Published in Mol Pharmacol on May 01, 2004
Mechanisms of neurosteroid interactions with GABA(A) receptors. Pharmacol Ther (2007) 1.60
Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids. Mol Pharmacol (2008) 1.46
Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis. J Neurosci (2010) 1.17
Treatment with and withdrawal from finasteride alter ethanol intake patterns in male C57BL/6J mice: potential role of endogenous neurosteroids? Alcohol (2005) 1.17
The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction. J Neurophysiol (2009) 1.14
Neurosteroid interactions with synaptic and extrasynaptic GABA(A) receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability. Psychopharmacology (Berl) (2013) 1.14
Neurosteroids, stress and depression: potential therapeutic opportunities. Neurosci Biobehav Rev (2012) 1.12
Neurosteroids and GABA(A) Receptor Interactions: A Focus on Stress. Front Neurosci (2011) 1.04
Cyclodextrins sequester neuroactive steroids and differentiate mechanisms that rate limit steroid actions. Br J Pharmacol (2006) 1.03
Acute and chronic effects of ethanol on learning-related synaptic plasticity. Alcohol (2013) 1.03
Neuroactive steroids and human recombinant rho1 GABAC receptors. J Pharmacol Exp Ther (2007) 1.00
The anti-convulsant stiripentol acts directly on the GABA(A) receptor as a positive allosteric modulator. Neuropharmacology (2008) 0.97
Neuroactive steroid stereospecificity of ethanol-like discriminative stimulus effects in monkeys. J Pharmacol Exp Ther (2008) 0.95
Mechanisms of potentiation of the mammalian GABAA receptor by the marine cembranoid eupalmerin acetate. Br J Pharmacol (2007) 0.91
The effect of age on the discriminative stimulus effects of ethanol and its GABA(A) receptor mediation in cynomolgus monkeys. Psychopharmacology (Berl) (2011) 0.84
Neurosteroids and GABA-A Receptor Function. Front Endocrinol (Lausanne) (2011) 0.82
Flavan-3-ol esters: new agents for exploring modulatory sites on GABA(A) receptors. Br J Pharmacol (2012) 0.82
GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response. Front Neuroendocrinol (2014) 0.82
Photodynamic effects of steroid-conjugated fluorophores on GABAA receptors. Mol Pharmacol (2009) 0.80
Antagonism of neurosteroid modulation of native gamma-aminobutyric acid receptors by (3alpha,5alpha)-17-phenylandrost-16-en-3-ol. Eur J Pharmacol (2007) 0.79
A spontaneous tonic chloride conductance in solitary glutamatergic hippocampal neurons. Brain Res (2006) 0.78
Intrathecal neurosteroids and a neurosteroid antagonist: effects on inflammation-evoked thermal hyperalgesia and tactile allodynia. Neurosci Lett (2013) 0.78
Allopregnanolone in the bed nucleus of the stria terminalis modulates contextual fear in rats. Front Behav Neurosci (2015) 0.77
Modulating GABA modulators. Br J Pharmacol (2006) 0.77
A 17beta-derivative of allopregnanolone is a neurosteroid antagonist at a cerebellar subpopulation of GABA A receptors with nanomolar affinity. Br J Pharmacol (2007) 0.75
Comparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed α1β2γ2L GABAA Receptors. Mol Pharmacol (2016) 0.75
A mutant residue in the third transmembrane region of the GABA(A) alpha1 subunit causes increased agonistic neurosteroid responses. Neurochem Int (2011) 0.75
Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes. Sci Rep (2017) 0.75
Anesthesia awareness and the bispectral index. N Engl J Med (2008) 8.08
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci (2003) 7.42
Prevention of intraoperative awareness in a high-risk surgical population. N Engl J Med (2011) 5.20
Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature (2009) 4.68
Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain. Anesthesiology (2010) 4.44
Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis. Science (2011) 4.13
Long-term cognitive decline in older subjects was not attributable to noncardiac surgery or major illness. Anesthesiology (2009) 3.56
The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell (2007) 3.54
