Increased neuronal nitric oxide synthase-derived NO production in the failing human heart.

PubWeight™: 3.07‹?› | Rank: Top 1%

🔗 View Article (PMID 15110495)

Published in Lancet on April 24, 2004

Authors

Thibaud Damy1, Philippe Ratajczak, Ajay M Shah, Emmanuel Camors, Isabelle Marty, Gerd Hasenfuss, Françoise Marotte, Jane-Lise Samuel, Christophe Heymes

Author Affiliations

1: INSERM U572 Hôpital Lariboisière, IFR J Marrey Paris-7, 41 Boulevard de la Chapelle, 75475 Paris Cedex 10, Université D Diderot, Paris, France.

Articles citing this

Nitric oxide and peroxynitrite in health and disease. Physiol Rev (2007) 15.49

Protein S-nitrosylation in health and disease: a current perspective. Trends Mol Med (2009) 3.75

S-nitrosylation in cardiovascular signaling. Circ Res (2010) 3.02

NO/redox disequilibrium in the failing heart and cardiovascular system. J Clin Invest (2005) 1.94

Deficient ryanodine receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytes. Proc Natl Acad Sci U S A (2007) 1.79

Cardioprotective effect of beta-3 adrenergic receptor agonism: role of neuronal nitric oxide synthase. J Am Coll Cardiol (2012) 1.72

Protein S-nitrosylation and cardioprotection. Circ Res (2010) 1.63

Redox signaling in cardiac myocytes. Free Radic Biol Med (2011) 1.62

Cardiovascular roles of nitric oxide: a review of insights from nitric oxide synthase gene disrupted mice. Cardiovasc Res (2008) 1.53

Nitrosative stress and pharmacological modulation of heart failure. Trends Pharmacol Sci (2005) 1.53

Nitric oxide signaling and the regulation of myocardial function. J Mol Cell Cardiol (2008) 1.50

Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure. Curr Vasc Pharmacol (2005) 1.42

Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model. Hypertension (2010) 1.39

Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Proc Natl Acad Sci U S A (2006) 1.36

Impaired S-nitrosylation of the ryanodine receptor caused by xanthine oxidase activity contributes to calcium leak in heart failure. J Biol Chem (2010) 1.35

The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS). PLoS Pathog (2009) 1.30

Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor. J Mol Cell Cardiol (2009) 1.24

SERCA2a gene transfer enhances eNOS expression and activity in endothelial cells. Mol Ther (2010) 1.18

S-Nitrosylation of cardiac ion channels. J Cardiovasc Pharmacol (2009) 1.12

Mechanisms by which exercise training benefits patients with heart failure. Nat Rev Cardiol (2009) 1.11

Endothelial nitric oxide synthase decreases beta-adrenergic responsiveness via inhibition of the L-type Ca2+ current. Am J Physiol Heart Circ Physiol (2008) 1.11

Endothelial dysfunction over the course of coronary artery disease. Eur Heart J (2013) 1.09

Reduced neuronal nitric oxide synthase expression contributes to cardiac oxidative stress and nitroso-redox imbalance in ob/ob mice. Nitric Oxide (2006) 1.08

Vagus nerve stimulation in experimental heart failure. Heart Fail Rev (2011) 1.07

Nitric oxide synthases in heart failure. Antioxid Redox Signal (2012) 1.07

Mechanisms of disease: detrimental adrenergic signaling in acute decompensated heart failure. Nat Clin Pract Cardiovasc Med (2008) 1.00

Molecular mechanisms of neuronal nitric oxide synthase in cardiac function and pathophysiology. J Physiol (2014) 0.99

Displacement-encoded and manganese-enhanced cardiac MRI reveal that nNOS, not eNOS, plays a dominant role in modulating contraction and calcium influx in the mammalian heart. Am J Physiol Heart Circ Physiol (2011) 0.99

Beta 3-adrenoreceptor regulation of nitric oxide in the cardiovascular system. J Mol Cell Cardiol (2010) 0.98

