Published in Steroids on February 01, 2003
Lipid rafts: heterogeneity on the high seas. Biochem J (2004) 3.46
Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects. Studies with cholesterol enantiomers. J Biol Chem (2003) 1.52
Lipid raft: A floating island of death or survival. Toxicol Appl Pharmacol (2012) 1.25
The enantiomer of cholesterol. J Membr Biol (2004) 1.13
Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies. Biochem J (2005) 1.06
Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIalpha at the trans-Golgi network. J Lipid Res (2010) 0.98
Enantioselective protein-sterol interactions mediate regulation of both prokaryotic and eukaryotic inward rectifier K+ channels by cholesterol. PLoS One (2011) 0.96
Cholesterol tuning of BK ethanol response is enantioselective, and is a function of accompanying lipids. PLoS One (2011) 0.94
Synthesis of a smoothened cholesterol: 18,19-di-nor-cholesterol. J Org Chem (2014) 0.79
Synthesis of 19-Trideuterated ent-Testosterone and the GABA(A) Receptor Potentiators ent-Androsterone and ent-Etiocholanolone. J Labelled Comp Radiopharm (2008) 0.77
Identification of a cholesterol-binding pocket in inward rectifier K(+) (Kir) channels. Biophys J (2014) 0.75
Anticonvulsant medications extend worm life-span. Science (2005) 2.18
The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. Immunity (2012) 1.96
Neurosteroid access to the GABAA receptor. J Neurosci (2005) 1.95
Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem (2006) 1.72
Oxysterols are allosteric activators of the oncoprotein Smoothened. Nat Chem Biol (2012) 1.72
Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease. Proc Natl Acad Sci U S A (2006) 1.62
Mechanisms of neurosteroid interactions with GABA(A) receptors. Pharmacol Ther (2007) 1.60
Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J Pharmacol Exp Ther (2007) 1.55
Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects. Studies with cholesterol enantiomers. J Biol Chem (2003) 1.52
Neuroactive steroids have multiple actions to potentiate GABAA receptors. J Physiol (2004) 1.47
Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids. Mol Pharmacol (2008) 1.46
Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone. J Cell Mol Med (2008) 1.33
Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor. Mol Pharmacol (2007) 1.33
Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analog on recombinant alpha1beta2gamma2 GABAA receptors. Mol Pharmacol (2006) 1.31
Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens. Eur J Med Chem (2007) 1.31
Slow actions of neuroactive steroids at GABAA receptors. J Neurosci (2004) 1.24
Effects of natural and enantiomeric cholesterol on the thermotropic phase behavior and structure of egg sphingomyelin bilayer membranes. Biophys J (2003) 1.24
Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors. Mol Pharmacol (2004) 1.23
The sticky issue of neurosteroids and GABA(A) receptors. Trends Neurosci (2010) 1.21
3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists. J Neurosci (2002) 1.18
Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions. J Biol Chem (2008) 1.17
Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo. Brain Res (2005) 1.16
Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice. Diabetes (2009) 1.15
Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling. Elife (2013) 1.15
The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction. J Neurophysiol (2009) 1.14
Neurosteroids, stress and depression: potential therapeutic opportunities. Neurosci Biobehav Rev (2012) 1.12
Energetics by NMR: site-specific binding in a positively cooperative system. Proc Natl Acad Sci U S A (2002) 1.11
Gastrointestinal absorption and plasma kinetics of soy Delta(5)-phytosterols and phytostanols in humans. Am J Physiol Endocrinol Metab (2002) 1.11
Estrogen-like compounds for ischemic neuroprotection. Stroke (2004) 1.10
Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation. J Physiol (2007) 1.07
Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells. Mol Pharmacol (2006) 1.06
Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies. Biochem J (2005) 1.06
Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor. Mol Pharmacol (2012) 1.05
Neurosteroids enhance spontaneous glutamate release in hippocampal neurons. Possible role of metabotropic sigma1-like receptors. J Biol Chem (2002) 1.03
Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light. Nat Neurosci (2007) 1.03
Characterization of enantiomeric bile acid-induced apoptosis in colon cancer cell lines. J Biol Chem (2008) 1.01
GABAergic neurosteroids mediate the effects of ethanol on long-term potentiation in rat hippocampal slices. Eur J Neurosci (2007) 1.01
Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain. J Biol Chem (2003) 1.01
Neuroprotective effects of a novel non-receptor-binding estrogen analogue: in vitro and in vivo analysis. Stroke (2002) 1.01
Neuroactive steroids and human recombinant rho1 GABAC receptors. J Pharmacol Exp Ther (2007) 1.00
Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids. J Med Chem (2007) 0.99
Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes. J Med Chem (2008) 0.98
Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIalpha at the trans-Golgi network. J Lipid Res (2010) 0.98
Total synthesis of ent-cholesterol via a steroid C,D-ring side-chain synthon. J Org Chem (2002) 0.97
Differential interaction of the two cholesterol-dependent, membrane-damaging toxins, streptolysin O and Vibrio cholerae cytolysin, with enantiomeric cholesterol. FEBS Lett (2003) 0.97
Enantioselective protein-sterol interactions mediate regulation of both prokaryotic and eukaryotic inward rectifier K+ channels by cholesterol. PLoS One (2011) 0.96
The enantiomer of progesterone acts as a molecular neuroprotectant after traumatic brain injury. Neuropharmacology (2006) 0.95
