Published in Eur J Neurosci on April 01, 2004
Pharmacology and therapeutic potential of sigma(1) receptor ligands. Curr Neuropharmacol (2008) 1.55
The sigma receptor: evolution of the concept in neuropsychopharmacology. Curr Neuropharmacol (2005) 1.16
The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neuropsychopharmacology (2008) 1.04
The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives. Chem Rev (2013) 0.98
Sigma receptors [σRs]: biology in normal and diseased states. J Recept Signal Transduct Res (2015) 0.78
Roles of sigma-1 receptors in Alzheimer's disease. Int J Clin Exp Med (2015) 0.78
Glioblastoma: looking at the currently marketed sigma-1 agonists and antagonists. Neoplasia (2007) 0.75
Nootropics with potential to (re)build neuroarchitecture. Neural Regen Res (2016) 0.75
Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival. Cell (2007) 6.13
MAM: more than just a housekeeper. Trends Cell Biol (2009) 4.27
Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving. J Neurosci (2003) 3.30
The pharmacology of sigma-1 receptors. Pharmacol Ther (2009) 3.12
The sigma-1 receptor chaperone as an inter-organelle signaling modulator. Trends Pharmacol Sci (2010) 2.11
Sigma-1 receptors (sigma(1) binding sites) form raft-like microdomains and target lipid droplets on the endoplasmic reticulum: roles in endoplasmic reticulum lipid compartmentalization and export. J Pharmacol Exp Ther (2003) 1.67
Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity. Proc Natl Acad Sci U S A (2008) 1.63
Intracellular dynamics of sigma-1 receptors (sigma(1) binding sites) in NG108-15 cells. J Pharmacol Exp Ther (2003) 1.61
Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders. CNS Drugs (2004) 1.60
Neuroinflammation and regulation of glial glutamate uptake in neurological disorders. J Neurosci Res (2007) 1.59
Deregulation of hypothalamic-pituitary-adrenal axis functions in an Alzheimer's disease rat model. Neurobiol Aging (2012) 1.49
Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration. Blood (2010) 1.44
Involvement of the sigma(1) receptor in cocaine-induced conditioned place preference: possible dependence on dopamine uptake blockade. Neuropsychopharmacology (2002) 1.39
Differential effects of sigma1 receptor blockade on self-administration and conditioned reinstatement motivated by cocaine vs natural reward. Neuropsychopharmacology (2007) 1.32
Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine. Cell (2013) 1.31
Sigma(1) (sigma(1)) receptor antagonists represent a new strategy against cocaine addiction and toxicity. Neurosci Biobehav Rev (2002) 1.31
Functionally selective cannabinoid receptor signalling: therapeutic implications and opportunities. Biochem Pharmacol (2010) 1.25
An update on the development of drugs for neuropsychiatric disorders: focusing on the sigma 1 receptor ligand. Expert Opin Ther Targets (2008) 1.24
Sigma1 receptor upregulation after chronic methamphetamine self-administration in rats: a study with yoked controls. Psychopharmacology (Berl) (2004) 1.22
Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders. Expert Opin Ther Targets (2011) 1.22
The sigma-1 receptor: roles in neuronal plasticity and disease. Trends Neurosci (2012) 1.22
Regulation of sigma-1 receptors and endoplasmic reticulum chaperones in the brain of methamphetamine self-administering rats. J Pharmacol Exp Ther (2009) 1.21
Cocaine hijacks σ1 receptor to initiate induction of activated leukocyte cell adhesion molecule: implication for increased monocyte adhesion and migration in the CNS. J Neurosci (2011) 1.21
Nerve growth factor-induced neurite sprouting in PC12 cells involves sigma-1 receptors: implications for antidepressants. J Pharmacol Exp Ther (2002) 1.20
Loss of metabotropic glutamate receptor-mediated regulation of glutamate transport in chemically activated astrocytes in a rat model of amyotrophic lateral sclerosis. J Neurochem (2005) 1.20
Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1xGTP pathway. Proc Natl Acad Sci U S A (2009) 1.18
Sigma-1 receptors at galactosylceramide-enriched lipid microdomains regulate oligodendrocyte differentiation. Proc Natl Acad Sci U S A (2004) 1.18
Sigma-1 receptors potentiate epidermal growth factor signaling towards neuritogenesis in PC12 cells: potential relation to lipid raft reconstitution. Synapse (2004) 1.17
A Role for Sigma Receptors in Stimulant Self Administration and Addiction. Pharmaceuticals (Basel) (2011) 1.16