Ca2+-ATPases in non-failing and failing heart: evidence for a novel cardiac sarco/endoplasmic reticulum Ca2+-ATPase 2 isoform (SERCA2c). Biochem J (2006) 0.97

Signaling by S-nitrosylation in the heart. J Mol Cell Cardiol (2014) 0.97

Electrical vagus nerve stimulation for the treatment of chronic heart failure. Cleve Clin J Med (2011) 0.95

Isoproterenol-induced heart failure in the rat is associated with nitric oxide-dependent functional alterations of cardiac function. Eur J Heart Fail (2009) 0.95

Activation of the poly(ADP-ribose) polymerase pathway in human heart failure. Mol Med (2006) 0.94

The NO/ONOO-cycle as the central cause of heart failure. Int J Mol Sci (2013) 0.94

Nitroso-redox imbalance affects cardiac structure and function. J Am Coll Cardiol (2013) 0.93

Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain. J Biol Chem (2011) 0.93

The regulation of endothelial nitric oxide synthase by caveolin: a paradigm validated in vivo and shared by the 'endothelium-derived hyperpolarizing factor'. Pflugers Arch (2010) 0.88

Physiological implications of the interaction between the plasma membrane calcium pump and nNOS. Pflugers Arch (2008) 0.86

Diesterified nitrone rescues nitroso-redox levels and increases myocyte contraction via increased SR Ca(2+) handling. PLoS One (2012) 0.86

Regulation of endothelial nitric-oxide synthase (NOS) S-glutathionylation by neuronal NOS: evidence of a functional interaction between myocardial constitutive NOS isoforms. J Biol Chem (2012) 0.86

Partial restoration of cardiac function with ΔPDZ nNOS in aged mdx model of Duchenne cardiomyopathy. Hum Mol Genet (2014) 0.86

Spatial confinement of isoforms of cardiac nitric-oxide synthase: unravelling the complexities of nitric oxide's cardiobiology. Lancet (2004) 0.85

Estradiol increases angiotensin II type 1 receptor in hearts of ovariectomized rats. J Endocrinol (2008) 0.85

Regulation of Ryanodine Receptor Ion Channels Through Posttranslational Modifications. Curr Top Membr (2010) 0.84

Abnormal Ca(2+) cycling in failing ventricular myocytes: role of NOS1-mediated nitroso-redox balance. Antioxid Redox Signal (2014) 0.83

Quality control systems in cardiac aging. Ageing Res Rev (2015) 0.83

Vascular endothelial dysfunction and pharmacological treatment. World J Cardiol (2015) 0.83

Ablation of iNOS delays cardiac contractile dysfunction in chronic hypertension. Front Biosci (Elite Ed) (2010) 0.82

Baroreflex activation for the treatment of heart failure. Curr Cardiol Rep (2012) 0.81

Role of xanthine oxidoreductase in cardiac nitroso-redox imbalance. Front Biosci (Landmark Ed) (2009) 0.81

Modulation of myocardial contraction by peroxynitrite. Front Physiol (2012) 0.81

The role of exercise on L-arginine nitric oxide pathway in chronic heart failure. Open Biochem J (2009) 0.81

Nitric oxide synthases, S-nitrosylation and cardiovascular health: from molecular mechanisms to therapeutic opportunities (review). Mol Med Rep (2014) 0.81

Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle. Naunyn Schmiedebergs Arch Pharmacol (2011) 0.81

Caveolins in cardioprotection - translatability and mechanisms. Br J Pharmacol (2015) 0.80

Effects of biological sex on the pathophysiology of the heart. Br J Pharmacol (2014) 0.80

Targeted antioxidant treatment decreases cardiac alternans associated with chronic myocardial infarction. Circ Arrhythm Electrophysiol (2014) 0.79

Inflammatory cytokines and nitric oxide in heart failure and potential modulation by vagus nerve stimulation. Heart Fail Rev (2011) 0.79

Prolonged Action Potential and After depolarizations Are Not due to Changes in Potassium Currents in NOS3 Knockout Ventricular Myocytes. J Signal Transduct (2012) 0.79

