Published in Hum Mol Genet on April 21, 2004
HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation. Proc Natl Acad Sci U S A (2008) 2.10
Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells. Nat Rev Drug Discov (2009) 2.00
Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J Neurosci (2008) 1.88
HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis. Cell Death Differ (2006) 1.82
Epigenetics in the nervous system. J Neurosci (2008) 1.65
The role of histone acetylation in memory formation and cognitive impairments. Neuropsychopharmacology (2012) 1.53
Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease. Proc Natl Acad Sci U S A (2005) 1.42
Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity. Neuroscience (2007) 1.42
Putting the 'HAT' back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions. Expert Opin Investig Drugs (2009) 1.28
Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia. Mol Pain (2010) 1.19
Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4. Proc Natl Acad Sci U S A (2012) 1.16
Histone deacetylase inhibitors prevent p53-dependent and p53-independent Bax-mediated neuronal apoptosis through two distinct mechanisms. J Neurosci (2009) 1.13
Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc. Proc Natl Acad Sci U S A (2012) 1.11
Atrophin proteins: an overview of a new class of nuclear receptor corepressors. Nucl Recept Signal (2008) 1.10
Phenylbutyrate up-regulates the DJ-1 protein and protects neurons in cell culture and in animal models of Parkinson disease. J Biol Chem (2011) 1.10
The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity. FASEB J (2008) 1.09
Microarray analysis of gene expression by skeletal muscle of three mouse models of Kennedy disease/spinal bulbar muscular atrophy. PLoS One (2010) 1.02
Spinal and bulbar muscular atrophy: a motoneuron or muscle disease? Curr Opin Pharmacol (2008) 1.01
Histone deacetylases as targets for the treatment of human neurodegenerative diseases. Drug News Perspect (2009) 1.00
Butyrate transcriptionally enhances peptide transporter PepT1 expression and activity. PLoS One (2008) 0.98
Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease. PLoS One (2012) 0.97
Epigenetic mechanisms in cerebral ischemia. J Cereb Blood Flow Metab (2013) 0.93
Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders. Curr Pharm Des (2013) 0.93
Searching for disease modifiers-PKC activation and HDAC inhibition - a dual drug approach to Alzheimer's disease that decreases Abeta production while blocking oxidative stress. ChemMedChem (2009) 0.93
Androgen receptor and Kennedy disease/spinal bulbar muscular atrophy. Horm Behav (2008) 0.92
Developing treatment for spinal and bulbar muscular atrophy. Prog Neurobiol (2012) 0.92
Sodium valproate alleviates neurodegeneration in SCA3/MJD via suppressing apoptosis and rescuing the hypoacetylation levels of histone H3 and H4. PLoS One (2013) 0.91
Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract. Nat Med (2012) 0.91
Acquisition of sexual receptivity: roles of chromatin acetylation, estrogen receptor-alpha, and ovarian hormones. Endocrinology (2011) 0.90
Spinal and bulbar muscular atrophy: pathogenesis and clinical management. Oral Dis (2013) 0.89
Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration. Nat Commun (2013) 0.88
Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease. J Biol Chem (2014) 0.87
The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging. Aging Cell (2015) 0.86
Mouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II. Mol Neurobiol (2012) 0.86
Acetyltransferases (HATs) as targets for neurological therapeutics. Neurotherapeutics (2013) 0.83
Histone acetylation, acetyltransferases, and ataxia--alteration of histone acetylation and chromatin dynamics is implicated in the pathogenesis of polyglutamine-expansion disorders. Adv Protein Chem Struct Biol (2010) 0.83
Experience-facilitated improvements in pup retrieval; evidence for an epigenetic effect. Horm Behav (2012) 0.82
Ataxin-3 protein and RNA toxicity in spinocerebellar ataxia type 3: current insights and emerging therapeutic strategies. Mol Neurobiol (2013) 0.81
The promise and perils of HDAC inhibitors in neurodegeneration. Ann Clin Transl Neurol (2014) 0.81
General Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus. Anesthesiology (2016) 0.80
Histone deacetylase inhibition induces long-lasting changes in maternal behavior and gene expression in female mice. Endocrinology (2014) 0.80
Involvement of HDAC1 and HDAC3 in the Pathology of Polyglutamine Disorders: Therapeutic Implications for Selective HDAC1/HDAC3 Inhibitors. Pharmaceuticals (Basel) (2014) 0.80
Pathogenic mechanisms and therapeutic strategies in spinobulbar muscular atrophy. CNS Neurol Disord Drug Targets (2013) 0.80
Epigenetic drugs in the treatment of skeletal muscle atrophy. Curr Opin Clin Nutr Metab Care (2008) 0.80
Altered gene expression, mitochondrial damage and oxidative stress: converging routes in motor neuron degeneration. Int J Cell Biol (2012) 0.79
c-Abl inhibition delays motor neuron degeneration in the G93A mouse, an animal model of amyotrophic lateral sclerosis. PLoS One (2012) 0.79
A critical time window for the survival of neural progenitor cells by HDAC inhibitors in the hippocampus. Mol Cells (2010) 0.78
Current status of treatment of spinal and bulbar muscular atrophy. Neural Plast (2012) 0.78
