl Acad Sci U S A (2007) 1.54
Structure of dimeric SecA, the Escherichia coli preprotein translocase motor. J Mol Biol (2006) 1.53
A dynamically localized histidine kinase controls the asymmetric distribution of polar pili proteins. EMBO J (2002) 1.52
Structural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase. Nat Struct Mol Biol (2012) 1.51
The CtrA response regulator essential for Caulobacter crescentus cell-cycle progression requires a bipartite degradation signal for temporally controlled proteolysis. J Mol Biol (2002) 1.50
Towards an atomic resolution understanding of the influenza virus replication machinery. Curr Opin Struct Biol (2010) 1.49