Chronic β1-adrenergic blockade enhances myocardial β3-adrenergic coupling with nitric oxide-cGMP signaling in a canine model of chronic volume overload: new insight into mechanisms of cardiac benefit with selective β1-blocker therapy. Basic Res Cardiol (2014) 0.79

Human Ischemic Cardiomyopathy Shows Cardiac Nos1 Translocation and its Increased Levels are Related to Left Ventricular Performance. Sci Rep (2016) 0.78

β3-Adrenoreceptor stimulation protects against myocardial infarction injury via eNOS and nNOS activation. PLoS One (2014) 0.78

Device-based autonomic modulation in arrhythmia patients: the role of vagal nerve stimulation. Curr Treat Options Cardiovasc Med (2015) 0.77

ROS and endothelial nitric oxide synthase (eNOS)-dependent trafficking of angiotensin II type 2 receptor begets neuronal NOS in cardiac myocytes. Basic Res Cardiol (2015) 0.77

Simvastatin attenuates the oxidative stress, endothelial thrombogenicity and the inducibility of atrial fibrillation in a rat model of ischemic heart failure. Int J Mol Sci (2014) 0.76

Calcium/calmodulin-dependent kinase II and nitric oxide synthase 1-dependent modulation of ryanodine receptors during β-adrenergic stimulation is restricted to the dyadic cleft. J Physiol (2016) 0.76

Is reversal of endothelial dysfunction still an attractive target in modern cardiology? World J Cardiol (2014) 0.76

Confounding variables and expression of myocardial NOS. Lancet (2004) 0.75

Caveolin-3 plays a critical role in autophagy after ischemia-reperfusion. Am J Physiol Cell Physiol (2016) 0.75

Neuronal nitric oxide synthase in hypertension - an update. Clin Hypertens (2016) 0.75

The Subcellular Localisation of Neuronal Nitric Oxide Synthase Determines the Downstream Effects of NO on Myocardial Function. Cardiovasc Res (2017) 0.75

Mechanotransduction and Metabolism in Cardiomyocyte Microdomains. Biomed Res Int (2016) 0.75

Nitric oxide signalling and neuronal nitric oxide synthase in the heart under stress. F1000Res (2017) 0.75

Articles by these authors

Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science (2013) 10.87

Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proc Natl Acad Sci U S A (2010) 7.77

Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy. N Engl J Med (2015) 6.00

Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial. JAMA (2013) 5.41

2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J (2015) 5.15

Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells. Sci Transl Med (2013) 4.74

Pluripotency of spermatogonial stem cells from adult mouse testis. Nature (2006) 4.29

Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase. Circ Res (2012) 4.19

Increased myocardial NADPH oxidase activity in human heart failure. J Am Coll Cardiol (2003) 3.73

Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J Clin Invest (2006) 3.33

Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. Am J Physiol Regul Integr Comp Physiol (2004) 3.27

Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study. J Am Coll Cardiol (2011) 3.13

Generation of functional murine cardiac myocytes from induced pluripotent stem cells. Circulation (2008) 3.11

Redox signaling in cardiac physiology and pathology. Circ Res (2012) 2.98

NADPH oxidases in cardiovascular health and disease. Antioxid Redox Signal (2006) 2.95

Essential role of the NADPH oxidase subunit p47(phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-alpha. Circ Res (2002) 2.79

Regulation of cardiac contractile function by troponin I phosphorylation. Cardiovasc Res (2005) 2.79

Low-energy control of electrical turbulence in the heart. Nature (2011) 2.75

Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS Biol (2010) 2.72

Pivotal role of a gp91(phox)-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice. Circulation (2002) 2.57

Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy. Circ Res (2003) 2.50

Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation. J Mol Cell Cardiol (2008) 2.49

Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo. Arterioscler Thromb Vasc Biol (2011) 2.44

Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves contractility in human failing myocardium. Circ Res (2010) 2.38

NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis. Proc Natl Acad Sci U S A (2010) 2.36

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29

Oxidative stress and redox signalling in cardiac hypertrophy and heart failure. Heart (2006) 2.28

