Published in Proc Natl Acad Sci U S A on December 11, 2009
The sigma-1 receptor chaperone as an inter-organelle signaling modulator. Trends Pharmacol Sci (2010) 2.11
Dendritic spine pathology in schizophrenia. Neuroscience (2012) 1.91
Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine. Cell (2013) 1.31
The sigma-1 receptor: roles in neuronal plasticity and disease. Trends Neurosci (2012) 1.22
Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders. Expert Opin Ther Targets (2011) 1.22
The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements. Eur J Pharmacol (2012) 1.16
A Role for Sigma Receptors in Stimulant Self Administration and Addiction. Pharmaceuticals (Basel) (2011) 1.16
Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival. PLoS One (2013) 1.02
Amelioration of acute sequelae of blast induced mild traumatic brain injury by N-acetyl cysteine: a double-blind, placebo controlled study. PLoS One (2013) 1.00
Sigma-1 receptor regulates Tau phosphorylation and axon extension by shaping p35 turnover via myristic acid. Proc Natl Acad Sci U S A (2015) 0.93
Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc(-), the Na(+)-independent glutamate-cystine exchanger. Free Radic Biol Med (2015) 0.92
Insights into the Sigma-1 receptor chaperone's cellular functions: a microarray report. Synapse (2011) 0.91
A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity. J Neural Transm (Vienna) (2013) 0.90
The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems. Trends Pharmacol Sci (2016) 0.90
Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope. Proc Natl Acad Sci U S A (2015) 0.87
A role for sigma receptors in stimulant self-administration and addiction. Behav Pharmacol (2016) 0.85
Paradoxical relationship between Mn superoxide dismutase deficiency and radiation-induced cognitive defects. PLoS One (2012) 0.85
Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration. Proc Natl Acad Sci U S A (2016) 0.84
UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior. PLoS One (2012) 0.83
Mitochondrial protection by the mixed muscarinic/σ1 ligand ANAVEX2-73, a tetrahydrofuran derivative, in Aβ25-35 peptide-injected mice, a nontransgenic Alzheimer's disease model. Front Cell Neurosci (2015) 0.83
Efficacy of N-acetyl cysteine in traumatic brain injury. PLoS One (2014) 0.82
Evaluation of σ-1 receptor radioligand 18F-FTC-146 in rats and squirrel monkeys using PET. J Nucl Med (2013) 0.81
A direct interaction between the sigma-1 receptor and the hERG voltage-gated K+ channel revealed by atomic force microscopy and homogeneous time-resolved fluorescence (HTRF®). J Biol Chem (2014) 0.80
Sigma-1 receptor chaperones in neurodegenerative and psychiatric disorders. Expert Opin Ther Targets (2014) 0.79
Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria. BMC Biochem (2015) 0.78
The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease. Neurobiol Dis (2016) 0.78
Phospholipase C, Ca2+, and calmodulin signaling are required for 5-HT2A receptor-mediated transamidation of Rac1 by transglutaminase. Psychopharmacology (Berl) (2010) 0.77
Sigma-1 Receptors and Neurodegenerative Diseases: Towards a Hypothesis of Sigma-1 Receptors as Amplifiers of Neurodegeneration and Neuroprotection. Adv Exp Med Biol (2017) 0.76
Neuropharmacology of N,N-dimethyltryptamine. Brain Res Bull (2016) 0.75
Transactivation of TrkB by Sigma-1 receptor mediates cocaine-induced changes in dendritic spine density and morphology in hippocampal and cortical neurons. Cell Death Dis (2016) 0.75
Potential Molecular Mechanisms on the Role of the Sigma-1 Receptor in the Action of Cocaine and Methamphetamine. J Drug Alcohol Res (2016) 0.75
AF710B, a Novel M1/σ1 Agonist with Therapeutic Efficacy in Animal Models of Alzheimer’s Disease. Neurodegener Dis (2016) 0.75
Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT. Sci Rep (2017) 0.75
Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, "selectivity pocket" and NAD(+)-binding site. Chem Sci (2017) 0.75
Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases. J Biomed Sci (2017) 0.75
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther (1976) 9.13
Mitochondria: more than just a powerhouse. Curr Biol (2006) 6.76
Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival. Cell (2007) 6.13
Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology (2004) 6.08
Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems. Science (1988) 3.01
The endoplasmic reticulum: folding, calcium homeostasis, signaling, and redox control. Antioxid Redox Signal (2006) 2.92
The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines. Neuron (2005) 2.91
The permeability transition pore complex: another view. Biochimie (2002) 2.88
VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. J Cell Biol (2001) 2.80
Making the connection: cytoskeletal rearrangements during growth cone guidance. Cell (1995) 2.51
The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator. Science (2009) 2.49
The sigma receptor as a ligand-regulated auxiliary potassium channel subunit. Neuron (2002) 2.44
A focus on the synapse for neuroprotection in Alzheimer disease and other dementias. Neurology (2004) 2.35
The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis. Nat Cell Biol (2006) 2.12
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nat Cell Biol (2002) 2.12
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Calcium and mitochondria. FEBS Lett (2004) 1.64
Key regulators in neuronal polarity. Neuron (2005) 1.46
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Convergent CaMK and RacGEF signals control dendritic structure and function. Trends Cell Biol (2008) 1.38
Lateral diffusion of inositol 1,4,5-trisphosphate receptor type 1 is regulated by actin filaments and 4.1N in neuronal dendrites. J Biol Chem (2004) 1.26
An update on the development of drugs for neuropsychiatric disorders: focusing on the sigma 1 receptor ligand. Expert Opin Ther Targets (2008) 1.24
Actin cleavage by CPP-32/apopain during the development of apoptosis. Oncogene (1997) 1.19
Do apoptotic mechanisms regulate synaptic plasticity and growth-cone motility? Neuromolecular Med (2002) 1.18
Sigma-1 receptors at galactosylceramide-enriched lipid microdomains regulate oligodendrocyte differentiation. Proc Natl Acad Sci U S A (2004) 1.18
Sigma-1 receptors potentiate epidermal growth factor signaling towards neuritogenesis in PC12 cells: potential relation to lipid raft reconstitution. Synapse (2004) 1.17
Neuroprotective and anti-amnesic potentials of sigma (sigma) receptor ligands. Prog Neuropsychopharmacol Biol Psychiatry (1997) 1.13
Regulators of Rho GTPases in neuronal development. J Neurosci (2006) 1.11
Receptor mechanisms in antipsychotic drug action: focus on sigma receptors. J Neuropsychiatry Clin Neurosci (1989) 1.08
Exercise-induced synaptogenesis in the hippocampus is dependent on UCP2-regulated mitochondrial adaptation. J Neurosci (2008) 1.06
Calcium-induced activation of the mitochondrial permeability transition in hippocampal neurons. J Neurosci Res (1998) 1.03
Caspase-mediated degradation of AMPA receptor subunits: a mechanism for preventing excitotoxic necrosis and ensuring apoptosis. J Neurosci (2000) 1.02
Probing the steroid binding domain-like I (SBDLI) of the sigma-1 receptor binding site using N-substituted photoaffinity labels. Biochemistry (2008) 0.98
Neuroprotective effect of N-acetyl cysteine on hypoxia-induced oxidative stress in primary hippocampal culture. Brain Res (2005) 0.96
Selective down-regulation of IP(3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells. Cell Calcium (2000) 0.91
Fluvoxamine as a sigma-1 receptor agonist improved cognitive impairments in a patient with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry (2008) 0.89
Biochemical and morphological analysis on the localization of Rac1 in neurons. Neurosci Res (2001) 0.89
N-acetyl cysteine supplementation prevents impairment of spatial working memory functions in rats following exposure to hypobaric hypoxia. Physiol Behav (2007) 0.85
Neuroleptic-sensitive binding sites in the nigrostriatal system: evidence for differential distribution of sigma sites in the substantia nigra, pars compacta of the cat. J Neurosci (1989) 0.83
Caspase-mediated cleavage of the TIAM1 guanine nucleotide exchange factor during apoptosis. Cell Growth Differ (2001) 0.83
Neuropeptide Y and the calcitonin gene-related peptide attenuate learning impairments induced by MK-801 via a sigma receptor-related mechanism. Eur J Neurosci (1997) 0.82
The anti-amnesic effects of sigma1 (sigma1) receptor agonists confirmed by in vivo antisense strategy in the mouse. Brain Res (2001) 0.80