Cholesterol tuning of BK ethanol response is enantioselective, and is a function of accompanying lipids. PLoS One (2011) 0.94
Hydrogen bonding between the 17beta-substituent of a neurosteroid and the GABA(A) receptor is not obligatory for channel potentiation. Br J Pharmacol (2009) 0.93
Palladium-catalyzed potassium enoxyborate alkylation of enantiopure Hajos-Parrish indenone to construct rearranged steroid ring systems. J Org Chem (2007) 0.93
Enantiomers of neuroactive steroids support a specific interaction with the GABA-C receptor as the mechanism of steroid action. Mol Pharmacol (2006) 0.92
Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes. Br J Pharmacol (2012) 0.92
Glucuronidation of the steroid enantiomers ent-17β-estradiol, ent-androsterone and ent-etiocholanolone by the human UDP-glucuronosyltransferases. J Steroid Biochem Mol Biol (2011) 0.91
5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo. Mol Pharmacol (2004) 0.91
The influence of the membrane on neurosteroid actions at GABA(A) receptors. Psychoneuroendocrinology (2009) 0.91
Lack of enantiomeric specificity in the effects of anesthetic steroids on lipid bilayers. Biochim Biophys Acta (2006) 0.91
Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids. Curr Neuropharmacol (2010) 0.90
The neurosteroids dehydroepiandrosterone sulfate and pregnenolone sulfate inhibit the UNC-49 GABA receptor through a common set of residues. Mol Pharmacol (2007) 0.90
Estrogen receptor-independent neuroprotection via protein phosphatase preservation and attenuation of persistent extracellular signal-regulated kinase 1/2 activation. J Pharmacol Exp Ther (2007) 0.89
Oxysterols as non-genomic regulators of cholesterol homeostasis. Trends Endocrinol Metab (2012) 0.89
T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor. Neuropharmacology (2010) 0.88
Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia. J Pharmacol Exp Ther (2003) 0.88
Enantiospecific interactions between cholesterol and phospholipids. Langmuir (2008) 0.88
Kinetic analysis of voltage-dependent potentiation and block of the glycine alpha 3 receptor by a neuroactive steroid analogue. J Physiol (2009) 0.88
Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels. Diabetes (2013) 0.87
Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog. Biochem Pharmacol (2004) 0.87
Racemic progesterone: predicted in silico and produced in the solid state. Chem Commun (Camb) (2006) 0.87
The assessment of non-feminizing estrogens for use in neuroprotection. Brain Res (2010) 0.87
A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors. J Pharmacol Exp Ther (2010) 0.87
The structural basis of cholesterol accessibility in membranes. Biophys J (2013) 0.86
The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21. Arch Biochem Biophys (2003) 0.86
Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone. J Med Chem (2013) 0.85
Synthesis of ent-25-hydroxycholesterol. Steroids (2006) 0.85
Role of nonfeminizing estrogen analogues in neuroprotection of rat retinal ganglion cells against glutamate-induced cytotoxicity. Free Radic Biol Med (2005) 0.85
Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues. Bioorg Med Chem Lett (2010) 0.85
Effects on membrane capacitance of steroids with antagonist properties at GABAA receptors. Biophys J (2008) 0.85
A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: a mass spectrometric analysis. Electrophoresis (2012) 0.85
A simple efficient synthesis of [23,24]-(13)C(2)-labeled bile salts as NMR probes of protein-ligand interactions. Bioorg Med Chem Lett (2002) 0.84
Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one. J Med Chem (2005) 0.84
The estrogen receptor is not essential for all estrogen neuroprotection: new evidence from a new analog. Neurobiol Dis (2002) 0.84
Mechanism of okadaic acid-induced neuronal death and the effect of estrogens. J Neurochem (2008) 0.83
Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain? Psychoneuroendocrinology (2009) 0.83
NMDA potentiation by visible light in the presence of a fluorescent neurosteroid analogue. J Physiol (2009) 0.83
Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on γ-aminobutyric acid type A receptors. J Med Chem (2012) 0.83
Steroid ring hydroxylation patterns govern cooperativity in human bile acid binding protein. Biochemistry (2003) 0.82
A single hydroxyl group governs ligand site selectivity in human ileal bile acid binding protein. J Am Chem Soc (2004) 0.82
Synthesis of [3,4-(13)c(2)]-enriched bile salts as NMR probes of protein-ligand interactions. J Org Chem (2002) 0.82
Enantiomeric deoxycholic acid: total synthesis, characterization, and preliminary toxicity toward colon cancer cell lines. J Org Chem (2007) 0.81
Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact rats. Pain (2006) 0.81
Neuroprotection with non-feminizing estrogen analogues: an overlooked possible therapeutic strategy. Horm Behav (2012) 0.80
Photodynamic effects of steroid-conjugated fluorophores on GABAA receptors. Mol Pharmacol (2009) 0.80
First synthesis of enantiopure 1,6-difunctionalized dodecahydrobenz[f]indenes. J Org Chem (2005) 0.79
Inhibition of T-type calcium current in the reticular thalamic nucleus by a novel neuroactive steroid. Ann N Y Acad Sci (2007) 0.79
Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters. J Lipid Res (2006) 0.79
Antagonism of neurosteroid modulation of native gamma-aminobutyric acid receptors by (3alpha,5alpha)-17-phenylandrost-16-en-3-ol. Eur J Pharmacol (2007) 0.79
Pregnenolone sulfate and its enantiomer: differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient mice. Eur Neuropsychopharmacol (2010) 0.79
The use of symmetry in enantioselective synthesis: four pairs of chrysene enantiomers prepared from 19-nortestosterone. Org Biomol Chem (2011) 0.79