Activation of NADPH oxidase during progression of cardiac hypertrophy to failure. Hypertension (2002) 2.20

The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4. J Biol Chem (2011) 2.20

Differential cardiac remodeling in preload versus afterload. Circulation (2010) 2.20

Circulating microparticles from patients with septic shock exert protective role in vascular function. Am J Respir Crit Care Med (2008) 2.09

Intracellular localization and preassembly of the NADPH oxidase complex in cultured endothelial cells. J Biol Chem (2002) 2.05

Altered Na(+) currents in atrial fibrillation effects of ranolazine on arrhythmias and contractility in human atrial myocardium. J Am Coll Cardiol (2010) 2.04

CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation. Circ Res (2010) 2.02

Changing characteristics and mode of death associated with chronic heart failure caused by left ventricular systolic dysfunction: a study across therapeutic eras. Circ Heart Fail (2011) 1.96

Rate dependence of [Na+]i and contractility in nonfailing and failing human myocardium. Circulation (2002) 1.95

Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase. FASEB J (2006) 1.90

Activation of p38 mitogen-activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor. J Am Coll Cardiol (2006) 1.89

NADPH oxidase-dependent redox signalling in cardiac hypertrophy, remodelling and failure. Cardiovasc Res (2006) 1.88

NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity. Circulation (2005) 1.87

Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction. Basic Res Cardiol (2011) 1.87

Remote intermittent ischemia before coronary artery bypass graft surgery: a strategy to reduce injury and inflammation? Basic Res Cardiol (2011) 1.81

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ Res (2013) 1.81

Leptin is an endothelial-independent vasodilator in humans with coronary artery disease: Evidence for tissue specificity of leptin resistance. Eur Heart J (2006) 1.81

Nox4 and nox2 NADPH oxidases mediate distinct cellular redox signaling responses to agonist stimulation. Arterioscler Thromb Vasc Biol (2008) 1.77

High precision quantitative proteomics using iTRAQ on an LTQ Orbitrap: a new mass spectrometric method combining the benefits of all. J Proteome Res (2009) 1.75

Abnormal plasma microparticles impair vasoconstrictor responses in patients with cirrhosis. Gastroenterology (2012) 1.69

Predictive value of the high-sensitivity troponin T assay and the simplified Pulmonary Embolism Severity Index in hemodynamically stable patients with acute pulmonary embolism: a prospective validation study. Circulation (2011) 1.68

Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction. Hypertension (2008) 1.68

Cardiac specific increase in aldosterone production induces coronary dysfunction in aldosterone synthase-transgenic mice. Circulation (2004) 1.67

Ca2+/calmodulin-dependent protein kinase II and protein kinase A differentially regulate sarcoplasmic reticulum Ca2+ leak in human cardiac pathology. Circulation (2013) 1.67

Leptin enhances the recruitment of endothelial progenitor cells into neointimal lesions after vascular injury by promoting integrin-mediated adhesion. Circ Res (2008) 1.66

Atrial overdrive pacing in patients with sleep apnea with implanted pacemaker. Am J Respir Crit Care Med (2005) 1.65

Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human. Hum Mol Genet (2012) 1.64

Smooth muscle cells differentiated from reprogrammed embryonic lung fibroblasts through DKK3 signaling are potent for tissue engineering of vascular grafts. Circ Res (2013) 1.62

Redox signaling in cardiac myocytes. Free Radic Biol Med (2011) 1.62

Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail (2009) 1.61

Mechanism of endothelial cell NADPH oxidase activation by angiotensin II. Role of the p47phox subunit. J Biol Chem (2003) 1.60

Elevated heart-type fatty acid-binding protein levels on admission predict an adverse outcome in normotensive patients with acute pulmonary embolism. J Am Coll Cardiol (2010) 1.59

Role of phosphoinositide 3-kinase {alpha}, protein kinase C, and L-type Ca2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractility. Hypertension (2010) 1.59

NADPH oxidase and endothelial cell function. Clin Sci (Lond) (2005) 1.58

Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. Circulation (2007) 1.57

Differential interaction of clinical characteristics with key functional parameters in heart failure with preserved ejection fraction--results of the Aldo-DHF trial. Int J Cardiol (2013) 1.56

