Published in Nature on April 22, 2004
Regulation of Raf-1 by direct feedback phosphorylation. Mol Cell (2005) 5.88
Unlocking the code of 14-3-3. J Cell Sci (2004) 2.58
Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol Cell Biol (2002) 2.54
Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites. Curr Biol (2003) 1.98
Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling. Mol Cell Biol (2009) 1.81
Signaling dynamics of the KSR1 scaffold complex. Proc Natl Acad Sci U S A (2009) 1.76
CK2 Is a component of the KSR1 scaffold complex that contributes to Raf kinase activation. Curr Biol (2006) 1.69
AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol (2010) 1.64
Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy. Genes Dev (2012) 1.60
KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity. Cell Metab (2009) 1.53
KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals. Mol Cell (2009) 1.39
Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling. Mol Cell (2013) 1.37
14-3-3 Proteins: diverse functions in cell proliferation and cancer progression. Semin Cell Dev Biol (2011) 1.31
Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway. J Biol Chem (2002) 1.30
Kinase suppressor of Ras1 compartmentalizes hippocampal signal transduction and subserves synaptic plasticity and memory formation. Neuron (2006) 1.26
RAF inhibitor-induced KSR1/B-RAF binding and its effects on ERK cascade signaling. Curr Biol (2011) 1.22
Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR). J Mol Biol (2002) 1.14
Morphogenesis during Xenopus gastrulation requires Wee1-mediated inhibition of cell proliferation. Development (2004) 1.09
The CNK1 scaffold binds cytohesins and promotes insulin pathway signaling. Genes Dev (2010) 1.05
Signal transduction: implications for Ras-dependent ERK signaling. Curr Biol (2004) 1.04
Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. EMBO J (2003) 1.01
Inhibition of lysophosphatidic acid acyltransferase beta disrupts proliferative and survival signals in normal cells and induces apoptosis of tumor cells. Mol Cancer Ther (2003) 1.00
FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4. Nat Commun (2013) 0.99
Identification of a Src tyrosine kinase/SIAH2 E3 ubiquitin ligase pathway that regulates C/EBPδ expression and contributes to transformation of breast tumor cells. Mol Cell Biol (2011) 0.97
BCL-2 and BCL-XL restrict lineage choice during hematopoietic differentiation. J Biol Chem (2003) 0.96
CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage. Proc Natl Acad Sci U S A (2010) 0.94
Caspase-dependent cleavage disrupts the ERK cascade scaffolding function of KSR1. J Biol Chem (2007) 0.93
dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila. Biochem J (2003) 0.92
LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation. Mol Cell (2012) 0.91
Overexpression of kinase suppressor of Ras upregulates the high-molecular-weight tropomyosin isoforms in ras-transformed NIH 3T3 fibroblasts. Mol Cell Biol (2003) 0.90
KSR regulation of the Raf-MEK-ERK cascade. Methods Enzymol (2006) 0.80
Complexity in KSR function revealed by Raf inhibitor and KSR structure studies. Small GTPases (2011) 0.79
A CC-SAM, for coiled coil-sterile α motif, domain targets the scaffold KSR-1 to specific sites in the plasma membrane. Sci Signal (2012) 0.79
Proteomic analysis of scaffold proteins in the ERK cascade. Methods Mol Biol (2010) 0.79
Assay of Raf-1 activity. Methods Enzymol (2002) 0.75