Brain-derived neurotrophic factor and hypothalamic-pituitary-adrenal axis adaptation processes in a depressive-like state induced by chronic restraint stress. Mol Cell Neurosci (2010) 1.13
The sigma1 protein as a target for the non-genomic effects of neuro(active)steroids: molecular, physiological, and behavioral aspects. J Pharmacol Sci (2006) 1.12
Diadenosine tetraphosphate protects against injuries induced by ischemia and 6-hydroxydopamine in rat brain. J Neurosci (2003) 1.11
The sigma1 (sigma1) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug priming. Psychopharmacology (Berl) (2004) 1.09
The potential role of sigma-1 receptors in lipid transport and lipid raft reconstitution in the brain: implication for drug abuse. Life Sci (2005) 1.09
Hibernation-like state induced by an opioid peptide protects against experimental stroke. BMC Biol (2009) 1.09
Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release. J Biol Chem (2006) 1.09
Sigma-1 receptor chaperones and diseases. Cent Nerv Syst Agents Med Chem (2009) 1.08
A mechanism for the inhibition of neural progenitor cell proliferation by cocaine. PLoS Med (2008) 1.07
Delta opioid peptide (D-Ala 2, D-Leu 5) enkephalin: linking hibernation and neuroprotection. Front Biosci (2004) 1.06
Versatility of GPCR recognition by drugs: from biological implications to therapeutic relevance. Trends Pharmacol Sci (2007) 1.05
Oxidative stress, inflammation, and autophagic stress as the key mechanisms of premature age-related hearing loss in SAMP8 mouse Cochlea. Antioxid Redox Signal (2011) 1.05
Sigma 1 receptor-related neuroactive steroids modulate cocaine-induced reward. J Neurosci (2003) 1.03
Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival. PLoS One (2013) 1.02
Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity. Neuroreport (2005) 1.02
Anxiolytic properties of green tea polyphenol (-)-epigallocatechin gallate (EGCG). Brain Res (2006) 1.00
Comparison of cannabinoid ligands affinities and efficacies in murine tissues and in transfected cells expressing human recombinant cannabinoid receptors. Eur J Pharm Sci (2004) 0.99
Time-course and regional analyses of the physiopathological changes induced after cerebral injection of an amyloid β fragment in rats. Am J Pathol (2011) 0.98
Chimerization of astroglial population in the lumbar spinal cord after mesenchymal stem cell transplantation prolongs survival in a rat model of amyotrophic lateral sclerosis. J Neurosci Res (2009) 0.98
Protein kinase A activation down-regulates, whereas extracellular signal-regulated kinase activation up-regulates sigma-1 receptors in B-104 cells: Implication for neuroplasticity. J Pharmacol Exp Ther (2006) 0.97
Late N-acetylcysteine treatment prevents the deficits induced in the offspring of dams exposed to an immune stress during gestation. Hippocampus (2008) 0.97
Involvement of the sigma 1 receptor in the motivational effects of ethanol in mice. Pharmacol Biochem Behav (2003) 0.95
Neurodevelopmental damage after prenatal infection: role of oxidative stress in the fetal brain. Free Radic Biol Med (2007) 0.95
Sex differences in learning deficits induced by prenatal stress in juvenile rats. Behav Brain Res (2004) 0.94
The role of cholesterol in the association of endoplasmic reticulum membranes with mitochondria. Biochem Biophys Res Commun (2011) 0.94
Cocaine and HIV-1 interplay: molecular mechanisms of action and addiction. J Neuroimmune Pharmacol (2011) 0.93
Induction of glial glutamate transporters in adult mesenchymal stem cells. J Neurochem (2004) 0.93
Cocaine and HIV-1 interplay in CNS: cellular and molecular mechanisms. Curr HIV Res (2012) 0.93
Acute up-regulation of glutamate uptake mediated by mGluR5a in reactive astrocytes. J Neurochem (2005) 0.92
Prevention of chronic postoperative pain: cellular, molecular, and clinical insights for mechanism-based treatment approaches. Prog Neurobiol (2013) 0.92
Insights into the Sigma-1 receptor chaperone's cellular functions: a microarray report. Synapse (2011) 0.91
Antiamnesic and neuroprotective effects of the aminotetrahydrofuran derivative ANAVEX1-41 against amyloid beta(25-35)-induced toxicity in mice. Neuropsychopharmacology (2008) 0.91
Induction of astrogliosis by activated microglia is associated with a down-regulation of metabotropic glutamate receptor 5. J Neuroimmunol (2007) 0.91
Time-dependent changes in GLT-1 functioning in striatum of hemi-Parkinson rats. Neurochem Int (2010) 0.91
Neuroactive steroids modulate HPA axis activity and cerebral brain-derived neurotrophic factor (BDNF) protein levels in adult male rats. Psychoneuroendocrinology (2007) 0.90