IGF-binding protein-2 protects against the development of obesity and insulin resistance. Diabetes (2007) 1.56

Heart-type fatty acid-binding protein permits early risk stratification of pulmonary embolism. Eur Heart J (2006) 1.55

Involvement of beta 3-adrenoceptor in altered beta-adrenergic response in senescent heart: role of nitric oxide synthase 1-derived nitric oxide. Anesthesiology (2008) 1.54

Role of cyclic GMP-dependent protein kinase in the contractile response to exogenous nitric oxide in rat cardiac myocytes. J Physiol (2002) 1.54

Ca(2+) /calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca(2+) leak in human ischaemic and dilated cardiomyopathy. Eur J Heart Fail (2014) 1.52

Effect of endothelium-specific insulin resistance on endothelial function in vivo. Diabetes (2008) 1.52

Pathological cardiac hypertrophy alters intracellular targeting of phosphodiesterase type 5 from nitric oxide synthase-3 to natriuretic peptide signaling. Circulation (2012) 1.51

Endothelial dysfunction caused by circulating microparticles from patients with metabolic syndrome. Am J Pathol (2008) 1.51

Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction. Diabetes (2013) 1.51

Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy. Circ Res (2008) 1.50

Acute tumor necrosis factor alpha signaling via NADPH oxidase in microvascular endothelial cells: role of p47phox phosphorylation and binding to TRAF4. Mol Cell Biol (2005) 1.50

Plasminogen activator inhibitor-1 from bone marrow-derived cells suppresses neointimal formation after vascular injury in mice. Arterioscler Thromb Vasc Biol (2006) 1.49

Myocardial adaptation of energy metabolism to elevated preload depends on calcineurin activity : a proteomic approach. Basic Res Cardiol (2008) 1.49

Strain-dependent variation in vascular responses to nitric oxide in the isolated murine heart. J Mol Cell Cardiol (2002) 1.49

2015 ESC Guidelines for the Management of Acute Coronary Syndromes in Patients Presenting Without Persistent ST-segment Elevation. Rev Esp Cardiol (Engl Ed) (2015) 1.49

Unbiased plasma proteomics for novel diagnostic biomarkers in cardiovascular disease: identification of quiescin Q6 as a candidate biomarker of acutely decompensated heart failure. Eur Heart J (2012) 1.48

Biventricular pacing improves the blunted force-frequency relation present during univentricular pacing in patients with heart failure and conduction delay. Circulation (2006) 1.47

Predicting death due to progressive heart failure in patients with mild-to-moderate chronic heart failure. J Am Coll Cardiol (2002) 1.47

Stimulated emission depletion live-cell super-resolution imaging shows proliferative remodeling of T-tubule membrane structures after myocardial infarction. Circ Res (2012) 1.47

The association between saphenous vein endothelial function, systemic inflammation, and statin therapy in patients undergoing coronary artery bypass surgery. J Thorac Cardiovasc Surg (2007) 1.46

Limitations of FKBP12.6-directed treatment strategies for maladaptive cardiac remodeling and heart failure. J Mol Cell Cardiol (2010) 1.46

Peroxidasin-like protein: a novel peroxidase homologue in the human heart. Cardiovasc Res (2013) 1.46

ROS generation by nonphagocytic NADPH oxidase: potential relevance in diabetic nephropathy. J Am Soc Nephrol (2003) 1.45

Absence of leptin resistance in platelets from morbidly obese individuals may contribute to the increased thrombosis risk in obesity. Thromb Haemost (2008) 1.45

Role of myocardial neuronal nitric oxide synthase-derived nitric oxide in beta-adrenergic hyporesponsiveness after myocardial infarction-induced heart failure in rat. Circulation (2004) 1.45

Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse. Circ Res (2008) 1.44

Enhanced expression of DYRK1A in cardiomyocytes inhibits acute NFAT activation but does not prevent hypertrophy in vivo. Cardiovasc Res (2011) 1.44