Neuropathology and therapeutic intervention in spinal and bulbar muscular atrophy. Int J Mol Sci (2009) 0.78
Polyglutamine androgen receptor-mediated neuromuscular disease. Cell Mol Life Sci (2016) 0.77
Activation of p38MAPK contributes to expanded polyglutamine-induced cytotoxicity. PLoS One (2008) 0.77
Animal models of Kennedy disease. NeuroRx (2005) 0.77
Epigenetics and Triplet-Repeat Neurological Diseases. Front Neurol (2015) 0.76
Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph Disease. PLoS One (2015) 0.76
Emerging roles for histone deacetylases in age-related muscle atrophy. Nutr Healthy Aging (2016) 0.75
Alleviating neurodegeneration in Drosophila models of PolyQ diseases. Cerebellum Ataxias (2014) 0.75
Post-translational Modifications and Protein Quality Control in Motor Neuron and Polyglutamine Diseases. Front Mol Neurosci (2017) 0.75
Sodium Butyrate and Valproic Acid as Splicing Restoring Agents in Erythroid Cells of β-Thalassemic Patients. Iran J Biotechnol (2016) 0.75
FD, a bZIP protein mediating signals from the floral pathway integrator FT at the shoot apex. Science (2005) 6.38
Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res (2011) 6.02
Hd3a, a rice ortholog of the Arabidopsis FT gene, promotes transition to flowering downstream of Hd1 under short-day conditions. Plant Cell Physiol (2002) 4.49
Reprogramming of mouse and human cells to pluripotency using mature microRNAs. Cell Stem Cell (2011) 4.02
Characterization of a side population of cancer cells from human gastrointestinal system. Stem Cells (2005) 3.66
The wide spectrum of clinical manifestations in Sjögren's syndrome-associated neuropathy. Brain (2005) 3.65
CD13 is a therapeutic target in human liver cancer stem cells. J Clin Invest (2010) 3.60
Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity (2011) 3.38
17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration. Nat Med (2005) 3.19
Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Neuron (2002) 2.98
Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein. Hum Mol Genet (2003) 2.89
TWIN SISTER OF FT (TSF) acts as a floral pathway integrator redundantly with FT. Plant Cell Physiol (2005) 2.80
Progression and prognosis in multiple system atrophy: an analysis of 230 Japanese patients. Brain (2002) 2.35
Over- and under-expressed microRNAs in human colorectal cancer. Int J Oncol (2009) 2.34
Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol (2010) 2.33
Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy. Neuron (2009) 2.26
Retinoic-acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells. Dev Biol (2004) 2.17
Defined factors induce reprogramming of gastrointestinal cancer cells. Proc Natl Acad Sci U S A (2009) 2.11
ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor. Nat Med (2007) 1.87
Natural history of transthyretin Val30Met familial amyloid polyneuropathy: analysis of late-onset cases from non-endemic areas. J Neurol Neurosurg Psychiatry (2012) 1.81
CD133+CD44+ population efficiently enriches colon cancer initiating cells. Ann Surg Oncol (2008) 1.76
Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. Cancer Res (2002) 1.75
Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy. Nat Med (2003) 1.73
Nationwide survey of juvenile muscular atrophy of distal upper extremity (Hirayama disease) in Japan. Amyotroph Lateral Scler (2006) 1.73
Usefulness of combined fractional anisotropy and apparent diffusion coefficient values for detection of involvement in multiple system atrophy. J Neurol Neurosurg Psychiatry (2007) 1.69
Spatiotemporal recapitulation of central nervous system development by murine embryonic stem cell-derived neural stem/progenitor cells. Stem Cells (2008) 1.67
MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab. Clin Cancer Res (2011) 1.66
Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem (2002) 1.63
Biological and genetic characteristics of tumor-initiating cells in colon cancer. Ann Surg Oncol (2007) 1.62
Clinical significance of TROP2 expression in colorectal cancer. Clin Cancer Res (2006) 1.61
Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis. Ann Neurol (2005) 1.59
Clinical and neuropathological correlates of Lewy body disease. Acta Neuropathol (2003) 1.58
Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions. Sci Rep (2012) 1.58
Natural history of spinal and bulbar muscular atrophy (SBMA): a study of 223 Japanese patients. Brain (2006) 1.57
Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1. J Biol Chem (2007) 1.57
Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein. J Neurosci (2003) 1.54
Clinical significance of miR-146a in gastric cancer cases. Clin Cancer Res (2011) 1.50
Suppression of UV-induced wrinkle formation by induction of HSP70 expression in mice. J Invest Dermatol (2012) 1.46
TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases. J Biol Chem (2009) 1.44
Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy. Ann Neurol (2009) 1.43
Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease. Proc Natl Acad Sci U S A (2005) 1.42
Extracellular signal-regulated kinase 2 (ERK2) knockdown mice show deficits in long-term memory; ERK2 has a specific function in learning and memory. J Neurosci (2007) 1.41
Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2. Nat Med (2012) 1.41