Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers.

PubWeight™: 6.02‹?› | Rank: Top 1%

🔗 View Article (PMID 21862635)

Published in Cancer Res on August 23, 2011

Authors

Ryunosuke Kogo1, Teppei Shimamura, Koshi Mimori, Kohichi Kawahara, Seiya Imoto, Tomoya Sudo, Fumiaki Tanaka, Kohei Shibata, Akira Suzuki, Shizuo Komune, Satoru Miyano, Masaki Mori

Author Affiliations

1: Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

Articles citing this

(truncated to the top 100)

Genome regulation by long noncoding RNAs. Annu Rev Biochem (2012) 11.70

The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol (2012) 5.60

HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene (2012) 4.30

Long non-coding RNAs and cancer: a new frontier of translational research? Oncogene (2012) 3.83

Long noncoding RNAs: past, present, and future. Genetics (2013) 3.16

Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer. Nat Struct Mol Biol (2013) 2.84

Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer. Mol Cancer (2014) 2.70

Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs. Nucleic Acids Res (2012) 2.47

Long non-coding RNA: a new player in cancer. J Hematol Oncol (2013) 2.26

Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer. PLoS One (2013) 2.26

Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18. J Biol Chem (2012) 2.16

The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer. BMC Cancer (2013) 2.11

Malat1 is not an essential component of nuclear speckles in mice. RNA (2012) 1.90

Targeted disruption of Hotair leads to homeotic transformation and gene derepression. Cell Rep (2013) 1.89

Regulation of mammalian cell differentiation by long non-coding RNAs. EMBO Rep (2012) 1.82

Targeting long non-coding RNA to therapeutically upregulate gene expression. Nat Rev Drug Discov (2013) 1.82

Concern The functional role of long non-coding RNAs and epigenetics. Biol Proced Online (2014) 1.73

Metastasis-associated long non-coding RNA drives gastric cancer development and promotes peritoneal metastasis. Carcinogenesis (2014) 1.72

A long non-coding RNA signature to improve prognosis prediction of colorectal cancer. Oncotarget (2014) 1.64

Long Noncoding RNAs in Cancer Pathways. Cancer Cell (2016) 1.63

LncRNA profile study reveals a three-lncRNA signature associated with the survival of patients with oesophageal squamous cell carcinoma. Gut (2014) 1.61

Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers. Br J Cancer (2013) 1.58

Intronic RNAs mediate EZH2 regulation of epigenetic targets. Nat Struct Mol Biol (2012) 1.56

The long noncoding RNA HOTAIR contributes to cisplatin resistance of human lung adenocarcinoma cells via downregualtion of p21(WAF1/CIP1) expression. PLoS One (2013) 1.55

Down-regulation of long non-coding RNA GAS5 is associated with the prognosis of hepatocellular carcinoma. Int J Clin Exp Pathol (2014) 1.54

Long non-coding RNA in cancer. Int J Mol Sci (2013) 1.52

HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma. Neuro Oncol (2013) 1.47

Low expression of LOC285194 is associated with poor prognosis in colorectal cancer. J Transl Med (2013) 1.45

Long noncoding RNA HOTAIR is a prognostic marker for esophageal squamous cell carcinoma progression and survival. PLoS One (2013) 1.44

Long non-coding RNA expression profile in human gastric cancer and its clinical significances. J Transl Med (2013) 1.43

Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiol. J Mol Biol (2013) 1.41

Perspectives of Long Non-Coding RNAs in Cancer Diagnostics. Front Genet (2012) 1.41

Long non-coding RNA HOTAIR, a driver of malignancy, predicts negative prognosis and exhibits oncogenic activity in oesophageal squamous cell carcinoma. Br J Cancer (2013) 1.40

Long non-coding RNAs in cancer progression. Front Genet (2012) 1.40

HOTAIR: an oncogenic long non-coding RNA in different cancers. Cancer Biol Med (2015) 1.40

A pathophysiological view of the long non-coding RNA world. Oncotarget (2014) 1.36

Expression and prognostic impact of lncRNAs in acute myeloid leukemia. Proc Natl Acad Sci U S A (2014) 1.35

Pathway-based personalized analysis of cancer. Proc Natl Acad Sci U S A (2013) 1.35

Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell apoptosis by epigenetic silencing of KLF2. J Hematol Oncol (2015) 1.34

Long noncoding RNAs in development and cancer: potential biomarkers and therapeutic targets. Mol Cell Ther (2015) 1.32