Association analyses identify six new psoriasis susceptibility loci in the Chinese population. Nat Genet (2010) 2.41
Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity. Proc Natl Acad Sci U S A (2002) 2.25
Anticonvulsant medications extend worm life-span. Science (2005) 2.18
Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture. Proc Natl Acad Sci U S A (2004) 2.14
Dependence of current and field driven depinning of domain walls on their structure and chirality in permalloy nanowires. Phys Rev Lett (2006) 2.11
The phosphodiesterase-5 inhibitor vardenafil reduces oxidative stress while reversing pulmonary arterial hypertension. Cardiovasc Res (2013) 2.08
Isoflurane inhibits transmitter release and the presynaptic action potential. Anesthesiology (2004) 2.07
[SSRI during pregnancy and risk of fetal neurotoxicity. Follow precautions and look for other therapeutic alternatives]. Lakartidningen (2005) 2.03
What are we looking for? The question of resident selection. Anesthesiology (2012) 1.97
The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. Immunity (2012) 1.96
Neurosteroid access to the GABAA receptor. J Neurosci (2005) 1.95
Relationship between bispectral index values and volatile anesthetic concentrations during the maintenance phase of anesthesia in the B-Unaware trial. Anesthesiology (2011) 1.81
Complete genome sequence of Paenibacillus polymyxa SC2, a strain of plant growth-promoting Rhizobacterium with broad-spectrum antimicrobial activity. J Bacteriol (2010) 1.76
Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem (2006) 1.72
Zipper-like interaction between proteins in adjacent daughter cells mediates protein localization. Genes Dev (2004) 1.72
Oxysterols are allosteric activators of the oncoprotein Smoothened. Nat Chem Biol (2012) 1.72
Performance of residents and anesthesiologists in a simulation-based skill assessment. Anesthesiology (2007) 1.68
Review of clinical evidence for persistent cognitive decline or incident dementia attributable to surgery or general anesthesia. J Alzheimers Dis (2011) 1.66
Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease. Proc Natl Acad Sci U S A (2006) 1.62
Mechanisms of neurosteroid interactions with GABA(A) receptors. Pharmacol Ther (2007) 1.60
Ketamine-induced neuroapoptosis in the fetal and neonatal rhesus macaque brain. Anesthesiology (2012) 1.59
Potential of xenon to induce or to protect against neuroapoptosis in the developing mouse brain. Can J Anaesth (2008) 1.57
Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J Pharmacol Exp Ther (2007) 1.55
Increased risk of intraoperative awareness in patients with a history of awareness. Anesthesiology (2013) 1.53
Targeted conditional gene knockout in human embryonic stem cells. Cell Res (2010) 1.53
Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects. Studies with cholesterol enantiomers. J Biol Chem (2003) 1.52
Anesthetic neurotoxicity--clinical implications of animal models. N Engl J Med (2015) 1.49
Neuroactive steroids have multiple actions to potentiate GABAA receptors. J Physiol (2004) 1.47
Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids. Mol Pharmacol (2008) 1.46
Tubular graphite cones. Science (2003) 1.44
Perspective: Upcoming paradigm shifts for psychiatry in clinical care, research, and education. Acad Med (2012) 1.43
Oscillatory dependence of current-driven magnetic domain wall motion on current pulse length. Nature (2006) 1.42
Performance of certified registered nurse anesthetists and anesthesiologists in a simulation-based skills assessment. Anesth Analg (2009) 1.40
Retracted Pathological dislocation of the hip due to coxotuberculosis in children: a 29-case report. J Orthop Surg Res (2014) 1.38
Zinc modulates bidirectional hippocampal plasticity by effects on NMDA receptors. J Neurosci (2006) 1.35
Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor. Mol Pharmacol (2007) 1.33
Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone. J Cell Mol Med (2008) 1.33
Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analog on recombinant alpha1beta2gamma2 GABAA receptors. Mol Pharmacol (2006) 1.31
Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens. Eur J Med Chem (2007) 1.31
Diverse voltage-sensitive dyes modulate GABAA receptor function. J Neurosci (2010) 1.24
Slow actions of neuroactive steroids at GABAA receptors. J Neurosci (2004) 1.24
Effects of natural and enantiomeric cholesterol on the thermotropic phase behavior and structure of egg sphingomyelin bilayer membranes. Biophys J (2003) 1.24
Inhibitory effect of ginsenoside Rg3 on ovarian cancer metastasis. Chin Med J (Engl) (2008) 1.23
Neuroexcitatory actions of Tamiflu and its carboxylate metabolite. Neurosci Lett (2007) 1.22
A propofol binding site on mammalian GABAA receptors identified by photolabeling. Nat Chem Biol (2013) 1.21
Continuous time random walk model better describes the tailing of atrazine transport in soil. Chemosphere (2008) 1.21
The sticky issue of neurosteroids and GABA(A) receptors. Trends Neurosci (2010) 1.21
Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system. Neurobiol Dis (2008) 1.20
3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists. J Neurosci (2002) 1.18
Analysis of eight organophosphorus pesticide residues in fresh vegetables retailed in agricultural product markets of Nanjing, China. Bull Environ Contam Toxicol (2008) 1.17
Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis. J Neurosci (2010) 1.17
Lower socioeconomic status is associated with worse outcomes in pulmonary arterial hypertension. Am J Respir Crit Care Med (2012) 1.17
Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions. J Biol Chem (2008) 1.17
Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo. Brain Res (2005) 1.16
Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice. Diabetes (2009) 1.15
Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling. Elife (2013) 1.15
Chromatin immunoprecipitation-based screen to identify functional genomic binding sites for sequence-specific transactivators. Mol Cell Biol (2005) 1.15
Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci (2007) 1.14
Psychiatric education in an era of rapidly occurring scientific advances. Acad Med (2003) 1.14
The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction. J Neurophysiol (2009) 1.14
Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA. Epilepsia (2004) 1.14
Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies. Cancer Res (2011) 1.13
Resonant amplification of magnetic domain-wall motion by a train of current pulses. Science (2007) 1.13
352 nm ultraviolet emission from high-quality crystalline AlN whiskers. Nanotechnology (2010) 1.12
Neurosteroids, stress and depression: potential therapeutic opportunities. Neurosci Biobehav Rev (2012) 1.12
Pathogenesis in menstrual cycle-linked CNS disorders. Ann N Y Acad Sci (2003) 1.11
Energetics by NMR: site-specific binding in a positively cooperative system. Proc Natl Acad Sci U S A (2002) 1.11
Gastrointestinal absorption and plasma kinetics of soy Delta(5)-phytosterols and phytostanols in humans. Am J Physiol Endocrinol Metab (2002) 1.11
The role of hormones and hormonal treatments in premenstrual syndrome. CNS Drugs (2003) 1.10
First synthesis of ent-desmosterol and its conversion to ent-deuterocholesterol. Steroids (2003) 1.10
Estrogen-like compounds for ischemic neuroprotection. Stroke (2004) 1.10
Application of canonical correspondence analysis to determine the ecological contribution of phytoplankton to PCBs bioaccumulation in Qinhuai River, Nanjing, China. Environ Sci Pollut Res Int (2013) 1.10
Contribution of presynaptic Na(+) channel inactivation to paired-pulse synaptic depression in cultured hippocampal neurons. J Neurophysiol (2002) 1.08
Inhibitory effect of ginsenoside Rg3 combined with cyclophosphamide on growth and angiogenesis of ovarian cancer. Chin Med J (Engl) (2007) 1.07
Dynamic processes involved in the pre-vascularization of silk fibroin constructs for bone regeneration using outgrowth endothelial cells. Biomaterials (2008) 1.07