Inhibition of selenite-catalyzed superoxide generation and formation of elemental selenium (Se(o)) by copper, zinc, and aurintricarboxylic acid (ATA). Biochem Pharmacol (1996) 0.79
Dynamic control of neuronal morphogenesis by rho signaling. J Biochem (2003) 0.78
Structural-functional correlates of neuroprotection in the aging rabbit by a calcium channel blocker. Nimodipine reverses neocortical dendritic atrophy and improves memory retention. Ann N Y Acad Sci (1995) 0.77
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Interneurons of the neocortical inhibitory system. Nat Rev Neurosci (2004) 13.33
The genetic association database. Nat Genet (2004) 11.29
Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci U S A (2004) 8.74
Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex. Nat Rev Neurosci (2008) 8.14
Analysis of microarray data using Z score transformation. J Mol Diagn (2003) 6.82
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival. Cell (2007) 6.13
Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. PLoS Med (2006) 6.04
An administrative claims measure suitable for profiling hospital performance on the basis of 30-day all-cause readmission rates among patients with heart failure. Circ Cardiovasc Qual Outcomes (2008) 6.00
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71
Patterns of hospital performance in acute myocardial infarction and heart failure 30-day mortality and readmission. Circ Cardiovasc Qual Outcomes (2009) 5.66
An administrative claims model suitable for profiling hospital performance based on 30-day mortality rates among patients with an acute myocardial infarction. Circulation (2006) 5.35
miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell (2009) 5.22
National and regional trends in heart failure hospitalization and mortality rates for Medicare beneficiaries, 1998-2008. JAMA (2011) 5.16
An administrative claims model suitable for profiling hospital performance based on 30-day mortality rates among patients with heart failure. Circulation (2006) 4.52
RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature (2002) 4.37
Trends in length of stay and short-term outcomes among Medicare patients hospitalized for heart failure, 1993-2006. JAMA (2010) 4.36
The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J Biol Chem (2006) 4.28
MAM: more than just a housekeeper. Trends Cell Biol (2009) 4.27
Reduction in acute myocardial infarction mortality in the United States: risk-standardized mortality rates from 1995-2006. JAMA (2009) 4.24
Association between maintenance of certification examination scores and quality of care for medicare beneficiaries. Arch Intern Med (2008) 4.20
The melting Himalayas: cascading effects of climate change on water, biodiversity, and livelihoods. Conserv Biol (2009) 4.02
Recent national trends in readmission rates after heart failure hospitalization. Circ Heart Fail (2009) 3.95
Effect of air pollution control on life expectancy in the United States: an analysis of 545 U.S. counties for the period from 2000 to 2007. Epidemiology (2013) 3.93
LincRNA-p21 suppresses target mRNA translation. Mol Cell (2012) 3.87
Global analysis of stress-regulated mRNA turnover by using cDNA arrays. Proc Natl Acad Sci U S A (2002) 3.71
Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria. Science (2011) 3.66
RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice. Neuron (2003) 3.58
Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet (2006) 3.34
Recent declines in hospitalizations for acute myocardial infarction for Medicare fee-for-service beneficiaries: progress and continuing challenges. Circulation (2010) 3.32
Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving. J Neurosci (2003) 3.30
Synaptic connections and small circuits involving excitatory and inhibitory neurons in layers 2-5 of adult rat and cat neocortex: triple intracellular recordings and biocytin labelling in vitro. Cereb Cortex (2002) 3.28
Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Proc Natl Acad Sci U S A (2006) 3.26
AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22
The pharmacology of sigma-1 receptors. Pharmacol Ther (2009) 3.12
White spot syndromes of the retina: a hypothesis based on the common genetic hypothesis of autoimmune/inflammatory disease. Am J Ophthalmol (2003) 2.97
Preconditioning results in S-nitrosylation of proteins involved in regulation of mitochondrial energetics and calcium transport. Circ Res (2007) 2.97