Long non-coding RNA HOTAIR promotes glioblastoma cell cycle progression in an EZH2 dependent manner. Oncotarget (2015) 1.29

Long noncoding RNA involvement in cancer. BMB Rep (2012) 1.28

Regulation and Role of EZH2 in Cancer. Cancer Res Treat (2014) 1.27

Long non-coding RNA HOTAIR is associated with human cervical cancer progression. Int J Oncol (2014) 1.26

Uncovering the role of genomic "dark matter" in human disease. J Clin Invest (2012) 1.26

Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers. Gastroenterology (2015) 1.24

Long non-coding RNA HOTAIR in carcinogenesis and metastasis. Acta Biochim Biophys Sin (Shanghai) (2013) 1.23

Functions of lncRNA HOTAIR in lung cancer. J Hematol Oncol (2014) 1.23

Junk DNA and the long non-coding RNA twist in cancer genetics. Oncogene (2015) 1.22

LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer. Biochim Biophys Acta (2015) 1.21

Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells. J Biol Chem (2014) 1.21

Genistein inhibits prostate cancer cell growth by targeting miR-34a and oncogenic HOTAIR. PLoS One (2013) 1.19

Downregulation of GAS5 promotes bladder cancer cell proliferation, partly by regulating CDK6. PLoS One (2013) 1.19

Long noncoding RNAs: a potential novel class of cancer biomarkers. Front Genet (2015) 1.17

Non-coding RNAs: key regulators of mammalian transcription. Trends Biochem Sci (2012) 1.17

Long non-coding RNAs: challenges for diagnosis and therapies. Nucleic Acid Ther (2013) 1.16

A long non-coding RNA, PTCSC3, as a tumor suppressor and a target of miRNAs in thyroid cancer cells. Exp Ther Med (2013) 1.15

MicroRNA-200c overexpression inhibits tumorigenicity and metastasis of CD117+CD44+ ovarian cancer stem cells by regulating epithelial-mesenchymal transition. J Ovarian Res (2013) 1.14

KSHV PAN RNA associates with demethylases UTX and JMJD3 to activate lytic replication through a physical interaction with the virus genome. PLoS Pathog (2012) 1.14

Emerging Roles for Long Non-Coding RNAs in Cancer and Neurological Disorders. Front Genet (2012) 1.13

Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell proliferation by epigenetic silencing of KLF2. J Hematol Oncol (2015) 1.12

Physiological roles of long noncoding RNAs: insight from knockout mice. Trends Cell Biol (2014) 1.12

The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration. Oncotarget (2015) 1.12

Argonaute and the nuclear RNAs: new pathways for RNA-mediated control of gene expression. Nucleic Acid Ther (2012) 1.10

Long non-coding RNA CCAT2 is up-regulated in gastric cancer and associated with poor prognosis. Int J Clin Exp Pathol (2015) 1.10

Long non-coding RNA HOTAIR promotes cell migration and invasion via down-regulation of RNA binding motif protein 38 in hepatocellular carcinoma cells. Int J Mol Sci (2014) 1.09

Binding interactions between long noncoding RNA HOTAIR and PRC2 proteins. Biochemistry (2013) 1.09

Long non-coding RNAs in stem cells and cancer. World J Clin Oncol (2014) 1.08

Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues. Epigenetics (2012) 1.08

Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer. Cancer Med (2014) 1.08

A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation. EMBO J (2013) 1.08

Up-regulation of 91H promotes tumor metastasis and predicts poor prognosis for patients with colorectal cancer. PLoS One (2014) 1.08

Upregulation of the long non-coding RNA PlncRNA-1 promotes esophageal squamous carcinoma cell proliferation and correlates with advanced clinical stage. Dig Dis Sci (2013) 1.07

Long noncoding RNA MRUL promotes ABCB1 expression in multidrug-resistant gastric cancer cell sublines. Mol Cell Biol (2014) 1.07

An emerging understanding of long noncoding RNAs in kidney cancer. J Cancer Res Clin Oncol (2014) 1.07

Long noncoding RNAs in cancer: from function to translation. Trends Cancer (2015) 1.06

LincHOTAIR epigenetically silences miR34a by binding to PRC2 to promote the epithelial-to-mesenchymal transition in human gastric cancer. Cell Death Dis (2015) 1.04

Long noncoding RNA HOTAIR as an independent prognostic marker in cancer: a meta-analysis. PLoS One (2014) 1.04