Phosphatidylethanol accumulation promotes intestinal hyperplasia by inducing ZONAB-mediated cell density increase in response to chronic ethanol exposure. Mol Cancer Res (2007) 0.90
Influence of intrathecal delivery of bone marrow-derived mesenchymal stem cells on spinal inflammation and pain hypersensitivity in a rat model of peripheral nerve injury. J Neuroinflammation (2014) 0.90
Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas. J Pharmacol Exp Ther (2006) 0.89
Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma 1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative. J Psychopharmacol (2010) 0.89
Blockade of Tau hyperphosphorylation and Aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ₁ receptor agonist, in a nontransgenic mouse model of Alzheimer's disease. Neuropsychopharmacology (2013) 0.88
Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor. Synapse (2012) 0.88
Altered expression of regulators of G-protein signaling (RGS) mRNAs in the striatum of rats undergoing dopamine depletion. Biochem Pharmacol (2003) 0.87
Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg Med Chem (2013) 0.87
Specific regulation of rat glial cell line-derived neurotrophic factor gene expression by riluzole in C6 glioma cells. J Neurochem (2006) 0.87
Antiapoptotic and cytotoxic properties of delta opioid peptide [D-Ala(2),D-Leu(5)]enkephalin in PC12 cells. Synapse (2002) 0.87
Down-regulation of astrocytic GLAST by microglia-related inflammation is abrogated in dibutyryl cAMP-differentiated cultures. J Neurochem (2008) 0.86
Beneficial effects of the sigma1 receptor agonists igmesine and dehydroepiandrosterone against learning impairments in rats prenatally exposed to cocaine. Neurotoxicol Teratol (2004) 0.85
Preserved sigma1 (sigma1) receptor expression and behavioral efficacy in the aged C57BL/6 mouse. Neurobiol Aging (2003) 0.85
Bcl-2 family in inter-organelle modulation of calcium signaling; roles in bioenergetics and cell survival. J Bioenerg Biomembr (2014) 0.85
Alteration of working memory but not in anxiety or stress response in p300/CBP associated factor (PCAF) histone acetylase knockout mice bred on a C57BL/6 background. Neurosci Lett (2010) 0.85
Up-regulation of spinal microglial Iba-1 expression persists after resolution of neuropathic pain hypersensitivity. Neurosci Lett (2013) 0.85
A role for sigma receptors in stimulant self-administration and addiction. Behav Pharmacol (2016) 0.85
Cytoskeleton-related trafficking of the EAAC1 glutamate transporter after activation of the G(q/11)-coupled neurotensin receptor NTS1. FEBS Lett (2002) 0.85
The lifetime of UDP-galactose:ceramide galactosyltransferase is controlled by a distinct endoplasmic reticulum-associated degradation (ERAD) regulated by sigma-1 receptor chaperones. J Biol Chem (2012) 0.84
Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-β peptide injection in rats. PLoS One (2013) 0.84
Neuroprotective effects of donepezil against Aβ42-induced neuronal toxicity are mediated through not only enhancing PP2A activity but also regulating GSK-3β and nAChRs activity. J Neurochem (2013) 0.84
The ocular anomalies in a cystinosis animal model mimic disease pathogenesis. Pediatr Res (2007) 0.84
Amantadine and memantine induce the expression of the glial cell line-derived neurotrophic factor in C6 glioma cells. Neurosci Lett (2005) 0.84
Enhanced neuroinflammation and pain hypersensitivity after peripheral nerve injury in rats expressing mutated superoxide dismutase 1. J Neuroinflammation (2011) 0.84
Glutamate-induced glioma cell proliferation is prevented by functional expression of the glutamate transporter GLT-1. FEBS Lett (2008) 0.83
Opposite modulation of regulators of G protein signalling-2 RGS2 and RGS4 expression by dopamine receptors in the rat striatum. Neurosci Lett (2002) 0.83
Memory impairments and oxidative stress in the hippocampus of in-utero cocaine-exposed rats. Neuroreport (2005) 0.83
Mitochondrial peroxiredoxin-5 as potential modulator of mitochondria-ER crosstalk in MPP+-induced cell death. J Neurochem (2013) 0.83
Cholesterol at the endoplasmic reticulum: roles of the sigma-1 receptor chaperone and implications thereof in human diseases. Subcell Biochem (2010) 0.83
Increasing the density of the D2L receptor and manipulating the receptor environment are required to evidence the partial agonist properties of aripiprazole. Prog Neuropsychopharmacol Biol Psychiatry (2011) 0.83