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell (2011) 2.90
Germline mitochondrial DNA mutations aggravate ageing and can impair brain development. Nature (2013) 2.90
Comparative study of three proteomic quantitative methods, DIGE, cICAT, and iTRAQ, using 2D gel- or LC-MALDI TOF/TOF. J Proteome Res (2006) 2.73
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
New insights into the classification and nomenclature of cortical GABAergic interneurons. Nat Rev Neurosci (2013) 2.65
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MicroRNA expression and identification of putative miRNA targets in ovarian cancer. PLoS One (2008) 2.60
Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB. PLoS Genet (2013) 2.59
Causes of blindness and visual impairment in urban and rural areas in Beijing: the Beijing Eye Study. Ophthalmology (2006) 2.59
Application of z-score transformation to Affymetrix data. Appl Bioinformatics (2003) 2.56
High myopia and glaucoma susceptibility the Beijing Eye Study. Ophthalmology (2006) 2.40
National patterns of risk-standardized mortality and readmission for acute myocardial infarction and heart failure. Update on publicly reported outcomes measures based on the 2010 release. Circ Cardiovasc Qual Outcomes (2010) 2.33
Dopaminergic differentiation of human embryonic stem cells. Stem Cells (2004) 2.30
Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization. Nat Neurosci (2009) 2.30
An administrative claims model for profiling hospital 30-day mortality rates for pneumonia patients. PLoS One (2011) 2.22
Hospital volume and 30-day mortality for three common medical conditions. N Engl J Med (2010) 2.20
Outcomes of deep anterior lamellar keratoplasty using the big-bubble technique in various corneal diseases. Am J Ophthalmol (2012) 2.20
The performance of US hospitals as reflected in risk-standardized 30-day mortality and readmission rates for medicare beneficiaries with pneumonia. J Hosp Med (2010) 2.20
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Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability. BMC Genomics (2005) 2.18
Association of retail tobacco marketing with adolescent smoking. Am J Public Health (2004) 2.15
GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. Proc Natl Acad Sci U S A (2009) 2.15
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Regional variation in the treatment and outcomes of myocardial infarction: investigating New England's advantage. Am Heart J (2003) 2.11
The sigma-1 receptor chaperone as an inter-organelle signaling modulator. Trends Pharmacol Sci (2010) 2.11
Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells. Immunity (2009) 2.11
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Relationship between hospital readmission and mortality rates for patients hospitalized with acute myocardial infarction, heart failure, or pneumonia. JAMA (2013) 2.06
Mitochondrial matrix phosphoproteome: effect of extra mitochondrial calcium. Biochemistry (2006) 2.06
Hospital-acquired pressure ulcers: results from the national Medicare Patient Safety Monitoring System study. J Am Geriatr Soc (2012) 2.03
Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus. Neuron (2009) 2.01
Themis, a T cell-specific protein important for late thymocyte development. Nat Immunol (2009) 2.00
Systematic review and meta-analysis of Meniett therapy for Meniere's disease. Laryngoscope (2014) 1.98
ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy. Autophagy (2010) 1.97
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Deprivation-induced synaptic depression by distinct mechanisms in different layers of mouse visual cortex. Proc Natl Acad Sci U S A (2007) 1.92
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. Proc Natl Acad Sci U S A (2009) 1.91
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Coronary heart disease mortality for six ethnic groups in California, 1990-2000. Ann Epidemiol (2004) 1.83
Glutamatergic and nonglutamatergic neurons of the ventral tegmental area establish local synaptic contacts with dopaminergic and nondopaminergic neurons. J Neurosci (2010) 1.82
Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression. Hepatology (2015) 1.81
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
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