A novel RNA in situ hybridization assay for the long noncoding RNA SChLAP1 predicts poor clinical outcome after radical prostatectomy in clinically localized prostate cancer. Neoplasia (2014) 1.04

Expression pattern of long non-coding RNAs in renal cell carcinoma revealed by microarray. PLoS One (2014) 1.04

Predicting lncRNA-disease associations and constructing lncRNA functional similarity network based on the information of miRNA. Sci Rep (2015) 1.04

Diverse involvement of EZH2 in cancer epigenetics. Am J Transl Res (2015) 1.04

BRAF-activated long non-coding RNA contributes to colorectal cancer migration by inducing epithelial-mesenchymal transition. Oncol Lett (2014) 1.04

LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2. Oncotarget (2015) 1.03

Long non-coding RNAs and complex human diseases. Int J Mol Sci (2013) 1.03

Noncoding RNA in oncogenesis: a new era of identifying key players. Int J Mol Sci (2013) 1.03

Long non-coding RNA LSINCT5 predicts negative prognosis and exhibits oncogenic activity in gastric cancer. Medicine (Baltimore) (2014) 1.01

Epigenetics: an emerging player in gastric cancer. World J Gastroenterol (2014) 1.01

Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo. J Steroid Biochem Mol Biol (2014) 1.01

Expression of lncRNA-CCAT1, E-cadherin and N-cadherin in colorectal cancer and its clinical significance. Int J Clin Exp Med (2015) 1.01

Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets. Oncogene (2015) 0.99

Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides. Nucleic Acids Res (2015) 0.99

Prediction of long noncoding RNA functions with co-expression network in esophageal squamous cell carcinoma. BMC Cancer (2015) 0.98

Knockdown of long non-coding RNA HOTAIR inhibits malignant biological behaviors of human glioma cells via modulation of miR-326. Oncotarget (2015) 0.98

From discovery to function: the expanding roles of long noncoding RNAs in physiology and disease. Endocr Rev (2014) 0.98

From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition? Clin Epigenetics (2015) 0.98

Long non-coding RNA AOC4P suppresses hepatocellular carcinoma metastasis by enhancing vimentin degradation and inhibiting epithelial-mesenchymal transition. Oncotarget (2015) 0.96

Large intervening non-coding RNA HOTAIR is an indicator of poor prognosis and a therapeutic target in human cancers. Int J Mol Sci (2014) 0.96

Expression profile of long non-coding RNAs in pancreatic cancer and their clinical significance as biomarkers. Oncotarget (2015) 0.96

LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer. Cell Rep (2015) 0.96

Articles by these authors

International network of cancer genome projects. Nature (2010) 20.35

Frequent pathway mutations of splicing machinery in myelodysplasia. Nature (2011) 11.44

Orangutan cultures and the evolution of material culture. Science (2003) 6.06

Extensive feature detection of N-terminal protein sorting signals. Bioinformatics (2002) 5.16

Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat Genet (2012) 4.84

Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet (2013) 4.61

Clinical significance of circulating tumor cells, including cancer stem-like cells, in peripheral blood for recurrence and prognosis in patients with Dukes' stage B and C colorectal cancer. J Clin Oncol (2011) 4.48

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell (2002) 4.35

Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature (2006) 4.09

Reprogramming of mouse and human cells to pluripotency using mature microRNAs. Cell Stem Cell (2011) 4.02

Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest (2004) 3.92

Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol (2002) 3.75

Characterization of a side population of cancer cells from human gastrointestinal system. Stem Cells (2005) 3.66

The wide spectrum of clinical manifestations in Sjögren's syndrome-associated neuropathy. Brain (2005) 3.65

CD13 is a therapeutic target in human liver cancer stem cells. J Clin Invest (2010) 3.60

Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia. N Engl J Med (2015) 3.42

Epithelial-mesenchymal transition in cancer development and its clinical significance. Cancer Sci (2009) 3.39

Familial cancer associated with a polymorphism in ARLTS1. N Engl J Med (2005) 3.35

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration. Nat Med (2005) 3.19

Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19

Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma. Cancer Cell (2002) 3.12

Nitrogen uptake, assimilation and remobilization in plants: challenges for sustainable and productive agriculture. Ann Bot (2010) 3.11

Survival benefit of bursectomy in patients with resectable gastric cancer: interim analysis results of a randomized controlled trial. Gastric Cancer (2011) 2.97

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein. Hum Mol Genet (2003) 2.89

Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas. Cancer Res (2011) 2.81

Abnormal conformation and impaired degradation of propylthiouracil-induced neutrophil extracellular traps: implications of disordered neutrophil extracellular traps in a rat model of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum (2012) 2.69

CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res (2013) 2.57

Prediction of transcriptional terminators in Bacillus subtilis and related species. PLoS Comput Biol (2005) 2.54

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest (2006) 2.38

Over- and under-expressed microRNAs in human colorectal cancer. Int J Oncol (2009) 2.34

Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol (2010) 2.33

A large-scale study of MT1-MMP as a marker for isolated tumor cells in peripheral blood and bone marrow in gastric cancer cases. Ann Surg Oncol (2008) 2.32

Estimation of genetic networks and functional structures between genes by using Bayesian networks and nonparametric regression. Pac Symp Biocomput (2002) 2.30

The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev (2005) 2.18

Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma. J Hepatol (2011) 2.18

Major issues and challenges of influenza pandemic preparedness in developing countries. Emerg Infect Dis (2008) 2.16

Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms. Nat Genet (2013) 2.14

Subcuticular sutures versus staples for skin closure after open gastrointestinal surgery: a phase 3, multicentre, open-label, randomised controlled trial. Lancet (2013) 2.14

Somatic SETBP1 mutations in myeloid malignancies. Nat Genet (2013) 2.12

Defined factors induce reprogramming of gastrointestinal cancer cells. Proc Natl Acad Sci U S A (2009) 2.11

Nonpolypoid neoplastic lesions of the colorectal mucosa. Gastrointest Endosc (2008) 2.09

Whole-genome sequencing and comprehensive variant analysis of a Japanese individual using massively parallel sequencing. Nat Genet (2010) 2.08

Inferring gene networks from time series microarray data using dynamic Bayesian networks. Brief Bioinform (2003) 2.08

Laparoscopy-assisted hybrid left-side donor hepatectomy. World J Surg (2013) 2.02

A Japanese Lung Cancer Registry study: prognosis of 13,010 resected lung cancers. J Thorac Oncol (2008) 2.01

The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma. J Hepatol (2010) 2.00

High prevalence of obstructive sleep apnea and its association with renal function among nondialysis chronic kidney disease patients in Japan: a cross-sectional study. Clin J Am Soc Nephrol (2011) 1.98

Enterovirus 68 among children with severe acute respiratory infection, the Philippines. Emerg Infect Dis (2011) 1.96

Optimal management of the branch duct type intraductal papillary mucinous neoplasms of the pancreas. J Clin Gastroenterol (2003) 1.96

Estimating gene networks from gene expression data by combining Bayesian network model with promoter element detection. Bioinformatics (2003) 1.95

Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol (2005) 1.93

Combining microarrays and biological knowledge for estimating gene networks via Bayesian networks. Proc IEEE Comput Soc Bioinform Conf (2003) 1.89

Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Invest (2007) 1.86

Natural history of transthyretin Val30Met familial amyloid polyneuropathy: analysis of late-onset cases from non-endemic areas. J Neurol Neurosurg Psychiatry (2012) 1.81

Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma. Oncol Rep (2012) 1.81

Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production. Development (2003) 1.80

Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients. Blood (2013) 1.79

CD133+CD44+ population efficiently enriches colon cancer initiating cells. Ann Surg Oncol (2008) 1.76

Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. Cancer Res (2002) 1.75

Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA family. Clin Cancer Res (2008) 1.73

Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia. Nat Genet (2013) 1.71

Influence of bursectomy on operative morbidity and mortality after radical gastrectomy for gastric cancer: results of a randomized controlled trial. World J Surg (2011) 1.70

Usefulness of combined fractional anisotropy and apparent diffusion coefficient values for detection of involvement in multiple system atrophy. J Neurol Neurosurg Psychiatry (2007) 1.69

A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. Nat Genet (2005) 1.69

Retracted Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice. Nat Med (2004) 1.69

Modeling gene expression regulatory networks with the sparse vector autoregressive model. BMC Syst Biol (2007) 1.69

The tumor-suppressive miR-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma. PLoS One (2013) 1.69

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten. Proc Natl Acad Sci U S A (2004) 1.67

MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab. Clin Cancer Res (2011) 1.66

A risk model for esophagectomy using data of 5354 patients included in a Japanese nationwide web-based database. Ann Surg (2014) 1.65

Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma. Cancer Res (2002) 1.62